(77 nodes) Ubiquitin-dependent ERAD pathway network (Neophocaena asiaeorientalis)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	DNAJC18	dnaJ homolog subfamily C member 18. (358 aa)
	DNAJB9	dnaJ homolog subfamily B member 9 isoform X1. (245 aa)
	LOC112415363	F-box only protein 17 isoform X1. (323 aa)
	NCCRP1	F-box only protein 50. (260 aa)
	CALR3	Calreticulin. (385 aa)
	CALR	Calreticulin. (417 aa)
	DNAJC10	DnaJ homolog subfamily C member 10; Endoplasmic reticulum disulfide reductase involved both in the correct folding of proteins and degradation of misfolded proteins. (793 aa)
	MARCH6	E3 ubiquitin-protein ligase MARCH6 isoform X1. (914 aa)
	AUP1	Ancient ubiquitous protein 1 isoform X2. (410 aa)
	TMEM67	Meckelin. (996 aa)
	ERLIN2	Erlin-2 isoform X1. (339 aa)
	UBXN8	UBX domain-containing protein 8 isoform X1. (275 aa)
	CANX	Calnexin. (593 aa)
	SELENOS	Selenoprotein S. (191 aa)
	UBXN4	UBX domain-containing protein 4. (508 aa)
	FAM8A1	Protein FAM8A1. (300 aa)
	DERL3	Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family. (132 aa)
	DNAJB2	dnaJ homolog subfamily B member 2 isoform X1. (325 aa)
	VCP	Transitional endoplasmic reticulum ATPase; Belongs to the AAA ATPase family. (806 aa)
	UFD1	Ubiquitin recognition factor in ER-associated degradation protein 1 isoform X1. (307 aa)
	ANKZF1	LOW QUALITY PROTEIN: ankyrin repeat and zinc finger domain-containing protein 1. (723 aa)
	HSPA5	Endoplasmic reticulum chaperone BiP; Belongs to the heat shock protein 70 family. (655 aa)
	MAN1B1	alpha-1,2-Mannosidase; Belongs to the glycosyl hydrolase 47 family. (667 aa)
	FOXRED2	FAD-dependent oxidoreductase domain-containing protein 2 isoform X1. (687 aa)
	CCDC47	Coiled-coil domain-containing protein 47. (483 aa)
	TMUB2	Transmembrane and ubiquitin-like domain-containing protein 2 isoform X1. (316 aa)
	UBE2J2	Ubiquitin-conjugating enzyme E2 J2. (259 aa)
	MAN1A1	alpha-1,2-Mannosidase; Belongs to the glycosyl hydrolase 47 family. (655 aa)
	UBE2G2	Ubiquitin-conjugating enzyme E2 G2 isoform X1; Belongs to the ubiquitin-conjugating enzyme family. (238 aa)
	TRIM25	E3 ubiquitin/ISG15 ligase TRIM25. (635 aa)
	RNF175	LOW QUALITY PROTEIN: RING finger protein 175. (429 aa)
	ECPAS	Proteasome adapter and scaffold protein ECM29 isoform X1. (1840 aa)
	TRIM13	E3 ubiquitin-protein ligase TRIM13. (407 aa)
	UBQLN2	Ubiquilin-2. (618 aa)
	TMUB1	Transmembrane and ubiquitin-like domain-containing protein 1. (246 aa)
	TTC33	Tetratricopeptide repeat protein 33. (262 aa)
	UBQLN1	Ubiquilin-1 isoform X1. (590 aa)
	LOC112404910	LOW QUALITY PROTEIN: F-box only protein 27-like. (303 aa)
	SGTB	Small glutamine-rich tetratricopeptide repeat-containing protein beta. (304 aa)
	AMFR	E3 ubiquitin-protein ligase AMFR. (647 aa)
	UBE4A	Ubiquitin conjugation factor E4 A. (1067 aa)
	YOD1	Ubiquitin thioesterase OTU1. (348 aa)
	EDEM3	alpha-1,2-Mannosidase; Belongs to the glycosyl hydrolase 47 family. (798 aa)
	UBXN10	UBX domain-containing protein 10. (279 aa)
	FBXO6	F-box only protein 6. (265 aa)
	FBXO2	F-box only protein 2. (298 aa)
	UBE4B	Ubiquitin conjugation factor E4 B isoform X2. (1360 aa)
	SYVN1	E3 ubiquitin-protein ligase synoviolin. (620 aa)
	HERPUD1	Homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 1 protein. (387 aa)
	UBE2J1	Ubiquitin-conjugating enzyme E2 J1. (318 aa)
	EDEM1	alpha-1,2-Mannosidase; Belongs to the glycosyl hydrolase 47 family. (462 aa)
	RHBDD2	Rhomboid domain-containing protein 2 isoform X2. (390 aa)
	UMOD	Uromodulin. (643 aa)
	RNF103	E3 ubiquitin-protein ligase RNF103 isoform X1. (685 aa)
	STT3B	Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3B isoform X2. (825 aa)
	FAF2	FAS-associated factor 2. (445 aa)
	LOC112398392	alpha-1,2-Mannosidase; Belongs to the glycosyl hydrolase 47 family. (578 aa)
	DERL1	Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family. (309 aa)
	ERLEC1	Endoplasmic reticulum lectin 1 isoform X1. (493 aa)
	DNAJB12	dnaJ homolog subfamily B member 12 isoform X1. (378 aa)
	SGTA	Small glutamine-rich tetratricopeptide repeat-containing protein alpha. (313 aa)
	LOC112395837	LOW QUALITY PROTEIN: calreticulin-like. (540 aa)
	FAF1	FAS-associated factor 1. (654 aa)
	RNF5	E3 ubiquitin-protein ligase RNF5. (180 aa)
	BAG6	Large proline-rich protein BAG6 isoform X1. (1164 aa)
	USP19	Ubiquitin carboxyl-terminal hydrolase 19. (1361 aa)
	OS9	Protein OS-9 isoform X1. (668 aa)
	CLGN	Calmegin. (610 aa)
	WFS1	Wolframin. (889 aa)
	ERLIN1	Erlin-1 isoform X1. (369 aa)
	DERL2	Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family. (239 aa)
	DNAJB14	dnaJ homolog subfamily B member 14. (329 aa)
	PSMC6	26S proteasome regulatory subunit 10B; Belongs to the AAA ATPase family. (403 aa)
	HSP90B1	Endoplasmin. (805 aa)
	TMEM129	E3 ubiquitin-protein ligase TM129 isoform X1. (362 aa)
	RNF121	RING finger protein 121. (327 aa)
	JKAMP	JNK1/MAPK8-associated membrane protein isoform X1. (311 aa)

Your Current Organism:

Neophocaena asiaeorientalis

NCBI taxonomy Id: 1706337
Other names: N. asiaeorientalis asiaeorientalis, Neophocaena asiaeorientalis asiaeorientalis, Yangtze finless porpoise

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AMFR	AUP1	A0A341BY96	A0A341D3Z8	E3 ubiquitin-protein ligase AMFR.	Ancient ubiquitous protein 1 isoform X2.	0.668
AMFR	BAG6	A0A341BY96	A0A341AV44	E3 ubiquitin-protein ligase AMFR.	Large proline-rich protein BAG6 isoform X1.	0.697
AMFR	DERL1	A0A341BY96	A0A341B4Z2	E3 ubiquitin-protein ligase AMFR.	Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family.	0.998
AMFR	DERL2	A0A341BY96	A0A341ANG4	E3 ubiquitin-protein ligase AMFR.	Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family.	0.975
AMFR	DERL3	A0A341BY96	A0A341CYV3	E3 ubiquitin-protein ligase AMFR.	Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family.	0.933
AMFR	ERLEC1	A0A341BY96	A0A341B4P2	E3 ubiquitin-protein ligase AMFR.	Endoplasmic reticulum lectin 1 isoform X1.	0.933
AMFR	ERLIN1	A0A341BY96	A0A341ANQ1	E3 ubiquitin-protein ligase AMFR.	Erlin-1 isoform X1.	0.605
AMFR	ERLIN2	A0A341BY96	A0A341D2D0	E3 ubiquitin-protein ligase AMFR.	Erlin-2 isoform X1.	0.776
AMFR	FAF1	A0A341BY96	A0A341AZX6	E3 ubiquitin-protein ligase AMFR.	FAS-associated factor 1.	0.582
AMFR	FAF2	A0A341BY96	A0A341B8C6	E3 ubiquitin-protein ligase AMFR.	FAS-associated factor 2.	0.885
AMFR	FAM8A1	A0A341BY96	A0A341CYY3	E3 ubiquitin-protein ligase AMFR.	Protein FAM8A1.	0.708
AMFR	FBXO6	A0A341BY96	A0A341BV01	E3 ubiquitin-protein ligase AMFR.	F-box only protein 6.	0.412
AMFR	HERPUD1	A0A341BY96	A0A341BN81	E3 ubiquitin-protein ligase AMFR.	Homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 1 protein.	0.761
AMFR	HSPA5	A0A341BY96	A0A341CV38	E3 ubiquitin-protein ligase AMFR.	Endoplasmic reticulum chaperone BiP; Belongs to the heat shock protein 70 family.	0.683
AMFR	MARCH6	A0A341BY96	A0A341D7V3	E3 ubiquitin-protein ligase AMFR.	E3 ubiquitin-protein ligase MARCH6 isoform X1.	0.758
AMFR	OS9	A0A341BY96	A0A341ATF7	E3 ubiquitin-protein ligase AMFR.	Protein OS-9 isoform X1.	0.972
AMFR	RNF5	A0A341BY96	A0A341AXQ7	E3 ubiquitin-protein ligase AMFR.	E3 ubiquitin-protein ligase RNF5.	0.750
AMFR	SELENOS	A0A341BY96	A0A341D007	E3 ubiquitin-protein ligase AMFR.	Selenoprotein S.	0.484
AMFR	SYVN1	A0A341BY96	A0A341BPD0	E3 ubiquitin-protein ligase AMFR.	E3 ubiquitin-protein ligase synoviolin.	0.640
AMFR	UBE2G2	A0A341BY96	A0A341CHG2	E3 ubiquitin-protein ligase AMFR.	Ubiquitin-conjugating enzyme E2 G2 isoform X1; Belongs to the ubiquitin-conjugating enzyme family.	0.957