STRINGSTRING
DLL4 DLL4 ADAMTS1 ADAMTS1 SAV1 SAV1 COL4A3BP COL4A3BP GJA5 GJA5 MEF2C MEF2C ATF2 ATF2 SUFU SUFU FGF8 FGF8 SMAD3 SMAD3 IFT57 IFT57 JAG1 JAG1 TGFBR1 TGFBR1 BMP4 BMP4 DNAAF1 DNAAF1 ZFPM1 ZFPM1 FOXF1 FOXF1 LBX1 LBX1 EDNRA EDNRA NPY1R NPY1R PKD2 PKD2 SMAD6 SMAD6 FLRT2 FLRT2 ARID2 ARID2 NPY5R NPY5R ACVRL1 ACVRL1 COL2A1 COL2A1 BMPR2 BMPR2 DNAH11 DNAH11 TWIST1 TWIST1 PSEN1 PSEN1 BMP10 BMP10 ZMPSTE24 ZMPSTE24 SHH SHH TGFB2 TGFB2 HEYL HEYL NRP2 NRP2 DSP DSP EYA1 EYA1 SHOX2 SHOX2 ZMIZ1 ZMIZ1 ADGRG6 ADGRG6 ISL1 ISL1 CITED2 CITED2 CAV3 CAV3 ANKRD1 ANKRD1 LOC112397124 LOC112397124 EXT1 EXT1 SOX4 SOX4 HTR2B HTR2B FOXH1 FOXH1 SYNPO2L SYNPO2L FLNA FLNA TBX3 TBX3 TBX5 TBX5 MED1 MED1 MSX1 MSX1 SEC24B SEC24B MYLK2 MYLK2 RBM15 RBM15 TCAP TCAP TBX19 TBX19 CCM2L CCM2L SOX17 SOX17 CHD7 CHD7 ASXL1 ASXL1 KDM6A KDM6A EMP2 EMP2 TGFBR3 TGFBR3 TBXT TBXT FHL2 FHL2 TBX6 TBX6 DLL1 DLL1 TGFBR3L TGFBR3L MYL10 MYL10 IFT52 IFT52 INSR INSR ELN ELN TNNC1 TNNC1 WNT5A WNT5A PKP2 PKP2 EFNA1 EFNA1 SIX1 SIX1 APLNR APLNR HIF1A HIF1A ADAM15 ADAM15 TNNI1 TNNI1 TNNT2 TNNT2 DHRS3 DHRS3 MTOR MTOR MYBPC3 MYBPC3 TBX20 TBX20 GATA5 GATA5 S1PR1 S1PR1 BMP7 BMP7 SNAI1 SNAI1 MYL3 MYL3 HAND2 HAND2 PROX1 PROX1 TREX1 TREX1 ADPRHL1 ADPRHL1 HES1 HES1 SLIT3 SLIT3 NKX2-5 NKX2-5 RTN4 RTN4 SOS1 SOS1 PTCH1 PTCH1 NIPBL NIPBL SMARCD3 SMARCD3 TEK TEK LOC112406076 LOC112406076 LOC112406197 LOC112406197 HEG1 HEG1 JUN JUN PLXND1 PLXND1 ZFPM2 ZFPM2 GRHL2 GRHL2 XIRP2 XIRP2 SMAD7 SMAD7 LRP2 LRP2 PRLHR PRLHR PTCD2 PTCD2 ILK ILK PARVA PARVA DCHS1 DCHS1 LOC112407979 LOC112407979 SMAD4 SMAD4 WNT11 WNT11 NOG NOG WNT16 WNT16 MKS1 MKS1 TBX2 TBX2 LOC112407716 LOC112407716 ASB2 ASB2 GATA6 GATA6 MIB1 MIB1 LOC112407988 LOC112407988 TMEM100 TMEM100 WNT2 WNT2 MYL2 MYL2 AHI1 AHI1 ARL13B ARL13B HEY2 HEY2 YAP1 YAP1 POU4F1 POU4F1 CLUAP1 CLUAP1 AXIN2 AXIN2 FZD2 FZD2 SOX9 SOX9 GAA GAA HAND1 HAND1 GATA4 GATA4 ZIC3 ZIC3 RYR2 RYR2 TAB1 TAB1 NPHP3 NPHP3 CCDC40 CCDC40 CCDC103 CCDC103 C2CD3 C2CD3 LOC112411262 LOC112411262 SEMA3C SEMA3C NSD2 NSD2 GATA3 GATA3 LOC112390775 LOC112390775 BMPR1A BMPR1A DVL2 DVL2 SMO SMO ENG ENG COL5A1 COL5A1 NOTCH1 NOTCH1 IHH IHH CRKL CRKL EDN1 EDN1 ADPRH ADPRH NOTCH2 NOTCH2 CPE CPE BMP2 BMP2 WNT3A WNT3A SRF SRF LEMD2 LEMD2 MESP2 MESP2 MESP1 MESP1 NODAL NODAL EGLN1 EGLN1 NPY2R NPY2R TEAD2 TEAD2 CYR61 CYR61 PPP1R13L PPP1R13L MEGF8 MEGF8 CCDC39 CCDC39 ALDH1A2 ALDH1A2 GSK3A GSK3A TGFB1 TGFB1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
DLL4Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (685 aa)
ADAMTS1A disintegrin and metalloproteinase with thrombospondin motifs 1. (940 aa)
SAV1Protein salvador homolog 1. (384 aa)
COL4A3BPCollagen type IV alpha-3-binding protein isoform X2. (755 aa)
GJA5Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. (358 aa)
MEF2CMyocyte-specific enhancer factor 2C isoform X4. (483 aa)
ATF2Cyclic AMP-dependent transcription factor ATF-2 isoform X1. (505 aa)
SUFUSuppressor of fused homolog; Negative regulator in the hedgehog signaling pathway. Down- regulates GLI1-mediated transactivation of target genes. Part of a corepressor complex that acts on DNA-bound GLI1. May also act by linking GLI1 to BTRC and thereby targeting GLI1 to degradation by the proteasome. Sequesters GLI1, GLI2 and GLI3 in the cytoplasm, this effect is overcome by binding of STK36 to both SUFU and a GLI protein. Negative regulator of beta-catenin signaling. Regulates the formation of either the repressor form (GLI3R) or the activator form (GLI3A) of the full-length form of [...] (469 aa)
FGF8Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (244 aa)
SMAD3Mothers against decapentaplegic homolog. (376 aa)
IFT57Intraflagellar transport protein 57 homolog. (427 aa)
JAG1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1177 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (438 aa)
BMP4Bone morphogenetic protein 4 isoform X1. (420 aa)
DNAAF1Dynein assembly factor 1, axonemal. (680 aa)
ZFPM1Zinc finger protein ZFPM1. (998 aa)
FOXF1Forkhead box protein F1. (375 aa)
LBX1Transcription factor LBX1. (281 aa)
EDNRAEndothelin-1 receptor isoform X1; Belongs to the G-protein coupled receptor 1 family. (427 aa)
NPY1RNeuropeptide Y receptor type 1; Belongs to the G-protein coupled receptor 1 family. (383 aa)
PKD2Polycystin-2 isoform X1. (782 aa)
SMAD6LOW QUALITY PROTEIN: mothers against decapentaplegic homolog 6. (422 aa)
FLRT2Leucine-rich repeat transmembrane protein FLRT2. (660 aa)
ARID2AT-rich interactive domain-containing protein 2. (1836 aa)
NPY5RNeuropeptide Y receptor type 5. (456 aa)
ACVRL1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (515 aa)
COL2A1Collagen alpha-1(II) chain. (1487 aa)
BMPR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1012 aa)
DNAH11LOW QUALITY PROTEIN: dynein heavy chain 11, axonemal. (4517 aa)
TWIST1LOW QUALITY PROTEIN: twist-related protein 1. (152 aa)
PSEN1Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (468 aa)
BMP10Bone morphogenetic protein 10. (423 aa)
ZMPSTE24CAAX prenyl protease; Proteolytically removes the C-terminal three residues of farnesylated proteins; Belongs to the peptidase M48A family. (473 aa)
SHHSonic hedgehog protein. (328 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
HEYLHairy/enhancer-of-split related with YRPW motif-like protein isoform X1. (357 aa)
NRP2Neuropilin; Belongs to the neuropilin family. (931 aa)
DSPDesmoplakin isoform X1. (2874 aa)
EYA1Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (589 aa)
SHOX2Short stature homeobox protein 2 isoform X1. (333 aa)
ZMIZ1Zinc finger MIZ domain-containing protein 1. (1065 aa)
ADGRG6Adhesion G-protein coupled receptor G6 isoform X1; Belongs to the G-protein coupled receptor 2 family. (1251 aa)
ISL1Insulin gene enhancer protein ISL-1. (349 aa)
CITED2Cbp/p300-interacting transactivator 2. (263 aa)
CAV3Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (151 aa)
ANKRD1Ankyrin repeat domain-containing protein 1. (319 aa)
LOC112397124Hyaluronan synthase 2. (552 aa)
EXT1Exostosin-1; Belongs to the glycosyltransferase 47 family. (746 aa)
SOX4Transcription factor SOX-4. (285 aa)
HTR2B5-hydroxytryptamine receptor 2B. (479 aa)
FOXH1Forkhead box protein H1. (360 aa)
SYNPO2LSynaptopodin 2-like protein. (978 aa)
FLNAfilamin-A isoform X1. (2592 aa)
TBX3LOW QUALITY PROTEIN: T-box transcription factor TBX3. (734 aa)
TBX5T-box transcription factor TBX5. (519 aa)
MED1Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1579 aa)
MSX1Homeobox protein MSX-1. (303 aa)
SEC24BProtein transport protein Sec24B isoform X1. (1168 aa)
MYLK2Myosin light chain kinase 2, skeletal/cardiac muscle. (615 aa)
RBM15Putative RNA-binding protein 15. (962 aa)
TCAPTelethonin isoform X1. (167 aa)
TBX19T-box transcription factor TBX19. (444 aa)
CCM2LCerebral cavernous malformations 2 protein-like. (440 aa)
SOX17LOW QUALITY PROTEIN: transcription factor SOX-17. (207 aa)
CHD7LOW QUALITY PROTEIN: chromodomain-helicase-DNA-binding protein 7. (3000 aa)
ASXL1Putative Polycomb group protein ASXL1. (1517 aa)
KDM6ALysine-specific demethylase 6A isoform X1. (1278 aa)
EMP2Epithelial membrane protein 2; Functions as a key regulator of cell membrane composition by regulating proteins surface expression. Also, plays a role in regulation of processes including cell migration, cell proliferation, cell contraction and cell adhesion; Belongs to the PMP-22/EMP/MP20 family. (167 aa)
TGFBR3Transforming growth factor beta receptor type 3 isoform X1. (851 aa)
TBXTBrachyury protein isoform X1. (435 aa)
FHL2Four and a half LIM domains protein 2. (279 aa)
TBX6T-box transcription factor TBX6 isoform X1. (463 aa)
DLL1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (759 aa)
TGFBR3LLOW QUALITY PROTEIN: transforming growth factor-beta receptor type 3-like protein. (412 aa)
MYL10Myosin regulatory light chain 10. (147 aa)
IFT52Intraflagellar transport protein 52 homolog isoform X1. (456 aa)
INSRTyrosine-protein kinase receptor. (1382 aa)
ELNElastin isoform X1. (744 aa)
TNNC1Troponin C, slow skeletal and cardiac muscles. (161 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (380 aa)
PKP2Plakophilin-2. (826 aa)
EFNA1ephrin-A1 isoform X1; Belongs to the ephrin family. (224 aa)
SIX1Homeobox protein SIX1. (284 aa)
APLNRApelin receptor; Belongs to the G-protein coupled receptor 1 family. (383 aa)
HIF1AHypoxia-inducible factor 1-alpha. (823 aa)
ADAM15Disintegrin and metalloproteinase domain-containing protein 15 isoform X1. (866 aa)
TNNI1Troponin I, slow skeletal muscle. (166 aa)
TNNT2Troponin T, cardiac muscle isoform X1. (333 aa)
DHRS3Short-chain dehydrogenase/reductase 3 isoform X1. (368 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2548 aa)
MYBPC3Myosin-binding protein C, cardiac-type. (1277 aa)
TBX20T-box transcription factor TBX20. (449 aa)
GATA5LOW QUALITY PROTEIN: transcription factor GATA-5. (364 aa)
S1PR1Sphingosine 1-phosphate receptor 1; Belongs to the G-protein coupled receptor 1 family. (382 aa)
BMP7Bone morphogenetic protein 7. (431 aa)
SNAI1Zinc finger protein SNAI1. (264 aa)
MYL3Myosin light chain 3. (197 aa)
HAND2Heart- and neural crest derivatives-expressed protein 2. (208 aa)
PROX1Prospero homeobox protein 1 isoform X1. (737 aa)
TREX1Three-prime repair exonuclease 1. (314 aa)
ADPRHL1Protein ADP-ribosylarginine hydrolase-like protein 1. (354 aa)
HES1Transcription factor HES-1. (280 aa)
SLIT3Slit homolog 3 protein isoform X2. (1523 aa)
NKX2-5Homeobox protein Nkx-2.5. (323 aa)
RTN4Reticulon. (1193 aa)
SOS1Son of sevenless homolog 1 isoform X1. (1350 aa)
PTCH1Protein patched homolog 1 isoform X1. (1297 aa)
NIPBLNipped-B protein. (2803 aa)
SMARCD3annotation not available (495 aa)
TEKAngiopoietin-1 receptor isoform X1. (1125 aa)
LOC112406076Protein HEG homolog 1-like. (419 aa)
LOC112406197Alpha-protein kinase 2-like isoform X4. (1680 aa)
HEG1Protein HEG homolog 1. (1138 aa)
JUNLOW QUALITY PROTEIN: transcription factor AP-1; Belongs to the bZIP family. (284 aa)
PLXND1plexin-D1. (1847 aa)
ZFPM2Zinc finger protein ZFPM2. (1150 aa)
GRHL2Grainyhead-like protein 2 homolog isoform X1. (625 aa)
XIRP2Xin actin-binding repeat-containing protein 2 isoform X1. (3323 aa)
SMAD7Mothers against decapentaplegic homolog. (426 aa)
LRP2Low-density lipoprotein receptor-related protein 2 isoform X1. (4651 aa)
PRLHRProlactin-releasing peptide receptor; Belongs to the G-protein coupled receptor 1 family. (370 aa)
PTCD2LOW QUALITY PROTEIN: pentatricopeptide repeat-containing protein 2, mitochondrial. (384 aa)
ILKIntegrin-linked protein kinase isoform X1. (485 aa)
PARVAAlpha-parvin. (347 aa)
DCHS1Protocadherin-16. (3294 aa)
LOC112407979Secreted frizzled-related protein 2-like. (105 aa)
SMAD4Mothers against decapentaplegic homolog. (599 aa)
WNT11Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa)
NOGNoggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. (232 aa)
WNT16Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (362 aa)
MKS1Meckel syndrome type 1 protein isoform X2. (607 aa)
TBX2T-box transcription factor TBX2. (588 aa)
LOC112407716F-actin-monooxygenase MICAL2 isoform X1. (1722 aa)
ASB2Ankyrin repeat and SOCS box protein 2. (600 aa)
GATA6Transcription factor GATA-6. (448 aa)
MIB1E3 ubiquitin-protein ligase MIB1. (1225 aa)
LOC112407988Secreted frizzled-related protein 2. (294 aa)
TMEM100Transmembrane protein 100. (134 aa)
WNT2Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (360 aa)
MYL2Myosin regulatory light chain 2, ventricular/cardiac muscle isoform. (166 aa)
AHI1Jouberin isoform X1. (1178 aa)
ARL13BADP-ribosylation factor-like protein 13B. (430 aa)
HEY2Hairy/enhancer-of-split related with YRPW motif protein 2. (337 aa)
YAP1Transcriptional coactivator YAP1. (416 aa)
POU4F1POU domain protein. (320 aa)
CLUAP1Clusterin-associated protein 1 isoform X1. (457 aa)
AXIN2Axin-2. (720 aa)
FZD2Frizzled-2; Belongs to the G-protein coupled receptor Fz/Smo family. (709 aa)
SOX9Transcription factor SOX-9. (486 aa)
GAALysosomal alpha-glucosidase isoform X1; Belongs to the glycosyl hydrolase 31 family. (943 aa)
HAND1Heart- and neural crest derivatives-expressed protein 1. (218 aa)
GATA4Transcription factor GATA-4. (291 aa)
ZIC3Zinc finger protein ZIC 3. (455 aa)
RYR2Ryanodine receptor 2. (4971 aa)
TAB1TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 isoform X1. (504 aa)
NPHP3Nephrocystin-3 isoform X2. (1234 aa)
CCDC40Coiled-coil domain-containing protein 40. (1132 aa)
CCDC103Coiled-coil domain-containing protein 103 isoform X1. (235 aa)
C2CD3C2 domain-containing protein 3 isoform X1. (2400 aa)
LOC112411262LOW QUALITY PROTEIN: transcriptional enhancer factor TEF-4-like. (282 aa)
SEMA3Csemaphorin-3C; Belongs to the semaphorin family. (751 aa)
NSD2Histone-lysine N-methyltransferase NSD2 isoform X1. (1373 aa)
GATA3Trans-acting T-cell-specific transcription factor GATA-3 isoform X1. (444 aa)
LOC112390775Folate receptor alpha-like. (251 aa)
BMPR1AReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
DVL2Segment polarity protein dishevelled homolog DVL-2 isoform X1. (785 aa)
SMOSmoothened homolog; Belongs to the G-protein coupled receptor Fz/Smo family. (783 aa)
ENGEndoglin. (652 aa)
COL5A1Collagen alpha-1(V) chain. (1652 aa)
NOTCH1LOW QUALITY PROTEIN: neurogenic locus notch homolog protein 1. (2633 aa)
IHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (410 aa)
CRKLCrk-like protein. (303 aa)
EDN1Endothelin-1. (202 aa)
ADPRHADP-ribosylarginine hydrolase. (373 aa)
NOTCH2Neurogenic locus notch homolog protein 2 isoform X1. (2485 aa)
CPECarboxypeptidase E. (364 aa)
BMP2Bone morphogenetic protein 2 isoform X1. (395 aa)
WNT3AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (352 aa)
SRFSerum response factor isoform X1. (535 aa)
LEMD2LEM domain-containing protein 2. (417 aa)
MESP2Mesoderm posterior protein 2. (366 aa)
MESP1Mesoderm posterior protein 1. (265 aa)
NODALNodal homolog. (348 aa)
EGLN1Egl nine homolog 1. (225 aa)
NPY2RNeuropeptide Y receptor type 2; Belongs to the G-protein coupled receptor 1 family. (384 aa)
TEAD2Transcriptional enhancer factor TEF-4 isoform X1. (462 aa)
CYR61Protein CYR61. (382 aa)
PPP1R13LrelA-associated inhibitor. (808 aa)
MEGF8Multiple epidermal growth factor-like domains protein 8. (2784 aa)
CCDC39Coiled-coil domain-containing protein 39. (941 aa)
ALDH1A2Retinal dehydrogenase 2 isoform X1; Belongs to the aldehyde dehydrogenase family. (526 aa)
GSK3AGlycogen synthase kinase-3 alpha. (320 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (391 aa)
Your Current Organism:
Neophocaena asiaeorientalis
NCBI taxonomy Id: 1706337
Other names: N. asiaeorientalis asiaeorientalis, Neophocaena asiaeorientalis asiaeorientalis, Yangtze finless porpoise
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