STRINGSTRING
NKX2-1 NKX2-1 LHX3 LHX3 SMO SMO LHX2 LHX2 EDN1 EDN1 SFRP1 SFRP1 TLL1 TLL1 WNT3A WNT3A DBX1 DBX1 MDFI MDFI CHRD CHRD IFT52 IFT52 ZFR2 ZFR2 GSX2 GSX2 BMP1 BMP1 LRP4 LRP4 AIDA AIDA DISP1 DISP1 TBX20 TBX20 NKX2-2 NKX2-2 PAX6 PAX6 SIX3 SIX3 PTCH1 PTCH1 CTNNB1 CTNNB1 FOXG1 FOXG1 HOXA11 HOXA11 HOXA2 HOXA2 ZFR ZFR VAX2 VAX2 NOG NOG LHX1 LHX1 TCTN1 TCTN1 TBC1D32 TBC1D32 AXIN1 AXIN1 ARL13B ARL13B GSC GSC CER1 CER1 RNF220 RNF220 WNT3 WNT3 FOXA1 FOXA1 BMPR1A BMPR1A RFX4 RFX4 WDR19 WDR19 DLL4 DLL4 TULP3 TULP3 ASCL1 ASCL1 GREM1 GREM1 DMRT3 DMRT3 GLI3 GLI3 EN1 EN1 SUFU SUFU FGF8 FGF8 BMP4 BMP4 TTC21B TTC21B BMPR1B BMPR1B SMAD6 SMAD6 FBXL15 FBXL15 TLL2 TLL2 ACVR1 ACVR1 ACVRL1 ACVRL1 HHIP HHIP GLI1 GLI1 PSEN1 PSEN1 SP8 SP8 SHH SHH LOC112399688 LOC112399688 HOXB2 HOXB2 FOXN4 FOXN4 INTU INTU
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
NKX2-1Homeobox protein Nkx-2.1 isoform X1. (396 aa)
LHX3LIM/homeobox protein Lhx3. (378 aa)
SMOSmoothened homolog; Belongs to the G-protein coupled receptor Fz/Smo family. (783 aa)
LHX2LIM/homeobox protein Lhx2. (406 aa)
EDN1Endothelin-1. (202 aa)
SFRP1Secreted frizzled-related protein 1. (296 aa)
TLL1Metalloendopeptidase. (451 aa)
WNT3AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (352 aa)
DBX1Homeobox protein DBX1. (345 aa)
MDFImyoD family inhibitor isoform X1. (245 aa)
CHRDChordin. (851 aa)
IFT52Intraflagellar transport protein 52 homolog isoform X1. (456 aa)
ZFR2Zinc finger RNA-binding protein 2. (1039 aa)
GSX2GS homeobox 2. (301 aa)
BMP1Metalloendopeptidase. (941 aa)
LRP4Low-density lipoprotein receptor-related protein 4. (1914 aa)
AIDAAxin interactor, dorsalization-associated protein. (306 aa)
DISP1Protein dispatched homolog 1 isoform X1. (1565 aa)
TBX20T-box transcription factor TBX20. (449 aa)
NKX2-2Homeobox protein Nkx-2.2. (273 aa)
PAX6Paired box protein Pax-6 isoform X1. (493 aa)
SIX3Homeobox protein SIX3. (329 aa)
PTCH1Protein patched homolog 1 isoform X1. (1297 aa)
CTNNB1Catenin beta-1. (781 aa)
FOXG1Forkhead box protein G1. (662 aa)
HOXA11Homeobox protein Hox-A11. (318 aa)
HOXA2Homeobox protein Hox-A2. (409 aa)
ZFRZinc finger RNA-binding protein. (1072 aa)
VAX2Ventral anterior homeobox 2. (287 aa)
NOGNoggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. (232 aa)
LHX1LIM/homeobox protein Lhx1. (406 aa)
TCTN1Tectonic-1 isoform X1. (616 aa)
TBC1D32Protein broad-minded. (1231 aa)
AXIN1Axin-1 isoform X1. (866 aa)
ARL13BADP-ribosylation factor-like protein 13B. (430 aa)
GSCHomeobox protein goosecoid. (256 aa)
CER1Cerberus isoform X1. (273 aa)
RNF220E3 ubiquitin-protein ligase RNF220. (571 aa)
WNT3Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (453 aa)
FOXA1Hepatocyte nuclear factor 3-alpha. (466 aa)
BMPR1AReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
RFX4Transcription factor RFX4 isoform X1. (735 aa)
WDR19WD repeat-containing protein 19 isoform X1. (1342 aa)
DLL4Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (685 aa)
TULP3Tubby-like protein; Belongs to the TUB family. (464 aa)
ASCL1LOW QUALITY PROTEIN: achaete-scute homolog 1. (228 aa)
GREM1Gremlin. (184 aa)
DMRT3Doublesex- and mab-3-related transcription factor 3. (473 aa)
GLI3Transcriptional activator GLI3. (1587 aa)
EN1Homeobox protein engrailed-like. (408 aa)
SUFUSuppressor of fused homolog; Negative regulator in the hedgehog signaling pathway. Down- regulates GLI1-mediated transactivation of target genes. Part of a corepressor complex that acts on DNA-bound GLI1. May also act by linking GLI1 to BTRC and thereby targeting GLI1 to degradation by the proteasome. Sequesters GLI1, GLI2 and GLI3 in the cytoplasm, this effect is overcome by binding of STK36 to both SUFU and a GLI protein. Negative regulator of beta-catenin signaling. Regulates the formation of either the repressor form (GLI3R) or the activator form (GLI3A) of the full-length form of [...] (469 aa)
FGF8Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (244 aa)
BMP4Bone morphogenetic protein 4 isoform X1. (420 aa)
TTC21BTetratricopeptide repeat protein 21B isoform X1. (1268 aa)
BMPR1BSerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
SMAD6LOW QUALITY PROTEIN: mothers against decapentaplegic homolog 6. (422 aa)
FBXL15F-box/LRR-repeat protein 15 isoform X1. (300 aa)
TLL2Metalloendopeptidase. (1020 aa)
ACVR1Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (509 aa)
ACVRL1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (515 aa)
HHIPHedgehog-interacting protein. (700 aa)
GLI1Zinc finger protein GLI1 isoform X1. (1106 aa)
PSEN1Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (468 aa)
SP8Transcription factor Sp8. (320 aa)
SHHSonic hedgehog protein. (328 aa)
LOC112399688Tolloid-like protein 1. (645 aa)
HOXB2Homeobox protein Hox-B2. (354 aa)
FOXN4Forkhead box protein N4. (518 aa)
INTUProtein inturned. (933 aa)
Your Current Organism:
Neophocaena asiaeorientalis
NCBI taxonomy Id: 1706337
Other names: N. asiaeorientalis asiaeorientalis, Neophocaena asiaeorientalis asiaeorientalis, Yangtze finless porpoise
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