STRINGSTRING
TOX TOX BARHL2 BARHL2 TBX19 TBX19 PRRX1 PRRX1 APC APC RARA RARA BRAF BRAF TBX5 TBX5 FOXN4 FOXN4 TBX3 TBX3 CDON CDON EXT1 EXT1 FGF10 FGF10 DMRTA2 DMRTA2 DOCK7 DOCK7 ISL1 ISL1 MNX1 MNX1 APC2 APC2 EYA1 EYA1 TAL1 TAL1 SHH SHH PRDM14 PRDM14 IL6 IL6 BATF BATF PSEN1 PSEN1 EHMT2 EHMT2 RHOA RHOA WNT7B WNT7B TBX22 TBX22 FOXN1 FOXN1 NEUROD4 NEUROD4 HOXC10 HOXC10 ID2 ID2 WNT10B WNT10B SMAD1 SMAD1 TBR1 TBR1 STAT6 STAT6 WNT1 WNT1 DHH DHH ATOH1 ATOH1 WNT8B WNT8B EDNRA EDNRA LBX1 LBX1 BMP4 BMP4 TGFBR1 TGFBR1 FGF8 FGF8 SUFU SUFU SOX5 SOX5 GLI3 GLI3 DLX1 DLX1 MEF2C MEF2C DMRT3 DMRT3 RTF1 RTF1 WNT5B WNT5B ETV2 ETV2 LOC112391706 LOC112391706 ASCL1 ASCL1 TBX18 TBX18 DLL4 DLL4 SOX6 SOX6 TEAD4 TEAD4 HOXD10 HOXD10 DLX2 DLX2 MGA MGA MYOD1 MYOD1 GATA3 GATA3 NR2F2 NR2F2 CTR9 CTR9 MYT1L MYT1L LOC112407189 LOC112407189 TCF7L2 TCF7L2 PRDM1 PRDM1 HOXA2 HOXA2 GCM1 GCM1 NR2E1 NR2E1 GBX1 GBX1 HOXA11 HOXA11 BCL2 BCL2 ONECUT2 ONECUT2 LOC112406365 LOC112406365 FOXG1 FOXG1 ONECUT1 ONECUT1 CTNNB1 CTNNB1 PTCH1 PTCH1 EPAS1 EPAS1 CTSL CTSL LATS2 LATS2 SIX2 SIX2 PAX6 PAX6 TLX3 TLX3 WNT8A WNT8A EOMES EOMES HES1 HES1 PITX1 PITX1 SMAD5 SMAD5 RAG2 RAG2 NEUROG1 NEUROG1 PROX1 PROX1 IL7 IL7 SLAMF6 SLAMF6 NKX2-2 NKX2-2 GATA5 GATA5 SOX13 SOX13 TBX20 TBX20 TENM4 TENM4 PDPN PDPN MTOR MTOR SOX18 SOX18 VWA5B1 VWA5B1 TBX10 TBX10 KDM6B KDM6B ARHGEF2 ARHGEF2 GDF7 GDF7 SIX1 SIX1 IL6R IL6R LATS1 LATS1 KDR KDR GSX2 GSX2 WNT5A WNT5A ARX ARX MITF MITF MYL10 MYL10 FEZF2 FEZF2 EPOP EPOP DLL1 DLL1 TBX6 TBX6 STAT3 STAT3 TBXT TBXT TBX21 TBX21 TGFB1I1 TGFB1I1 TM2D3 TM2D3 SOX17 SOX17 GATA1 GATA1 NTF4 NTF4 ISL2 ISL2 VWA5B2 VWA5B2 EBF2 EBF2 PAF1 PAF1 TEAD3 TEAD3 SOSTDC1 SOSTDC1 WNT4 WNT4 NODAL NODAL NEUROD1 NEUROD1 MESP1 MESP1 ITGB1 ITGB1 IRF4 IRF4 SPDEF SPDEF RUNX2 RUNX2 PTF1A PTF1A DBX1 DBX1 WNT3A WNT3A NKX6-3 NKX6-3 WNT9A WNT9A TBX15 TBX15 BMP2 BMP2 SFRP1 SFRP1 WNT2B WNT2B GAP43 GAP43 PRADC1 PRADC1 WNT7A WNT7A EDN1 EDN1 KIAA1549 KIAA1549 PTCH2 PTCH2 GATA2 GATA2 WNT10A WNT10A IHH IHH ERBB4 ERBB4 WNT6 WNT6 NOTCH1 NOTCH1 NKX6-2 NKX6-2 SMO SMO LHX3 LHX3 NKX2-1 NKX2-1 FOXA1 FOXA1 LOC112411009 LOC112411009 LEO1 LEO1 PML PML WNT3 WNT3 LOC112410714 LOC112410714 GATA4 GATA4 HES5 HES5 SOX9 SOX9 WNT9B WNT9B POU4F1 POU4F1 SPRY2 SPRY2 GSC GSC SOX8 SOX8 JAG2 JAG2 HEY2 HEY2 POU3F2 POU3F2 OLIG1 OLIG1 OLIG3 OLIG3 MYL2 MYL2 ZNF521 ZNF521 OLIG2 OLIG2 LOC112407988 LOC112407988 LOC112408488 LOC112408488 BCL11B BCL11B GATA6 GATA6 TBX2 TBX2 TBX4 TBX4 WNT16 WNT16 WNT11 WNT11 SMAD4 SMAD4 LOC112407979 LOC112407979
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
TOXThymocyte selection-associated high mobility group box protein TOX. (478 aa)
BARHL2barH-like 2 homeobox protein. (386 aa)
TBX19T-box transcription factor TBX19. (444 aa)
PRRX1Paired mesoderm homeobox protein 1. (245 aa)
APCAdenomatous polyposis coli protein isoform X1. (2863 aa)
RARALOW QUALITY PROTEIN: retinoic acid receptor alpha. (572 aa)
BRAFSerine/threonine-protein kinase B-raf isoform X1. (581 aa)
TBX5T-box transcription factor TBX5. (519 aa)
FOXN4Forkhead box protein N4. (518 aa)
TBX3LOW QUALITY PROTEIN: T-box transcription factor TBX3. (734 aa)
CDONCell adhesion molecule-related/down-regulated by oncogenes. (1279 aa)
EXT1Exostosin-1; Belongs to the glycosyltransferase 47 family. (746 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
DMRTA2LOW QUALITY PROTEIN: doublesex- and mab-3-related transcription factor A2. (533 aa)
DOCK7Dedicator of cytokinesis protein 7 isoform X1; Belongs to the DOCK family. (2100 aa)
ISL1Insulin gene enhancer protein ISL-1. (349 aa)
MNX1Motor neuron and pancreas homeobox protein 1. (368 aa)
APC2Adenomatous polyposis coli protein 2. (1995 aa)
EYA1Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (589 aa)
TAL1T-cell acute lymphocytic leukemia protein 1 isoform X1. (199 aa)
SHHSonic hedgehog protein. (328 aa)
PRDM14PR domain zinc finger protein 14. (571 aa)
IL6Interleukin-6. (208 aa)
BATFBasic leucine zipper transcriptional factor ATF-like. (125 aa)
PSEN1Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (468 aa)
EHMT2Histone-lysine N-methyltransferase EHMT2. (1242 aa)
RHOATransforming protein RhoA. (193 aa)
WNT7BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (356 aa)
TBX22T-box transcription factor TBX22. (522 aa)
FOXN1Forkhead box protein N1. (645 aa)
NEUROD4Neurogenic differentiation factor. (347 aa)
HOXC10Homeobox protein Hox-C10. (342 aa)
ID2DNA-binding protein inhibitor ID-2. (134 aa)
WNT10BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (389 aa)
SMAD1Mothers against decapentaplegic homolog. (465 aa)
TBR1LOW QUALITY PROTEIN: T-box brain protein 1. (642 aa)
STAT6Signal transducer and activator of transcription. (859 aa)
WNT1Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (370 aa)
DHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (396 aa)
ATOH1Protein atonal homolog 1. (352 aa)
WNT8BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (325 aa)
EDNRAEndothelin-1 receptor isoform X1; Belongs to the G-protein coupled receptor 1 family. (427 aa)
LBX1Transcription factor LBX1. (281 aa)
BMP4Bone morphogenetic protein 4 isoform X1. (420 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (438 aa)
FGF8Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (244 aa)
SUFUSuppressor of fused homolog; Negative regulator in the hedgehog signaling pathway. Down- regulates GLI1-mediated transactivation of target genes. Part of a corepressor complex that acts on DNA-bound GLI1. May also act by linking GLI1 to BTRC and thereby targeting GLI1 to degradation by the proteasome. Sequesters GLI1, GLI2 and GLI3 in the cytoplasm, this effect is overcome by binding of STK36 to both SUFU and a GLI protein. Negative regulator of beta-catenin signaling. Regulates the formation of either the repressor form (GLI3R) or the activator form (GLI3A) of the full-length form of [...] (469 aa)
SOX5Transcription factor SOX-5 isoform X2. (763 aa)
GLI3Transcriptional activator GLI3. (1587 aa)
DLX1Homeobox protein DLX-1 isoform X1. (255 aa)
MEF2CMyocyte-specific enhancer factor 2C isoform X4. (483 aa)
DMRT3Doublesex- and mab-3-related transcription factor 3. (473 aa)
RTF1RNA polymerase-associated protein RTF1 homolog. (710 aa)
WNT5BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (361 aa)
ETV2LOW QUALITY PROTEIN: ETS translocation variant 2. (374 aa)
LOC112391706Homeobox protein NANOG-like. (225 aa)
ASCL1LOW QUALITY PROTEIN: achaete-scute homolog 1. (228 aa)
TBX18T-box transcription factor TBX18. (612 aa)
DLL4Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (685 aa)
SOX6Transcription factor SOX-6 isoform X5. (835 aa)
TEAD4Transcriptional enhancer factor TEF-3; Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. (449 aa)
HOXD10Homeobox protein Hox-D10. (410 aa)
DLX2Homeobox protein DLX-2. (387 aa)
MGAMAX gene-associated protein isoform X1. (3169 aa)
MYOD1Myogenic factor; Induces fibroblasts to differentiate into myoblasts. Acts as a transcriptional activator that promotes transcription of muscle- specific target genes and plays a role in muscle differentiation. (319 aa)
GATA3Trans-acting T-cell-specific transcription factor GATA-3 isoform X1. (444 aa)
NR2F2COUP transcription factor 2 isoform X1. (281 aa)
CTR9RNA polymerase-associated protein CTR9 homolog isoform X1. (1214 aa)
MYT1LMyelin transcription factor 1-like protein. (1219 aa)
LOC112407189Cytochrome P450 26B1; Belongs to the cytochrome P450 family. (512 aa)
TCF7L2Transcription factor 7-like 2 isoform X1. (510 aa)
PRDM1LOW QUALITY PROTEIN: PR domain zinc finger protein 1. (809 aa)
HOXA2Homeobox protein Hox-A2. (409 aa)
GCM1Chorion-specific transcription factor GCMa. (434 aa)
NR2E1Nuclear receptor subfamily 2 group E member 1. (385 aa)
GBX1Homeobox protein GBX-1. (420 aa)
HOXA11Homeobox protein Hox-A11. (318 aa)
BCL2Apoptosis regulator Bcl-2 isoform X1. (233 aa)
ONECUT2One cut domain family member. (367 aa)
LOC112406365LOW QUALITY PROTEIN: homeobox protein NANOG-like. (294 aa)
FOXG1Forkhead box protein G1. (662 aa)
ONECUT1One cut domain family member. (465 aa)
CTNNB1Catenin beta-1. (781 aa)
PTCH1Protein patched homolog 1 isoform X1. (1297 aa)
EPAS1Endothelial PAS domain-containing protein 1 isoform X1. (871 aa)
CTSLCathepsin L1 isoform X1; Belongs to the peptidase C1 family. (333 aa)
LATS2Serine/threonine-protein kinase LATS2. (805 aa)
SIX2Homeobox protein SIX2 isoform X1. (298 aa)
PAX6Paired box protein Pax-6 isoform X1. (493 aa)
TLX3T-cell leukemia homeobox protein 3. (291 aa)
WNT8AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (352 aa)
EOMESLOW QUALITY PROTEIN: eomesodermin homolog. (703 aa)
HES1Transcription factor HES-1. (280 aa)
PITX1Homeobox protein. (435 aa)
SMAD5Mothers against decapentaplegic homolog. (465 aa)
RAG2V(D)J recombination-activating protein 2. (527 aa)
NEUROG1Neurogenin-1. (244 aa)
PROX1Prospero homeobox protein 1 isoform X1. (737 aa)
IL7Interleukin-7 isoform X1. (226 aa)
SLAMF6SLAM family member 6 isoform X1. (351 aa)
NKX2-2Homeobox protein Nkx-2.2. (273 aa)
GATA5LOW QUALITY PROTEIN: transcription factor GATA-5. (364 aa)
SOX13Transcription factor SOX-13. (592 aa)
TBX20T-box transcription factor TBX20. (449 aa)
TENM4Teneurin-4. (2769 aa)
PDPNPodoplanin isoform X1. (234 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2548 aa)
SOX18Transcription factor SOX-18. (87 aa)
VWA5B1Von Willebrand factor A domain-containing protein 5B1. (1214 aa)
TBX10LOW QUALITY PROTEIN: T-box transcription factor TBX10. (403 aa)
KDM6BLOW QUALITY PROTEIN: lysine-specific demethylase 6B. (1382 aa)
ARHGEF2Rho guanine nucleotide exchange factor 2 isoform X1. (1175 aa)
GDF7Growth/differentiation factor 7. (381 aa)
SIX1Homeobox protein SIX1. (284 aa)
IL6RInterleukin-6 receptor subunit alpha. (465 aa)
LATS1Serine/threonine-protein kinase LATS1. (1128 aa)
KDRVascular endothelial growth factor receptor 2 isoform X4; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1356 aa)
GSX2GS homeobox 2. (301 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (380 aa)
ARXLOW QUALITY PROTEIN: homeobox protein ARX. (445 aa)
MITFMicrophthalmia-associated transcription factor isoform X1. (526 aa)
MYL10Myosin regulatory light chain 10. (147 aa)
FEZF2Fez family zinc finger protein 2. (458 aa)
EPOPElongin BC and Polycomb repressive complex 2-associated protein. (379 aa)
DLL1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (759 aa)
TBX6T-box transcription factor TBX6 isoform X1. (463 aa)
STAT3Signal transducer and activator of transcription. (770 aa)
TBXTBrachyury protein isoform X1. (435 aa)
TBX21T-box transcription factor TBX21. (501 aa)
TGFB1I1Transforming growth factor beta-1-induced transcript 1 protein isoform X1; Belongs to the paxillin family. (456 aa)
TM2D3TM2 domain-containing protein 3 isoform X1. (252 aa)
SOX17LOW QUALITY PROTEIN: transcription factor SOX-17. (207 aa)
GATA1Erythroid transcription factor. (413 aa)
NTF4Neurotrophin-4; Belongs to the NGF-beta family. (210 aa)
ISL2Insulin gene enhancer protein ISL-2. (359 aa)
VWA5B2Von Willebrand factor A domain-containing protein 5B2. (1248 aa)
EBF2Transcription factor COE2 isoform X2. (581 aa)
PAF1RNA polymerase II-associated factor 1 homolog isoform X1. (533 aa)
TEAD3LOW QUALITY PROTEIN: transcriptional enhancer factor TEF-5. (561 aa)
SOSTDC1Sclerostin domain-containing protein 1. (206 aa)
WNT4Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (361 aa)
NODALNodal homolog. (348 aa)
NEUROD1Neurogenic differentiation factor. (356 aa)
MESP1Mesoderm posterior protein 1. (265 aa)
ITGB1Integrin beta; Belongs to the integrin beta chain family. (801 aa)
IRF4Interferon regulatory factor 4. (452 aa)
SPDEFSAM pointed domain-containing Ets transcription factor isoform X1. (337 aa)
RUNX2Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. (408 aa)
PTF1APancreas transcription factor 1 subunit alpha. (310 aa)
DBX1Homeobox protein DBX1. (345 aa)
WNT3AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (352 aa)
NKX6-3Homeobox protein Nkx-6.3. (257 aa)
WNT9AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (428 aa)
TBX15T-box transcription factor TBX15. (602 aa)
BMP2Bone morphogenetic protein 2 isoform X1. (395 aa)
SFRP1Secreted frizzled-related protein 1. (296 aa)
WNT2BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (393 aa)
GAP43Neuromodulin. (242 aa)
PRADC1Protease-associated domain-containing protein 1. (188 aa)
WNT7AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (349 aa)
EDN1Endothelin-1. (202 aa)
KIAA1549UPF0606 protein KIAA1549 homolog. (1905 aa)
PTCH2Protein patched homolog 2 isoform X1. (1234 aa)
GATA2Endothelial transcription factor GATA-2. (480 aa)
WNT10AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (417 aa)
IHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (410 aa)
ERBB4Receptor protein-tyrosine kinase. (1308 aa)
WNT6Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (365 aa)
NOTCH1LOW QUALITY PROTEIN: neurogenic locus notch homolog protein 1. (2633 aa)
NKX6-2Homeobox protein Nkx-6.2. (376 aa)
SMOSmoothened homolog; Belongs to the G-protein coupled receptor Fz/Smo family. (783 aa)
LHX3LIM/homeobox protein Lhx3. (378 aa)
NKX2-1Homeobox protein Nkx-2.1 isoform X1. (396 aa)
FOXA1Hepatocyte nuclear factor 3-alpha. (466 aa)
LOC112411009RNA polymerase-associated protein LEO1-like. (292 aa)
LEO1RNA polymerase-associated protein LEO1 isoform X1. (672 aa)
PMLProtein PML isoform X1. (965 aa)
WNT3Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (453 aa)
LOC112410714Cathepsin L1; Belongs to the peptidase C1 family. (334 aa)
GATA4Transcription factor GATA-4. (291 aa)
HES5Transcription factor HES-5. (94 aa)
SOX9Transcription factor SOX-9. (486 aa)
WNT9BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (602 aa)
POU4F1POU domain protein. (320 aa)
SPRY2Protein sprouty homolog 2. (315 aa)
GSCHomeobox protein goosecoid. (256 aa)
SOX8Transcription factor SOX-8. (378 aa)
JAG2Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1064 aa)
HEY2Hairy/enhancer-of-split related with YRPW motif protein 2. (337 aa)
POU3F2POU domain protein. (436 aa)
OLIG1Oligodendrocyte transcription factor 1. (228 aa)
OLIG3Oligodendrocyte transcription factor 3. (271 aa)
MYL2Myosin regulatory light chain 2, ventricular/cardiac muscle isoform. (166 aa)
ZNF521Zinc finger protein 521 isoform X1. (1534 aa)
OLIG2Oligodendrocyte transcription factor 2. (251 aa)
LOC112407988Secreted frizzled-related protein 2. (294 aa)
LOC112408488Serine/threonine-protein kinase B-raf-like. (250 aa)
BCL11BB-cell lymphoma/leukemia 11B. (740 aa)
GATA6Transcription factor GATA-6. (448 aa)
TBX2T-box transcription factor TBX2. (588 aa)
TBX4T-box transcription factor TBX4. (548 aa)
WNT16Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (362 aa)
WNT11Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa)
SMAD4Mothers against decapentaplegic homolog. (599 aa)
LOC112407979Secreted frizzled-related protein 2-like. (105 aa)
Your Current Organism:
Neophocaena asiaeorientalis
NCBI taxonomy Id: 1706337
Other names: N. asiaeorientalis asiaeorientalis, Neophocaena asiaeorientalis asiaeorientalis, Yangtze finless porpoise
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