STRINGSTRING
ACKR3 ACKR3 RYR3 RYR3 CGAS CGAS HTR2C HTR2C SYK SYK LOC112392069 LOC112392069 RYR1 RYR1 PDE3A PDE3A ITPR2 ITPR2 GRIN2B GRIN2B NFATC3 NFATC3 PLCG2 PLCG2 PTGFR PTGFR PPP3R2 PPP3R2 PKD2 PKD2 KSR1 KSR1 PPP3CA PPP3CA RAPGEF2 RAPGEF2 ATF1 ATF1 LOC112395196 LOC112395196 CREB1 CREB1 ZMPSTE24 ZMPSTE24 CAP1 CAP1 AZU1 AZU1 ADGRG6 ADGRG6 LRRK2 LRRK2 NMUR1 NMUR1 PPP3CB PPP3CB LOC112396164 LOC112396164 TBXA2R TBXA2R CCL20 CCL20 HTR2B HTR2B NMUR2 NMUR2 TPCN1 TPCN1 CCR4 CCR4 ATP1B1 ATP1B1 SELP SELP PDE7A PDE7A PPP1R9B PPP1R9B SAMD14 SAMD14 LAT LAT NDNF NDNF BHLHA15 BHLHA15 FIS1 FIS1 DGKQ DGKQ EDN2 EDN2 PRKG1 PRKG1 CCR6 CCR6 MCOLN1 MCOLN1 GUCY1A1 GUCY1A1 CCR10 CCR10 STIMATE STIMATE CCR7 CCR7 GUCY1B1 GUCY1B1 ADCY1 ADCY1 GPR62 GPR62 KDR KDR DMTN DMTN LAT2 LAT2 ADA ADA ITPR1 ITPR1 PPP3CC PPP3CC TBC1D10C TBC1D10C TPCN2 TPCN2 PTGDR2 PTGDR2 MTOR MTOR TRPM5 TRPM5 INS INS NFATC2 NFATC2 CASQ1 CASQ1 CCR3 CCR3 LOC112403768 LOC112403768 CCRL2 CCRL2 CCR1 CCR1 CCR2 CCR2 CXCR6 CXCR6 XCR1 XCR1 CXCR5 CXCR5 TRPM8 TRPM8 NFATC4 NFATC4 PDE2A PDE2A LOC112404949 LOC112404949 MAPK7 MAPK7 ADORA2B ADORA2B TMEM38B TMEM38B CCR8 CCR8 PRKAA1 PRKAA1 AQP1 AQP1 TNFSF11 TNFSF11 HDAC4 HDAC4 LOC112406682 LOC112406682 NFATC1 NFATC1 PDX1 PDX1 GHRHR GHRHR GPR143 GPR143 NCALD NCALD BCAP31 BCAP31 ACKR2 ACKR2 MRVI1 MRVI1 LOC112408084 LOC112408084 ATP2A2 ATP2A2 RCAN1 RCAN1 TRPM2 TRPM2 KSR2 KSR2 CAMKK2 CAMKK2 ADCYAP1 ADCYAP1 P2RX4 P2RX4 PDE7B PDE7B PDE9A PDE9A SAMD3 SAMD3 PLN PLN PDPK1 PDPK1 CXCR3 CXCR3 GRIN2A GRIN2A SGCD SGCD EDNRB EDNRB GRIN2C GRIN2C SPHK1 SPHK1 SOX9 SOX9 RYR2 RYR2 EDN1 EDN1 FKBP1B FKBP1B PRNP PRNP CASQ2 CASQ2 ITPR3 ITPR3 RCAN2 RCAN2 HOMER2 HOMER2 NEUROD1 NEUROD1 ADGRB2 ADGRB2 SLC9A1 SLC9A1 PPP1R9A PPP1R9A GLP1R GLP1R AHR AHR ADGRL1 ADGRL1 TMEM38A TMEM38A PTPRC PTPRC CXCR4 CXCR4 CX3CR1 CX3CR1 AGTR1 AGTR1 DMPK DMPK MCOLN2 MCOLN2 GUCY1A2 GUCY1A2 TRPM4 TRPM4 GRIN2D GRIN2D MCOLN3 MCOLN3 RCAN3 RCAN3 CHRM3 CHRM3 GRM5 GRM5 ACKR4 ACKR4 INPP5A INPP5A CXCR1 CXCR1 CAP2 CAP2 NFAT5 NFAT5
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ACKR3Atypical chemokine receptor 3; Belongs to the G-protein coupled receptor 1 family. (362 aa)
RYR3Ryanodine receptor 3. (4869 aa)
CGASCyclic GMP-AMP synthase. (513 aa)
HTR2C5-hydroxytryptamine receptor 2C. (457 aa)
SYKTyrosine-protein kinase. (626 aa)
LOC112392069Transient receptor potential cation channel subfamily M member 4-like. (313 aa)
RYR1Ryanodine receptor 1. (4879 aa)
PDE3APhosphodiesterase. (1134 aa)
ITPR2Inositol 1,4,5-trisphosphate receptor type 2 isoform X1. (2701 aa)
GRIN2BGlutamate receptor ionotropic, NMDA 2B. (1481 aa)
NFATC3Nuclear factor of activated T-cells, cytoplasmic 3 isoform X1. (1073 aa)
PLCG21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1265 aa)
PTGFRProstaglandin F2-alpha receptor. (362 aa)
PPP3R2LOW QUALITY PROTEIN: calcineurin subunit B type 2. (229 aa)
PKD2Polycystin-2 isoform X1. (782 aa)
KSR1Kinase suppressor of Ras 1 isoform X1. (886 aa)
PPP3CASerine/threonine-protein phosphatase. (511 aa)
RAPGEF2Rap guanine nucleotide exchange factor 2. (1744 aa)
ATF1Cyclic AMP-dependent transcription factor ATF-1 isoform X1. (336 aa)
LOC112395196Serine protease inhibitor Kazal-type 1-like. (79 aa)
CREB1Cyclic AMP-responsive element-binding protein 1 isoform X1. (341 aa)
ZMPSTE24CAAX prenyl protease; Proteolytically removes the C-terminal three residues of farnesylated proteins; Belongs to the peptidase M48A family. (473 aa)
CAP1Adenylyl cyclase-associated protein; Belongs to the CAP family. (475 aa)
AZU1Azurocidin. (252 aa)
ADGRG6Adhesion G-protein coupled receptor G6 isoform X1; Belongs to the G-protein coupled receptor 2 family. (1251 aa)
LRRK2Leucine-rich repeat serine/threonine-protein kinase 2 isoform X1. (2527 aa)
NMUR1neuromedin-U receptor 1. (432 aa)
PPP3CBSerine/threonine-protein phosphatase. (480 aa)
LOC112396164Calcium uniporter protein, mitochondrial-like. (89 aa)
TBXA2RThromboxane A2 receptor isoform X1; Belongs to the G-protein coupled receptor 1 family. (343 aa)
CCL20C-C motif chemokine. (97 aa)
HTR2B5-hydroxytryptamine receptor 2B. (479 aa)
NMUR2neuromedin-U receptor 2; Belongs to the G-protein coupled receptor 1 family. (412 aa)
TPCN1Two pore calcium channel protein 1 isoform X1. (818 aa)
CCR4C-C chemokine receptor type 4; Belongs to the G-protein coupled receptor 1 family. (359 aa)
ATP1B1Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (303 aa)
SELPP-selectin isoform X1. (856 aa)
PDE7APhosphodiesterase. (483 aa)
PPP1R9BNeurabin-2. (815 aa)
SAMD14Sterile alpha motif domain-containing protein 14. (417 aa)
LATLinker for activation of T-cells family member 1 isoform X1. (260 aa)
NDNFProtein NDNF. (568 aa)
BHLHA15Class A basic helix-loop-helix protein 15. (215 aa)
FIS1Mitochondrial fission 1 protein; Involved in the fragmentation of the mitochondrial network and its perinuclear clustering. (152 aa)
DGKQDiacylglycerol kinase. (1041 aa)
EDN2Endothelin-2. (177 aa)
PRKG1cGMP-dependent protein kinase. (686 aa)
CCR6C-C chemokine receptor type 6; Belongs to the G-protein coupled receptor 1 family. (375 aa)
MCOLN1Mucolipin-1. (582 aa)
GUCY1A1Guanylate cyclase soluble subunit alpha-1; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (691 aa)
CCR10C-C chemokine receptor type 10; Belongs to the G-protein coupled receptor 1 family. (363 aa)
STIMATEStore-operated calcium entry regulator STIMATE isoform X1. (312 aa)
CCR7C-C chemokine receptor type 7; Belongs to the G-protein coupled receptor 1 family. (379 aa)
GUCY1B1Guanylate cyclase soluble subunit beta-1 isoform X1; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (551 aa)
ADCY1Adenylate cyclase type 1. (907 aa)
GPR62Probable G-protein coupled receptor 62. (311 aa)
KDRVascular endothelial growth factor receptor 2 isoform X4; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1356 aa)
DMTNDematin isoform X1. (405 aa)
LAT2Linker for activation of T-cells family member 2 isoform X1. (214 aa)
ADAAdenosine deaminase isoform X1. (402 aa)
ITPR1Inositol 1,4,5-trisphosphate receptor type 1 isoform X1. (2709 aa)
PPP3CCSerine/threonine-protein phosphatase. (549 aa)
TBC1D10CCarabin isoform X1. (458 aa)
TPCN2Two pore calcium channel protein 2. (781 aa)
PTGDR2Prostaglandin D2 receptor 2; Belongs to the G-protein coupled receptor 1 family. (357 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2548 aa)
TRPM5LOW QUALITY PROTEIN: transient receptor potential cation channel subfamily M member 5. (1378 aa)
INSInsulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (110 aa)
NFATC2Nuclear factor of activated T-cells, cytoplasmic 2 isoform X1. (943 aa)
CASQ1Calsequestrin; Calsequestrin is a high-capacity, moderate affinity, calcium- binding protein and thus acts as an internal calcium store in muscle. (400 aa)
CCR3C-C chemokine receptor type 3; Belongs to the G-protein coupled receptor 1 family. (358 aa)
LOC112403768C-C chemokine receptor type 5; Belongs to the G-protein coupled receptor 1 family. (351 aa)
CCRL2C-C chemokine receptor-like 2 isoform X1; Belongs to the G-protein coupled receptor 1 family. (384 aa)
CCR1C-C chemokine receptor type 1; Belongs to the G-protein coupled receptor 1 family. (355 aa)
CCR2C-C chemokine receptor type 2; Belongs to the G-protein coupled receptor 1 family. (373 aa)
CXCR6C-X-C chemokine receptor type 6; Belongs to the G-protein coupled receptor 1 family. (341 aa)
XCR1Chemokine XC receptor 1; Belongs to the G-protein coupled receptor 1 family. (333 aa)
CXCR5C-X-C chemokine receptor type 5; Belongs to the G-protein coupled receptor 1 family. (374 aa)
TRPM8Transient receptor potential cation channel subfamily M member 8. (1104 aa)
NFATC4Nuclear factor of activated T-cells, cytoplasmic 4 isoform X1. (831 aa)
PDE2APhosphodiesterase. (964 aa)
LOC112404949Calcium uniporter protein, mitochondrial. (109 aa)
MAPK7Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (732 aa)
ADORA2BAdenosine receptor A2; Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Belongs to the G-protein coupled receptor 1 family. (333 aa)
TMEM38BTrimeric intracellular cation channel type B isoform X1. (291 aa)
CCR8C-C chemokine receptor type 8; Belongs to the G-protein coupled receptor 1 family. (353 aa)
PRKAA1Non-specific serine/threonine protein kinase. (559 aa)
AQP1Aquaporin-1; Belongs to the MIP/aquaporin (TC 1.A.8) family. (271 aa)
TNFSF11Tumor necrosis factor ligand superfamily member 11; Belongs to the tumor necrosis factor family. (323 aa)
HDAC4Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1071 aa)
LOC112406682LOW QUALITY PROTEIN: guanylate cyclase soluble subunit beta-2-like. (748 aa)
NFATC1Nuclear factor of activated T-cells, cytoplasmic 1. (700 aa)
PDX1Pancreas/duodenum homeobox protein 1. (289 aa)
GHRHRGrowth hormone-releasing hormone receptor isoform X1; Belongs to the G-protein coupled receptor 2 family. (456 aa)
GPR143G-protein coupled receptor 143. (351 aa)
NCALDNeurocalcin-delta. (193 aa)
BCAP31B-cell receptor-associated protein 31. (245 aa)
ACKR2Atypical chemokine receptor 2; Belongs to the G-protein coupled receptor 1 family. (391 aa)
MRVI1Protein MRVI1. (902 aa)
LOC112408084C-C motif chemokine 3-like. (87 aa)
ATP2A2Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1042 aa)
RCAN1Calcipressin-1 isoform X1. (246 aa)
TRPM2Transient receptor potential cation channel subfamily M member 2 isoform X1. (1497 aa)
KSR2Kinase suppressor of Ras 2. (827 aa)
CAMKK2Calcium/calmodulin-dependent protein kinase kinase 2 isoform X1. (606 aa)
ADCYAP1Pituitary adenylate cyclase-activating polypeptide. (176 aa)
P2RX4P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. (388 aa)
PDE7BPhosphodiesterase. (505 aa)
PDE9APhosphodiesterase. (510 aa)
SAMD3Sterile alpha motif domain-containing protein 3. (517 aa)
PLNCardiac phospholamban; Reversibly inhibits the activity of ATP2A2 in cardiac sarcoplasmic reticulum by decreasing the apparent affinity of the ATPase for Ca(2+). Modulates the contractility of the heart muscle in response to physiological stimuli via its effects on ATP2A2. Modulates calcium re-uptake during muscle relaxation and plays an important role in calcium homeostasis in the heart muscle. The degree of ATP2A2 inhibition depends on the oligomeric state of PLN. (52 aa)
PDPK13-phosphoinositide-dependent protein kinase 1 isoform X1. (531 aa)
CXCR3C-X-C chemokine receptor type 3; Belongs to the G-protein coupled receptor 1 family. (366 aa)
GRIN2AGlutamate receptor ionotropic, NMDA 2A isoform X1. (1464 aa)
SGCDDelta-sarcoglycan. (289 aa)
EDNRBEndothelin receptor type B; Belongs to the G-protein coupled receptor 1 family. (443 aa)
GRIN2CGlutamate receptor ionotropic, NMDA 2C. (1137 aa)
SPHK1Sphingosine kinase 1. (391 aa)
SOX9Transcription factor SOX-9. (486 aa)
RYR2Ryanodine receptor 2. (4971 aa)
EDN1Endothelin-1. (202 aa)
FKBP1BPeptidylprolyl isomerase. (80 aa)
PRNPMajor prion protein; Belongs to the prion family. (261 aa)
CASQ2Calsequestrin; Calsequestrin is a high-capacity, moderate affinity, calcium- binding protein and thus acts as an internal calcium store in muscle. (408 aa)
ITPR3Inositol 1,4,5-trisphosphate receptor type 3. (2670 aa)
RCAN2Calcipressin-2 isoform X1. (243 aa)
HOMER2Homer protein homolog 2 isoform X1. (298 aa)
NEUROD1Neurogenic differentiation factor. (356 aa)
ADGRB2Adhesion G protein-coupled receptor B2; Belongs to the G-protein coupled receptor 2 family. (1571 aa)
SLC9A1Sodium/hydrogen exchanger; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. (816 aa)
PPP1R9ANeurabin-1 isoform X1. (1309 aa)
GLP1RGlucagon-like peptide 1 receptor; Belongs to the G-protein coupled receptor 2 family. (442 aa)
AHRAryl hydrocarbon receptor. (845 aa)
ADGRL1Adhesion G protein-coupled receptor L1 isoform X1; Belongs to the G-protein coupled receptor 2 family. (1468 aa)
TMEM38ATrimeric intracellular cation channel type A. (299 aa)
PTPRCReceptor-type tyrosine-protein phosphatase C isoform X1. (1258 aa)
CXCR4C-X-C chemokine receptor type 4; Belongs to the G-protein coupled receptor 1 family. (353 aa)
CX3CR1CX3C chemokine receptor 1; Belongs to the G-protein coupled receptor 1 family. (358 aa)
AGTR1Type-1 angiotensin II receptor; Belongs to the G-protein coupled receptor 1 family. (359 aa)
DMPKMyotonin-protein kinase isoform X1. (722 aa)
MCOLN2Mucolipin-2 isoform X1. (566 aa)
GUCY1A2Guanylate cyclase soluble subunit alpha-2; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (647 aa)
TRPM4Transient receptor potential cation channel subfamily M member 4 isoform X1. (921 aa)
GRIN2DGlutamate receptor ionotropic, NMDA 2D; Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. (940 aa)
MCOLN3Mucolipin-3 isoform X1. (552 aa)
RCAN3Calcipressin-3. (241 aa)
CHRM3Muscarinic acetylcholine receptor; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. (590 aa)
GRM5LOW QUALITY PROTEIN: metabotropic glutamate receptor 5. (1106 aa)
ACKR4Atypical chemokine receptor 4; Belongs to the G-protein coupled receptor 1 family. (350 aa)
INPP5AType I inositol 1,4,5-trisphosphate 5-phosphatase isoform X1. (434 aa)
CXCR1C-X-C chemokine receptor type 1; Belongs to the G-protein coupled receptor 1 family. (368 aa)
CAP2Adenylyl cyclase-associated protein; Belongs to the CAP family. (483 aa)
NFAT5Nuclear factor of activated T-cells 5 isoform X1. (1553 aa)
Your Current Organism:
Neophocaena asiaeorientalis
NCBI taxonomy Id: 1706337
Other names: N. asiaeorientalis asiaeorientalis, Neophocaena asiaeorientalis asiaeorientalis, Yangtze finless porpoise
Server load: low (30%) [HD]