STRINGSTRING
RAB25 RAB25 ALOX12 ALOX12 PDCD6 PDCD6 GATA3 GATA3 ARF6 ARF6 THBS1 THBS1 LOC112392060 LOC112392060 ATP5F1A ATP5F1A GPI GPI BMP4 BMP4 PLCG2 PLCG2 RAB11A RAB11A IFNG IFNG BCAR1 BCAR1 ATP5F1B ATP5F1B HDAC7 HDAC7 LGMN LGMN SP1 SP1 ITGB1BP1 ITGB1BP1 BMPR2 BMPR2 TGFB2 TGFB2 ZC3H12A ZC3H12A RREB1 RREB1 ANXA1 ANXA1 LOC112395837 LOC112395837 ETS1 ETS1 FGF10 FGF10 ENPP2 ENPP2 FGFBP1 FGFBP1 EGF EGF ANGPT4 ANGPT4 PLCG1 PLCG1 SRC SRC CTSH CTSH STAT5A STAT5A HMOX1 HMOX1 ATOH8 ATOH8 FGF2 FGF2 HSPB1 HSPB1 FOXP1 FOXP1 WNT5A WNT5A DOCK5 DOCK5 KDR KDR MMP9 MMP9 CD40 CD40 SASH1 SASH1 CAPN7 CAPN7 FGF7 FGF7 HIF1A HIF1A RHOJ RHOJ MTOR MTOR PIK3CD PIK3CD JCAD JCAD PIK3CB PIK3CB GPLD1 GPLD1 PROX1 PROX1 HBEGF HBEGF MAP2K3 MAP2K3 FGF18 FGF18 RTN4 RTN4 PRKCE PRKCE EPB41L4B EPB41L4B RIN2 RIN2 AKT3 AKT3 ANXA3 ANXA3 NOS3 NOS3 IRS2 IRS2 TEK TEK CCBE1 CCBE1 PRKD1 PRKD1 ZNF580 ZNF580 JUN JUN PLPP3 PLPP3 NUS1 NUS1 MET MET P2RX4 P2RX4 EPB41L5 EPB41L5 PDPK1 PDPK1 SOX9 SOX9 PRKCA PRKCA ITGB3 ITGB3 MAP3K3 MAP3K3 PDGFB PDGFB PIK3CG PIK3CG ABL1 ABL1 GLIPR2 GLIPR2 VIL1 VIL1 AAMP AAMP PPM1F PPM1F MAPRE2 MAPRE2 FGFR1 FGFR1 ADGRA2 ADGRA2 ADAM9 ADAM9 PLK2 PLK2 AGT AGT NRP1 NRP1 VEGFA VEGFA FLT4 FLT4 SIRT1 SIRT1 CIB1 CIB1 PTK2B PTK2B CALR CALR INSL3 INSL3 TGFB1 TGFB1 PRKD2 PRKD2 FUT1 FUT1 RRAS RRAS HDAC6 HDAC6 EMC10 EMC10
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
RAB25Ras-related protein Rab-25 isoform X1. (238 aa)
ALOX12Arachidonate 12-lipoxygenase, 12S-type. (663 aa)
PDCD6Programmed cell death protein 6 isoform X1. (189 aa)
GATA3Trans-acting T-cell-specific transcription factor GATA-3 isoform X1. (444 aa)
ARF6ADP-ribosylation factor 6; Belongs to the small GTPase superfamily. Arf family. (175 aa)
THBS1Thrombospondin-1. (1170 aa)
LOC112392060Fibroblast growth factor receptor 1-like. (98 aa)
ATP5F1AATP synthase subunit alpha; Produces ATP from ADP in the presence of a proton gradient across the membrane. (553 aa)
GPIGlucose-6-phosphate isomerase; Belongs to the GPI family. (558 aa)
BMP4Bone morphogenetic protein 4 isoform X1. (420 aa)
PLCG21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1265 aa)
RAB11ARas-related protein Rab-11A isoform X1. (218 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (166 aa)
BCAR1Breast cancer anti-estrogen resistance protein 1 isoform X1. (875 aa)
ATP5F1BATP synthase subunit beta; Produces ATP from ADP in the presence of a proton gradient across the membrane. (528 aa)
HDAC7Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1114 aa)
LGMNLegumain. (433 aa)
SP1Transcription factor Sp1. (780 aa)
ITGB1BP1Integrin beta-1-binding protein 1 isoform X1. (206 aa)
BMPR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1012 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
ZC3H12AEndoribonuclease ZC3H12A. (583 aa)
RREB1Ras-responsive element-binding protein 1. (1784 aa)
ANXA1Annexin. (346 aa)
LOC112395837LOW QUALITY PROTEIN: calreticulin-like. (540 aa)
ETS1Protein C-ets-1 isoform X1. (441 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
ENPP2LOW QUALITY PROTEIN: ectonucleotide pyrophosphatase/phosphodiesterase family member 2. (955 aa)
FGFBP1Fibroblast growth factor-binding protein 1. (237 aa)
EGFPro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (1238 aa)
ANGPT4Angiopoietin-4. (498 aa)
PLCG11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1179 aa)
SRCTyrosine-protein kinase. (601 aa)
CTSHPro-cathepsin H; Belongs to the peptidase C1 family. (297 aa)
STAT5ASignal transducer and activator of transcription. (726 aa)
HMOX1Heme oxygenase; Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase. (288 aa)
ATOH8LOW QUALITY PROTEIN: protein atonal homolog 8. (317 aa)
FGF2Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (304 aa)
HSPB1Heat shock protein beta-1; Belongs to the small heat shock protein (HSP20) family. (195 aa)
FOXP1Forkhead box protein P1 isoform X1. (673 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (380 aa)
DOCK5Dedicator of cytokinesis protein 5 isoform X1; Belongs to the DOCK family. (1864 aa)
KDRVascular endothelial growth factor receptor 2 isoform X4; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1356 aa)
MMP9Matrix metalloproteinase-9. (709 aa)
CD40Tumor necrosis factor receptor superfamily member 5 isoform X1. (293 aa)
SASH1SAM and SH3 domain-containing protein 1 isoform X1. (1200 aa)
CAPN7Calpain-7; Belongs to the peptidase C2 family. (813 aa)
FGF7Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (194 aa)
HIF1AHypoxia-inducible factor 1-alpha. (823 aa)
RHOJRho-related GTP-binding protein RhoJ. (236 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2548 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1; Belongs to the PI3/PI4-kinase family. (1078 aa)
JCADLOW QUALITY PROTEIN: junctional protein associated with coronary artery disease. (1227 aa)
PIK3CBPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1064 aa)
GPLD1Phosphatidylinositol-glycan-specific phospholipase D. (849 aa)
PROX1Prospero homeobox protein 1 isoform X1. (737 aa)
HBEGFProheparin-binding EGF-like growth factor. (208 aa)
MAP2K3Dual specificity mitogen-activated protein kinase kinase 3; Belongs to the protein kinase superfamily. (347 aa)
FGF18Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (300 aa)
RTN4Reticulon. (1193 aa)
PRKCEProtein kinase C epsilon type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays essential roles in the regulation of multiple cellular processes linked to cytoskeletal proteins, such as cell adhesion, motility, migration and cell cycle, functions in neuron growth and ion channel regulation, and is involved in immune response, cancer cell invasion and regulation of apoptosis. Mediates cell adhesion to the extracellular matrix via integrin- dependent signaling, by mediating angiotensin-2-induced activation of integrin beta- [...] (737 aa)
EPB41L4BBand 4.1-like protein 4B. (847 aa)
RIN2Ras and Rab interactor 2. (827 aa)
AKT3Non-specific serine/threonine protein kinase. (531 aa)
ANXA3Annexin. (323 aa)
NOS3Nitric oxide synthase; Produces nitric oxide (NO). (1205 aa)
IRS2Insulin receptor substrate 2. (702 aa)
TEKAngiopoietin-1 receptor isoform X1. (1125 aa)
CCBE1Collagen and calcium-binding EGF domain-containing protein 1 isoform X1. (429 aa)
PRKD1Serine/threonine-protein kinase D1 isoform X1. (796 aa)
ZNF580Zinc finger protein 580 isoform X1. (300 aa)
JUNLOW QUALITY PROTEIN: transcription factor AP-1; Belongs to the bZIP family. (284 aa)
PLPP3Phospholipid phosphatase 3. (272 aa)
NUS1Dehydrodolichyl diphosphate synthase complex subunit NUS1. (316 aa)
METHepatocyte growth factor receptor isoform X1. (1382 aa)
P2RX4P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. (388 aa)
EPB41L5Band 4.1-like protein 5 isoform X1. (746 aa)
PDPK13-phosphoinositide-dependent protein kinase 1 isoform X1. (531 aa)
SOX9Transcription factor SOX-9. (486 aa)
PRKCANon-specific serine/threonine protein kinase. (541 aa)
ITGB3Integrin beta; Belongs to the integrin beta chain family. (789 aa)
MAP3K3Mitogen-activated protein kinase kinase kinase 3. (616 aa)
PDGFBPlatelet-derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (209 aa)
PIK3CGPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform isoform X1; Belongs to the PI3/PI4-kinase family. (1121 aa)
ABL1Tyrosine-protein kinase. (1148 aa)
GLIPR2Golgi-associated plant pathogenesis-related protein 1 isoform X1; Belongs to the CRISP family. (154 aa)
VIL1Villin-1. (827 aa)
AAMPAngio-associated migratory cell protein isoform X1. (435 aa)
PPM1FProtein phosphatase 1F isoform X1. (433 aa)
MAPRE2Microtubule-associated protein RP/EB family member 2 isoform X1. (326 aa)
FGFR1Fibroblast growth factor receptor. (722 aa)
ADGRA2Adhesion G protein-coupled receptor A2; Belongs to the G-protein coupled receptor 2 family. (1129 aa)
ADAM9Disintegrin and metalloproteinase domain-containing protein 9. (819 aa)
PLK2Serine/threonine-protein kinase PLK. (685 aa)
AGTAngiotensinogen; Belongs to the serpin family. (477 aa)
NRP1Neuropilin; Belongs to the neuropilin family. (924 aa)
VEGFAVascular endothelial growth factor A; Belongs to the PDGF/VEGF growth factor family. (632 aa)
FLT4Vascular endothelial growth factor receptor 3 isoform X1; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1368 aa)
SIRT1NAD-dependent protein deacetylase sirtuin-1 isoform X1. (557 aa)
CIB1Calcium and integrin-binding protein 1. (191 aa)
PTK2BProtein-tyrosine kinase 2-beta isoform X1; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1009 aa)
CALRCalreticulin. (417 aa)
INSL3Insulin-like 3. (133 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (391 aa)
PRKD2LOW QUALITY PROTEIN: serine/threonine-protein kinase D2. (806 aa)
FUT1L-Fucosyltransferase; Belongs to the glycosyltransferase 11 family. (532 aa)
RRASRas-related protein R-Ras. (209 aa)
HDAC6Histone deacetylase 6 isoform X1. (1176 aa)
EMC10ER membrane protein complex subunit 10 isoform X1. (260 aa)
Your Current Organism:
Neophocaena asiaeorientalis
NCBI taxonomy Id: 1706337
Other names: N. asiaeorientalis asiaeorientalis, Neophocaena asiaeorientalis asiaeorientalis, Yangtze finless porpoise
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