STRINGSTRING
SIRT1 SIRT1 LEP LEP BBS4 BBS4 UGCG UGCG BBS2 BBS2 EBI3 EBI3 STAT3 STAT3 MKKS MKKS LEPR LEPR
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SIRT1NAD-dependent protein deacetylase sirtuin-1 isoform X1. (557 aa)
LEPLeptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...] (167 aa)
BBS4Bardet-Biedl syndrome 4 protein isoform X1. (519 aa)
UGCGCeramide glucosyltransferase. (394 aa)
BBS2Bardet-Biedl syndrome 2 protein homolog. (721 aa)
EBI3Interleukin-27 subunit beta isoform X1. (254 aa)
STAT3Signal transducer and activator of transcription. (770 aa)
MKKSMcKusick-Kaufman/Bardet-Biedl syndromes putative chaperonin. (570 aa)
LEPRLeptin receptor isoform X1. (1165 aa)
Your Current Organism:
Neophocaena asiaeorientalis
NCBI taxonomy Id: 1706337
Other names: N. asiaeorientalis asiaeorientalis, Neophocaena asiaeorientalis asiaeorientalis, Yangtze finless porpoise
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