STRINGSTRING
LRP5 LRP5 AAMDC AAMDC CCDC85B CCDC85B LOC112401545 LOC112401545 FTO FTO SIX1 SIX1 ZBTB7B ZBTB7B WNT5A WNT5A LGALS12 LGALS12 SOX13 SOX13 CEBPB CEBPB PTGS2 PTGS2 BMP7 BMP7 DUSP10 DUSP10 ZBTB16 ZBTB16 HES1 HES1 LPL LPL FLCN FLCN ZFP36L2 ZFP36L2 KLF5 KLF5 RARRES2 RARRES2 HNRNPU HNRNPU ZADH2 ZADH2 FNDC3B FNDC3B HTR2A HTR2A FOXO1 FOXO1 MEDAG MEDAG WDFY2 WDFY2 ZFPM2 ZFPM2 KALRN KALRN ZBTB7C ZBTB7C STK3 STK3 MEX3C MEX3C LOC112407979 LOC112407979 LOC112407988 LOC112407988 ENPP1 ENPP1 AXIN1 AXIN1 YAP1 YAP1 TMEM64 TMEM64 GATA3 GATA3 LEP LEP GPER1 GPER1 MMP11 MMP11 CDS1 CDS1 VSTM2A VSTM2A ASXL2 ASXL2 SFRP1 SFRP1 BMP2 BMP2 FNDC5 FNDC5 WNT3A WNT3A TAF8 TAF8 PPARD PPARD DLK2 DLK2 PIM1 PIM1 SIRT1 SIRT1 FRZB FRZB ADIRF ADIRF TPH1 TPH1 GPS2 GPS2 SAV1 SAV1 ANKRD26 ANKRD26 CREBL2 CREBL2 GNB3 GNB3 LRP3 LRP3 SMAD3 SMAD3 JAG1 JAG1 ZFPM1 ZFPM1 FERMT2 FERMT2 RORA RORA WNT1 WNT1 WNT10B WNT10B C1QL4 C1QL4 ZNF385A ZNF385A WIF1 WIF1 CREB1 CREB1 DDIT3 DDIT3 LOC112395043 LOC112395043 TRIB2 TRIB2 JDP2 JDP2 ALOX5 ALOX5 ATAT1 ATAT1 NAPEPLD NAPEPLD ZC3H12A ZC3H12A RREB1 RREB1 FFAR4 FFAR4 ZFP36L1 ZFP36L1 PPARG PPARG INSIG1 INSIG1 SYAP1 SYAP1 WISP1 WISP1 CMKLR1 CMKLR1 SULT1E1 SULT1E1 SORT1 SORT1 TRPV4 TRPV4 TRIB3 TRIB3 TRIO TRIO NR1D1 NR1D1 E2F1 E2F1 ASXL1 ASXL1 TGFB1I1 TGFB1I1 ADIG ADIG BBS12 BBS12 FAM57B FAM57B NOCT NOCT STK4 STK4 TGFB1 TGFB1 ADIPOQ ADIPOQ SIRT2 SIRT2 DKKL1 DKKL1 XBP1 XBP1 WWTR1 WWTR1 HDAC6 HDAC6 ZFP36 ZFP36
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
LRP5Low-density lipoprotein receptor-related protein 5 isoform X1. (1461 aa)
AAMDCMth938 domain-containing protein. (122 aa)
CCDC85BCoiled-coil domain-containing protein 85B. (202 aa)
LOC112401545LOW QUALITY PROTEIN: serine/threonine-protein kinase 3-like. (375 aa)
FTOAlpha-ketoglutarate-dependent dioxygenase FTO isoform X1. (505 aa)
SIX1Homeobox protein SIX1. (284 aa)
ZBTB7BZinc finger and BTB domain-containing protein 7B. (542 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (380 aa)
LGALS12Galectin. (314 aa)
SOX13Transcription factor SOX-13. (592 aa)
CEBPBCCAAT/enhancer-binding protein. (346 aa)
PTGS2Prostaglandin G/H synthase 2. (604 aa)
BMP7Bone morphogenetic protein 7. (431 aa)
DUSP10Dual specificity protein phosphatase 10; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (482 aa)
ZBTB16Zinc finger and BTB domain-containing protein 16. (673 aa)
HES1Transcription factor HES-1. (280 aa)
LPLLipoprotein lipase; Key enzyme in triglyceride metabolism. Catalyzes the hydrolysis of triglycerides from circulating chylomicrons and very low density lipoproteins (VLDL), and thereby plays an important role in lipid clearance from the blood stream, lipid utilization and storage. Mediates margination of triglyceride-rich lipoprotein particles in capillaries. Recruited to its site of action on the luminal surface of vascular endothelium by binding to GPIHBP1 and cell surface heparan sulfate proteoglycans. (478 aa)
FLCNFolliculin isoform X1. (576 aa)
ZFP36L2mRNA decay activator protein ZFP36L2. (492 aa)
KLF5Krueppel-like factor 5. (454 aa)
RARRES2Retinoic acid receptor responder protein 2. (166 aa)
HNRNPUHeterogeneous nuclear ribonucleoprotein U isoform X1. (825 aa)
ZADH2Prostaglandin reductase 3. (316 aa)
FNDC3BFibronectin type III domain-containing protein 3B isoform X1. (1147 aa)
HTR2A5-hydroxytryptamine receptor 2A. (470 aa)
FOXO1Forkhead box protein O1. (511 aa)
MEDAGMesenteric estrogen-dependent adipogenesis protein. (303 aa)
WDFY2WD repeat and FYVE domain-containing protein 2 isoform X1. (484 aa)
ZFPM2Zinc finger protein ZFPM2. (1150 aa)
KALRNKalirin isoform X1. (2985 aa)
ZBTB7CZinc finger and BTB domain-containing protein 7C. (568 aa)
STK3Serine/threonine-protein kinase 3. (491 aa)
MEX3CRNA-binding E3 ubiquitin-protein ligase MEX3C. (625 aa)
LOC112407979Secreted frizzled-related protein 2-like. (105 aa)
LOC112407988Secreted frizzled-related protein 2. (294 aa)
ENPP1Ectonucleotide pyrophosphatase/phosphodiesterase family member 1. (857 aa)
AXIN1Axin-1 isoform X1. (866 aa)
YAP1Transcriptional coactivator YAP1. (416 aa)
TMEM64Transmembrane protein 64 isoform X1. (330 aa)
GATA3Trans-acting T-cell-specific transcription factor GATA-3 isoform X1. (444 aa)
LEPLeptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...] (167 aa)
GPER1G-protein coupled estrogen receptor 1; Belongs to the G-protein coupled receptor 1 family. (358 aa)
MMP11Stromelysin-3. (505 aa)
CDS1Phosphatidate cytidylyltransferase; Provides CDP-diacylglycerol, an important precursor for the synthesis of phosphatidylinositol, phosphatidylglycerol, and cardiolipin. (461 aa)
VSTM2AV-set and transmembrane domain-containing protein 2A. (240 aa)
ASXL2Putative Polycomb group protein ASXL2 isoform X1. (1453 aa)
SFRP1Secreted frizzled-related protein 1. (296 aa)
BMP2Bone morphogenetic protein 2 isoform X1. (395 aa)
FNDC5Fibronectin type III domain-containing protein 5 isoform X3. (252 aa)
WNT3AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (352 aa)
TAF8Transcription initiation factor TFIID subunit 8 isoform X1. (326 aa)
PPARDPeroxisome proliferator-activated receptor delta. (441 aa)
DLK2Protein delta homolog 2. (383 aa)
PIM1Serine/threonine-protein kinase; Proto-oncogene with serine/threonine kinase activity involved in cell survival and cell proliferation. Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. PIM subfamily. (349 aa)
SIRT1NAD-dependent protein deacetylase sirtuin-1 isoform X1. (557 aa)
FRZBSecreted frizzled-related protein 3. (325 aa)
ADIRFAdipogenesis regulatory factor. (76 aa)
TPH1Tryptophan 5-hydroxylase 1. (455 aa)
GPS2G protein pathway suppressor 2 isoform X1. (330 aa)
SAV1Protein salvador homolog 1. (384 aa)
ANKRD26Ankyrin repeat domain-containing protein 26 isoform X2. (1787 aa)
CREBL2cAMP-responsive element-binding protein-like 2 isoform X1. (132 aa)
GNB3Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 isoform X1. (340 aa)
LRP3Low-density lipoprotein receptor-related protein 3. (687 aa)
SMAD3Mothers against decapentaplegic homolog. (376 aa)
JAG1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1177 aa)
ZFPM1Zinc finger protein ZFPM1. (998 aa)
FERMT2Fermitin family homolog 2. (680 aa)
RORANuclear receptor ROR-alpha. (386 aa)
WNT1Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (370 aa)
WNT10BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (389 aa)
C1QL4Complement C1q-like protein 4. (238 aa)
ZNF385AZinc finger protein 385A isoform X1. (403 aa)
WIF1Wnt inhibitory factor 1. (379 aa)
CREB1Cyclic AMP-responsive element-binding protein 1 isoform X1. (341 aa)
DDIT3DNA damage-inducible transcript 3 protein; Multifunctional transcription factor in ER stress response. Plays an essential role in the response to a wide variety of cell stresses and induces cell cycle arrest and apoptosis in response to ER stress. Plays a dual role both as an inhibitor of CCAAT/enhancer- binding protein (C/EBP) function and as an activator of other genes. Acts as a dominant-negative regulator of C/EBP-induced transcription: dimerizes with members of the C/EBP family, impairs their association with C/EBP binding sites in the promoter regions, and inhibits the expression [...] (168 aa)
LOC112395043LOW QUALITY PROTEIN: putative Polycomb group protein ASXL2. (710 aa)
TRIB2Tribbles homolog 2. (343 aa)
JDP2Jun dimerization protein 2. (173 aa)
ALOX5Arachidonate 5-lipoxygenase isoform X1. (696 aa)
ATAT1Alpha-tubulin N-acetyltransferase 1; Specifically acetylates 'Lys-40' in alpha-tubulin on the lumenal side of microtubules. Promotes microtubule destabilization and accelerates microtubule dynamics; this activity may be independent of acetylation activity. Acetylates alpha-tubulin with a slow enzymatic rate, due to a catalytic site that is not optimized for acetyl transfer. Enters the microtubule through each end and diffuses quickly throughout the lumen of microtubules. Acetylates only long/old microtubules because of its slow acetylation rate since it does not have time to act on dyn [...] (447 aa)
NAPEPLDN-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D isoform X1. (478 aa)
ZC3H12AEndoribonuclease ZC3H12A. (583 aa)
RREB1Ras-responsive element-binding protein 1. (1784 aa)
FFAR4Free fatty acid receptor 4 isoform X1. (375 aa)
ZFP36L1mRNA decay activator protein ZFP36L1. (338 aa)
PPARGPeroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] (505 aa)
INSIG1Insulin-induced gene protein; Mediates feedback control of cholesterol synthesis. Belongs to the INSIG family. (294 aa)
SYAP1Synapse-associated protein 1 isoform X1. (358 aa)
WISP1WNT1-inducible-signaling pathway protein 1. (281 aa)
CMKLR1Chemokine-like receptor 1; Belongs to the G-protein coupled receptor 1 family. (365 aa)
SULT1E1Sulfotransferase; Belongs to the sulfotransferase 1 family. (300 aa)
SORT1Sortilin. (694 aa)
TRPV4Transient receptor potential cation channel subfamily V member 4 isoform X1; Belongs to the transient receptor (TC 1.A.4) family. (881 aa)
TRIB3Tribbles homolog 3. (357 aa)
TRIOLOW QUALITY PROTEIN: triple functional domain protein. (2815 aa)
NR1D1LOW QUALITY PROTEIN: nuclear receptor subfamily 1 group D member 1. (595 aa)
E2F1Transcription factor E2F1. (360 aa)
ASXL1Putative Polycomb group protein ASXL1. (1517 aa)
TGFB1I1Transforming growth factor beta-1-induced transcript 1 protein isoform X1; Belongs to the paxillin family. (456 aa)
ADIGAdipogenin. (79 aa)
BBS12Bardet-Biedl syndrome 12 protein. (714 aa)
FAM57BProtein FAM57B. (275 aa)
NOCTNocturnin. (362 aa)
STK4Serine/threonine-protein kinase 4 isoform X1. (487 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (391 aa)
ADIPOQAdiponectin. (243 aa)
SIRT2NAD-dependent protein deacetylase; NAD-dependent protein deacetylase. (389 aa)
DKKL1Dickkopf-like protein 1 isoform X1. (235 aa)
XBP1LOW QUALITY PROTEIN: X-box-binding protein 1. (379 aa)
WWTR1WW domain-containing transcription regulator protein 1. (400 aa)
HDAC6Histone deacetylase 6 isoform X1. (1176 aa)
ZFP36mRNA decay activator protein ZFP36. (325 aa)
Your Current Organism:
Neophocaena asiaeorientalis
NCBI taxonomy Id: 1706337
Other names: N. asiaeorientalis asiaeorientalis, Neophocaena asiaeorientalis asiaeorientalis, Yangtze finless porpoise
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