STRINGSTRING
PIK3R4 PIK3R4 PDGFRB PDGFRB FGFR3 FGFR3 ATG14 ATG14 SOCS4 SOCS4 WDR81 WDR81 PIP4K2C PIP4K2C WDR91 WDR91 LOC112397808 LOC112397808 PIP4K2B PIP4K2B LYN LYN SLA2 SLA2 RBL1 RBL1 SOCS1 SOCS1 CD19 CD19 FGF2 FGF2 SOCS7 SOCS7 LOC112400411 LOC112400411 LOC112400438 LOC112400438 PDGFRA PDGFRA CISH CISH RBL2 RBL2 NOD2 NOD2 CCL21 CCL21 CCL19 CCL19 SOCS2 SOCS2 TEK TEK RUBCN RUBCN SOCS6 SOCS6 FLT1 FLT1 LOC112406619 LOC112406619 RB1 RB1 LOC112408000 LOC112408000 PDGFB PDGFB SOCS3 SOCS3 VAV2 VAV2 DAB2IP DAB2IP NRBF2 NRBF2 PIP4K2A PIP4K2A EPHA8 EPHA8 FGR FGR PTK2B PTK2B PIK3R2 PIK3R2 TGFB1 TGFB1 PIK3IP1 PIK3IP1 CD81 CD81 PIK3R5 PIK3R5 PIK3R6 PIK3R6 F2 F2 DGKZ DGKZ AMBRA1 AMBRA1 EEF1A2 EEF1A2 PPP2R5A PPP2R5A PIK3R1 PIK3R1 SOCS5 SOCS5
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PIK3R4Phosphoinositide 3-kinase regulatory subunit 4. (1358 aa)
PDGFRBPlatelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. (1103 aa)
FGFR3Fibroblast growth factor receptor. (804 aa)
ATG14Beclin 1-associated autophagy-related key regulator. (492 aa)
SOCS4Suppressor of cytokine signaling 4. (440 aa)
WDR81WD repeat-containing protein 81. (1944 aa)
PIP4K2CPhosphatidylinositol 5-phosphate 4-kinase type-2 gamma. (421 aa)
WDR91WD repeat-containing protein 91 isoform X1. (784 aa)
LOC112397808Guanine nucleotide exchange factor VAV3-like. (757 aa)
PIP4K2BPhosphatidylinositol 5-phosphate 4-kinase type-2 beta. (416 aa)
LYNTyrosine-protein kinase. (518 aa)
SLA2Src-like-adapter 2. (277 aa)
RBL1Retinoblastoma-like protein 1 isoform X1. (1073 aa)
SOCS1Suppressor of cytokine signaling 1. (214 aa)
CD19B-lymphocyte antigen CD19 isoform X1. (571 aa)
FGF2Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (304 aa)
SOCS7Suppressor of cytokine signaling 7. (543 aa)
LOC112400411LOW QUALITY PROTEIN: uncharacterized LOC110117498 homolog. (102 aa)
LOC112400438Phosphatidylinositol 3-kinase regulatory subunit gamma. (461 aa)
PDGFRAPlatelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. (1089 aa)
CISHCytokine-inducible SH2-containing protein. (254 aa)
RBL2Retinoblastoma-like protein 2 isoform X1. (1141 aa)
NOD2Nucleotide-binding oligomerization domain-containing protein 2 isoform X1. (1021 aa)
CCL21C-C motif chemokine 21 isoform X1. (131 aa)
CCL19C-C motif chemokine. (174 aa)
SOCS2Suppressor of cytokine signaling 2. (198 aa)
TEKAngiopoietin-1 receptor isoform X1. (1125 aa)
RUBCNRun domain Beclin-1-interacting and cysteine-rich domain-containing protein isoform X1. (996 aa)
SOCS6Suppressor of cytokine signaling 6. (535 aa)
FLT1Vascular endothelial growth factor receptor 1; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (803 aa)
LOC112406619Nuclear receptor-binding factor 2-like isoform X1. (232 aa)
RB1Retinoblastoma-associated protein. (816 aa)
LOC112408000Guanine nucleotide exchange factor VAV3. (209 aa)
PDGFBPlatelet-derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (209 aa)
SOCS3Suppressor of cytokine signaling 3. (237 aa)
VAV2Guanine nucleotide exchange factor VAV2. (868 aa)
DAB2IPDisabled homolog 2-interacting protein isoform X1. (1071 aa)
NRBF2Nuclear receptor-binding factor 2 isoform X1. (288 aa)
PIP4K2APhosphatidylinositol 5-phosphate 4-kinase type-2 alpha. (347 aa)
EPHA8Ephrin type-A receptor 8. (980 aa)
FGRTyrosine-protein kinase. (526 aa)
PTK2BProtein-tyrosine kinase 2-beta isoform X1; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1009 aa)
PIK3R2Phosphatidylinositol 3-kinase regulatory subunit beta. (723 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (391 aa)
PIK3IP1Phosphoinositide-3-kinase-interacting protein 1 isoform X1. (264 aa)
CD81Tetraspanin. (442 aa)
PIK3R5LOW QUALITY PROTEIN: phosphoinositide 3-kinase regulatory subunit 5. (874 aa)
PIK3R6Phosphoinositide 3-kinase regulatory subunit 6. (763 aa)
F2Prothrombin; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing; Belongs to the peptidase S1 family. (623 aa)
DGKZDiacylglycerol kinase. (1185 aa)
AMBRA1Activating molecule in BECN1-regulated autophagy protein 1 isoform X2. (1295 aa)
EEF1A2Elongation factor 1-alpha 2. (732 aa)
PPP2R5ASerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (488 aa)
PIK3R1Phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1. (724 aa)
SOCS5Suppressor of cytokine signaling 5. (536 aa)
Your Current Organism:
Neophocaena asiaeorientalis
NCBI taxonomy Id: 1706337
Other names: N. asiaeorientalis asiaeorientalis, Neophocaena asiaeorientalis asiaeorientalis, Yangtze finless porpoise
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