STRINGSTRING
FOXP1 FOXP1 STAT3 STAT3 LOC112399174 LOC112399174 KAT7 KAT7 ACVR2A ACVR2A CSF3 CSF3 STAT5A STAT5A EIF6 EIF6 RBFOX2 RBFOX2 LYN LYN MAFB MAFB RBM15 RBM15 RARA RARA HOXB8 HOXB8 MED1 MED1 MEIS1 MEIS1 TNFRSF11B TNFRSF11B SLC9B2 SLC9B2 MYC MYC CSF1 CSF1 LEF1 LEF1 GPR55 GPR55 FAM213A FAM213A UBASH3B UBASH3B TRIB1 TRIB1 HSF1 HSF1 ZNF16 ZNF16 FSTL3 FSTL3 ETS1 ETS1 INPP5D INPP5D FBN1 FBN1 ZFP36L1 ZFP36L1 CSF3R CSF3R ITPKB ITPKB TAL1 TAL1 PPARGC1B PPARGC1B CNOT4 CNOT4 CDC73 CDC73 RIPK1 RIPK1 P4HTM P4HTM BRD1 BRD1 CREB1 CREB1 TCTA TCTA LRRC17 LRRC17 TOB2 TOB2 EVI2B EVI2B NCKAP1L NCKAP1L IL23A IL23A RNF41 RNF41 PPP3CA PPP3CA IFNG IFNG RARG RARG NF1 NF1 ACVR1B ACVR1B LDB1 LDB1 GPR68 GPR68 POU4F2 POU4F2 ZFPM1 ZFPM1 IL34 IL34 JAG1 JAG1 LOC112392034 LOC112392034 MEF2C MEF2C STAT1 STAT1 INHBA INHBA GABPA GABPA CD74 CD74 PIAS3 PIAS3 MEIS2 MEIS2 SMAP1 SMAP1 IL17A IL17A CIB1 CIB1 PITHD1 PITHD1 C1QC C1QC SCIN SCIN CDK6 CDK6 FES FES PTK2B PTK2B IL12B IL12B TGFB1 TGFB1 ADIPOQ ADIPOQ PAF1 PAF1 FBXW9 FBXW9 LIF LIF PRMT1 PRMT1 GPR171 GPR171 PLA2G3 PLA2G3 GATA1 GATA1 TFE3 TFE3 HCLS1 HCLS1 ZFP36 ZFP36 OCSTAMP OCSTAMP MITF MITF DLL1 DLL1 HAX1 HAX1 HIF1A HIF1A GPR137 GPR137 MTOR MTOR FADD FADD APCS APCS ZBTB46 ZBTB46 CLDN18 CLDN18 CTNNBIP1 CTNNBIP1 IL20 IL20 CEBPB CEBPB FAM210B FAM210B RAB7B RAB7B RHEX RHEX LTF LTF ZBTB16 ZBTB16 HSPA9 HSPA9 CUL4A CUL4A TRAF6 TRAF6 PIK3R1 PIK3R1 TNFAIP6 TNFAIP6 NDFIP1 NDFIP1 FSHR FSHR TMEM178A TMEM178A CTNNB1 CTNNB1 WDR61 WDR61 HOXA5 HOXA5 HOXA9 HOXA9 MTURN MTURN TNFSF11 TNFSF11 FOXO3 FOXO3 HOXA7 HOXA7 RB1 RB1 DCSTAMP DCSTAMP KLF10 KLF10 CTR9 CTR9 CASP8 CASP8 LOX LOX CASP10 CASP10 RCOR1 RCOR1 LOC112408084 LOC112408084 RUNX1 RUNX1 TESC TESC FAXDC2 FAXDC2 TMEM64 TMEM64 POU4F1 POU4F1 PRKCA PRKCA ISG15 ISG15 GPR137B GPR137B LEO1 LEO1 LOC112411009 LOC112411009 ANKRD54 ANKRD54 NFKBIA NFKBIA NEDD9 NEDD9 PTPN2 PTPN2 LOC112412378 LOC112412378 RASSF2 RASSF2 NOTCH2 NOTCH2 SFRP1 SFRP1 CD101 CD101 ABCB10 ABCB10 TREM2 TREM2
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
FOXP1Forkhead box protein P1 isoform X1. (673 aa)
STAT3Signal transducer and activator of transcription. (770 aa)
LOC112399174Signal transducer and activator of transcription. (618 aa)
KAT7Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (611 aa)
ACVR2ASerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (513 aa)
CSF3Granulocyte colony-stimulating factor. (195 aa)
STAT5ASignal transducer and activator of transcription. (726 aa)
EIF6Eukaryotic translation initiation factor 6; Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. Behaves as a stimulatory translation initiation factor downstream insulin/growth factors. Is also involved in ribosome biogenesis. Associates with pre-60S subunits in the nucleus and is involved in its nuclear export. Cytoplasmic release of TIF6 from 60S subunits and nuclear relocalization is promoted by a RACK1 (RACK1)- dependent protein kinase C activity. In tissues responsive to insulin, contro [...] (245 aa)
RBFOX2RNA binding protein fox-1 homolog; RNA-binding protein that regulates alternative splicing events. (428 aa)
LYNTyrosine-protein kinase. (518 aa)
MAFBTranscription factor MafB. (323 aa)
RBM15Putative RNA-binding protein 15. (962 aa)
RARALOW QUALITY PROTEIN: retinoic acid receptor alpha. (572 aa)
HOXB8Homeobox protein Hox-B8 isoform X1. (243 aa)
MED1Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1579 aa)
MEIS1Homeobox protein Meis1 isoform X1. (465 aa)
TNFRSF11BTumor necrosis factor receptor superfamily member 11B; Acts as decoy receptor for TNFSF11/RANKL and thereby neutralizes its function in osteoclastogenesis. (401 aa)
SLC9B2Sodium/hydrogen exchanger 9B2 isoform X1. (536 aa)
MYCMyc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (439 aa)
CSF1Macrophage colony-stimulating factor 1. (513 aa)
LEF1Lymphoid enhancer-binding factor 1 isoform X1. (414 aa)
GPR55G-protein coupled receptor 55 isoform X1; Belongs to the G-protein coupled receptor 1 family. (407 aa)
FAM213ARedox-regulatory protein FAM213A isoform X1. (230 aa)
UBASH3BUbiquitin-associated and SH3 domain-containing protein B isoform X1. (649 aa)
TRIB1Tribbles homolog 1. (372 aa)
HSF1Heat shock factor protein 1 isoform X1. (526 aa)
ZNF16Zinc finger protein 16 isoform X1. (653 aa)
FSTL3Follistatin-related protein 3. (317 aa)
ETS1Protein C-ets-1 isoform X1. (441 aa)
INPP5DPhosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1. (1187 aa)
FBN1Fibrillin-1. (2871 aa)
ZFP36L1mRNA decay activator protein ZFP36L1. (338 aa)
CSF3RGranulocyte colony-stimulating factor receptor isoform X1. (847 aa)
ITPKBKinase; Belongs to the inositol phosphokinase (IPK) family. (939 aa)
TAL1T-cell acute lymphocytic leukemia protein 1 isoform X1. (199 aa)
PPARGC1BPeroxisome proliferator-activated receptor gamma coactivator 1-beta isoform X1. (1019 aa)
CNOT4CCR4-NOT transcription complex subunit 4 isoform X1. (714 aa)
CDC73Parafibromin. (355 aa)
RIPK1Receptor-interacting serine/threonine-protein kinase 1. (667 aa)
P4HTMTransmembrane prolyl 4-hydroxylase. (494 aa)
BRD1Bromodomain-containing protein 1. (1291 aa)
CREB1Cyclic AMP-responsive element-binding protein 1 isoform X1. (341 aa)
TCTAT-cell leukemia translocation-altered gene protein homolog; May be required for cellular fusion during osteoclastogenesis; Belongs to the TCTA family. (122 aa)
LRRC17Leucine-rich repeat-containing protein 17. (440 aa)
TOB2Protein Tob2. (343 aa)
EVI2BProtein EVI2B. (452 aa)
NCKAP1LNck-associated protein 1-like isoform X1. (1156 aa)
IL23AInterleukin-23 subunit alpha. (189 aa)
RNF41E3 ubiquitin-protein ligase NRDP1 isoform X1. (317 aa)
PPP3CASerine/threonine-protein phosphatase. (511 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (166 aa)
RARGRetinoic acid receptor gamma isoform X2. (458 aa)
NF1Neurofibromin isoform X1. (2841 aa)
ACVR1BReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (453 aa)
LDB1LIM domain-binding protein 1 isoform X1. (411 aa)
GPR68Ovarian cancer G-protein coupled receptor 1; Belongs to the G-protein coupled receptor 1 family. (371 aa)
POU4F2POU domain protein. (408 aa)
ZFPM1Zinc finger protein ZFPM1. (998 aa)
IL34Interleukin-34. (219 aa)
JAG1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1177 aa)
LOC112392034Signal transducer and activator of transcription 5A-like. (105 aa)
MEF2CMyocyte-specific enhancer factor 2C isoform X4. (483 aa)
STAT1Signal transducer and activator of transcription. (749 aa)
INHBAInhibin beta A chain. (474 aa)
GABPALOW QUALITY PROTEIN: GA-binding protein alpha chain. (454 aa)
CD74HLA class II histocompatibility antigen gamma chain isoform X1. (278 aa)
PIAS3E3 SUMO-protein ligase PIAS3 isoform X1. (628 aa)
MEIS2Homeobox protein Meis2 isoform X1. (477 aa)
SMAP1Stromal membrane-associated protein 1. (541 aa)
IL17Ainterleukin-17A isoform X1. (155 aa)
CIB1Calcium and integrin-binding protein 1. (191 aa)
PITHD1PITH domain-containing protein 1 isoform X1. (211 aa)
C1QCComplement C1q subcomponent subunit C. (245 aa)
SCINAdseverin isoform X1. (715 aa)
CDK6Cyclin-dependent kinase 6; Belongs to the protein kinase superfamily. (326 aa)
FESTyrosine-protein kinase; Belongs to the protein kinase superfamily. Tyr protein kinase family. Fes/fps subfamily. (855 aa)
PTK2BProtein-tyrosine kinase 2-beta isoform X1; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1009 aa)
IL12BInterleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. (329 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (391 aa)
ADIPOQAdiponectin. (243 aa)
PAF1RNA polymerase II-associated factor 1 homolog isoform X1. (533 aa)
FBXW9F-box/WD repeat-containing protein 9 isoform X1. (463 aa)
LIFLeukemia inhibitory factor. (202 aa)
PRMT1Protein arginine N-methyltransferase 1 isoform X1; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. (371 aa)
GPR171Probable G-protein coupled receptor 171; Belongs to the G-protein coupled receptor 1 family. (319 aa)
PLA2G3Group 3 secretory phospholipase A2 isoform X1. (516 aa)
GATA1Erythroid transcription factor. (413 aa)
TFE3Transcription factor E3 isoform X1. (601 aa)
HCLS1Hematopoietic lineage cell-specific protein. (479 aa)
ZFP36mRNA decay activator protein ZFP36. (325 aa)
OCSTAMPLOW QUALITY PROTEIN: osteoclast stimulatory transmembrane protein. (566 aa)
MITFMicrophthalmia-associated transcription factor isoform X1. (526 aa)
DLL1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (759 aa)
HAX1HCLS1-associated protein X-1; Recruits the Arp2/3 complex to the cell cortex and regulates reorganization of the cortical actin cytoskeleton via its interaction with KCNC3 and the Arp2/3 complex. Slows down the rate of inactivation of KCNC3 channels. Promotes GNA13-mediated cell migration. Involved in the clathrin-mediated endocytosis pathway. May be involved in internalization of ABC transporters such as ABCB11. May inhibit CASP9 and CASP3. Promotes cell survival. May regulate intracellular calcium pools. (277 aa)
HIF1AHypoxia-inducible factor 1-alpha. (823 aa)
GPR137Integral membrane protein GPR137 isoform X1. (395 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2548 aa)
FADDFAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. (211 aa)
APCSPentaxin. (171 aa)
ZBTB46Zinc finger and BTB domain-containing protein 46 isoform X1. (590 aa)
CLDN18Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (261 aa)
CTNNBIP1Beta-catenin-interacting protein 1. (81 aa)
IL20LOW QUALITY PROTEIN: interleukin-20. (190 aa)
CEBPBCCAAT/enhancer-binding protein. (346 aa)
FAM210BProtein FAM210B, mitochondrial. (143 aa)
RAB7BRas-related protein Rab-7b isoform X1. (210 aa)
RHEXRegulator of hemoglobinization and erythroid cell expansion protein isoform X1. (172 aa)
LTFLactotransferrin isoform X1; Belongs to the transferrin family. (711 aa)
ZBTB16Zinc finger and BTB domain-containing protein 16. (673 aa)
HSPA9LOW QUALITY PROTEIN: stress-70 protein, mitochondrial; Belongs to the heat shock protein 70 family. (682 aa)
CUL4Acullin-4A; Belongs to the cullin family. (734 aa)
TRAF6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (570 aa)
PIK3R1Phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1. (724 aa)
TNFAIP6Tumor necrosis factor-inducible gene 6 protein isoform X1. (284 aa)
NDFIP1NEDD4 family-interacting protein 1. (221 aa)
FSHRFollicle-stimulating hormone receptor; G protein-coupled receptor for follitropin, the follicle- stimulating hormone. Through cAMP production activates the downstream PI3K-AKT and ERK1/ERK2 signaling pathways. (695 aa)
TMEM178ATransmembrane protein 178A isoform X1. (132 aa)
CTNNB1Catenin beta-1. (781 aa)
WDR61WD repeat-containing protein 61. (305 aa)
HOXA5Homeobox protein Hox-A5. (381 aa)
HOXA9Homeobox protein; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Belongs to the Abd-B homeobox family. (272 aa)
MTURNMaturin. (131 aa)
TNFSF11Tumor necrosis factor ligand superfamily member 11; Belongs to the tumor necrosis factor family. (323 aa)
FOXO3Forkhead box protein O3. (672 aa)
HOXA7Homeobox protein Hox-A7. (233 aa)
RB1Retinoblastoma-associated protein. (816 aa)
DCSTAMPDendritic cell-specific transmembrane protein isoform X1. (470 aa)
KLF10Krueppel-like factor 10. (479 aa)
CTR9RNA polymerase-associated protein CTR9 homolog isoform X1. (1214 aa)
CASP8Caspase-8 isoform X1; Belongs to the peptidase C14A family. (497 aa)
LOXProtein-lysine 6-oxidase isoform X1. (414 aa)
CASP10Caspase-10; Belongs to the peptidase C14A family. (517 aa)
RCOR1REST corepressor 1. (435 aa)
LOC112408084C-C motif chemokine 3-like. (87 aa)
RUNX1Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. (480 aa)
TESCCalcineurin B homologous protein 3. (214 aa)
FAXDC2Fatty acid hydroxylase domain-containing protein 2; Belongs to the sterol desaturase family. (333 aa)
TMEM64Transmembrane protein 64 isoform X1. (330 aa)
POU4F1POU domain protein. (320 aa)
PRKCANon-specific serine/threonine protein kinase. (541 aa)
ISG15Ubiquitin-like protein ISG15. (170 aa)
GPR137BIntegral membrane protein GPR137B. (385 aa)
LEO1RNA polymerase-associated protein LEO1 isoform X1. (672 aa)
LOC112411009RNA polymerase-associated protein LEO1-like. (292 aa)
ANKRD54Ankyrin repeat domain-containing protein 54. (299 aa)
NFKBIANF-kappa-B inhibitor alpha. (324 aa)
NEDD9Enhancer of filamentation 1 isoform X2. (829 aa)
PTPN2Tyrosine-protein phosphatase non-receptor type. (396 aa)
LOC112412378F-box/WD repeat-containing protein 7. (540 aa)
RASSF2Ras association domain-containing protein 2. (326 aa)
NOTCH2Neurogenic locus notch homolog protein 2 isoform X1. (2485 aa)
SFRP1Secreted frizzled-related protein 1. (296 aa)
CD101Immunoglobulin superfamily member 2 isoform X1. (1018 aa)
ABCB10ATP-binding cassette sub-family B member 10, mitochondrial. (553 aa)
TREM2Triggering receptor expressed on myeloid cells 2. (230 aa)
Your Current Organism:
Neophocaena asiaeorientalis
NCBI taxonomy Id: 1706337
Other names: N. asiaeorientalis asiaeorientalis, Neophocaena asiaeorientalis asiaeorientalis, Yangtze finless porpoise
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