(65 nodes) Dicarboxylic acid metabolic process network (Neophocaena asiaeorientalis)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	UROC1	Urocanate hydratase. (677 aa)
	LOC112390775	Folate receptor alpha-like. (251 aa)
	SDHA	Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial; Flavoprotein (FP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). (665 aa)
	ALDH1L2	10-formyltetrahydrofolate dehydrogenase; In the C-terminal section; belongs to the aldehyde dehydrogenase family. ALDH1L subfamily. (923 aa)
	PRODH2	Proline dehydrogenase; Converts proline to delta-1-pyrroline-5-carboxylate. (460 aa)
	GLS	LOW QUALITY PROTEIN: glutaminase kidney isoform, mitochondrial. (674 aa)
	CUNH10orf62	Uncharacterized protein C10orf62 homolog. (340 aa)
	HOGA1	4-hydroxy-2-oxoglutarate aldolase, mitochondrial isoform X1; Belongs to the DapA family. (333 aa)
	GOT1	Aspartate aminotransferase. (413 aa)
	ACSF3	acyl-CoA synthetase family member 3, mitochondrial. (628 aa)
	DGLUCY	LOW QUALITY PROTEIN: D-glutamate cyclase, mitochondrial. (619 aa)
	TAT	Tyrosine aminotransferase; Transaminase involved in tyrosine breakdown. Converts tyrosine to p-hydroxyphenylpyruvate. (454 aa)
	DLST	annotation not available (455 aa)
	GLS2	Glutaminase liver isoform, mitochondrial. (602 aa)
	SHMT2	Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family. (504 aa)
	MDH1B	Putative malate dehydrogenase 1B isoform X1. (505 aa)
	IDH1	Isocitrate dehydrogenase [NADP]; Belongs to the isocitrate and isopropylmalate dehydrogenases family. (414 aa)
	DDO	D-aspartate oxidase. (341 aa)
	FH	Fumarate hydratase, mitochondrial. (510 aa)
	KMO	Kynurenine 3-monooxygenase; Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid, a neurotoxic NMDA receptor antagonist and potential endogenous inhibitor of NMDA receptor signaling in axonal targeting, synaptogenesis and apoptosis during brain development. Quinolinic acid may also affect NMDA receptor signaling in pancreatic beta cells, osteoblasts, myocardial cells, and the gastrointestinal tract. (493 aa)
	ACLY	ATP-citrate synthase; Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate for de novo cholesterol and fatty acid synthesis; In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family. (1101 aa)
	ADHFE1	Hydroxyacid-oxoacid transhydrogenase, mitochondrial isoform X1. (525 aa)
	KYAT3	Kynurenine--oxoglutarate transaminase 3 isoform X2. (455 aa)
	QPRT	Nicotinate-nucleotide pyrophosphorylase [carboxylating]; Involved in the catabolism of quinolinic acid (QA). Belongs to the NadC/ModD family. (299 aa)
	KYNU	Kynureninase; Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively. Has a preference for the L-3-hydroxy form. Also has cysteine-conjugate-beta-lyase activity. Belongs to the kynureninase family. (472 aa)
	ASL	Argininosuccinate lyase. (464 aa)
	OGDH	2-oxoglutarate dehydrogenase, mitochondrial isoform X3. (1039 aa)
	MDH2	Malate dehydrogenase. (338 aa)
	ACOT8	Acyl-coenzyme A thioesterase 8. (315 aa)
	MTHFD1L	Monofunctional C1-tetrahydrofolate synthase, mitochondrial isoform X1. (867 aa)
	ALDH4A1	Delta-1-pyrroline-5-carboxylate dehydrogenase; Belongs to the aldehyde dehydrogenase family. (565 aa)
	ALDH18A1	Delta-1-pyrroline-5-carboxylate synthase; In the C-terminal section; belongs to the gamma-glutamyl phosphate reductase family. (795 aa)
	GOT2	Aspartate aminotransferase. (430 aa)
	PCK1	Phosphoenolpyruvate carboxykinase, cytosolic [GTP]. (622 aa)
	GCLM	Glutamate--cysteine ligase regulatory subunit. (363 aa)
	MTHFD1	C-1-tetrahydrofolate synthase, cytoplasmic isoform X1. (961 aa)
	OAT	Ornithine aminotransferase, mitochondrial; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (438 aa)
	ALDH5A1	Succinate-semialdehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (526 aa)
	GPT2	Alanine aminotransferase 2. (523 aa)
	MTRR	Methionine synthase reductase. (696 aa)
	SHMT1	Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family. (484 aa)
	MDH1	Malate dehydrogenase. (334 aa)
	HAL	Histidine ammonia-lyase; Belongs to the PAL/histidase family. (657 aa)
	HAAO	3-hydroxyanthranilate 3,4-dioxygenase isoform X1. (293 aa)
	ADSS	Adenylosuccinate synthetase isozyme 2; Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP. (456 aa)
	AMDHD1	Probable imidazolonepropionase. (426 aa)
	MRPS36	28S ribosomal protein S36, mitochondrial. (103 aa)
	D2HGDH	D-2-hydroxyglutarate dehydrogenase, mitochondrial isoform X1. (543 aa)
	FTCDNL1	Formiminotransferase N-terminal subdomain-containing protein. (328 aa)
	ME1	Malic enzyme. (496 aa)
	ME2	Malic enzyme. (584 aa)
	FTCD	Formimidoyltransferase-cyclodeaminase isoform X1. (547 aa)
	NIT2	LOW QUALITY PROTEIN: omega-amidase NIT2. (347 aa)
	NAGS	N-acetylglutamate synthase, mitochondrial. (368 aa)
	FPGS	Folylpolyglutamate synthase; Catalyzes conversion of folates to polyglutamate derivatives allowing concentration of folate compounds in the cell and the intracellular retention of these cofactors, which are important substrates for most of the folate-dependent enzymes that are involved in one-carbon transfer reactions involved in purine, pyrimidine and amino acid synthesis; Belongs to the folylpolyglutamate synthase family. (580 aa)
	ASS1	Argininosuccinate synthase. (412 aa)
	ME3	Malic enzyme. (604 aa)
	LOC112412177	Proline dehydrogenase; Converts proline to delta-1-pyrroline-5-carboxylate. (557 aa)
	ALDH1L1	Cytosolic 10-formyltetrahydrofolate dehydrogenase; Belongs to the aldehyde dehydrogenase family. (991 aa)
	GOT1L1	Putative aspartate aminotransferase, cytoplasmic 2. (424 aa)
	GAD1	Glutamate decarboxylase 1 isoform X1. (594 aa)
	GAD2	Glutamate decarboxylase 2. (585 aa)
	GCLC	LOW QUALITY PROTEIN: glutamate--cysteine ligase catalytic subunit. (637 aa)
	IDH2	Isocitrate dehydrogenase [NADP]; Belongs to the isocitrate and isopropylmalate dehydrogenases family. (452 aa)
	SDHAF3	Succinate dehydrogenase assembly factor 3, mitochondrial isoform X1. (132 aa)

Your Current Organism:

Neophocaena asiaeorientalis

NCBI taxonomy Id: 1706337
Other names: N. asiaeorientalis asiaeorientalis, Neophocaena asiaeorientalis asiaeorientalis, Yangtze finless porpoise

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACLY	ADHFE1	A0A341B539	A0A341B9H1	ATP-citrate synthase; Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate for de novo cholesterol and fatty acid synthesis; In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family.	Hydroxyacid-oxoacid transhydrogenase, mitochondrial isoform X1.	0.613
ACLY	ALDH18A1	A0A341B539	A0A341BUP8	ATP-citrate synthase; Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate for de novo cholesterol and fatty acid synthesis; In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family.	Delta-1-pyrroline-5-carboxylate synthase; In the C-terminal section; belongs to the gamma-glutamyl phosphate reductase family.	0.556
ACLY	ALDH1L1	A0A341B539	A0A341CXW2	ATP-citrate synthase; Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate for de novo cholesterol and fatty acid synthesis; In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family.	Cytosolic 10-formyltetrahydrofolate dehydrogenase; Belongs to the aldehyde dehydrogenase family.	0.539
ACLY	ALDH1L2	A0A341B539	A0A341AE51	ATP-citrate synthase; Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate for de novo cholesterol and fatty acid synthesis; In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family.	10-formyltetrahydrofolate dehydrogenase; In the C-terminal section; belongs to the aldehyde dehydrogenase family. ALDH1L subfamily.	0.539
ACLY	ALDH4A1	A0A341B539	A0A341BUG6	ATP-citrate synthase; Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate for de novo cholesterol and fatty acid synthesis; In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family.	Delta-1-pyrroline-5-carboxylate dehydrogenase; Belongs to the aldehyde dehydrogenase family.	0.635
ACLY	ALDH5A1	A0A341B539	A0A341BYU7	ATP-citrate synthase; Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate for de novo cholesterol and fatty acid synthesis; In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family.	Succinate-semialdehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family.	0.883
ACLY	ASL	A0A341B539	A0A341BCT4	ATP-citrate synthase; Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate for de novo cholesterol and fatty acid synthesis; In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family.	Argininosuccinate lyase.	0.879
ACLY	DDO	A0A341B539	A0A341B1N3	ATP-citrate synthase; Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate for de novo cholesterol and fatty acid synthesis; In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family.	D-aspartate oxidase.	0.865
ACLY	DLST	A0A341B539	A0A341ASR8	ATP-citrate synthase; Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate for de novo cholesterol and fatty acid synthesis; In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family.	annotation not available	0.913
ACLY	FH	A0A341B539	A0A341B367	ATP-citrate synthase; Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate for de novo cholesterol and fatty acid synthesis; In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family.	Fumarate hydratase, mitochondrial.	0.826
ACLY	GOT1	A0A341B539	A0A341ANJ5	ATP-citrate synthase; Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate for de novo cholesterol and fatty acid synthesis; In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family.	Aspartate aminotransferase.	0.897
ACLY	GOT1L1	A0A341B539	A0A341D1T8	ATP-citrate synthase; Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate for de novo cholesterol and fatty acid synthesis; In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family.	Putative aspartate aminotransferase, cytoplasmic 2.	0.875
ACLY	GOT2	A0A341B539	A0A341BVY4	ATP-citrate synthase; Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate for de novo cholesterol and fatty acid synthesis; In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family.	Aspartate aminotransferase.	0.884
ACLY	IDH1	A0A341B539	A0A341AUF9	ATP-citrate synthase; Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate for de novo cholesterol and fatty acid synthesis; In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family.	Isocitrate dehydrogenase [NADP]; Belongs to the isocitrate and isopropylmalate dehydrogenases family.	0.875
ACLY	IDH2	A0A341B539	A0A341D5P6	ATP-citrate synthase; Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate for de novo cholesterol and fatty acid synthesis; In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family.	Isocitrate dehydrogenase [NADP]; Belongs to the isocitrate and isopropylmalate dehydrogenases family.	0.878
ACLY	MDH1	A0A341B539	A0A341C4A8	ATP-citrate synthase; Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate for de novo cholesterol and fatty acid synthesis; In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family.	Malate dehydrogenase.	0.961
ACLY	MDH1B	A0A341B539	A0A341AUE3	ATP-citrate synthase; Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate for de novo cholesterol and fatty acid synthesis; In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family.	Putative malate dehydrogenase 1B isoform X1.	0.756
ACLY	MDH2	A0A341B539	A0A341BG96	ATP-citrate synthase; Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate for de novo cholesterol and fatty acid synthesis; In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family.	Malate dehydrogenase.	0.959
ACLY	ME1	A0A341B539	A0A341CF25	ATP-citrate synthase; Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate for de novo cholesterol and fatty acid synthesis; In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family.	Malic enzyme.	0.735
ACLY	ME2	A0A341B539	A0A341CFC3	ATP-citrate synthase; Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate for de novo cholesterol and fatty acid synthesis; In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family.	Malic enzyme.	0.617