STRINGSTRING
TNFRSF1A TNFRSF1A BTG1 BTG1 CTNNB1 CTNNB1 PTCH1 PTCH1 TRIM16 TRIM16 SIX2 SIX2 PAX6 PAX6 HES1 HES1 LOC112404331 LOC112404331 BMP7 BMP7 NKX2-2 NKX2-2 CEBPB CEBPB ZEB1 ZEB1 BAD BAD ERRFI1 ERRFI1 CCND1 CCND1 PRKCH PRKCH LOC112401898 LOC112401898 MMP9 MMP9 OSR1 OSR1 SRSF6 SRSF6 NCOA3 NCOA3 S1PR2 S1PR2 SPRY1 SPRY1 ADD1 ADD1 DLL1 DLL1 KEAP1 KEAP1 FGF2 FGF2 LOC112399174 LOC112399174 ATOH8 ATOH8 STAT5A STAT5A IL1B IL1B NFE2L1 NFE2L1 SFRP4 SFRP4 KRT36 KRT36 EZH2 EZH2 MED1 MED1 TBX3 TBX3 PROM1 PROM1 COMMD5 COMMD5 VCL VCL FGF10 FGF10 FST FST ZFP36L1 ZFP36L1 BMP6 BMP6 KLF7 KLF7 LOC112395012 LOC112395012 GDF2 GDF2 MYCL MYCL PROC PROC FOXN1 FOXN1 LOC112394343 LOC112394343 GRHL1 GRHL1 WNT10B WNT10B ATOH1 ATOH1 VDR VDR ACVRL1 ACVRL1 KRT84 KRT84 BMP4 BMP4 JAG1 JAG1 LOC112392034 LOC112392034 FOXJ2 FOXJ2 LOC112392042 LOC112392042 ETV2 ETV2 APOLD1 APOLD1 ASCL1 ASCL1 CDH5 CDH5 CD109 CD109 CDKN1B CDKN1B XDH XDH KRAS KRAS SPRED1 SPRED1 GATA3 GATA3 S1PR3 S1PR3 NUMA1 NUMA1 GDNF GDNF HOXA7 HOXA7 PRKX PRKX GRHL2 GRHL2 VEZF1 VEZF1 F11R F11R LHX1 LHX1 ROCK1 ROCK1 TMEM100 TMEM100 CAV1 CAV1 AHI1 AHI1 HEY2 HEY2 AJAP1 AJAP1 YAP1 YAP1 TP73 TP73 SPRY2 SPRY2 ZDHHC21 ZDHHC21 FOXJ1 FOXJ1 ETV4 ETV4 WNT9B WNT9B SOX9 SOX9 MAFG MAFG HES5 HES5 MAFF MAFF SMO SMO NOTCH1 NOTCH1 PAX4 PAX4 PTCH2 PTCH2 CLDN5 CLDN5 VHL VHL IKBKB IKBKB BMP2 BMP2 NKX6-3 NKX6-3 LOC112413545 LOC112413545 MESP1 MESP1 NODAL NODAL SFN SFN FRZB FRZB KDF1 KDF1 TP63 TP63 LIF LIF WWTR1 WWTR1 ZFP36 ZFP36
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
TNFRSF1ATumor necrosis factor receptor superfamily member 1A. (445 aa)
BTG1Protein BTG1. (134 aa)
CTNNB1Catenin beta-1. (781 aa)
PTCH1Protein patched homolog 1 isoform X1. (1297 aa)
TRIM16Tripartite motif-containing protein 16. (556 aa)
SIX2Homeobox protein SIX2 isoform X1. (298 aa)
PAX6Paired box protein Pax-6 isoform X1. (493 aa)
HES1Transcription factor HES-1. (280 aa)
LOC112404331Core histone macro-H2A; Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. (372 aa)
BMP7Bone morphogenetic protein 7. (431 aa)
NKX2-2Homeobox protein Nkx-2.2. (273 aa)
CEBPBCCAAT/enhancer-binding protein. (346 aa)
ZEB1LOW QUALITY PROTEIN: zinc finger E-box-binding homeobox 1. (1042 aa)
BADBcl2-associated agonist of cell death. (168 aa)
ERRFI1ERBB receptor feedback inhibitor 1. (459 aa)
CCND1G1/S-specific cyclin-D1; Belongs to the cyclin family. (295 aa)
PRKCHProtein kinase C eta type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that is involved in the regulation of cell differentiation in keratinocytes and pre-B cell receptor, mediates regulation of epithelial tight junction integrity and foam cell formation, and is required for glioblastoma proliferation and apoptosis prevention in MCF-7 cells. In keratinocytes, binds and activates the tyrosine kinase FYN, which in turn blocks epidermal growth factor receptor (EGFR) signaling and leads to keratinocyte growth arrest and differentia [...] (683 aa)
LOC112401898Arachidonate 15-lipoxygenase B-like. (677 aa)
MMP9Matrix metalloproteinase-9. (709 aa)
OSR1LOW QUALITY PROTEIN: protein odd-skipped-related 1. (326 aa)
SRSF6Serine/arginine-rich splicing factor 6. (345 aa)
NCOA3Nuclear receptor coactivator. (1400 aa)
S1PR2Sphingosine 1-phosphate receptor 2; Belongs to the G-protein coupled receptor 1 family. (352 aa)
SPRY1Protein sprouty homolog 1. (319 aa)
ADD1Alpha-adducin isoform X2. (773 aa)
DLL1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (759 aa)
KEAP1Kelch-like ECH-associated protein 1. (624 aa)
FGF2Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (304 aa)
LOC112399174Signal transducer and activator of transcription. (618 aa)
ATOH8LOW QUALITY PROTEIN: protein atonal homolog 8. (317 aa)
STAT5ASignal transducer and activator of transcription. (726 aa)
IL1BMultifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (266 aa)
NFE2L1Endoplasmic reticulum membrane sensor NFE2L1 isoform X1. (777 aa)
SFRP4Secreted frizzled-related protein 4 isoform X1. (346 aa)
KRT36Keratin, type I cuticular Ha6; Belongs to the intermediate filament family. (459 aa)
EZH2Histone-lysine N-methyltransferase EZH2 isoform X1. (751 aa)
MED1Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1579 aa)
TBX3LOW QUALITY PROTEIN: T-box transcription factor TBX3. (734 aa)
PROM1Prominin-1. (836 aa)
COMMD5COMM domain-containing protein 5. (224 aa)
VCLVinculin isoform X2. (1134 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
FSTFollistatin. (344 aa)
ZFP36L1mRNA decay activator protein ZFP36L1. (338 aa)
BMP6Bone morphogenetic protein 6. (309 aa)
KLF7Krueppel-like factor 7 isoform X1. (303 aa)
LOC112395012Cytochrome P450 27C1; Belongs to the cytochrome P450 family. (399 aa)
GDF2Growth/differentiation factor 2. (431 aa)
MYCLProtein L-Myc. (186 aa)
PROCVitamin K-dependent protein C. (480 aa)
FOXN1Forkhead box protein N1. (645 aa)
LOC11239434325-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial; Belongs to the cytochrome P450 family. (508 aa)
GRHL1Grainyhead-like protein 1 homolog. (747 aa)
WNT10BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (389 aa)
ATOH1Protein atonal homolog 1. (352 aa)
VDRVitamin D3 receptor. (427 aa)
ACVRL1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (515 aa)
KRT84LOW QUALITY PROTEIN: keratin, type II cuticular Hb4; Belongs to the intermediate filament family. (624 aa)
BMP4Bone morphogenetic protein 4 isoform X1. (420 aa)
JAG1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1177 aa)
LOC112392034Signal transducer and activator of transcription 5A-like. (105 aa)
FOXJ2LOW QUALITY PROTEIN: forkhead box protein J2. (510 aa)
LOC112392042Protein L-Myc-like. (165 aa)
ETV2LOW QUALITY PROTEIN: ETS translocation variant 2. (374 aa)
APOLD1Apolipoprotein L domain-containing protein 1. (246 aa)
ASCL1LOW QUALITY PROTEIN: achaete-scute homolog 1. (228 aa)
CDH5Cadherin-5; Cadherins are calcium-dependent cell adhesion proteins. (782 aa)
CD109CD109 antigen isoform X1. (1358 aa)
CDKN1BCyclin-dependent kinase inhibitor 1B. (198 aa)
XDHXanthine dehydrogenase/oxidase isoform X1. (1334 aa)
KRASGTPase KRas isoform X3. (227 aa)
SPRED1Sprouty-related, EVH1 domain-containing protein 1 isoform X1. (445 aa)
GATA3Trans-acting T-cell-specific transcription factor GATA-3 isoform X1. (444 aa)
S1PR3Sphingosine 1-phosphate receptor 3; Belongs to the G-protein coupled receptor 1 family. (378 aa)
NUMA1Nuclear mitotic apparatus protein 1 isoform X1. (2125 aa)
GDNFGlial cell line-derived neurotrophic factor isoform X1. (211 aa)
HOXA7Homeobox protein Hox-A7. (233 aa)
PRKXcAMP-dependent protein kinase catalytic subunit PRKX isoform X1. (327 aa)
GRHL2Grainyhead-like protein 2 homolog isoform X1. (625 aa)
VEZF1Vascular endothelial zinc finger 1 isoform X1. (525 aa)
F11RJunctional adhesion molecule A isoform X1. (299 aa)
LHX1LIM/homeobox protein Lhx1. (406 aa)
ROCK1Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1354 aa)
TMEM100Transmembrane protein 100. (134 aa)
CAV1Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (178 aa)
AHI1Jouberin isoform X1. (1178 aa)
HEY2Hairy/enhancer-of-split related with YRPW motif protein 2. (337 aa)
AJAP1Adherens junction-associated protein 1. (399 aa)
YAP1Transcriptional coactivator YAP1. (416 aa)
TP73Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (718 aa)
SPRY2Protein sprouty homolog 2. (315 aa)
ZDHHC21Palmitoyltransferase; Belongs to the DHHC palmitoyltransferase family. (265 aa)
FOXJ1Forkhead box protein J1. (421 aa)
ETV4ETS translocation variant 4 isoform X2. (488 aa)
WNT9BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (602 aa)
SOX9Transcription factor SOX-9. (486 aa)
MAFGTranscription factor MafG. (162 aa)
HES5Transcription factor HES-5. (94 aa)
MAFFTranscription factor MafF. (166 aa)
SMOSmoothened homolog; Belongs to the G-protein coupled receptor Fz/Smo family. (783 aa)
NOTCH1LOW QUALITY PROTEIN: neurogenic locus notch homolog protein 1. (2633 aa)
PAX4Paired box protein Pax-4. (370 aa)
PTCH2Protein patched homolog 2 isoform X1. (1234 aa)
CLDN5Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (218 aa)
VHLVon Hippel-Lindau disease tumor suppressor. (219 aa)
IKBKBInhibitor of nuclear factor kappa-B kinase subunit beta isoform X1. (821 aa)
BMP2Bone morphogenetic protein 2 isoform X1. (395 aa)
NKX6-3Homeobox protein Nkx-6.3. (257 aa)
LOC112413545Core histone macro-H2A; Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. (372 aa)
MESP1Mesoderm posterior protein 1. (265 aa)
NODALNodal homolog. (348 aa)
SFN14-3-3 protein sigma; Belongs to the 14-3-3 family. (248 aa)
FRZBSecreted frizzled-related protein 3. (325 aa)
KDF1Keratinocyte differentiation factor 1. (398 aa)
TP63Tumor protein 63 (p63); Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. (680 aa)
LIFLeukemia inhibitory factor. (202 aa)
WWTR1WW domain-containing transcription regulator protein 1. (400 aa)
ZFP36mRNA decay activator protein ZFP36. (325 aa)
Your Current Organism:
Neophocaena asiaeorientalis
NCBI taxonomy Id: 1706337
Other names: N. asiaeorientalis asiaeorientalis, Neophocaena asiaeorientalis asiaeorientalis, Yangtze finless porpoise
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