STRINGSTRING
LOC112390775 LOC112390775 MEF2C MEF2C SUFU SUFU FGF8 FGF8 SMAD3 SMAD3 IFT57 IFT57 DNAAF1 DNAAF1 LBX1 LBX1 PKD2 PKD2 PSEN1 PSEN1 SHH SHH CITED2 CITED2 FOXH1 FOXH1 TBX3 TBX3 SOX17 SOX17 TBX6 TBX6 DLL1 DLL1 IFT52 IFT52 WNT5A WNT5A APLNR APLNR HIF1A HIF1A TBX20 TBX20 HAND2 HAND2 LOC112407716 LOC112407716 ASB2 ASB2 MIB1 MIB1 AHI1 AHI1 ARL13B ARL13B CLUAP1 CLUAP1 HAND1 HAND1 ZIC3 ZIC3 NPHP3 NPHP3 CCDC40 CCDC40 CCDC103 CCDC103 C2CD3 C2CD3 SMO SMO ENG ENG NOTCH1 NOTCH1 IHH IHH NOTCH2 NOTCH2 WNT3A WNT3A SRF SRF MESP1 MESP1 NODAL NODAL CCDC39 CCDC39
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
LOC112390775Folate receptor alpha-like. (251 aa)
MEF2CMyocyte-specific enhancer factor 2C isoform X4. (483 aa)
SUFUSuppressor of fused homolog; Negative regulator in the hedgehog signaling pathway. Down- regulates GLI1-mediated transactivation of target genes. Part of a corepressor complex that acts on DNA-bound GLI1. May also act by linking GLI1 to BTRC and thereby targeting GLI1 to degradation by the proteasome. Sequesters GLI1, GLI2 and GLI3 in the cytoplasm, this effect is overcome by binding of STK36 to both SUFU and a GLI protein. Negative regulator of beta-catenin signaling. Regulates the formation of either the repressor form (GLI3R) or the activator form (GLI3A) of the full-length form of [...] (469 aa)
FGF8Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (244 aa)
SMAD3Mothers against decapentaplegic homolog. (376 aa)
IFT57Intraflagellar transport protein 57 homolog. (427 aa)
DNAAF1Dynein assembly factor 1, axonemal. (680 aa)
LBX1Transcription factor LBX1. (281 aa)
PKD2Polycystin-2 isoform X1. (782 aa)
PSEN1Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (468 aa)
SHHSonic hedgehog protein. (328 aa)
CITED2Cbp/p300-interacting transactivator 2. (263 aa)
FOXH1Forkhead box protein H1. (360 aa)
TBX3LOW QUALITY PROTEIN: T-box transcription factor TBX3. (734 aa)
SOX17LOW QUALITY PROTEIN: transcription factor SOX-17. (207 aa)
TBX6T-box transcription factor TBX6 isoform X1. (463 aa)
DLL1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (759 aa)
IFT52Intraflagellar transport protein 52 homolog isoform X1. (456 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (380 aa)
APLNRApelin receptor; Belongs to the G-protein coupled receptor 1 family. (383 aa)
HIF1AHypoxia-inducible factor 1-alpha. (823 aa)
TBX20T-box transcription factor TBX20. (449 aa)
HAND2Heart- and neural crest derivatives-expressed protein 2. (208 aa)
LOC112407716F-actin-monooxygenase MICAL2 isoform X1. (1722 aa)
ASB2Ankyrin repeat and SOCS box protein 2. (600 aa)
MIB1E3 ubiquitin-protein ligase MIB1. (1225 aa)
AHI1Jouberin isoform X1. (1178 aa)
ARL13BADP-ribosylation factor-like protein 13B. (430 aa)
CLUAP1Clusterin-associated protein 1 isoform X1. (457 aa)
HAND1Heart- and neural crest derivatives-expressed protein 1. (218 aa)
ZIC3Zinc finger protein ZIC 3. (455 aa)
NPHP3Nephrocystin-3 isoform X2. (1234 aa)
CCDC40Coiled-coil domain-containing protein 40. (1132 aa)
CCDC103Coiled-coil domain-containing protein 103 isoform X1. (235 aa)
C2CD3C2 domain-containing protein 3 isoform X1. (2400 aa)
SMOSmoothened homolog; Belongs to the G-protein coupled receptor Fz/Smo family. (783 aa)
ENGEndoglin. (652 aa)
NOTCH1LOW QUALITY PROTEIN: neurogenic locus notch homolog protein 1. (2633 aa)
IHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (410 aa)
NOTCH2Neurogenic locus notch homolog protein 2 isoform X1. (2485 aa)
WNT3AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (352 aa)
SRFSerum response factor isoform X1. (535 aa)
MESP1Mesoderm posterior protein 1. (265 aa)
NODALNodal homolog. (348 aa)
CCDC39Coiled-coil domain-containing protein 39. (941 aa)
Your Current Organism:
Neophocaena asiaeorientalis
NCBI taxonomy Id: 1706337
Other names: N. asiaeorientalis asiaeorientalis, Neophocaena asiaeorientalis asiaeorientalis, Yangtze finless porpoise
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