STRINGSTRING
UCMA UCMA BMPR1A BMPR1A IGF1 IGF1 SEMA4D SEMA4D GREM1 GREM1 FGF23 FGF23 MEF2C MEF2C GLI3 GLI3 LOC112392028 LOC112392028 LRP3 LRP3 SMAD3 SMAD3 JAG1 JAG1 BMP4 BMP4 HEMGN HEMGN BMPR1B BMPR1B SMAD6 SMAD6 FERMT2 FERMT2 PPP3CA PPP3CA HDAC7 HDAC7 SMAD1 SMAD1 WNT10B WNT10B GLI1 GLI1 BMPR2 BMPR2 RIOX1 RIOX1 TWIST1 TWIST1 ATF4 ATF4 RORB RORB GDF10 GDF10 BMP6 BMP6 FFAR4 FFAR4 SMOC1 SMOC1 SUCO SUCO WISP1 WISP1 OSTN OSTN NBR1 NBR1 TMEM119 TMEM119 SNAI2 SNAI2 ZHX3 ZHX3 ACVR2A ACVR2A CTHRC1 CTHRC1 VEGFC VEGFC FGF2 FGF2 NOCT NOCT PDLIM7 PDLIM7 TOB1 TOB1 REST REST FBXO5 FBXO5 TCIRG1 TCIRG1 LOC112402169 LOC112402169 LOC112401995 LOC112401995 LRP5 LRP5 MEN1 MEN1 BAMBI BAMBI CTNNBIP1 CTNNBIP1 CEBPB CEBPB BMP7 BMP7 LTF LTF HAND2 HAND2 DDR2 DDR2 SMAD5 SMAD5 TNFAIP6 TNFAIP6 CRIM1 CRIM1 NPNT NPNT PTCH1 PTCH1 CTNNB1 CTNNB1 RANBP3L RANBP3L FNDC3B FNDC3B HDAC4 HDAC4 PRKD1 PRKD1 HOXA2 HOXA2 GDPD2 GDPD2 SCUBE2 SCUBE2 SOX11 SOX11 FBN2 FBN2 ILK ILK FAM46A FAM46A LOC112407979 LOC112407979 NOG NOG LOC112407988 LOC112407988 TNN TNN YAP1 YAP1 SKI SKI TMEM64 TMEM64 AXIN2 AXIN2 SOX9 SOX9 TWIST2 TWIST2 NOTCH1 NOTCH1 TWSG1 TWSG1 RASSF2 RASSF2 ATRAID ATRAID SFRP1 SFRP1 BMP2 BMP2 LIMD1 LIMD1 RUNX2 RUNX2 IL6ST IL6ST ID3 ID3 CDK6 CDK6 SCUBE3 SCUBE3 WDR63 WDR63 CYR61 CYR61 CHRD CHRD PRKACA PRKACA JUND JUND TP63 TP63 WWTR1 WWTR1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
UCMAUnique cartilage matrix-associated protein. (138 aa)
BMPR1AReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
IGF1Insulin-like growth factor I isoform X1. (208 aa)
SEMA4Dsemaphorin-4D; Belongs to the semaphorin family. (863 aa)
GREM1Gremlin. (184 aa)
FGF23Fibroblast growth factor 23; Belongs to the heparin-binding growth factors family. (212 aa)
MEF2CMyocyte-specific enhancer factor 2C isoform X4. (483 aa)
GLI3Transcriptional activator GLI3. (1587 aa)
LOC112392028RE1-silencing transcription factor-like. (305 aa)
LRP3Low-density lipoprotein receptor-related protein 3. (687 aa)
SMAD3Mothers against decapentaplegic homolog. (376 aa)
JAG1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1177 aa)
BMP4Bone morphogenetic protein 4 isoform X1. (420 aa)
HEMGNHemogen isoform X1. (451 aa)
BMPR1BSerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
SMAD6LOW QUALITY PROTEIN: mothers against decapentaplegic homolog 6. (422 aa)
FERMT2Fermitin family homolog 2. (680 aa)
PPP3CASerine/threonine-protein phosphatase. (511 aa)
HDAC7Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1114 aa)
SMAD1Mothers against decapentaplegic homolog. (465 aa)
WNT10BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (389 aa)
GLI1Zinc finger protein GLI1 isoform X1. (1106 aa)
BMPR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1012 aa)
RIOX1Bifunctional lysine-specific demethylase and histidyl-hydroxylase; Oxygenase that can act as both a histone lysine demethylase and a ribosomal histidine hydroxylase. (657 aa)
TWIST1LOW QUALITY PROTEIN: twist-related protein 1. (152 aa)
ATF4Cyclic AMP-dependent transcription factor ATF-4. (350 aa)
RORBNuclear receptor ROR-beta. (459 aa)
GDF10Bone morphogenetic protein 3; Belongs to the TGF-beta family. (477 aa)
BMP6Bone morphogenetic protein 6. (309 aa)
FFAR4Free fatty acid receptor 4 isoform X1. (375 aa)
SMOC1SPARC-related modular calcium-binding protein 1 isoform X1. (446 aa)
SUCOSUN domain-containing ossification factor isoform X1. (1249 aa)
WISP1WNT1-inducible-signaling pathway protein 1. (281 aa)
OSTNOsteocrin. (132 aa)
NBR1Next to BRCA1 gene 1 protein isoform X1. (895 aa)
TMEM119Transmembrane protein 119 isoform X1. (363 aa)
SNAI2Zinc finger protein SNAI2. (268 aa)
ZHX3Zinc fingers and homeoboxes protein 3. (953 aa)
ACVR2ASerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (513 aa)
CTHRC1Collagen triple helix repeat-containing protein 1. (244 aa)
VEGFCVascular endothelial growth factor C; Belongs to the PDGF/VEGF growth factor family. (350 aa)
FGF2Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (304 aa)
NOCTNocturnin. (362 aa)
PDLIM7PDZ and LIM domain protein 7 isoform X1. (458 aa)
TOB1Protein Tob1. (345 aa)
RESTRE1-silencing transcription factor isoform X2. (450 aa)
FBXO5F-box only protein 5 isoform X1. (448 aa)
TCIRG1V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. (589 aa)
LOC112402169V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. (259 aa)
LOC112401995LOW QUALITY PROTEIN: protein Tob1-like. (394 aa)
LRP5Low-density lipoprotein receptor-related protein 5 isoform X1. (1461 aa)
MEN1Menin isoform X1. (616 aa)
BAMBIBMP and activin membrane-bound inhibitor homolog. (218 aa)
CTNNBIP1Beta-catenin-interacting protein 1. (81 aa)
CEBPBCCAAT/enhancer-binding protein. (346 aa)
BMP7Bone morphogenetic protein 7. (431 aa)
LTFLactotransferrin isoform X1; Belongs to the transferrin family. (711 aa)
HAND2Heart- and neural crest derivatives-expressed protein 2. (208 aa)
DDR2Discoidin domain-containing receptor 2. (820 aa)
SMAD5Mothers against decapentaplegic homolog. (465 aa)
TNFAIP6Tumor necrosis factor-inducible gene 6 protein isoform X1. (284 aa)
CRIM1Cysteine-rich motor neuron 1 protein isoform X1. (973 aa)
NPNTNephronectin isoform X1. (581 aa)
PTCH1Protein patched homolog 1 isoform X1. (1297 aa)
CTNNB1Catenin beta-1. (781 aa)
RANBP3LRan-binding protein 3-like isoform X1. (491 aa)
FNDC3BFibronectin type III domain-containing protein 3B isoform X1. (1147 aa)
HDAC4Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1071 aa)
PRKD1Serine/threonine-protein kinase D1 isoform X1. (796 aa)
HOXA2Homeobox protein Hox-A2. (409 aa)
GDPD2Glycerophosphoinositol inositolphosphodiesterase GDPD2. (539 aa)
SCUBE2Signal peptide, CUB and EGF-like domain-containing protein 2. (890 aa)
SOX11Transcription factor SOX. (452 aa)
FBN2Fibrillin-2. (2912 aa)
ILKIntegrin-linked protein kinase isoform X1. (485 aa)
FAM46APutative nucleotidyltransferase FAM46A isoform X1. (451 aa)
LOC112407979Secreted frizzled-related protein 2-like. (105 aa)
NOGNoggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. (232 aa)
LOC112407988Secreted frizzled-related protein 2. (294 aa)
TNNtenascin-N. (1296 aa)
YAP1Transcriptional coactivator YAP1. (416 aa)
SKISki oncogene. (669 aa)
TMEM64Transmembrane protein 64 isoform X1. (330 aa)
AXIN2Axin-2. (720 aa)
SOX9Transcription factor SOX-9. (486 aa)
TWIST2Twist-related protein 2. (151 aa)
NOTCH1LOW QUALITY PROTEIN: neurogenic locus notch homolog protein 1. (2633 aa)
TWSG1Twisted gastrulation protein homolog 1. (223 aa)
RASSF2Ras association domain-containing protein 2. (326 aa)
ATRAIDAll-trans retinoic acid-induced differentiation factor. (229 aa)
SFRP1Secreted frizzled-related protein 1. (296 aa)
BMP2Bone morphogenetic protein 2 isoform X1. (395 aa)
LIMD1LIM domain-containing protein 1. (669 aa)
RUNX2Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. (408 aa)
IL6STInterleukin-6 receptor subunit beta. (918 aa)
ID3DNA-binding protein inhibitor ID-3. (119 aa)
CDK6Cyclin-dependent kinase 6; Belongs to the protein kinase superfamily. (326 aa)
SCUBE3Signal peptide, CUB and EGF-like domain-containing protein 3 isoform X1. (1009 aa)
WDR63WD repeat-containing protein 63. (924 aa)
CYR61Protein CYR61. (382 aa)
CHRDChordin. (851 aa)
PRKACAcAMP-dependent protein kinase catalytic subunit alpha. (293 aa)
JUNDTranscription factor jun-D. (345 aa)
TP63Tumor protein 63 (p63); Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. (680 aa)
WWTR1WW domain-containing transcription regulator protein 1. (400 aa)
Your Current Organism:
Neophocaena asiaeorientalis
NCBI taxonomy Id: 1706337
Other names: N. asiaeorientalis asiaeorientalis, Neophocaena asiaeorientalis asiaeorientalis, Yangtze finless porpoise
Server load: low (22%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.