STRINGSTRING
SMAD1 SMAD1 ENG ENG TWSG1 TWSG1 CLDN5 CLDN5 ADAM9 ADAM9 SIRT1 SIRT1 NODAL NODAL COL1A2 COL1A2 TGFB1 TGFB1 EID2 EID2 LTBP4 LTBP4 CAV2 CAV2 ZYX ZYX PTPRK PTPRK LOC112409615 LOC112409615 LOC112409616 LOC112409616 TAB1 TAB1 PML PML MTMR4 MTMR4 SMAD4 SMAD4 LRRC32 LRRC32 SMAD2 SMAD2 ITGB5 ITGB5 SMAD7 SMAD7 JUN JUN SMAD9 SMAD9 ONECUT2 ONECUT2 ONECUT1 ONECUT1 NPNT NPNT FLCN FLCN SMAD5 SMAD5 NRROS NRROS HPGD HPGD FUT8 FUT8 LPXN LPXN LTBP3 LTBP3 GCNT2 GCNT2 APPL1 APPL1 TGFBR3L TGFBR3L WFIKKN2 WFIKKN2 STAT3 STAT3 TGFBR3 TGFBR3 TGFBR2 TGFBR2 CITED1 CITED1 SRC SRC HIPK2 HIPK2 PXN PXN FOXH1 FOXH1 LOC112397373 LOC112397373 LOC112396051 LOC112396051 CITED2 CITED2 ZMIZ1 ZMIZ1 ZFYVE9 ZFYVE9 ITGB8 ITGB8 TGFB2 TGFB2 TGFB3 TGFB3 NLK NLK USP15 USP15 ACVRL1 ACVRL1 ACVR1 ACVR1 FERMT2 FERMT2 SMAD6 SMAD6 ARRB2 ARRB2 SKIL SKIL TGFBR1 TGFBR1 GLG1 GLG1 SMAD3 SMAD3 CDH5 CDH5 APPL2 APPL2 COL3A1 COL3A1 MSTN MSTN CHST11 CHST11
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SMAD1Mothers against decapentaplegic homolog. (465 aa)
ENGEndoglin. (652 aa)
TWSG1Twisted gastrulation protein homolog 1. (223 aa)
CLDN5Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (218 aa)
ADAM9Disintegrin and metalloproteinase domain-containing protein 9. (819 aa)
SIRT1NAD-dependent protein deacetylase sirtuin-1 isoform X1. (557 aa)
NODALNodal homolog. (348 aa)
COL1A2Collagen alpha-2(I) chain. (1366 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (391 aa)
EID2EP300-interacting inhibitor of differentiation 2. (195 aa)
LTBP4Latent-transforming growth factor beta-binding protein 4 isoform X1. (1433 aa)
CAV2Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (162 aa)
ZYXZyxin. (575 aa)
PTPRKReceptor-type tyrosine-protein phosphatase kappa isoform X1. (1439 aa)
LOC112409615Probable ubiquitin carboxyl-terminal hydrolase FAF-X. (235 aa)
LOC112409616Probable ubiquitin carboxyl-terminal hydrolase FAF-X; Belongs to the peptidase C19 family. (2060 aa)
TAB1TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 isoform X1. (504 aa)
PMLProtein PML isoform X1. (965 aa)
MTMR4Myotubularin-related protein 4 isoform X1. (1211 aa)
SMAD4Mothers against decapentaplegic homolog. (599 aa)
LRRC32Leucine-rich repeat-containing protein 32. (663 aa)
SMAD2Mothers against decapentaplegic homolog. (467 aa)
ITGB5Integrin beta; Belongs to the integrin beta chain family. (692 aa)
SMAD7Mothers against decapentaplegic homolog. (426 aa)
JUNLOW QUALITY PROTEIN: transcription factor AP-1; Belongs to the bZIP family. (284 aa)
SMAD9Mothers against decapentaplegic homolog. (440 aa)
ONECUT2One cut domain family member. (367 aa)
ONECUT1One cut domain family member. (465 aa)
NPNTNephronectin isoform X1. (581 aa)
FLCNFolliculin isoform X1. (576 aa)
SMAD5Mothers against decapentaplegic homolog. (465 aa)
NRROSNegative regulator of reactive oxygen species isoform X1. (699 aa)
HPGD15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform X1; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (266 aa)
FUT8Alpha-(1,6)-fucosyltransferase; Catalyzes the addition of fucose in alpha 1-6 linkage to the first GlcNAc residue, next to the peptide chains in N-glycans. Belongs to the glycosyltransferase 23 family. (575 aa)
LPXNLeupaxin isoform X1; Belongs to the paxillin family. (387 aa)
LTBP3Latent-transforming growth factor beta-binding protein 3 isoform X1. (1211 aa)
GCNT2N-acetyllactosaminide beta-1,6-N-acetylglucosaminyl-transferase isoform X1. (419 aa)
APPL1DCC-interacting protein 13-alpha isoform X1. (708 aa)
TGFBR3LLOW QUALITY PROTEIN: transforming growth factor-beta receptor type 3-like protein. (412 aa)
WFIKKN2WAP, Kazal, immunoglobulin, Kunitz and NTR domain-containing protein 2. (574 aa)
STAT3Signal transducer and activator of transcription. (770 aa)
TGFBR3Transforming growth factor beta receptor type 3 isoform X1. (851 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (567 aa)
CITED1Cbp/p300-interacting transactivator 1. (221 aa)
SRCTyrosine-protein kinase. (601 aa)
HIPK2Homeodomain-interacting protein kinase 2. (1027 aa)
PXNPaxillin isoform X2. (626 aa)
FOXH1Forkhead box protein H1. (360 aa)
LOC112397373Uncharacterized protein LOC112397373. (224 aa)
LOC112396051Probable ubiquitin carboxyl-terminal hydrolase FAF-X isoform X1; Belongs to the peptidase C19 family. (2556 aa)
CITED2Cbp/p300-interacting transactivator 2. (263 aa)
ZMIZ1Zinc finger MIZ domain-containing protein 1. (1065 aa)
ZFYVE9Zinc finger FYVE domain-containing protein. (1422 aa)
ITGB8Integrin beta; Belongs to the integrin beta chain family. (767 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
TGFB3Transforming growth factor beta-3. (456 aa)
NLKMitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (527 aa)
USP15Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (981 aa)
ACVRL1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (515 aa)
ACVR1Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (509 aa)
FERMT2Fermitin family homolog 2. (680 aa)
SMAD6LOW QUALITY PROTEIN: mothers against decapentaplegic homolog 6. (422 aa)
ARRB2Beta-arrestin-2. (409 aa)
SKILLOW QUALITY PROTEIN: ski-like protein. (664 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (438 aa)
GLG1Golgi apparatus protein 1. (1177 aa)
SMAD3Mothers against decapentaplegic homolog. (376 aa)
CDH5Cadherin-5; Cadherins are calcium-dependent cell adhesion proteins. (782 aa)
APPL2DCC-interacting protein 13-beta isoform X1. (661 aa)
COL3A1Collagen alpha-1(III) chain. (1463 aa)
MSTNGrowth/differentiation factor 8. (375 aa)
CHST11Carbohydrate sulfotransferase. (418 aa)
Your Current Organism:
Neophocaena asiaeorientalis
NCBI taxonomy Id: 1706337
Other names: N. asiaeorientalis asiaeorientalis, Neophocaena asiaeorientalis asiaeorientalis, Yangtze finless porpoise
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