STRINGSTRING
RBM22 RBM22 GLI3 GLI3 CDH1 CDH1 BMP4 BMP4 NF1 NF1 IFNG IFNG PSEN1 PSEN1 SHH SHH ZC3H12A ZC3H12A ECT2 ECT2 IPO5 IPO5 CABP1 CABP1 TRIM28 TRIM28 FLNA FLNA MAVS MAVS CHP2 CHP2 HCLS1 HCLS1 PRKCD PRKCD JUP JUP LOC112400718 LOC112400718 PKIG PKIG EPM2A EPM2A TARDBP TARDBP ZPR1 ZPR1 TPR TPR HDAC3 HDAC3 APOD APOD PIK3R1 PIK3R1 RAB23 RAB23 PRKD1 PRKD1 BAG3 BAG3 UBR5 UBR5 DMAP1 DMAP1 SMO SMO LEP LEP EFCAB7 EFCAB7 PTPN22 PTPN22 TGFB1 TGFB1 FERMT1 FERMT1 PIK3R2 PIK3R2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
RBM22pre-mRNA-splicing factor RBM22 isoform X1. (420 aa)
GLI3Transcriptional activator GLI3. (1587 aa)
CDH1Cadherin-1; Cadherins are calcium-dependent cell adhesion proteins. (885 aa)
BMP4Bone morphogenetic protein 4 isoform X1. (420 aa)
NF1Neurofibromin isoform X1. (2841 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (166 aa)
PSEN1Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (468 aa)
SHHSonic hedgehog protein. (328 aa)
ZC3H12AEndoribonuclease ZC3H12A. (583 aa)
ECT2Protein ECT2 isoform X1. (973 aa)
IPO5Importin-5. (1037 aa)
CABP1Calcium-binding protein 1 isoform X1. (226 aa)
TRIM28Transcription intermediary factor 1-beta. (983 aa)
FLNAfilamin-A isoform X1. (2592 aa)
MAVSMitochondrial antiviral-signaling protein isoform X1. (581 aa)
CHP2Calcineurin B homologous protein 2. (196 aa)
HCLS1Hematopoietic lineage cell-specific protein. (479 aa)
PRKCDProtein kinase C delta type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays contrasting roles in cell death and cell survival by functioning as a pro-apoptotic protein during DNA damage-induced apoptosis, but acting as an anti- apoptotic protein during cytokine receptor-initiated cell death, is involved in tumor suppression; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (675 aa)
JUPJunction plakoglobin. (744 aa)
LOC112400718Hyaluronidase. (781 aa)
PKIGcAMP-dependent protein kinase inhibitor; Belongs to the PKI family. (76 aa)
EPM2ALaforin isoform X1. (331 aa)
TARDBPTAR DNA-binding protein 43. (414 aa)
ZPR1Zinc finger protein ZPR1. (459 aa)
TPRNucleoprotein TPR isoform X1. (2438 aa)
HDAC3Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily. (428 aa)
APODApolipoprotein D isoform X1; Belongs to the calycin superfamily. Lipocalin family. (243 aa)
PIK3R1Phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1. (724 aa)
RAB23Ras-related protein Rab-23. (237 aa)
PRKD1Serine/threonine-protein kinase D1 isoform X1. (796 aa)
BAG3BAG family molecular chaperone regulator 3. (577 aa)
UBR5E3 ubiquitin-protein ligase UBR5 isoform X1. (2552 aa)
DMAP1DNA methyltransferase 1-associated protein 1 isoform X1. (468 aa)
SMOSmoothened homolog; Belongs to the G-protein coupled receptor Fz/Smo family. (783 aa)
LEPLeptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...] (167 aa)
EFCAB7EF-hand calcium-binding domain-containing protein 7 isoform X1. (633 aa)
PTPN22Tyrosine-protein phosphatase non-receptor type 22 isoform X1. (801 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (391 aa)
FERMT1Fermitin family homolog 1 isoform X1. (677 aa)
PIK3R2Phosphatidylinositol 3-kinase regulatory subunit beta. (723 aa)
Your Current Organism:
Neophocaena asiaeorientalis
NCBI taxonomy Id: 1706337
Other names: N. asiaeorientalis asiaeorientalis, Neophocaena asiaeorientalis asiaeorientalis, Yangtze finless porpoise
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