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SFRP4 SFRP4 NUMA1 NUMA1 BMP4 BMP4 ACVRL1 ACVRL1 VDR VDR ATOH1 ATOH1 WNT10B WNT10B LOC112394343 LOC112394343 FOXN1 FOXN1 ETV2 ETV2 GDF2 GDF2 LOC112395012 LOC112395012 BMP6 BMP6 COMMD5 COMMD5 PROM1 PROM1 MED1 MED1 PTCH1 PTCH1 CTNNB1 CTNNB1 BTG1 BTG1 GDNF GDNF VEZF1 VEZF1 LHX1 LHX1 TMEM100 TMEM100 AHI1 AHI1 TP73 TP73 FOXJ1 FOXJ1 ETV4 ETV4 SOX9 SOX9 NOTCH1 NOTCH1 PAX4 PAX4 PTCH2 PTCH2 BMP2 BMP2 LOC112413545 LOC112413545 MESP1 MESP1 SFN SFN KDF1 KDF1 LIF LIF ATOH8 ATOH8 FGF2 FGF2 NCOA3 NCOA3 LOC112401898 LOC112401898 PRKCH PRKCH BAD BAD NKX2-2 NKX2-2 BMP7 BMP7 LOC112404331 LOC112404331 PAX6 PAX6 TRIM16 TRIM16
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SFRP4Secreted frizzled-related protein 4 isoform X1. (346 aa)
NUMA1Nuclear mitotic apparatus protein 1 isoform X1. (2125 aa)
BMP4Bone morphogenetic protein 4 isoform X1. (420 aa)
ACVRL1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (515 aa)
VDRVitamin D3 receptor. (427 aa)
ATOH1Protein atonal homolog 1. (352 aa)
WNT10BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (389 aa)
LOC11239434325-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial; Belongs to the cytochrome P450 family. (508 aa)
FOXN1Forkhead box protein N1. (645 aa)
ETV2LOW QUALITY PROTEIN: ETS translocation variant 2. (374 aa)
GDF2Growth/differentiation factor 2. (431 aa)
LOC112395012Cytochrome P450 27C1; Belongs to the cytochrome P450 family. (399 aa)
BMP6Bone morphogenetic protein 6. (309 aa)
COMMD5COMM domain-containing protein 5. (224 aa)
PROM1Prominin-1. (836 aa)
MED1Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1579 aa)
PTCH1Protein patched homolog 1 isoform X1. (1297 aa)
CTNNB1Catenin beta-1. (781 aa)
BTG1Protein BTG1. (134 aa)
GDNFGlial cell line-derived neurotrophic factor isoform X1. (211 aa)
VEZF1Vascular endothelial zinc finger 1 isoform X1. (525 aa)
LHX1LIM/homeobox protein Lhx1. (406 aa)
TMEM100Transmembrane protein 100. (134 aa)
AHI1Jouberin isoform X1. (1178 aa)
TP73Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (718 aa)
FOXJ1Forkhead box protein J1. (421 aa)
ETV4ETS translocation variant 4 isoform X2. (488 aa)
SOX9Transcription factor SOX-9. (486 aa)
NOTCH1LOW QUALITY PROTEIN: neurogenic locus notch homolog protein 1. (2633 aa)
PAX4Paired box protein Pax-4. (370 aa)
PTCH2Protein patched homolog 2 isoform X1. (1234 aa)
BMP2Bone morphogenetic protein 2 isoform X1. (395 aa)
LOC112413545Core histone macro-H2A; Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. (372 aa)
MESP1Mesoderm posterior protein 1. (265 aa)
SFN14-3-3 protein sigma; Belongs to the 14-3-3 family. (248 aa)
KDF1Keratinocyte differentiation factor 1. (398 aa)
LIFLeukemia inhibitory factor. (202 aa)
ATOH8LOW QUALITY PROTEIN: protein atonal homolog 8. (317 aa)
FGF2Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (304 aa)
NCOA3Nuclear receptor coactivator. (1400 aa)
LOC112401898Arachidonate 15-lipoxygenase B-like. (677 aa)
PRKCHProtein kinase C eta type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that is involved in the regulation of cell differentiation in keratinocytes and pre-B cell receptor, mediates regulation of epithelial tight junction integrity and foam cell formation, and is required for glioblastoma proliferation and apoptosis prevention in MCF-7 cells. In keratinocytes, binds and activates the tyrosine kinase FYN, which in turn blocks epidermal growth factor receptor (EGFR) signaling and leads to keratinocyte growth arrest and differentia [...] (683 aa)
BADBcl2-associated agonist of cell death. (168 aa)
NKX2-2Homeobox protein Nkx-2.2. (273 aa)
BMP7Bone morphogenetic protein 7. (431 aa)
LOC112404331Core histone macro-H2A; Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. (372 aa)
PAX6Paired box protein Pax-6 isoform X1. (493 aa)
TRIM16Tripartite motif-containing protein 16. (556 aa)
Your Current Organism:
Neophocaena asiaeorientalis
NCBI taxonomy Id: 1706337
Other names: N. asiaeorientalis asiaeorientalis, Neophocaena asiaeorientalis asiaeorientalis, Yangtze finless porpoise
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