STRINGSTRING
ASCL2 ASCL2 MED17 MED17 BMPR1A BMPR1A LOC112391706 LOC112391706 RTF1 RTF1 MED21 MED21 LOC112392028 LOC112392028 TRIM8 TRIM8 JAG1 JAG1 LDB1 LDB1 LOC112394149 LOC112394149 EIF4E EIF4E PRDM14 PRDM14 SMC5 SMC5 CDH2 CDH2 DIS3L2 DIS3L2 FGF10 FGF10 ZHX2 ZHX2 PELO PELO MED30 MED30 LDB2 LDB2 LOC112397865 LOC112397865 TBX3 TBX3 BRAF BRAF PRRX1 PRRX1 TCF15 TCF15 MMP24 MMP24 MTF2 MTF2 METTL14 METTL14 STAT3 STAT3 IGF2BP1 IGF2BP1 DLL1 DLL1 GNL3 GNL3 SRRT SRRT HESX1 HESX1 REST REST PIWIL2 PIWIL2 LRP5 LRP5 FGF4 FGF4 SALL4 SALL4 LOC112402756 LOC112402756 SETD6 SETD6 PROX1 PROX1 BCL9L BCL9L DDX6 DDX6 RIF1 RIF1 CUL4A CUL4A HES1 HES1 SIX2 SIX2 ZFP36L2 ZFP36L2 FANCC FANCC LIG4 LIG4 NIPBL NIPBL LOC112406365 LOC112406365 LOC112406614 LOC112406614 NR2E1 NR2E1 FOXO3 FOXO3 LIN28B LIN28B SMC3 SMC3 RAF1 RAF1 KLF10 KLF10 CTR9 CTR9 NOG NOG SS18 SS18 FZD7 FZD7 SMC1A SMC1A LOC112408488 LOC112408488 MED12 MED12 FAXC FAXC MED14 MED14 PCM1 PCM1 YAP1 YAP1 WNT9B WNT9B SOX9 SOX9 MED7 MED7 HES5 HES5 ZIC3 ZIC3 LEO1 LEO1 LOC112411009 LOC112411009 MED27 MED27 NOTCH1 NOTCH1 PHF19 PHF19 VPS72 VPS72 MED15 MED15 FANCD2 FANCD2 LSM1 LSM1 HOOK3 HOOK3 SFRP1 SFRP1 FUT10 FUT10 NODAL NODAL EIF4ENIF1 EIF4ENIF1 PAF1 PAF1 LIF LIF NANOS2 NANOS2
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ASCL2Achaete-scute homolog 2. (191 aa)
MED17Mediator of RNA polymerase II transcription subunit 17; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (651 aa)
BMPR1AReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
LOC112391706Homeobox protein NANOG-like. (225 aa)
RTF1RNA polymerase-associated protein RTF1 homolog. (710 aa)
MED21Mediator of RNA polymerase II transcription subunit 21; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (144 aa)
LOC112392028RE1-silencing transcription factor-like. (305 aa)
TRIM8E3 ubiquitin-protein ligase TRIM8. (551 aa)
JAG1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1177 aa)
LDB1LIM domain-binding protein 1 isoform X1. (411 aa)
LOC112394149LOW QUALITY PROTEIN: LIM domain-binding protein 2-like. (241 aa)
EIF4EEukaryotic translation initiation factor 4E; Belongs to the eukaryotic initiation factor 4E family. (303 aa)
PRDM14PR domain zinc finger protein 14. (571 aa)
SMC5Structural maintenance of chromosomes protein 5 isoform X1. (1106 aa)
CDH2Cadherin-2; Cadherins are calcium-dependent cell adhesion proteins. (995 aa)
DIS3L2DIS3-like exonuclease 2; 3'-5'-exoribonuclease that specifically recognizes RNAs polyuridylated at their 3' end and mediates their degradation. Component of an exosome-independent RNA degradation pathway that mediates degradation of both mRNAs and miRNAs that have been polyuridylated by a terminal uridylyltransferase, such as ZCCHC11/TUT4. Mediates degradation of cytoplasmic mRNAs that have been deadenylated and subsequently uridylated at their 3'. Mediates degradation of uridylated pre-let-7 miRNAs, contributing to the maintenance of embryonic stem (ES) cells. Essential for correct mi [...] (930 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
ZHX2Zinc fingers and homeoboxes protein 2. (838 aa)
PELOProtein pelota homolog; May function in recognizing stalled ribosomes and triggering endonucleolytic cleavage of the mRNA, a mechanism to release non- functional ribosomes and degrade damaged mRNAs. (385 aa)
MED30Mediator of RNA polymerase II transcription subunit 30. (178 aa)
LDB2LIM domain-binding protein 2 isoform X1. (373 aa)
LOC112397865Mediator of RNA polymerase II transcription subunit 14; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (661 aa)
TBX3LOW QUALITY PROTEIN: T-box transcription factor TBX3. (734 aa)
BRAFSerine/threonine-protein kinase B-raf isoform X1. (581 aa)
PRRX1Paired mesoderm homeobox protein 1. (245 aa)
TCF15Transcription factor 15. (229 aa)
MMP24Matrix metalloproteinase-24. (532 aa)
MTF2Metal-response element-binding transcription factor 2 isoform X1. (602 aa)
METTL14N6-adenosine-methyltransferase non-catalytic subunit; Belongs to the MT-A70-like family. (456 aa)
STAT3Signal transducer and activator of transcription. (770 aa)
IGF2BP1Insulin-like growth factor 2 mRNA-binding protein 1 isoform X1. (578 aa)
DLL1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (759 aa)
GNL3Guanine nucleotide-binding protein-like 3 isoform X1. (547 aa)
SRRTSerrate RNA effector molecule homolog. (873 aa)
HESX1Homeobox expressed in ES cells 1 isoform X1. (185 aa)
RESTRE1-silencing transcription factor isoform X2. (450 aa)
PIWIL2Piwi-like protein 2 isoform X1; Belongs to the argonaute family. (971 aa)
LRP5Low-density lipoprotein receptor-related protein 5 isoform X1. (1461 aa)
FGF4Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (156 aa)
SALL4Sal-like protein 4 isoform X1. (1055 aa)
LOC112402756LOW QUALITY PROTEIN: protein-arginine deiminase type-4-like. (680 aa)
SETD6N-lysine methyltransferase SETD6; Protein-lysine N-methyltransferase. Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. SETD6 subfamily. (526 aa)
PROX1Prospero homeobox protein 1 isoform X1. (737 aa)
BCL9LB-cell CLL/lymphoma 9-like protein isoform X1. (1493 aa)
DDX6Probable ATP-dependent RNA helicase DDX6; Belongs to the DEAD box helicase family. (483 aa)
RIF1Telomere-associated protein RIF1. (2389 aa)
CUL4Acullin-4A; Belongs to the cullin family. (734 aa)
HES1Transcription factor HES-1. (280 aa)
SIX2Homeobox protein SIX2 isoform X1. (298 aa)
ZFP36L2mRNA decay activator protein ZFP36L2. (492 aa)
FANCCFanconi anemia group C protein homolog; DNA repair protein that may operate in a postreplication repair or a cell cycle checkpoint function. May be implicated in interstrand DNA cross-link repair and in the maintenance of normal chromosome stability. Upon IFNG induction, may facilitate STAT1 activation by recruiting STAT1 to IFNGR1. (562 aa)
LIG4DNA ligase. (911 aa)
NIPBLNipped-B protein. (2803 aa)
LOC112406365LOW QUALITY PROTEIN: homeobox protein NANOG-like. (294 aa)
LOC112406614LOW QUALITY PROTEIN: eukaryotic translation initiation factor 4E-like; Belongs to the eukaryotic initiation factor 4E family. (217 aa)
NR2E1Nuclear receptor subfamily 2 group E member 1. (385 aa)
FOXO3Forkhead box protein O3. (672 aa)
LIN28BProtein lin-28 homolog B isoform X1. (270 aa)
SMC3Structural maintenance of chromosomes protein. (1217 aa)
RAF1RAF proto-oncogene serine/threonine-protein kinase isoform X1. (648 aa)
KLF10Krueppel-like factor 10. (479 aa)
CTR9RNA polymerase-associated protein CTR9 homolog isoform X1. (1214 aa)
NOGNoggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. (232 aa)
SS18Protein SSXT isoform X1. (418 aa)
FZD7Frizzled-7; Belongs to the G-protein coupled receptor Fz/Smo family. (574 aa)
SMC1AStructural maintenance of chromosomes protein. (1235 aa)
LOC112408488Serine/threonine-protein kinase B-raf-like. (250 aa)
MED12Mediator of RNA polymerase II transcription subunit 12. (2097 aa)
FAXCFailed axon connections homolog isoform X1. (409 aa)
MED14Mediator of RNA polymerase II transcription subunit 14; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1527 aa)
PCM1Pericentriolar material 1 protein isoform X1. (2132 aa)
YAP1Transcriptional coactivator YAP1. (416 aa)
WNT9BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (602 aa)
SOX9Transcription factor SOX-9. (486 aa)
MED7Mediator of RNA polymerase II transcription subunit 7; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. (233 aa)
HES5Transcription factor HES-5. (94 aa)
ZIC3Zinc finger protein ZIC 3. (455 aa)
LEO1RNA polymerase-associated protein LEO1 isoform X1. (672 aa)
LOC112411009RNA polymerase-associated protein LEO1-like. (292 aa)
MED27Mediator of RNA polymerase II transcription subunit 27 isoform X1. (311 aa)
NOTCH1LOW QUALITY PROTEIN: neurogenic locus notch homolog protein 1. (2633 aa)
PHF19PHD finger protein 19 isoform X1. (601 aa)
VPS72Vacuolar protein sorting-associated protein 72 homolog. (364 aa)
MED15Mediator of RNA polymerase II transcription subunit 15; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (770 aa)
FANCD2Fanconi anemia group D2 protein. (1449 aa)
LSM1U6 snRNA-associated Sm-like protein LSm1; Plays a role in the degradation of histone mRNAs, the only eukaryotic mRNAs that are not polyadenylated. Probably also part of an LSm subunits-containing complex involved in the general process of mRNA degradation. (133 aa)
HOOK3Protein Hook homolog 3 isoform X1. (714 aa)
SFRP1Secreted frizzled-related protein 1. (296 aa)
FUT10Alpha-(1,3)-fucosyltransferase; Probable fucosyltransferase; Belongs to the glycosyltransferase 10 family. (486 aa)
NODALNodal homolog. (348 aa)
EIF4ENIF1Eukaryotic translation initiation factor 4E transporter isoform X1. (1022 aa)
PAF1RNA polymerase II-associated factor 1 homolog isoform X1. (533 aa)
LIFLeukemia inhibitory factor. (202 aa)
NANOS2Nanos homolog 2; Belongs to the nanos family. (138 aa)
Your Current Organism:
Neophocaena asiaeorientalis
NCBI taxonomy Id: 1706337
Other names: N. asiaeorientalis asiaeorientalis, Neophocaena asiaeorientalis asiaeorientalis, Yangtze finless porpoise
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