STRINGSTRING
PIDD1 PIDD1 FAM162A FAM162A BAX BAX BBC3 BBC3 RACK1 RACK1 CYR61 CYR61 TBC1D10A TBC1D10A NDUFA13 NDUFA13 BCL10 BCL10 YJEFN3 YJEFN3 DAP DAP LCK LCK LAPTM5 LAPTM5 NODAL NODAL SIRT1 SIRT1 BAK1 BAK1 TTBK1 TTBK1 MTCH1 MTCH1 DLC1 DLC1 APH1A APH1A WNT3A WNT3A HTRA2 HTRA2 EPHA4 EPHA4 PPM1F PPM1F PICALM PICALM GPER1 GPER1 CARD9 CARD9 TNFSF15 TNFSF15 GSN GSN RPS3 RPS3 USP50 USP50 PML PML CYFIP2 CYFIP2 BOK BOK TFAP4 TFAP4 DDX3X DDX3X MAP3K5 MAP3K5 APAF1 APAF1 AIFM1 AIFM1 SMAD3 SMAD3 APH1B APH1B IFT57 IFT57 HIP1R HIP1R DIABLO DIABLO LOC112407988 LOC112407988 CASP2 CASP2 CASP10 CASP10 LOC112407979 LOC112407979 CFLAR CFLAR CASP8 CASP8 BCAP31 BCAP31 RIPK2 RIPK2 NOD1 NOD1 LOC112406668 LOC112406668 PMAIP1 PMAIP1 MBP MBP CRADD CRADD MALT1 MALT1 DAPK1 DAPK1 PSME1 PSME1 CIDEB CIDEB PSME2 PSME2 F3 F3 NCSTN NCSTN ADRM1 ADRM1 FOXL2 FOXL2 MUL1 MUL1 FADD FADD BAD BAD CASP9 CASP9 NLRP6 NLRP6 S100A8 S100A8 UACA UACA EFNA1 EFNA1 EFNA3 EFNA3 LOC112401809 LOC112401809 LOC112401122 LOC112401122 ACER2 ACER2 SOX7 SOX7 NKX3-1 NKX3-1 REST REST PRELID1 PRELID1 PRR7 PRR7 PDCD2 PDCD2 LOC112399406 LOC112399406 HIP1 HIP1 FIS1 FIS1 STAT3 STAT3 NGFR NGFR PSME3 PSME3 FAS FAS LOC112399310 LOC112399310 CTSH CTSH BCL2L11 BCL2L11 LYN LYN ASPH ASPH EGLN3 EGLN3 MYC MYC COL4A3 COL4A3 ROBO1 ROBO1 TNFSF10 TNFSF10 LOC112396076 LOC112396076 VSIR VSIR AGER AGER PAWR PAWR SENP1 SENP1 GRAMD4 GRAMD4 LGMN LGMN ACVR1C ACVR1C PSMD14 PSMD14 PSENEN PSENEN ALOX12 ALOX12 CASP8AP2 CASP8AP2 PDCD6 PDCD6 SYK SYK FASLG FASLG XDH XDH LOC112391834 LOC112391834 BID BID NLRC4 NLRC4 F2R F2R ATP2A3 ATP2A3 LOC112391536 LOC112391536 ANP32B ANP32B PDCD5 PDCD5 P2RX1 P2RX1 LOC112392028 LOC112392028
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PIDD1P53-induced death domain-containing protein 1. (914 aa)
FAM162AProtein FAM162A isoform X1. (183 aa)
BAXApoptosis regulator BAX. (192 aa)
BBC3LOW QUALITY PROTEIN: bcl-2-binding component 3. (201 aa)
RACK1Receptor of activated protein C kinase 1. (317 aa)
CYR61Protein CYR61. (382 aa)
TBC1D10ATBC1 domain family member 10A isoform X1. (506 aa)
NDUFA13LOW QUALITY PROTEIN: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13. (164 aa)
BCL10B-cell lymphoma/leukemia 10. (233 aa)
YJEFN3yjeF N-terminal domain-containing protein 3. (249 aa)
DAPDeath-associated protein 1. (102 aa)
LCKTyrosine-protein kinase. (509 aa)
LAPTM5Lysosomal-associated transmembrane protein 5. (264 aa)
NODALNodal homolog. (348 aa)
SIRT1NAD-dependent protein deacetylase sirtuin-1 isoform X1. (557 aa)
BAK1Bcl-2 homologous antagonist/killer isoform X1. (239 aa)
TTBK1Tau-tubulin kinase 1. (1313 aa)
MTCH1Mitochondrial carrier homolog 1 isoform X1; Belongs to the mitochondrial carrier (TC 2.A.29) family. (395 aa)
DLC1Rho GTPase-activating protein 7 isoform X1. (1528 aa)
APH1AGamma-secretase subunit APH-1A. (322 aa)
WNT3AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (352 aa)
HTRA2Serine protease HTRA2, mitochondrial. (458 aa)
EPHA4Ephrin type-A receptor 4 isoform X1. (986 aa)
PPM1FProtein phosphatase 1F isoform X1. (433 aa)
PICALMPhosphatidylinositol-binding clathrin assembly protein isoform X11. (686 aa)
GPER1G-protein coupled estrogen receptor 1; Belongs to the G-protein coupled receptor 1 family. (358 aa)
CARD9Caspase recruitment domain-containing protein 9 isoform X2. (539 aa)
TNFSF15Tumor necrosis factor ligand superfamily member 15 isoform X1. (256 aa)
GSNGelsolin isoform X1. (770 aa)
RPS340S ribosomal protein S3; Belongs to the universal ribosomal protein uS3 family. (243 aa)
USP50Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (380 aa)
PMLProtein PML isoform X1. (965 aa)
CYFIP2Cytoplasmic FMR1-interacting protein; Belongs to the CYFIP family. (1253 aa)
BOKBcl-2-related ovarian killer protein. (246 aa)
TFAP4Transcription factor AP-4. (334 aa)
DDX3XATP-dependent RNA helicase DDX3X isoform X1; Belongs to the DEAD box helicase family. (662 aa)
MAP3K5Mitogen-activated protein kinase kinase kinase 5 isoform X2. (1366 aa)
APAF1Apoptotic protease-activating factor 1 isoform X1. (1301 aa)
AIFM1Apoptosis-inducing factor 1, mitochondrial. (613 aa)
SMAD3Mothers against decapentaplegic homolog. (376 aa)
APH1BGamma-secretase subunit APH-1B. (257 aa)
IFT57Intraflagellar transport protein 57 homolog. (427 aa)
HIP1RHuntingtin-interacting protein 1-related protein isoform X1. (1043 aa)
DIABLODiablo homolog, mitochondrial. (237 aa)
LOC112407988Secreted frizzled-related protein 2. (294 aa)
CASP2Caspase-2 isoform X1; Belongs to the peptidase C14A family. (452 aa)
CASP10Caspase-10; Belongs to the peptidase C14A family. (517 aa)
LOC112407979Secreted frizzled-related protein 2-like. (105 aa)
CFLARCASP8 and FADD-like apoptosis regulator isoform X1; Belongs to the peptidase C14A family. (532 aa)
CASP8Caspase-8 isoform X1; Belongs to the peptidase C14A family. (497 aa)
BCAP31B-cell receptor-associated protein 31. (245 aa)
RIPK2Receptor-interacting serine/threonine-protein kinase 2. (387 aa)
NOD1Nucleotide-binding oligomerization domain-containing protein 1 isoform X1. (963 aa)
LOC112406668Serine/threonine-protein kinase Nek5-like isoform X1. (782 aa)
PMAIP1Phorbol-12-myristate-13-acetate-induced protein 1. (54 aa)
MBPMyelin basic protein isoform X2. (326 aa)
CRADDDeath domain-containing protein CRADD isoform X1. (199 aa)
MALT1Mucosa-associated lymphoid tissue lymphoma translocation protein 1. (832 aa)
DAPK1Death-associated protein kinase 1 isoform X1. (1440 aa)
PSME1Proteasome activator complex subunit 1. (249 aa)
CIDEBCell death activator CIDE-B. (219 aa)
PSME2Proteasome activator complex subunit 2. (239 aa)
F3Tissue factor. (297 aa)
NCSTNNicastrin. (709 aa)
ADRM1Proteasomal ubiquitin receptor ADRM1. (407 aa)
FOXL2LOW QUALITY PROTEIN: forkhead box protein L2. (191 aa)
MUL1Mitochondrial ubiquitin ligase activator of NFKB 1. (352 aa)
FADDFAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. (211 aa)
BADBcl2-associated agonist of cell death. (168 aa)
CASP9Caspase-9; Belongs to the peptidase C14A family. (442 aa)
NLRP6LOW QUALITY PROTEIN: NACHT, LRR and PYD domains-containing protein 6. (895 aa)
S100A8Protein S100; Belongs to the S-100 family. (89 aa)
UACAUveal autoantigen with coiled-coil domains and ankyrin repeats isoform X1. (1415 aa)
EFNA1ephrin-A1 isoform X1; Belongs to the ephrin family. (224 aa)
EFNA3ephrin-A3 isoform X1; Belongs to the ephrin family. (238 aa)
LOC112401809Protein S100-A9-like; Belongs to the S-100 family. (128 aa)
LOC112401122Huntingtin-interacting protein 1. (914 aa)
ACER2Alkaline ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid. (275 aa)
SOX7Transcription factor SOX-7. (320 aa)
NKX3-1Homeobox protein Nkx-3.1. (241 aa)
RESTRE1-silencing transcription factor isoform X2. (450 aa)
PRELID1PRELI domain-containing protein 1, mitochondrial. (220 aa)
PRR7Proline-rich protein 7. (269 aa)
PDCD2Programmed cell death protein 2 isoform X1. (344 aa)
LOC112399406Apoptosis-associated speck-like protein containing a CARD isoform X1. (191 aa)
HIP1LOW QUALITY PROTEIN: huntingtin-interacting protein 1. (106 aa)
FIS1Mitochondrial fission 1 protein; Involved in the fragmentation of the mitochondrial network and its perinuclear clustering. (152 aa)
STAT3Signal transducer and activator of transcription. (770 aa)
NGFRTumor necrosis factor receptor superfamily member 16. (427 aa)
PSME3Proteasome activator complex subunit 3 isoform X1. (265 aa)
FASTumor necrosis factor receptor superfamily member 6 isoform X1. (334 aa)
LOC112399310Apoptosis-associated speck-like protein containing a CARD isoform X1. (195 aa)
CTSHPro-cathepsin H; Belongs to the peptidase C1 family. (297 aa)
BCL2L11Bcl-2-like protein 11; Induces apoptosis and anoikis. Belongs to the Bcl-2 family. (196 aa)
LYNTyrosine-protein kinase. (518 aa)
ASPHAspartyl/asparaginyl beta-hydroxylase isoform X1. (754 aa)
EGLN3Egl nine homolog 3. (239 aa)
MYCMyc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (439 aa)
COL4A3Collagen alpha-3(IV) chain isoform X1. (1674 aa)
ROBO1Roundabout homolog 1. (1613 aa)
TNFSF10Tumor necrosis factor ligand superfamily member. (288 aa)
LOC112396076ATP-dependent RNA helicase DDX3X-like; Belongs to the DEAD box helicase family. (656 aa)
VSIRV-type immunoglobulin domain-containing suppressor of T-cell activation. (310 aa)
AGERAdvanced glycosylation end product-specific receptor isoform X1. (513 aa)
PAWRPRKC apoptosis WT1 regulator protein. (183 aa)
SENP1Sentrin-specific protease 1 isoform X1. (690 aa)
GRAMD4GRAM domain-containing protein 4. (843 aa)
LGMNLegumain. (433 aa)
ACVR1CReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (493 aa)
PSMD1426S proteasome non-ATPase regulatory subunit 14 isoform X1. (310 aa)
PSENENGamma-secretase subunit PEN-2. (101 aa)
ALOX12Arachidonate 12-lipoxygenase, 12S-type. (663 aa)
CASP8AP2CASP8-associated protein 2 isoform X1. (1973 aa)
PDCD6Programmed cell death protein 6 isoform X1. (189 aa)
SYKTyrosine-protein kinase. (626 aa)
FASLGTumor necrosis factor ligand superfamily member 6; Belongs to the tumor necrosis factor family. (262 aa)
XDHXanthine dehydrogenase/oxidase isoform X1. (1334 aa)
LOC112391834C-type lectin domain family 7 member A-like isoform X1. (244 aa)
BIDBH3-interacting domain death agonist isoform X1. (326 aa)
NLRC4NLR family CARD domain-containing protein 4 isoform X1. (1024 aa)
F2RProteinase-activated receptor 1; Belongs to the G-protein coupled receptor 1 family. (427 aa)
ATP2A3Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1057 aa)
LOC112391536Cytochrome c 2; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
ANP32BAcidic leucine-rich nuclear phosphoprotein 32 family member B. (261 aa)
PDCD5Programmed cell death protein 5. (125 aa)
P2RX1P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. Belongs to the P2X receptor family. (512 aa)
LOC112392028RE1-silencing transcription factor-like. (305 aa)
Your Current Organism:
Neophocaena asiaeorientalis
NCBI taxonomy Id: 1706337
Other names: N. asiaeorientalis asiaeorientalis, Neophocaena asiaeorientalis asiaeorientalis, Yangtze finless porpoise
Server load: low (26%) [HD]