STRINGSTRING
APP APP LOC112391556 LOC112391556 CREBL2 CREBL2 NTF3 NTF3 NTRK3 NTRK3 TERF2IP TERF2IP RAPGEF3 RAPGEF3 IFNG IFNG GCG GCG LOC112395023 LOC112395023 LOC112395027 LOC112395027 IFNE IFNE WNT3A WNT3A AKAP9 AKAP9 EIF4G1 EIF4G1 PTGS2 PTGS2 PINK1 PINK1 PAK1 PAK1 PARK7 PARK7 MAD2L2 MAD2L2 TNKS1BP1 TNKS1BP1 HAX1 HAX1 LATS1 LATS1 WNT5A WNT5A RAMP3 RAMP3 FNIP2 FNIP2 SH2D3A SH2D3A STK4 STK4 CSF3 CSF3 LOC112398466 LOC112398466 BRAF BRAF PDCD10 PDCD10 FNIP1 FNIP1 DOCK7 DOCK7 LOC112395028 LOC112395028 LOC112395029 LOC112395029 LOC112395020 LOC112395020 OPRD1 OPRD1 TGFB1 TGFB1 OSM OSM PRKD2 PRKD2 GSK3A GSK3A LIF LIF NTF4 NTF4 PFN2 PFN2 HDAC6 HDAC6 HCLS1 HCLS1 STOX1 STOX1 LOC112413381 LOC112413381 EGFR EGFR BAG4 BAG4 NGF NGF CAMK1 CAMK1 UCN UCN CNOT9 CNOT9 SH2D3C SH2D3C MAPKAP1 MAPKAP1 RPTOR RPTOR SPRY2 SPRY2 AXIN1 AXIN1 CAV1 CAV1 NOS1 NOS1 LOC112407988 LOC112407988 LOC112408488 LOC112408488 TCL1A TCL1A TCL1B TCL1B LOC112407979 LOC112407979 TRIM6 TRIM6 LOC112407025 LOC112407025 RAF1 RAF1 IFNB1 IFNB1 RIPK2 RIPK2 PIK3CA PIK3CA PRKD1 PRKD1 IL11 IL11 BCL2 BCL2 MTCP1 MTCP1 IFNK IFNK LOC112405728 LOC112405728 NTRK2 NTRK2 GAS6 GAS6 CD44 CD44 ATP2B4 ATP2B4 RET RET BCAR3 BCAR3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
APPAmyloid-beta A4 protein isoform X1. (767 aa)
LOC112391556Tyrosine-protein kinase receptor. (342 aa)
CREBL2cAMP-responsive element-binding protein-like 2 isoform X1. (132 aa)
NTF3Neurotrophin-3; Seems to promote the survival of visceral and proprioceptive sensory neurons; Belongs to the NGF-beta family. (252 aa)
NTRK3NT-3 growth factor receptor. (514 aa)
TERF2IPLOW QUALITY PROTEIN: telomeric repeat-binding factor 2-interacting protein 1. (398 aa)
RAPGEF3Rap guanine nucleotide exchange factor 3. (951 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (166 aa)
GCGGlucagon isoform X1. (180 aa)
LOC112395023Interferon alpha-1-like. (189 aa)
LOC112395027Interferon alpha-1-like. (189 aa)
IFNEInterferon epsilon. (193 aa)
WNT3AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (352 aa)
AKAP9A-kinase anchor protein 9 isoform X1. (3905 aa)
EIF4G1Eukaryotic translation initiation factor 4 gamma 1 isoform X1. (1601 aa)
PTGS2Prostaglandin G/H synthase 2. (604 aa)
PINK1Serine/threonine-protein kinase PINK1, mitochondrial isoform X1. (530 aa)
PAK1Non-specific serine/threonine protein kinase. (544 aa)
PARK7Protein/nucleic acid deglycase DJ-1. (189 aa)
MAD2L2Mitotic spindle assembly checkpoint protein MAD2B. (211 aa)
TNKS1BP1182 kDa tankyrase-1-binding protein isoform X1. (1718 aa)
HAX1HCLS1-associated protein X-1; Recruits the Arp2/3 complex to the cell cortex and regulates reorganization of the cortical actin cytoskeleton via its interaction with KCNC3 and the Arp2/3 complex. Slows down the rate of inactivation of KCNC3 channels. Promotes GNA13-mediated cell migration. Involved in the clathrin-mediated endocytosis pathway. May be involved in internalization of ABC transporters such as ABCB11. May inhibit CASP9 and CASP3. Promotes cell survival. May regulate intracellular calcium pools. (277 aa)
LATS1Serine/threonine-protein kinase LATS1. (1128 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (380 aa)
RAMP3Receptor activity-modifying protein 3. (151 aa)
FNIP2Folliculin-interacting protein 2. (950 aa)
SH2D3ASH2 domain-containing protein 3A. (601 aa)
STK4Serine/threonine-protein kinase 4 isoform X1. (487 aa)
CSF3Granulocyte colony-stimulating factor. (195 aa)
LOC112398466Vasopressin-neurophysin 2-copeptin-like; Belongs to the vasopressin/oxytocin family. (200 aa)
BRAFSerine/threonine-protein kinase B-raf isoform X1. (581 aa)
PDCD10Programmed cell death protein 10. (212 aa)
FNIP1Folliculin-interacting protein 1 isoform X1. (1165 aa)
DOCK7Dedicator of cytokinesis protein 7 isoform X1; Belongs to the DOCK family. (2100 aa)
LOC112395028LOW QUALITY PROTEIN: interferon alpha-8-like. (171 aa)
LOC112395029LOW QUALITY PROTEIN: interferon alpha-8-like. (171 aa)
LOC112395020Interferon alpha-1-like. (189 aa)
OPRD1Delta-type opioid receptor; Belongs to the G-protein coupled receptor 1 family. (368 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (391 aa)
OSMoncostatin-M. (248 aa)
PRKD2LOW QUALITY PROTEIN: serine/threonine-protein kinase D2. (806 aa)
GSK3AGlycogen synthase kinase-3 alpha. (320 aa)
LIFLeukemia inhibitory factor. (202 aa)
NTF4Neurotrophin-4; Belongs to the NGF-beta family. (210 aa)
PFN2Profilin; Belongs to the profilin family. (122 aa)
HDAC6Histone deacetylase 6 isoform X1. (1176 aa)
HCLS1Hematopoietic lineage cell-specific protein. (479 aa)
STOX1Storkhead-box protein 1 isoform X1. (989 aa)
LOC112413381Histone-lysine N-methyltransferase SMYD3-like. (187 aa)
EGFRReceptor protein-tyrosine kinase. (1156 aa)
BAG4BAG family molecular chaperone regulator 4 isoform X1. (459 aa)
NGFBeta-nerve growth factor; Belongs to the NGF-beta family. (241 aa)
CAMK1Calcium/calmodulin-dependent protein kinase type 1 isoform X1; Belongs to the protein kinase superfamily. (387 aa)
UCNUrocortin. (126 aa)
CNOT9CCR4-NOT transcription complex subunit 9. (299 aa)
SH2D3CSH2 domain-containing protein 3C isoform X1. (861 aa)
MAPKAP1Target of rapamycin complex 2 subunit MAPKAP1 isoform X1. (522 aa)
RPTORRegulatory-associated protein of mTOR isoform X1. (1336 aa)
SPRY2Protein sprouty homolog 2. (315 aa)
AXIN1Axin-1 isoform X1. (866 aa)
CAV1Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (178 aa)
NOS1Nitric oxide synthase, brain. (1461 aa)
LOC112407988Secreted frizzled-related protein 2. (294 aa)
LOC112408488Serine/threonine-protein kinase B-raf-like. (250 aa)
TCL1AT-cell leukemia/lymphoma protein 1A. (115 aa)
TCL1BT-cell leukemia/lymphoma protein 1B. (111 aa)
LOC112407979Secreted frizzled-related protein 2-like. (105 aa)
TRIM6Tripartite motif-containing protein 6. (553 aa)
LOC112407025Interferon alpha-1-like. (189 aa)
RAF1RAF proto-oncogene serine/threonine-protein kinase isoform X1. (648 aa)
IFNB1Interferon beta. (185 aa)
RIPK2Receptor-interacting serine/threonine-protein kinase 2. (387 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
PRKD1Serine/threonine-protein kinase D1 isoform X1. (796 aa)
IL11Interleukin-11. (199 aa)
BCL2Apoptosis regulator Bcl-2 isoform X1. (233 aa)
MTCP1Protein p13 MTCP-1. (107 aa)
IFNKInterferon kappa. (207 aa)
LOC112405728Histone-lysine N-methyltransferase SMYD3. (239 aa)
NTRK2Tyrosine-protein kinase receptor. (838 aa)
GAS6Growth arrest-specific protein 6. (540 aa)
CD44CD44 antigen isoform X15. (783 aa)
ATP2B4Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1243 aa)
RETProto-oncogene tyrosine-protein kinase receptor Ret; Receptor tyrosine-protein kinase involved in numerous cellular mechanisms including cell proliferation, neuronal navigation, cell migration, and cell differentiation upon binding with glial cell derived neurotrophic factor family ligands. (1113 aa)
BCAR3Breast cancer anti-estrogen resistance protein 3 isoform X1. (825 aa)
Your Current Organism:
Neophocaena asiaeorientalis
NCBI taxonomy Id: 1706337
Other names: N. asiaeorientalis asiaeorientalis, Neophocaena asiaeorientalis asiaeorientalis, Yangtze finless porpoise
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