STRINGSTRING
TGFB1 TGFB1 CSMD2 CSMD2 LRRC1 LRRC1 POLB POLB SFRP1 SFRP1 NOTCH2 NOTCH2 PLXNA1 PLXNA1 CUL3 CUL3 TWSG1 TWSG1 LAMA1 LAMA1 LOC112409981 LOC112409981 NFIB NFIB SOX9 SOX9 SLC9A3R1 SLC9A3R1 PML PML FOXA1 FOXA1 SEMA3C SEMA3C HOXD13 HOXD13 PHB2 PHB2 GLI3 GLI3 FGF8 FGF8 ESRP2 ESRP2 BMP4 BMP4 NFKB1 NFKB1 BTRC BTRC NKX2-3 NKX2-3 FRS2 FRS2 RARG RARG VDR VDR STAT6 STAT6 MST1 MST1 LOC112394306 LOC112394306 TGFB3 TGFB3 IL6 IL6 SHH SHH TGFB2 TGFB2 DDR1 DDR1 NRG3 NRG3 FGF10 FGF10 BSX BSX SCRIB SCRIB CSF1 CSF1 TBX3 TBX3 PLAG1 PLAG1 MED1 MED1 SRC SRC TGM2 TGM2 HOXB13 HOXB13 RXFP1 RXFP1 WNT5A WNT5A FEM1B FEM1B NKX3-1 NKX3-1 TNC TNC ESR1 ESR1 GDF7 GDF7 FGF7 FGF7 NTN1 NTN1 KDM5B KDM5B LRP5 LRP5 SELENOH SELENOH ELF3 ELF3 LAMA5 LAMA5 EPHA2 EPHA2 CEBPB CEBPB BMP7 BMP7 PROX1 PROX1 AR AR MKI67 MKI67 MSN MSN PAX6 PAX6 PTCH1 PTCH1 AREG AREG SERPINB5 SERPINB5 BCL2 BCL2 EDA EDA TGFA TGFA PLXND1 PLXND1 NOG NOG TBX2 TBX2 EDAR EDAR CAV1 CAV1 FGL1 FGL1 NOTCH1 NOTCH1 TP63 TP63 SOSTDC1 SOSTDC1 CSMD1 CSMD1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (391 aa)
CSMD2CUB and sushi domain-containing protein 2. (3656 aa)
LRRC1Leucine-rich repeat-containing protein 1. (443 aa)
POLBDNA polymerase; DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template- independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity. (328 aa)
SFRP1Secreted frizzled-related protein 1. (296 aa)
NOTCH2Neurogenic locus notch homolog protein 2 isoform X1. (2485 aa)
PLXNA1LOW QUALITY PROTEIN: plexin-A1. (2367 aa)
CUL3Cullin-3 isoform X1; Belongs to the cullin family. (746 aa)
TWSG1Twisted gastrulation protein homolog 1. (223 aa)
LAMA1Laminin subunit alpha-1. (3081 aa)
LOC112409981ectodysplasin-A-like. (214 aa)
NFIBNuclear factor 1; Recognizes and binds the palindromic sequence 5'- TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication. (570 aa)
SOX9Transcription factor SOX-9. (486 aa)
SLC9A3R1Na(+)/H(+) exchange regulatory cofactor NHE-RF; Scaffold protein that connects plasma membrane proteins with members of the ezrin/moesin/radixin family and thereby helps to link them to the actin cytoskeleton and to regulate their surface expression. (366 aa)
PMLProtein PML isoform X1. (965 aa)
FOXA1Hepatocyte nuclear factor 3-alpha. (466 aa)
SEMA3Csemaphorin-3C; Belongs to the semaphorin family. (751 aa)
HOXD13Homeobox protein Hox-D13. (264 aa)
PHB2Prohibitin. (299 aa)
GLI3Transcriptional activator GLI3. (1587 aa)
FGF8Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (244 aa)
ESRP2Epithelial splicing regulatory protein 2 isoform X1. (767 aa)
BMP4Bone morphogenetic protein 4 isoform X1. (420 aa)
NFKB1Nuclear factor NF-kappa-B p105 subunit isoform X1. (977 aa)
BTRCF-box/WD repeat-containing protein 1A isoform X1. (605 aa)
NKX2-3Homeobox protein Nkx-2.3. (363 aa)
FRS2Fibroblast growth factor receptor substrate 2. (508 aa)
RARGRetinoic acid receptor gamma isoform X2. (458 aa)
VDRVitamin D3 receptor. (427 aa)
STAT6Signal transducer and activator of transcription. (859 aa)
MST1LOW QUALITY PROTEIN: hepatocyte growth factor-like protein; Belongs to the peptidase S1 family. (732 aa)
LOC112394306C-C motif chemokine. (97 aa)
TGFB3Transforming growth factor beta-3. (456 aa)
IL6Interleukin-6. (208 aa)
SHHSonic hedgehog protein. (328 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
DDR1Tyrosine-protein kinase receptor. (932 aa)
NRG3Pro-neuregulin-3, membrane-bound isoform isoform X3. (613 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
BSXBrain-specific homeobox protein homolog. (232 aa)
SCRIBLOW QUALITY PROTEIN: protein scribble homolog. (1575 aa)
CSF1Macrophage colony-stimulating factor 1. (513 aa)
TBX3LOW QUALITY PROTEIN: T-box transcription factor TBX3. (734 aa)
PLAG1Zinc finger protein PLAG1 isoform X1. (499 aa)
MED1Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1579 aa)
SRCTyrosine-protein kinase. (601 aa)
TGM2Protein-glutamine gamma-glutamyltransferase 2. (687 aa)
HOXB13Homeobox protein Hox-B13. (285 aa)
RXFP1Relaxin receptor 1. (653 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (380 aa)
FEM1BProtein fem-1 homolog B. (627 aa)
NKX3-1Homeobox protein Nkx-3.1. (241 aa)
TNCTenascin isoform X4. (2201 aa)
ESR1Estrogen receptor. (604 aa)
GDF7Growth/differentiation factor 7. (381 aa)
FGF7Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (194 aa)
NTN1Netrin-1. (604 aa)
KDM5BLysine-specific demethylase 5B. (1311 aa)
LRP5Low-density lipoprotein receptor-related protein 5 isoform X1. (1461 aa)
SELENOHSelenoprotein H. (122 aa)
ELF3ETS-related transcription factor Elf-3. (372 aa)
LAMA5LOW QUALITY PROTEIN: laminin subunit alpha-5. (3401 aa)
EPHA2Ephrin type-A receptor 2. (975 aa)
CEBPBCCAAT/enhancer-binding protein. (346 aa)
BMP7Bone morphogenetic protein 7. (431 aa)
PROX1Prospero homeobox protein 1 isoform X1. (737 aa)
ARAndrogen receptor isoform X1. (893 aa)
MKI67Proliferation marker protein Ki-67. (2619 aa)
MSNMoesin isoform X1. (579 aa)
PAX6Paired box protein Pax-6 isoform X1. (493 aa)
PTCH1Protein patched homolog 1 isoform X1. (1297 aa)
AREGAmphiregulin isoform X1. (253 aa)
SERPINB5Serpin B5; Belongs to the serpin family. (375 aa)
BCL2Apoptosis regulator Bcl-2 isoform X1. (233 aa)
EDAectodysplasin-A; Belongs to the tumor necrosis factor family. (259 aa)
TGFAProtransforming growth factor alpha isoform X1. (290 aa)
PLXND1plexin-D1. (1847 aa)
NOGNoggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. (232 aa)
TBX2T-box transcription factor TBX2. (588 aa)
EDARTumor necrosis factor receptor superfamily member EDAR isoform X1. (456 aa)
CAV1Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (178 aa)
FGL1Fibrinogen-like protein 1. (315 aa)
NOTCH1LOW QUALITY PROTEIN: neurogenic locus notch homolog protein 1. (2633 aa)
TP63Tumor protein 63 (p63); Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. (680 aa)
SOSTDC1Sclerostin domain-containing protein 1. (206 aa)
CSMD1CUB and sushi domain-containing protein 1. (3778 aa)
Your Current Organism:
Neophocaena asiaeorientalis
NCBI taxonomy Id: 1706337
Other names: N. asiaeorientalis asiaeorientalis, Neophocaena asiaeorientalis asiaeorientalis, Yangtze finless porpoise
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