(32 nodes) Regulation of fatty acid biosynthetic process network (Neophocaena asiaeorientalis)

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Predicted Interactions

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Your Input:
	ACADVL	Very long-chain specific acyl-CoA dehydrogenase, mitochondrial isoform X1. (655 aa)
	FABP5	Fatty acid-binding protein, epidermal; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. (135 aa)
	CD74	HLA class II histocompatibility antigen gamma chain isoform X1. (278 aa)
	INSIG2	Insulin-induced gene protein; Mediates feedback control of cholesterol synthesis. Belongs to the INSIG family. (225 aa)
	ERLIN1	Erlin-1 isoform X1. (369 aa)
	ANXA1	Annexin. (346 aa)
	INSIG1	Insulin-induced gene protein; Mediates feedback control of cholesterol synthesis. Belongs to the INSIG family. (294 aa)
	BRCA1	Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...] (1870 aa)
	TRIB3	Tribbles homolog 3. (357 aa)
	EIF6	Eukaryotic translation initiation factor 6; Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. Behaves as a stimulatory translation initiation factor downstream insulin/growth factors. Is also involved in ribosome biogenesis. Associates with pre-60S subunits in the nucleus and is involved in its nuclear export. Cytoplasmic release of TIF6 from 60S subunits and nuclear relocalization is promoted by a RACK1 (RACK1)- dependent protein kinase C activity. In tissues responsive to insulin, contro [...] (245 aa)
	IL1B	Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (266 aa)
	GIP	Gastric inhibitory polypeptide isoform X1. (143 aa)
	MLXIPL	Carbohydrate-responsive element-binding protein isoform X1. (929 aa)
	NR1H3	Oxysterols receptor LXR-alpha isoform X1. (447 aa)
	SLC45A3	Solute carrier family 45 member 3. (553 aa)
	LPGAT1	acyl-CoA:lysophosphatidylglycerol acyltransferase 1. (370 aa)
	PTGS2	Prostaglandin G/H synthase 2. (604 aa)
	SCAP	Sterol regulatory element-binding protein cleavage-activating protein isoform X1. (1306 aa)
	ABCD2	ATP-binding cassette sub-family D member 2 isoform X1. (741 aa)
	APOC3	Apolipoprotein C-III. (99 aa)
	APOA4	Apolipoprotein A-IV. (380 aa)
	APOA5	Apolipoprotein A-V. (369 aa)
	PIBF1	Progesterone-induced-blocking factor 1 isoform X1. (757 aa)
	ABCD1	ATP-binding cassette sub-family D member 1 isoform X1. (774 aa)
	ELOVL5	Elongation of very long chain fatty acids protein 5; Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that acts specifically toward polyunsaturated acyl-CoA with the higher activity toward C18:3(n-6) acyl-CoA. May participate to the production of monounsaturated and of polyunsaturated VLCFAs of different chain lengths that are involv [...] (295 aa)
	MID1IP1	Mid1-interacting protein 1. (183 aa)
	ERLIN2	Erlin-2 isoform X1. (339 aa)
	SIRT1	NAD-dependent protein deacetylase sirtuin-1 isoform X1. (557 aa)
	WDTC1	WD and tetratricopeptide repeats protein 1 isoform X1. (679 aa)
	PDK4	Protein-serine/threonine kinase. (407 aa)
	NR1H2	Oxysterols receptor LXR-beta isoform X1. (450 aa)
	PLA2G3	Group 3 secretory phospholipase A2 isoform X1. (516 aa)

Your Current Organism:

Neophocaena asiaeorientalis

NCBI taxonomy Id: 1706337
Other names: N. asiaeorientalis asiaeorientalis, Neophocaena asiaeorientalis asiaeorientalis, Yangtze finless porpoise

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ABCD1	ABCD2	A0A341CAI8	A0A341BXD0	ATP-binding cassette sub-family D member 1 isoform X1.	ATP-binding cassette sub-family D member 2 isoform X1.	0.953
ABCD2	ABCD1	A0A341BXD0	A0A341CAI8	ATP-binding cassette sub-family D member 2 isoform X1.	ATP-binding cassette sub-family D member 1 isoform X1.	0.953
ACADVL	PDK4	A0A341A8Y3	A0A341D784	Very long-chain specific acyl-CoA dehydrogenase, mitochondrial isoform X1.	Protein-serine/threonine kinase.	0.510
ANXA1	IL1B	A0A341AZD7	A0A341BAA0	Annexin.	Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family.	0.450
APOA4	APOA5	A0A341BZ91	A0A341C0X5	Apolipoprotein A-IV.	Apolipoprotein A-V.	0.660
APOA4	APOC3	A0A341BZ91	A0A341BY79	Apolipoprotein A-IV.	Apolipoprotein C-III.	0.961
APOA5	APOA4	A0A341C0X5	A0A341BZ91	Apolipoprotein A-V.	Apolipoprotein A-IV.	0.660
APOA5	APOC3	A0A341C0X5	A0A341BY79	Apolipoprotein A-V.	Apolipoprotein C-III.	0.838
APOA5	MLXIPL	A0A341C0X5	A0A341BMK8	Apolipoprotein A-V.	Carbohydrate-responsive element-binding protein isoform X1.	0.444
APOC3	APOA4	A0A341BY79	A0A341BZ91	Apolipoprotein C-III.	Apolipoprotein A-IV.	0.961
APOC3	APOA5	A0A341BY79	A0A341C0X5	Apolipoprotein C-III.	Apolipoprotein A-V.	0.838
ELOVL5	SLC45A3	A0A341CAN5	A0A341BW31	Elongation of very long chain fatty acids protein 5; Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that acts specifically toward polyunsaturated acyl-CoA with the higher activity toward C18:3(n-6) acyl-CoA. May participate to the production of monounsaturated and of polyunsaturated VLCFAs of different chain lengths that are involv [...]	Solute carrier family 45 member 3.	0.414
ERLIN1	ERLIN2	A0A341ANQ1	A0A341D2D0	Erlin-1 isoform X1.	Erlin-2 isoform X1.	0.995
ERLIN2	ERLIN1	A0A341D2D0	A0A341ANQ1	Erlin-2 isoform X1.	Erlin-1 isoform X1.	0.995
ERLIN2	INSIG1	A0A341D2D0	A0A341B026	Erlin-2 isoform X1.	Insulin-induced gene protein; Mediates feedback control of cholesterol synthesis. Belongs to the INSIG family.	0.423
ERLIN2	INSIG2	A0A341D2D0	A0A341AK68	Erlin-2 isoform X1.	Insulin-induced gene protein; Mediates feedback control of cholesterol synthesis. Belongs to the INSIG family.	0.423
IL1B	ANXA1	A0A341BAA0	A0A341AZD7	Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family.	Annexin.	0.450
IL1B	PTGS2	A0A341BAA0	A0A341BW81	Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family.	Prostaglandin G/H synthase 2.	0.871
IL1B	SIRT1	A0A341BAA0	A0A341D5L9	Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family.	NAD-dependent protein deacetylase sirtuin-1 isoform X1.	0.641
INSIG1	ERLIN2	A0A341B026	A0A341D2D0	Insulin-induced gene protein; Mediates feedback control of cholesterol synthesis. Belongs to the INSIG family.	Erlin-2 isoform X1.	0.423