STRINGSTRING
SESN3 SESN3 EIF2AK4 EIF2AK4 ITFG2 ITFG2 ATF2 ATF2 DAPL1 DAPL1 WDR59 WDR59 CUNH12orf66 CUNH12orf66 ATF4 ATF4 LOC112396523 LOC112396523 GCN1 GCN1 FAS FAS EIF2AK3 EIF2AK3 MAPK3 MAPK3 SZT2 SZT2 NPRL2 NPRL2 EIF2S1 EIF2S1 RRAGD RRAGD MTOR MTOR ATF3 ATF3 LARS LARS FLCN FLCN EIF2AK2 EIF2AK2 RNF152 RNF152 SESN1 SESN1 PRKD1 PRKD1 IMPACT IMPACT BMT2 BMT2 MAP3K5 MAP3K5 WDR24 WDR24 NPRL3 NPRL3 MAPK1 MAPK1 SEH1L SEH1L CDKN1A CDKN1A TFEB TFEB MIOS MIOS SESN2 SESN2 DAP DAP SH3GLB1 SH3GLB1 DEPDC5 DEPDC5 KPTN KPTN
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SESN3Sestrin-3. (414 aa)
EIF2AK4eIF-2-alpha kinase GCN2 isoform X1. (1670 aa)
ITFG2KICSTOR complex protein ITFG2. (444 aa)
ATF2Cyclic AMP-dependent transcription factor ATF-2 isoform X1. (505 aa)
DAPL1Death-associated protein-like 1. (107 aa)
WDR59GATOR complex protein WDR59 isoform X1. (974 aa)
CUNH12orf66KICSTOR complex protein C12orf66 homolog. (445 aa)
ATF4Cyclic AMP-dependent transcription factor ATF-4. (350 aa)
LOC112396523Ras-related GTP-binding protein B isoform X1. (374 aa)
GCN1eIF-2-alpha kinase activator GCN1. (2671 aa)
FASTumor necrosis factor receptor superfamily member 6 isoform X1. (334 aa)
EIF2AK3Eukaryotic translation initiation factor 2-alpha kinase 3 isoform X1. (1128 aa)
MAPK3Mitogen-activated protein kinase 3. (265 aa)
SZT2KICSTOR complex protein SZT2 isoform X1. (3434 aa)
NPRL2GATOR complex protein NPRL2 isoform X1. (380 aa)
EIF2S1Eukaryotic translation initiation factor 2 subunit 1. (315 aa)
RRAGDRas-related GTP-binding protein D. (396 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2548 aa)
ATF3Cyclic AMP-dependent transcription factor ATF-3. (181 aa)
LARSleucine--tRNA ligase, cytoplasmic; Belongs to the class-I aminoacyl-tRNA synthetase family. (1159 aa)
FLCNFolliculin isoform X1. (576 aa)
EIF2AK2Interferon-induced, double-stranded RNA-activated protein kinase isoform X1. (539 aa)
RNF152E3 ubiquitin-protein ligase RNF152. (203 aa)
SESN1Sestrin-1 isoform X1. (551 aa)
PRKD1Serine/threonine-protein kinase D1 isoform X1. (796 aa)
IMPACTProtein IMPACT isoform X1. (318 aa)
BMT2S-adenosylmethionine sensor upstream of mTORC1; S-adenosyl-L-methionine-binding protein that acts as an inhibitor of mTORC1 signaling via interaction with the GATOR1 and KICSTOR complexes. Acts as a sensor of S-adenosyl-L-methionine to signal methionine sufficiency to mTORC1: in presence of methionine, binds S-adenosyl-L-methionine, leading to disrupt interaction with the GATOR1 and KICSTOR complexes and promote mTORC1 signaling. Upon methionine starvation, S-adenosyl-L-methionine levels are reduced, thereby promoting the association with GATOR1 and KICSTOR, leading to inhibit mTORC1 s [...] (405 aa)
MAP3K5Mitogen-activated protein kinase kinase kinase 5 isoform X2. (1366 aa)
WDR24GATOR complex protein WDR24. (809 aa)
NPRL3GATOR complex protein NPRL3 isoform X1. (621 aa)
MAPK1Mitogen-activated protein kinase. (343 aa)
SEH1LNucleoporin SEH1 isoform X2; Belongs to the WD repeat SEC13 family. (423 aa)
CDKN1ACyclin-dependent kinase inhibitor 1. (164 aa)
TFEBLOW QUALITY PROTEIN: transcription factor EB. (473 aa)
MIOSGATOR complex protein MIOS isoform X1. (875 aa)
SESN2Sestrin-2. (471 aa)
DAPDeath-associated protein 1. (102 aa)
SH3GLB1endophilin-B1. (365 aa)
DEPDC5GATOR complex protein DEPDC5 isoform X1. (1650 aa)
KPTNKICSTOR complex protein kaptin. (435 aa)
Your Current Organism:
Neophocaena asiaeorientalis
NCBI taxonomy Id: 1706337
Other names: N. asiaeorientalis asiaeorientalis, Neophocaena asiaeorientalis asiaeorientalis, Yangtze finless porpoise
Server load: low (14%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.