STRINGSTRING
PDGFRA PDGFRA PJVK PJVK SMPD3 SMPD3 FXN FXN NFE2L2 NFE2L2 CHUK CHUK RIPK1 RIPK1 PPARGC1B PPARGC1B LOC112396093 LOC112396093 ADPRHL2 ADPRHL2 ANXA1 ANXA1 ECT2 ECT2 PPIF PPIF EZH2 EZH2 PDCD10 PDCD10 FER FER SRC SRC LOC112399095 LOC112399095 PDK2 PDK2 MAPK3 MAPK3 PCGF2 PCGF2 SOD3 SOD3 PRKCD PRKCD PRDX1 PRDX1 MMP2 MMP2 NCF1 NCF1 MMP9 MMP9 OSER1 OSER1 SOD2 SOD2 PRDX5 PRDX5 CCS CCS PARK7 PARK7 RELA RELA TREX1 TREX1 CAT CAT RNF112 RNF112 LOC112405151 LOC112405151 LOC112404678 LOC112404678 MAPK7 MAPK7 FANCC FANCC RIPK3 RIPK3 SIGMAR1 SIGMAR1 NOS3 NOS3 AQP1 AQP1 STK25 STK25 PLEKHA1 PLEKHA1 ZNF580 ZNF580 PRDX3 PRDX3 JUN JUN LOC112407442 LOC112407442 NET1 NET1 ZNF277 ZNF277 MPO MPO IMPACT IMPACT SOD1 SOD1 TRPM2 TRPM2 MAP3K5 MAP3K5 TNFAIP3 TNFAIP3 PTPRK PTPRK SPHK1 SPHK1 RPS3 RPS3 ABL1 ABL1 SETX SETX ANKZF1 ANKZF1 MAPK1 MAPK1 NQO1 NQO1 EDN1 EDN1 MAPK9 MAPK9 EGFR EGFR MAPK13 MAPK13 SIRT1 SIRT1 PRDX2 PRDX2 HDAC6 HDAC6
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PDGFRAPlatelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. (1089 aa)
PJVKPejvakin. (355 aa)
SMPD3Sphingomyelin phosphodiesterase 3. (653 aa)
FXNLOW QUALITY PROTEIN: frataxin, mitochondrial. (244 aa)
NFE2L2Nuclear factor erythroid 2-related factor 2 isoform X1. (622 aa)
CHUKInhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1. (744 aa)
RIPK1Receptor-interacting serine/threonine-protein kinase 1. (667 aa)
PPARGC1BPeroxisome proliferator-activated receptor gamma coactivator 1-beta isoform X1. (1019 aa)
LOC112396093Superoxide dismutase [Cu-Zn]; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the Cu-Zn superoxide dismutase family. (153 aa)
ADPRHL2poly(ADP-ribose) glycohydrolase ARH3. (365 aa)
ANXA1Annexin. (346 aa)
ECT2Protein ECT2 isoform X1. (973 aa)
PPIFPeptidyl-prolyl cis-trans isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family. (205 aa)
EZH2Histone-lysine N-methyltransferase EZH2 isoform X1. (751 aa)
PDCD10Programmed cell death protein 10. (212 aa)
FERTyrosine-protein kinase; Belongs to the protein kinase superfamily. Tyr protein kinase family. Fes/fps subfamily. (822 aa)
SRCTyrosine-protein kinase. (601 aa)
LOC112399095Reactive oxygen species modulator 1. (79 aa)
PDK2Protein-serine/threonine kinase. (407 aa)
MAPK3Mitogen-activated protein kinase 3. (265 aa)
PCGF2Polycomb group RING finger protein 2 isoform X1. (389 aa)
SOD3Superoxide dismutase [Cu-Zn]; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the Cu-Zn superoxide dismutase family. (244 aa)
PRKCDProtein kinase C delta type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays contrasting roles in cell death and cell survival by functioning as a pro-apoptotic protein during DNA damage-induced apoptosis, but acting as an anti- apoptotic protein during cytokine receptor-initiated cell death, is involved in tumor suppression; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (675 aa)
PRDX1Peroxiredoxin-1. (199 aa)
MMP272 kDa type IV collagenase. (661 aa)
NCF1Neutrophil cytosol factor 1 isoform X1. (393 aa)
MMP9Matrix metalloproteinase-9. (709 aa)
OSER1Oxidative stress-responsive serine-rich protein 1. (292 aa)
SOD2Superoxide dismutase; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the iron/manganese superoxide dismutase family. (232 aa)
PRDX5Peroxiredoxin; Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides; Belongs to the peroxiredoxin family. Prx5 subfamily. (219 aa)
CCSCopper chaperone for superoxide dismutase. (274 aa)
PARK7Protein/nucleic acid deglycase DJ-1. (189 aa)
RELATranscription factor p65. (562 aa)
TREX1Three-prime repair exonuclease 1. (314 aa)
CATCatalase; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. (527 aa)
RNF112RING finger protein 112. (604 aa)
LOC112405151Cytochrome P450 1B1; Belongs to the cytochrome P450 family. (543 aa)
LOC112404678LOW QUALITY PROTEIN: peroxiredoxin-1-like. (343 aa)
MAPK7Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (732 aa)
FANCCFanconi anemia group C protein homolog; DNA repair protein that may operate in a postreplication repair or a cell cycle checkpoint function. May be implicated in interstrand DNA cross-link repair and in the maintenance of normal chromosome stability. Upon IFNG induction, may facilitate STAT1 activation by recruiting STAT1 to IFNGR1. (562 aa)
RIPK3LOW QUALITY PROTEIN: receptor-interacting serine/threonine-protein kinase 3. (518 aa)
SIGMAR1Sigma non-opioid intracellular receptor 1. (223 aa)
NOS3Nitric oxide synthase; Produces nitric oxide (NO). (1205 aa)
AQP1Aquaporin-1; Belongs to the MIP/aquaporin (TC 1.A.8) family. (271 aa)
STK25Serine/threonine-protein kinase 25. (458 aa)
PLEKHA1Pleckstrin homology domain-containing family A member 1 isoform X1. (404 aa)
ZNF580Zinc finger protein 580 isoform X1. (300 aa)
PRDX3Thioredoxin-dependent peroxide reductase, mitochondrial. (257 aa)
JUNLOW QUALITY PROTEIN: transcription factor AP-1; Belongs to the bZIP family. (284 aa)
LOC112407442LOW QUALITY PROTEIN: frataxin, mitochondrial-like. (215 aa)
NET1Neuroepithelial cell-transforming gene 1 protein isoform X1. (548 aa)
ZNF277Zinc finger protein 277 isoform X1. (456 aa)
MPOMyeloperoxidase. (718 aa)
IMPACTProtein IMPACT isoform X1. (318 aa)
SOD1Superoxide dismutase [Cu-Zn]; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the Cu-Zn superoxide dismutase family. (153 aa)
TRPM2Transient receptor potential cation channel subfamily M member 2 isoform X1. (1497 aa)
MAP3K5Mitogen-activated protein kinase kinase kinase 5 isoform X2. (1366 aa)
TNFAIP3Tumor necrosis factor alpha-induced protein 3. (785 aa)
PTPRKReceptor-type tyrosine-protein phosphatase kappa isoform X1. (1439 aa)
SPHK1Sphingosine kinase 1. (391 aa)
RPS340S ribosomal protein S3; Belongs to the universal ribosomal protein uS3 family. (243 aa)
ABL1Tyrosine-protein kinase. (1148 aa)
SETXProbable helicase senataxin isoform X1. (2684 aa)
ANKZF1LOW QUALITY PROTEIN: ankyrin repeat and zinc finger domain-containing protein 1. (723 aa)
MAPK1Mitogen-activated protein kinase. (343 aa)
NQO1LOW QUALITY PROTEIN: NAD(P)H dehydrogenase [quinone] 1. (200 aa)
EDN1Endothelin-1. (202 aa)
MAPK9Mitogen-activated protein kinase. (424 aa)
EGFRReceptor protein-tyrosine kinase. (1156 aa)
MAPK13Mitogen-activated protein kinase. (366 aa)
SIRT1NAD-dependent protein deacetylase sirtuin-1 isoform X1. (557 aa)
PRDX2Peroxiredoxin-2. (198 aa)
HDAC6Histone deacetylase 6 isoform X1. (1176 aa)
Your Current Organism:
Neophocaena asiaeorientalis
NCBI taxonomy Id: 1706337
Other names: N. asiaeorientalis asiaeorientalis, Neophocaena asiaeorientalis asiaeorientalis, Yangtze finless porpoise
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