STRINGSTRING
HECTD1 HECTD1 SPINT1 SPINT1 TULP3 TULP3 WDR19 WDR19 LIAS LIAS SEMA3C SEMA3C DACT1 DACT1 LOC112390775 LOC112390775 DVL2 DVL2 PKD2 PKD2 PRKACB PRKACB ALDH1A2 ALDH1A2 FUZ FUZ ARHGAP35 ARHGAP35 PRKACA PRKACA VASP VASP TGFB1 TGFB1 DVL3 DVL3 TEAD2 TEAD2 LUZP1 LUZP1 BCL10 BCL10 FZD3 FZD3 PTK7 PTK7 PHACTR4 PHACTR4 BRD2 BRD2 GRHL3 GRHL3 NODAL NODAL LRRC1 LRRC1 LOC112413803 LOC112413803 NUP133 NUP133 WNT3A WNT3A SFRP1 SFRP1 PHGDH PHGDH COBL COBL LHX2 LHX2 NOTCH1 NOTCH1 TSC1 TSC1 CBY1 CBY1 SMO SMO ABL1 ABL1 LOC112411262 LOC112411262 FOXA1 FOXA1 C2CD3 C2CD3 BBS4 BBS4 SALL2 SALL2 HES5 HES5 FZD2 FZD2 RNF220 RNF220 CLUAP1 CLUAP1 DVL1 DVL1 GSC GSC PKD1 PKD1 ARL13B ARL13B IFT140 IFT140 APAF1 APAF1 TBC1D32 TBC1D32 KDM2B KDM2B TCTN1 TCTN1 LOC112407988 LOC112407988 MED12 MED12 MIB1 MIB1 MKS1 MKS1 NOG NOG LOC112407979 LOC112407979 DCHS1 DCHS1 ST14 ST14 LRP2 LRP2 STK3 STK3 GRHL2 GRHL2 SHROOM3 SHROOM3 PTCH1 PTCH1 PAX6 PAX6 GBX2 GBX2 TRAF6 TRAF6 HES1 HES1 OPA1 OPA1 PLXNA2 PLXNA2 SETD2 SETD2 MTHFD1 MTHFD1 RALA RALA BMP7 BMP7 EPHA2 EPHA2 SALL4 SALL4 AMBRA1 AMBRA1 MTHFR MTHFR TMEM107 TMEM107 HIF1A HIF1A KAT5 KAT5 LOC112401545 LOC112401545 GDF7 GDF7 RPGRIP1L RPGRIP1L MTHFD1L MTHFD1L WNT5A WNT5A STK4 STK4 IFT52 IFT52 KAT2A KAT2A INTU INTU PLOD3 PLOD3 CTHRC1 CTHRC1 FZD6 FZD6 TBXT TBXT LMO4 LMO4 SEMA4C SEMA4C KDM6A KDM6A TRIM71 TRIM71 SOX17 SOX17 GLMN GLMN RARA RARA SEC24B SEC24B SCRIB SCRIB CC2D2A CC2D2A SOX4 SOX4 PRICKLE1 PRICKLE1 CITED2 CITED2 SSBP3 SSBP3 ZFP36L1 ZFP36L1 SHH SHH FERD3L FERD3L PSEN1 PSEN1 TWIST1 TWIST1 PLXNB2 PLXNB2 FAM212A FAM212A ITPK1 ITPK1 CELSR1 CELSR1 WNT1 WNT1 RARG RARG NF1 NF1 FOXB1 FOXB1 BMP4 BMP4 IFT57 IFT57 FGF8 FGF8 SUFU SUFU SPINT2 SPINT2 EN1 EN1 GLI3 GLI3 LOC112391874 LOC112391874
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Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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HECTD1E3 ubiquitin-protein ligase HECTD1 isoform X1. (2610 aa)
SPINT1Kunitz-type protease inhibitor 1. (510 aa)
TULP3Tubby-like protein; Belongs to the TUB family. (464 aa)
WDR19WD repeat-containing protein 19 isoform X1. (1342 aa)
LIASLipoyl synthase, mitochondrial; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. (372 aa)
SEMA3Csemaphorin-3C; Belongs to the semaphorin family. (751 aa)
DACT1Dapper homolog 1. (691 aa)
LOC112390775Folate receptor alpha-like. (251 aa)
DVL2Segment polarity protein dishevelled homolog DVL-2 isoform X1. (785 aa)
PKD2Polycystin-2 isoform X1. (782 aa)
PRKACBcAMP-dependent protein kinase catalytic subunit beta isoform X1; Belongs to the protein kinase superfamily. (397 aa)
ALDH1A2Retinal dehydrogenase 2 isoform X1; Belongs to the aldehyde dehydrogenase family. (526 aa)
FUZProtein fuzzy homolog isoform X1. (440 aa)
ARHGAP35Rho GTPase-activating protein 35. (1500 aa)
PRKACAcAMP-dependent protein kinase catalytic subunit alpha. (293 aa)
VASPVasodilator-stimulated phosphoprotein isoform X1; Ena/VASP proteins are actin-associated proteins involved in a range of processes dependent on cytoskeleton remodeling and cell polarity such as axon guidance, lamellipodial and filopodial dynamics, platelet activation and cell migration. Belongs to the Ena/VASP family. (380 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (391 aa)
DVL3Segment polarity protein dishevelled homolog DVL-3 isoform X1. (716 aa)
TEAD2Transcriptional enhancer factor TEF-4 isoform X1. (462 aa)
LUZP1Leucine zipper protein 1. (1071 aa)
BCL10B-cell lymphoma/leukemia 10. (233 aa)
FZD3Frizzled-3; Belongs to the G-protein coupled receptor Fz/Smo family. (468 aa)
PTK7Inactive tyrosine-protein kinase 7; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1070 aa)
PHACTR4Phosphatase and actin regulator. (747 aa)
BRD2Bromodomain-containing protein 2 isoform X1. (803 aa)
GRHL3Grainyhead-like protein 3 homolog. (602 aa)
NODALNodal homolog. (348 aa)
LRRC1Leucine-rich repeat-containing protein 1. (443 aa)
LOC112413803Polycomb complex protein BMI-1. (326 aa)
NUP133Nuclear pore complex protein Nup133 isoform X1. (1156 aa)
WNT3AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (352 aa)
SFRP1Secreted frizzled-related protein 1. (296 aa)
PHGDHD-3-phosphoglycerate dehydrogenase; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (533 aa)
COBLProtein cordon-bleu isoform X1. (1274 aa)
LHX2LIM/homeobox protein Lhx2. (406 aa)
NOTCH1LOW QUALITY PROTEIN: neurogenic locus notch homolog protein 1. (2633 aa)
TSC1Hamartin isoform X1. (1169 aa)
CBY1Protein chibby homolog 1 isoform X1. (156 aa)
SMOSmoothened homolog; Belongs to the G-protein coupled receptor Fz/Smo family. (783 aa)
ABL1Tyrosine-protein kinase. (1148 aa)
LOC112411262LOW QUALITY PROTEIN: transcriptional enhancer factor TEF-4-like. (282 aa)
FOXA1Hepatocyte nuclear factor 3-alpha. (466 aa)
C2CD3C2 domain-containing protein 3 isoform X1. (2400 aa)
BBS4Bardet-Biedl syndrome 4 protein isoform X1. (519 aa)
SALL2Sal-like protein 2 isoform X3. (1037 aa)
HES5Transcription factor HES-5. (94 aa)
FZD2Frizzled-2; Belongs to the G-protein coupled receptor Fz/Smo family. (709 aa)
RNF220E3 ubiquitin-protein ligase RNF220. (571 aa)
CLUAP1Clusterin-associated protein 1 isoform X1. (457 aa)
DVL1Segment polarity protein dishevelled homolog DVL-1. (706 aa)
GSCHomeobox protein goosecoid. (256 aa)
PKD1Polycystin-1. (4487 aa)
ARL13BADP-ribosylation factor-like protein 13B. (430 aa)
IFT140Intraflagellar transport protein 140 homolog isoform X1. (1489 aa)
APAF1Apoptotic protease-activating factor 1 isoform X1. (1301 aa)
TBC1D32Protein broad-minded. (1231 aa)
KDM2BLysine-specific demethylase 2B. (1309 aa)
TCTN1Tectonic-1 isoform X1. (616 aa)
LOC112407988Secreted frizzled-related protein 2. (294 aa)
MED12Mediator of RNA polymerase II transcription subunit 12. (2097 aa)
MIB1E3 ubiquitin-protein ligase MIB1. (1225 aa)
MKS1Meckel syndrome type 1 protein isoform X2. (607 aa)
NOGNoggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. (232 aa)
LOC112407979Secreted frizzled-related protein 2-like. (105 aa)
DCHS1Protocadherin-16. (3294 aa)
ST14Suppressor of tumorigenicity 14 protein. (877 aa)
LRP2Low-density lipoprotein receptor-related protein 2 isoform X1. (4651 aa)
STK3Serine/threonine-protein kinase 3. (491 aa)
GRHL2Grainyhead-like protein 2 homolog isoform X1. (625 aa)
SHROOM3Protein Shroom3 isoform X2. (1794 aa)
PTCH1Protein patched homolog 1 isoform X1. (1297 aa)
PAX6Paired box protein Pax-6 isoform X1. (493 aa)
GBX2Homeobox protein GBX-2 isoform X1. (348 aa)
TRAF6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (570 aa)
HES1Transcription factor HES-1. (280 aa)
OPA1Dynamin-like 120 kDa protein, mitochondrial isoform X1; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (1022 aa)
PLXNA2plexin-A2. (1894 aa)
SETD2Histone-lysine N-methyltransferase SETD2 isoform X1. (2547 aa)
MTHFD1C-1-tetrahydrofolate synthase, cytoplasmic isoform X1. (961 aa)
RALARas-related protein Ral-A. (206 aa)
BMP7Bone morphogenetic protein 7. (431 aa)
EPHA2Ephrin type-A receptor 2. (975 aa)
SALL4Sal-like protein 4 isoform X1. (1055 aa)
AMBRA1Activating molecule in BECN1-regulated autophagy protein 1 isoform X2. (1295 aa)
MTHFRMethylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. (696 aa)
TMEM107Transmembrane protein 107 isoform X1. (140 aa)
HIF1AHypoxia-inducible factor 1-alpha. (823 aa)
KAT5Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (546 aa)
LOC112401545LOW QUALITY PROTEIN: serine/threonine-protein kinase 3-like. (375 aa)
GDF7Growth/differentiation factor 7. (381 aa)
RPGRIP1LProtein fantom. (1269 aa)
MTHFD1LMonofunctional C1-tetrahydrofolate synthase, mitochondrial isoform X1. (867 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (380 aa)
STK4Serine/threonine-protein kinase 4 isoform X1. (487 aa)
IFT52Intraflagellar transport protein 52 homolog isoform X1. (456 aa)
KAT2AHistone acetyltransferase KAT2A. (872 aa)
INTUProtein inturned. (933 aa)
PLOD3Procollagen-lysine,2-oxoglutarate 5-dioxygenase 3. (739 aa)
CTHRC1Collagen triple helix repeat-containing protein 1. (244 aa)
FZD6Frizzled-6; Belongs to the G-protein coupled receptor Fz/Smo family. (712 aa)
TBXTBrachyury protein isoform X1. (435 aa)
LMO4LIM domain transcription factor LMO4. (165 aa)
SEMA4Csemaphorin-4C; Belongs to the semaphorin family. (833 aa)
KDM6ALysine-specific demethylase 6A isoform X1. (1278 aa)
TRIM71E3 ubiquitin-protein ligase TRIM71. (596 aa)
SOX17LOW QUALITY PROTEIN: transcription factor SOX-17. (207 aa)
GLMNGlomulin. (592 aa)
RARALOW QUALITY PROTEIN: retinoic acid receptor alpha. (572 aa)
SEC24BProtein transport protein Sec24B isoform X1. (1168 aa)
SCRIBLOW QUALITY PROTEIN: protein scribble homolog. (1575 aa)
CC2D2ACoiled-coil and C2 domain-containing protein 2A. (1619 aa)
SOX4Transcription factor SOX-4. (285 aa)
PRICKLE1Prickle-like protein 1 isoform X1. (874 aa)
CITED2Cbp/p300-interacting transactivator 2. (263 aa)
SSBP3Single-stranded DNA-binding protein 3. (278 aa)
ZFP36L1mRNA decay activator protein ZFP36L1. (338 aa)
SHHSonic hedgehog protein. (328 aa)
FERD3LFer3-like protein. (163 aa)
PSEN1Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (468 aa)
TWIST1LOW QUALITY PROTEIN: twist-related protein 1. (152 aa)
PLXNB2plexin-B2. (1799 aa)
FAM212APAK4-inhibitor INKA1. (337 aa)
ITPK1Inositol-tetrakisphosphate 1-kinase. (441 aa)
CELSR1Cadherin EGF LAG seven-pass G-type receptor 1; Belongs to the G-protein coupled receptor 2 family. (2288 aa)
WNT1Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (370 aa)
RARGRetinoic acid receptor gamma isoform X2. (458 aa)
NF1Neurofibromin isoform X1. (2841 aa)
FOXB1Forkhead box protein B1. (325 aa)
BMP4Bone morphogenetic protein 4 isoform X1. (420 aa)
IFT57Intraflagellar transport protein 57 homolog. (427 aa)
FGF8Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (244 aa)
SUFUSuppressor of fused homolog; Negative regulator in the hedgehog signaling pathway. Down- regulates GLI1-mediated transactivation of target genes. Part of a corepressor complex that acts on DNA-bound GLI1. May also act by linking GLI1 to BTRC and thereby targeting GLI1 to degradation by the proteasome. Sequesters GLI1, GLI2 and GLI3 in the cytoplasm, this effect is overcome by binding of STK36 to both SUFU and a GLI protein. Negative regulator of beta-catenin signaling. Regulates the formation of either the repressor form (GLI3R) or the activator form (GLI3A) of the full-length form of [...] (469 aa)
SPINT2Kunitz-type protease inhibitor 2. (249 aa)
EN1Homeobox protein engrailed-like. (408 aa)
GLI3Transcriptional activator GLI3. (1587 aa)
LOC112391874Cat eye syndrome critical region protein 2 isoform X2. (1222 aa)
Your Current Organism:
Neophocaena asiaeorientalis
NCBI taxonomy Id: 1706337
Other names: N. asiaeorientalis asiaeorientalis, Neophocaena asiaeorientalis asiaeorientalis, Yangtze finless porpoise
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