STRINGSTRING
OSGIN2 OSGIN2 GMFG GMFG PDGFD PDGFD NTF4 NTF4 LIF LIF CLEC11A CLEC11A FGF21 FGF21 GDF15 GDF15 CERS1 CERS1 OSM OSM MIA MIA TGFB1 TGFB1 IL12B IL12B GDF1 GDF1 BMP3 BMP3 NODAL NODAL VEGFA VEGFA BDNF BDNF LOC112413273 LOC112413273 BMP2 BMP2 NGF NGF FAM71F1 FAM71F1 LOC112412347 LOC112412347 PDGFA PDGFA FAM71F2 FAM71F2 INHA INHA PDGFB PDGFB KITLG KITLG ARTN ARTN JAG2 JAG2 FGF20 FGF20 INHBB INHBB GDF6 GDF6 TGFA TGFA THBS4 THBS4 IL11 IL11 GDNF GDNF BMP5 BMP5 IL12A IL12A FGF14 FGF14 EPGN EPGN PPBP PPBP AMBN AMBN AREG AREG LOC112405603 LOC112405603 FGF9 FGF9 EREG EREG FGF5 FGF5 LOC112405635 LOC112405635 BTC BTC LOC112405641 LOC112405641 LOC112404954 LOC112404954 FGF18 FGF18 LOC112404952 LOC112404952 HBEGF HBEGF HGF HGF FGF13 FGF13 IL9 IL9 FGF1 FGF1 NRG2 NRG2 CSPG5 CSPG5 FGF12 FGF12 TDGF1 TDGF1 IL7 IL7 NENF NENF BMP7 BMP7 BMP15 BMP15 FGF19 FGF19 FGF4 FGF4 TIMP1 TIMP1 FGF11 FGF11 IGF2 IGF2 MDK MDK VEGFB VEGFB LOC112401879 LOC112401879 FGF7 FGF7 HDGF HDGF GDF7 GDF7 FGF17 FGF17 CNTF CNTF CHRNB1 CHRNB1 GDF9 GDF9 IL4 IL4 IL5 IL5 MANF MANF CD320 CD320 VGF VGF IL2 IL2 PDGFC PDGFC NRTN NRTN PSPN PSPN FGF2 FGF2 RABEP2 RABEP2 VEGFC VEGFC VEGFD VEGFD GDF5 GDF5 CSF3 CSF3 FBRS FBRS PROK1 PROK1 EGF EGF PTN PTN CSF1 CSF1 LOC112397463 LOC112397463 CSF2 CSF2 FGF10 FGF10 NRG3 NRG3 ANGPTL3 ANGPTL3 CXCL12 CXCL12 FGF22 FGF22 AMH AMH BMP6 BMP6 GKN1 GKN1 TGFB2 TGFB2 CDNF CDNF GDF2 GDF2 GDF10 GDF10 IL6 IL6 PGF PGF TGFB3 TGFB3 BMP8A BMP8A BMP10 BMP10 MACC1 MACC1 GDF11 GDF11 INHBC INHBC OSGIN1 OSGIN1 INHBE INHBE RABEP1 RABEP1 GMFB GMFB BMP4 BMP4 IL34 IL34 FGF8 FGF8 FGF6 FGF6 FGF23 FGF23 NTF3 NTF3 OGN OGN INHBA INHBA MSTN MSTN LOC112392000 LOC112392000 GDF3 GDF3 IGF1 IGF1 SPEM2 SPEM2 LOC112390403 LOC112390403
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
OSGIN2Oxidative stress-induced growth inhibitor 2 isoform X1. (551 aa)
GMFGGlia maturation factor; Belongs to the actin-binding proteins ADF family. GMF subfamily. (153 aa)
PDGFDPlatelet-derived growth factor D isoform X1. (396 aa)
NTF4Neurotrophin-4; Belongs to the NGF-beta family. (210 aa)
LIFLeukemia inhibitory factor. (202 aa)
CLEC11AC-type lectin domain family 11 member A. (324 aa)
FGF21Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
GDF15Growth/differentiation factor 15. (308 aa)
CERS1Ceramide synthase 1. (239 aa)
OSMoncostatin-M. (248 aa)
MIAMelanoma-derived growth regulatory protein isoform X1. (204 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (391 aa)
IL12BInterleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. (329 aa)
GDF1Embryonic growth/differentiation factor 1. (203 aa)
BMP3Bone morphogenetic protein 3; Belongs to the TGF-beta family. (475 aa)
NODALNodal homolog. (348 aa)
VEGFAVascular endothelial growth factor A; Belongs to the PDGF/VEGF growth factor family. (632 aa)
BDNFBrain-derived neurotrophic factor; During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. (248 aa)
LOC112413273LOW QUALITY PROTEIN: uncharacterized protein SPEM2-like. (520 aa)
BMP2Bone morphogenetic protein 2 isoform X1. (395 aa)
NGFBeta-nerve growth factor; Belongs to the NGF-beta family. (241 aa)
FAM71F1Protein FAM71F1. (340 aa)
LOC112412347LOW QUALITY PROTEIN: fibroblast growth factor 11-like; Belongs to the heparin-binding growth factors family. (211 aa)
PDGFAPlatelet-derived growth factor subunit A isoform X1; Belongs to the PDGF/VEGF growth factor family. (211 aa)
FAM71F2LOW QUALITY PROTEIN: protein FAM71F2. (301 aa)
INHAInhibin alpha chain; Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition; Belongs to the TGF-beta family. (364 aa)
PDGFBPlatelet-derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (209 aa)
KITLGKit ligand isoform X1. (295 aa)
ARTNArtemin. (161 aa)
JAG2Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1064 aa)
FGF20Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (211 aa)
INHBBInhibin beta B chain. (345 aa)
GDF6Growth/differentiation factor 6. (462 aa)
TGFAProtransforming growth factor alpha isoform X1. (290 aa)
THBS4Thrombospondin-4. (961 aa)
IL11Interleukin-11. (199 aa)
GDNFGlial cell line-derived neurotrophic factor isoform X1. (211 aa)
BMP5Bone morphogenetic protein 5 isoform X2. (455 aa)
IL12AInterleukin-12 subunit alpha; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated Killer cells, and stimulate the production of IFN-gamma by resting PBMC. (222 aa)
FGF14Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (252 aa)
EPGNEpigen isoform X1. (153 aa)
PPBPC-X-C motif chemokine. (119 aa)
AMBNAmeloblastin. (420 aa)
AREGAmphiregulin isoform X1. (253 aa)
LOC112405603C-X-C motif chemokine. (104 aa)
FGF9Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
EREGProepiregulin. (163 aa)
FGF5Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (270 aa)
LOC112405635C-X-C motif chemokine. (104 aa)
BTCProbetacellulin isoform X1. (178 aa)
LOC112405641C-X-C motif chemokine. (104 aa)
LOC112404954Left-right determination factor 2-like. (252 aa)
FGF18Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (300 aa)
LOC112404952Left-right determination factor 2-like. (217 aa)
HBEGFProheparin-binding EGF-like growth factor. (208 aa)
HGFHepatocyte growth factor isoform X1; Belongs to the peptidase S1 family. (734 aa)
FGF13Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (245 aa)
IL9Interleukin-9. (141 aa)
FGF1Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (155 aa)
NRG2Pro-neuregulin-2, membrane-bound isoform isoform X2. (850 aa)
CSPG5Chondroitin sulfate proteoglycan 5. (680 aa)
FGF12Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (243 aa)
TDGF1Growth factor; Belongs to the EGF-CFC (Cripto-1/FRL1/Cryptic) family. (186 aa)
IL7Interleukin-7 isoform X1. (226 aa)
NENFNeudesin; Belongs to the cytochrome b5 family. (186 aa)
BMP7Bone morphogenetic protein 7. (431 aa)
BMP15Bone morphogenetic protein 15. (394 aa)
FGF19Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (363 aa)
FGF4Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (156 aa)
TIMP1Metalloproteinase inhibitor 1. (260 aa)
FGF11Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (202 aa)
IGF2Insulin-like growth factor II isoform X1. (184 aa)
MDKMidkine isoform X1. (295 aa)
VEGFBVascular endothelial growth factor B; Belongs to the PDGF/VEGF growth factor family. (286 aa)
LOC112401879Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (174 aa)
FGF7Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (194 aa)
HDGFHepatoma-derived growth factor. (205 aa)
GDF7Growth/differentiation factor 7. (381 aa)
FGF17Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (204 aa)
CNTFCiliary neurotrophic factor. (200 aa)
CHRNB1Acetylcholine receptor subunit beta. (506 aa)
GDF9Growth/differentiation factor 9 isoform X1. (454 aa)
IL4Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Belongs to the IL-4/IL-13 family. (133 aa)
IL5Interleukin-5; Factor that induces terminal differentiation of late- developing B-cells to immunoglobulin secreting cells. (135 aa)
MANFLOW QUALITY PROTEIN: mesencephalic astrocyte-derived neurotrophic factor. (226 aa)
CD320CD320 antigen. (370 aa)
VGFNeurosecretory protein VGF. (527 aa)
IL2Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Belongs to the IL-2 family. (154 aa)
PDGFCPlatelet-derived growth factor C isoform X1. (314 aa)
NRTNNeurturin. (197 aa)
PSPNPersephin. (153 aa)
FGF2Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (304 aa)
RABEP2Rab GTPase-binding effector protein 2 isoform X1. (540 aa)
VEGFCVascular endothelial growth factor C; Belongs to the PDGF/VEGF growth factor family. (350 aa)
VEGFDVascular endothelial growth factor D; Belongs to the PDGF/VEGF growth factor family. (354 aa)
GDF5Growth/differentiation factor 5. (499 aa)
CSF3Granulocyte colony-stimulating factor. (195 aa)
FBRSProbable fibrosin-1. (1010 aa)
PROK1LOW QUALITY PROTEIN: prokineticin-1. (105 aa)
EGFPro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (1238 aa)
PTNPleiotrophin isoform X1. (168 aa)
CSF1Macrophage colony-stimulating factor 1. (513 aa)
LOC112397463Interleukin-3-like. (149 aa)
CSF2Granulocyte-macrophage colony-stimulating factor. (134 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
NRG3Pro-neuregulin-3, membrane-bound isoform isoform X3. (613 aa)
ANGPTL3Angiopoietin-related protein 3. (460 aa)
CXCL12Stromal cell-derived factor 1 isoform X3; Belongs to the intercrine alpha (chemokine CxC) family. (119 aa)
FGF22Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (265 aa)
AMHMuellerian-inhibiting factor. (383 aa)
BMP6Bone morphogenetic protein 6. (309 aa)
GKN1Gastrokine-1. (184 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
CDNFCerebral dopamine neurotrophic factor. (187 aa)
GDF2Growth/differentiation factor 2. (431 aa)
GDF10Bone morphogenetic protein 3; Belongs to the TGF-beta family. (477 aa)
IL6Interleukin-6. (208 aa)
PGFPlacenta growth factor isoform X1; Belongs to the PDGF/VEGF growth factor family. (170 aa)
TGFB3Transforming growth factor beta-3. (456 aa)
BMP8ABone morphogenetic protein 8A. (402 aa)
BMP10Bone morphogenetic protein 10. (423 aa)
MACC1LOW QUALITY PROTEIN: metastasis-associated in colon cancer protein 1. (850 aa)
GDF11Growth/differentiation factor 11. (263 aa)
INHBCInhibin beta C chain. (352 aa)
OSGIN1Oxidative stress-induced growth inhibitor 1. (478 aa)
INHBEInhibin beta E chain. (351 aa)
RABEP1Rab GTPase-binding effector protein 1. (872 aa)
GMFBGlia maturation factor; Belongs to the actin-binding proteins ADF family. GMF subfamily. (143 aa)
BMP4Bone morphogenetic protein 4 isoform X1. (420 aa)
IL34Interleukin-34. (219 aa)
FGF8Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (244 aa)
FGF6Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
FGF23Fibroblast growth factor 23; Belongs to the heparin-binding growth factors family. (212 aa)
NTF3Neurotrophin-3; Seems to promote the survival of visceral and proprioceptive sensory neurons; Belongs to the NGF-beta family. (252 aa)
OGNMimecan. (299 aa)
INHBAInhibin beta A chain. (474 aa)
MSTNGrowth/differentiation factor 8. (375 aa)
LOC112392000C-X-C motif chemokine. (74 aa)
GDF3Growth/differentiation factor 3. (364 aa)
IGF1Insulin-like growth factor I isoform X1. (208 aa)
SPEM2LOW QUALITY PROTEIN: uncharacterized protein SPEM2. (482 aa)
LOC112390403LOW QUALITY PROTEIN: spermatid maturation protein 1-like. (310 aa)
Your Current Organism:
Neophocaena asiaeorientalis
NCBI taxonomy Id: 1706337
Other names: N. asiaeorientalis asiaeorientalis, Neophocaena asiaeorientalis asiaeorientalis, Yangtze finless porpoise
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