STRINGSTRING
OGT OGT AKT2 AKT2 ADIPOQ ADIPOQ PTK2B PTK2B PDK4 PDK4 SIRT1 SIRT1 GNMT GNMT PPP1R3B PPP1R3B KHK KHK LEPR LEPR GCKR GCKR ADIPOR1 ADIPOR1 FOXK1 FOXK1 PTPN2 PTPN2 GPER1 GPER1 LEP LEP P2RY6 P2RY6 WDR5 WDR5 SIRT7 SIRT7 C1QTNF6 C1QTNF6 SLC4A1 SLC4A1 GCGR GCGR C1QTNF1 C1QTNF1 FOXK2 FOXK2 C1QTNF12 C1QTNF12 USP7 USP7 PGP PGP LOC112408652 LOC112408652 ENPP1 ENPP1 SIK1 SIK1 PASK PASK AKT1 AKT1 LOC112408377 LOC112408377 PPP1R3A PPP1R3A FAM3C FAM3C PTH PTH LOC112408063 LOC112408063 EPM2AIP1 EPM2AIP1 INMT INMT FOXO1 FOXO1 PMAIP1 PMAIP1 HDAC4 HDAC4 RUBCNL RUBCNL IRS2 IRS2 C1QTNF3 C1QTNF3 FBP1 FBP1 SCARB2 SCARB2 NLN NLN LHCGR LHCGR NCOR1 NCOR1 PPP1R3E PPP1R3E PRKCE PRKCE FLCN FLCN ERFE ERFE LOC112404007 LOC112404007 GPLD1 GPLD1 AVPR1B AVPR1B LOC112403916 LOC112403916 LOC112403911 LOC112403911 SLC45A3 SLC45A3 ZNF692 ZNF692 PHLDA2 PHLDA2 INS INS BAD BAD PPP1R3D PPP1R3D ACTN3 ACTN3 IGFBP3 IGFBP3 DDB1 DDB1 GCK GCK LOC112401115 LOC112401115 PRKN PRKN FAM3A FAM3A INSR INSR PDK3 PDK3 SIRT6 SIRT6 KAT2A KAT2A NUPR1 NUPR1 DGKQ DGKQ BCKDK BCKDK STAT3 STAT3 PPP1R3F PPP1R3F IGFBP4 IGFBP4 LCMT1 LCMT1 PDK2 PDK2 KAT2B KAT2B PLEK PLEK ACACB ACACB DDIT4 DDIT4 IRS1 IRS1 MIDN MIDN PPP1R3G PPP1R3G PPP1R3C PPP1R3C NCOA2 NCOA2 ZMPSTE24 ZMPSTE24 EP300 EP300 PPARA PPARA MST1 MST1 SLC35B4 SLC35B4 DYRK2 DYRK2 CBFA2T3 CBFA2T3 MLYCD MLYCD GCG GCG INPP5K INPP5K RORA RORA ACADM ACADM GIT1 GIT1 TIGAR TIGAR GNB3 GNB3 LOC112392089 LOC112392089 NKX1-1 NKX1-1 CRY1 CRY1 IGF1 IGF1 PDK1 PDK1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
OGTUDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit isoform X1. (1046 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
ADIPOQAdiponectin. (243 aa)
PTK2BProtein-tyrosine kinase 2-beta isoform X1; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1009 aa)
PDK4Protein-serine/threonine kinase. (407 aa)
SIRT1NAD-dependent protein deacetylase sirtuin-1 isoform X1. (557 aa)
GNMTGlycine N-methyltransferase. (295 aa)
PPP1R3BProtein phosphatase 1 regulatory subunit. (366 aa)
KHKKetohexokinase isoform X1. (343 aa)
LEPRLeptin receptor isoform X1. (1165 aa)
GCKRLOW QUALITY PROTEIN: glucokinase regulatory protein. (576 aa)
ADIPOR1Adiponectin receptor protein 1. (375 aa)
FOXK1Forkhead box protein K1. (558 aa)
PTPN2Tyrosine-protein phosphatase non-receptor type. (396 aa)
GPER1G-protein coupled estrogen receptor 1; Belongs to the G-protein coupled receptor 1 family. (358 aa)
LEPLeptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...] (167 aa)
P2RY6P2Y purinoceptor 6. (328 aa)
WDR5WD repeat-containing protein 5. (334 aa)
SIRT7NAD-dependent protein deacetylase sirtuin-7. (400 aa)
C1QTNF6Complement C1q tumor necrosis factor-related protein 6. (266 aa)
SLC4A1Anion exchange protein. (963 aa)
GCGRGlucagon receptor; Belongs to the G-protein coupled receptor 2 family. (479 aa)
C1QTNF1Complement C1q tumor necrosis factor-related protein 1. (279 aa)
FOXK2Forkhead box protein K2 isoform X1. (471 aa)
C1QTNF12Adipolin. (267 aa)
USP7Ubiquitin carboxyl-terminal hydrolase 7 isoform X2; Belongs to the peptidase C19 family. (1055 aa)
PGPGlycerol-3-phosphate phosphatase. (396 aa)
LOC112408652Trefoil factor 3-like. (80 aa)
ENPP1Ectonucleotide pyrophosphatase/phosphodiesterase family member 1. (857 aa)
SIK1Serine/threonine-protein kinase SIK1. (657 aa)
PASKPAS domain-containing serine/threonine-protein kinase. (1334 aa)
AKT1RAC-alpha serine/threonine-protein kinase; Belongs to the protein kinase superfamily. (339 aa)
LOC112408377E3 SUMO-protein ligase RanBP2-like isoform X1. (3098 aa)
PPP1R3AProtein phosphatase 1 regulatory subunit 3A. (1116 aa)
FAM3CLOW QUALITY PROTEIN: protein FAM3C. (227 aa)
PTHParathyroid hormone; PTH elevates calcium level by dissolving the salts in bone and preventing their renal excretion; Belongs to the parathyroid hormone family. (119 aa)
LOC112408063Cytochrome c oxidase assembly protein COX11, mitochondrial. (271 aa)
EPM2AIP1EPM2A-interacting protein 1. (608 aa)
INMTLOW QUALITY PROTEIN: indolethylamine N-methyltransferase. (295 aa)
FOXO1Forkhead box protein O1. (511 aa)
PMAIP1Phorbol-12-myristate-13-acetate-induced protein 1. (54 aa)
HDAC4Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1071 aa)
RUBCNLProtein RUBCNL-like isoform X1. (667 aa)
IRS2Insulin receptor substrate 2. (702 aa)
C1QTNF3Complement C1q tumor necrosis factor-related protein 3 isoform X1. (319 aa)
FBP1Fructose-1,6-bisphosphatase 1; Belongs to the FBPase class 1 family. (338 aa)
SCARB2Lysosome membrane protein 2; Belongs to the CD36 family. (478 aa)
NLNNeurolysin, mitochondrial isoform X1. (704 aa)
LHCGRLutropin-choriogonadotropic hormone receptor; Receptor for lutropin-choriogonadotropic hormone. The activity of this receptor is mediated by G proteins which activate adenylate cyclase; Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily. (528 aa)
NCOR1Nuclear receptor corepressor 1 isoform X1. (2454 aa)
PPP1R3ELOW QUALITY PROTEIN: protein phosphatase 1 regulatory subunit 3E. (265 aa)
PRKCEProtein kinase C epsilon type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays essential roles in the regulation of multiple cellular processes linked to cytoskeletal proteins, such as cell adhesion, motility, migration and cell cycle, functions in neuron growth and ion channel regulation, and is involved in immune response, cancer cell invasion and regulation of apoptosis. Mediates cell adhesion to the extracellular matrix via integrin- dependent signaling, by mediating angiotensin-2-induced activation of integrin beta- [...] (737 aa)
FLCNFolliculin isoform X1. (576 aa)
ERFEErythroferrone. (273 aa)
LOC112404007Nicotinamide N-methyltransferase. (264 aa)
GPLD1Phosphatidylinositol-glycan-specific phospholipase D. (849 aa)
AVPR1BVasopressin V1b receptor; Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate a phosphatidyl- inositol-calcium second messenger system. Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily. (423 aa)
LOC112403916Dual specificity protein phosphatase 12-like. (353 aa)
LOC112403911Dual specificity protein phosphatase 12-like. (325 aa)
SLC45A3Solute carrier family 45 member 3. (553 aa)
ZNF692Zinc finger protein 692 isoform X1. (512 aa)
PHLDA2Pleckstrin homology-like domain family A member 2. (131 aa)
INSInsulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (110 aa)
BADBcl2-associated agonist of cell death. (168 aa)
PPP1R3DProtein phosphatase 1 regulatory subunit 3D. (428 aa)
ACTN3Alpha-actinin-3. (902 aa)
IGFBP3Insulin-like growth factor-binding protein 3. (120 aa)
DDB1DNA damage-binding protein 1. (1140 aa)
GCKPhosphotransferase. (537 aa)
LOC112401115General transcription factor II-I repeat domain-containing protein 2. (948 aa)
PRKNE3 ubiquitin-protein ligase parkin; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. (465 aa)
FAM3AProtein FAM3A isoform X3. (230 aa)
INSRTyrosine-protein kinase receptor. (1382 aa)
PDK3Protein-serine/threonine kinase. (369 aa)
SIRT6NAD-dependent protein deacetylase sirtuin-6. (354 aa)
KAT2AHistone acetyltransferase KAT2A. (872 aa)
NUPR1Nuclear protein 1. (82 aa)
DGKQDiacylglycerol kinase. (1041 aa)
BCKDKProtein-serine/threonine kinase. (412 aa)
STAT3Signal transducer and activator of transcription. (770 aa)
PPP1R3FProtein phosphatase 1 regulatory subunit 3F isoform X1. (484 aa)
IGFBP4Insulin-like growth factor-binding protein 4. (258 aa)
LCMT1Leucine carboxyl methyltransferase 1; Methylates the carboxyl group of the C-terminal leucine residue of protein phosphatase 2A catalytic subunits to form alpha- leucine ester residues; Belongs to the methyltransferase superfamily. LCMT family. (332 aa)
PDK2Protein-serine/threonine kinase. (407 aa)
KAT2BHistone acetyltransferase; Belongs to the acetyltransferase family. GCN5 subfamily. (823 aa)
PLEKPleckstrin. (350 aa)
ACACBacetyl-CoA carboxylase 2. (2456 aa)
DDIT4DNA damage-inducible transcript 4 protein. (229 aa)
IRS1Insulin receptor substrate 1. (1248 aa)
MIDNMidnolin. (442 aa)
PPP1R3GProtein phosphatase 1 regulatory subunit 3G. (354 aa)
PPP1R3CProtein phosphatase 1 regulatory subunit 3C; Acts as a glycogen-targeting subunit for PP1 and regulates its activity. Activates glycogen synthase, reduces glycogen phosphorylase activity and limits glycogen breakdown. (317 aa)
NCOA2Nuclear receptor coactivator. (1464 aa)
ZMPSTE24CAAX prenyl protease; Proteolytically removes the C-terminal three residues of farnesylated proteins; Belongs to the peptidase M48A family. (473 aa)
EP300Histone acetyltransferase p300. (2399 aa)
PPARAPeroxisome proliferator-activated receptor alpha. (468 aa)
MST1LOW QUALITY PROTEIN: hepatocyte growth factor-like protein; Belongs to the peptidase S1 family. (732 aa)
SLC35B4UDP-xylose and UDP-N-acetylglucosamine transporter isoform X1. (339 aa)
DYRK2Dual specificity tyrosine-phosphorylation-regulated kinase 2 isoform X1. (537 aa)
CBFA2T3Protein CBFA2T3. (823 aa)
MLYCDmalonyl-CoA decarboxylase, mitochondrial. (498 aa)
GCGGlucagon isoform X1. (180 aa)
INPP5KInositol polyphosphate 5-phosphatase K isoform X3. (476 aa)
RORANuclear receptor ROR-alpha. (386 aa)
ACADMMedium-chain specific acyl-CoA dehydrogenase, mitochondrial isoform X1. (421 aa)
GIT1ARF GTPase-activating protein GIT1 isoform X1. (708 aa)
TIGARFructose-2,6-bisphosphatase TIGAR isoform X1. (269 aa)
GNB3Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 isoform X1. (340 aa)
LOC112392089RAC-alpha serine/threonine-protein kinase. (138 aa)
NKX1-1LOW QUALITY PROTEIN: NK1 transcription factor-related protein 1. (271 aa)
CRY1Cryptochrome-1 isoform X1. (587 aa)
IGF1Insulin-like growth factor I isoform X1. (208 aa)
PDK1Protein-serine/threonine kinase. (378 aa)
Your Current Organism:
Neophocaena asiaeorientalis
NCBI taxonomy Id: 1706337
Other names: N. asiaeorientalis asiaeorientalis, Neophocaena asiaeorientalis asiaeorientalis, Yangtze finless porpoise
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