STRINGSTRING
DLL1 DLL1 PDCD6 PDCD6 THBS1 THBS1 C3AR1 C3AR1 CDH5 CDH5 HSPB6 HSPB6 GREM1 GREM1 AGGF1 AGGF1 ITGA5 ITGA5 RAPGEF3 RAPGEF3 ACVRL1 ACVRL1 GAB1 GAB1 APELA APELA SP1 SP1 SMAD1 SMAD1 LOC112394306 LOC112394306 PGF PGF GDF2 GDF2 ZC3H12A ZC3H12A ITGB8 ITGB8 ISL1 ISL1 ANGPTL3 ANGPTL3 ETS1 ETS1 AGO2 AGO2 LOC112397972 LOC112397972 BRCA1 BRCA1 ANGPT4 ANGPT4 LOC112398001 LOC112398001 HIPK2 HIPK2 IL1A IL1A CTSH CTSH IL1B IL1B EMP2 EMP2 HMOX1 HMOX1 PDCL3 PDCL3 PRKCB PRKCB VEGFD VEGFD TIE1 TIE1 STAT3 STAT3 VEGFC VEGFC FGF2 FGF2 LOC112399814 LOC112399814 HSPB1 HSPB1 SIRT6 SIRT6 RAMP2 RAMP2 JUP JUP TMIGD2 TMIGD2 MYDGF MYDGF LRG1 LRG1 WNT5A WNT5A KDR KDR CD40 CD40 SASH1 SASH1 APLNR APLNR VEGFB VEGFB HIF1A HIF1A S100A1 S100A1 PIK3R6 PIK3R6 JCAD JCAD VASH2 VASH2 BMPER BMPER PTGIS PTGIS CCR3 CCR3 HK2 HK2 F3 F3 CHI3L1 CHI3L1 FGF18 FGF18 LOC112405151 LOC112405151 CXCL8 CXCL8 AKT3 AKT3 CHRNA7 CHRNA7 ANXA3 ANXA3 NOS3 NOS3 BTG1 BTG1 TEK TEK AQP1 AQP1 FLT1 FLT1 NR2E1 NR2E1 CCBE1 CCBE1 PRKD1 PRKD1 MTDH MTDH LOC112407979 LOC112407979 GATA6 GATA6 EPHA1 EPHA1 LOC112407988 LOC112407988 TNN TNN EMILIN2 EMILIN2 PDPK1 PDPK1 CXCR3 CXCR3 TLR3 TLR3 JMJD8 JMJD8 SPHK1 SPHK1 PRKCA PRKCA PARP6 PARP6 ABL1 ABL1 ENG ENG C5 C5 AAMP AAMP EMILIN1 EMILIN1 JAK1 JAK1 ECM1 ECM1 VEGFA VEGFA SIRT1 SIRT1 NODAL NODAL PTK2B PTK2B PRKD2 PRKD2 FUT1 FUT1 RRAS RRAS PAK4 PAK4 XBP1 XBP1 EMC10 EMC10 CX3CR1 CX3CR1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
DLL1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (759 aa)
PDCD6Programmed cell death protein 6 isoform X1. (189 aa)
THBS1Thrombospondin-1. (1170 aa)
C3AR1C3a anaphylatoxin chemotactic receptor; Belongs to the G-protein coupled receptor 1 family. (484 aa)
CDH5Cadherin-5; Cadherins are calcium-dependent cell adhesion proteins. (782 aa)
HSPB6Heat shock protein beta-6; Belongs to the small heat shock protein (HSP20) family. (164 aa)
GREM1Gremlin. (184 aa)
AGGF1Angiogenic factor with G patch and FHA domains 1. (714 aa)
ITGA5Integrin alpha-5; Belongs to the integrin alpha chain family. (1053 aa)
RAPGEF3Rap guanine nucleotide exchange factor 3. (951 aa)
ACVRL1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (515 aa)
GAB1GRB2-associated-binding protein 1 isoform X3. (724 aa)
APELAApelin receptor early endogenous ligand. (54 aa)
SP1Transcription factor Sp1. (780 aa)
SMAD1Mothers against decapentaplegic homolog. (465 aa)
LOC112394306C-C motif chemokine. (97 aa)
PGFPlacenta growth factor isoform X1; Belongs to the PDGF/VEGF growth factor family. (170 aa)
GDF2Growth/differentiation factor 2. (431 aa)
ZC3H12AEndoribonuclease ZC3H12A. (583 aa)
ITGB8Integrin beta; Belongs to the integrin beta chain family. (767 aa)
ISL1Insulin gene enhancer protein ISL-1. (349 aa)
ANGPTL3Angiopoietin-related protein 3. (460 aa)
ETS1Protein C-ets-1 isoform X1. (441 aa)
AGO2Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...] (865 aa)
LOC112397972Zinc finger protein 304-like. (659 aa)
BRCA1Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...] (1870 aa)
ANGPT4Angiopoietin-4. (498 aa)
LOC112398001Zinc finger protein 304-like. (717 aa)
HIPK2Homeodomain-interacting protein kinase 2. (1027 aa)
IL1AInterleukin-1; Belongs to the IL-1 family. (265 aa)
CTSHPro-cathepsin H; Belongs to the peptidase C1 family. (297 aa)
IL1BMultifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (266 aa)
EMP2Epithelial membrane protein 2; Functions as a key regulator of cell membrane composition by regulating proteins surface expression. Also, plays a role in regulation of processes including cell migration, cell proliferation, cell contraction and cell adhesion; Belongs to the PMP-22/EMP/MP20 family. (167 aa)
HMOX1Heme oxygenase; Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase. (288 aa)
PDCL3Phosducin-like protein 3. (240 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (673 aa)
VEGFDVascular endothelial growth factor D; Belongs to the PDGF/VEGF growth factor family. (354 aa)
TIE1Tyrosine-protein kinase receptor Tie-1. (1139 aa)
STAT3Signal transducer and activator of transcription. (770 aa)
VEGFCVascular endothelial growth factor C; Belongs to the PDGF/VEGF growth factor family. (350 aa)
FGF2Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (304 aa)
LOC112399814LOW QUALITY PROTEIN: phosducin-like protein 3. (237 aa)
HSPB1Heat shock protein beta-1; Belongs to the small heat shock protein (HSP20) family. (195 aa)
SIRT6NAD-dependent protein deacetylase sirtuin-6. (354 aa)
RAMP2Receptor activity-modifying protein 2. (100 aa)
JUPJunction plakoglobin. (744 aa)
TMIGD2Transmembrane and immunoglobulin domain-containing protein 2. (231 aa)
MYDGFMyeloid-derived growth factor. (175 aa)
LRG1Leucine-rich alpha-2-glycoprotein. (354 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (380 aa)
KDRVascular endothelial growth factor receptor 2 isoform X4; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1356 aa)
CD40Tumor necrosis factor receptor superfamily member 5 isoform X1. (293 aa)
SASH1SAM and SH3 domain-containing protein 1 isoform X1. (1200 aa)
APLNRApelin receptor; Belongs to the G-protein coupled receptor 1 family. (383 aa)
VEGFBVascular endothelial growth factor B; Belongs to the PDGF/VEGF growth factor family. (286 aa)
HIF1AHypoxia-inducible factor 1-alpha. (823 aa)
S100A1Protein S100; Belongs to the S-100 family. (94 aa)
PIK3R6Phosphoinositide 3-kinase regulatory subunit 6. (763 aa)
JCADLOW QUALITY PROTEIN: junctional protein associated with coronary artery disease. (1227 aa)
VASH2Vasohibin-2. (355 aa)
BMPERBMP-binding endothelial regulator protein. (685 aa)
PTGISProstacyclin synthase isoform X1; Belongs to the cytochrome P450 family. (701 aa)
CCR3C-C chemokine receptor type 3; Belongs to the G-protein coupled receptor 1 family. (358 aa)
HK2Hexokinase-2. (917 aa)
F3Tissue factor. (297 aa)
CHI3L1LOW QUALITY PROTEIN: chitinase-3-like protein 1; Belongs to the glycosyl hydrolase 18 family. (383 aa)
FGF18Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (300 aa)
LOC112405151Cytochrome P450 1B1; Belongs to the cytochrome P450 family. (543 aa)
CXCL8Multifunctional fusion protein; Belongs to the intercrine alpha (chemokine CxC) family. (101 aa)
AKT3Non-specific serine/threonine protein kinase. (531 aa)
CHRNA7Neuronal acetylcholine receptor subunit alpha-7. (612 aa)
ANXA3Annexin. (323 aa)
NOS3Nitric oxide synthase; Produces nitric oxide (NO). (1205 aa)
BTG1Protein BTG1. (134 aa)
TEKAngiopoietin-1 receptor isoform X1. (1125 aa)
AQP1Aquaporin-1; Belongs to the MIP/aquaporin (TC 1.A.8) family. (271 aa)
FLT1Vascular endothelial growth factor receptor 1; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (803 aa)
NR2E1Nuclear receptor subfamily 2 group E member 1. (385 aa)
CCBE1Collagen and calcium-binding EGF domain-containing protein 1 isoform X1. (429 aa)
PRKD1Serine/threonine-protein kinase D1 isoform X1. (796 aa)
MTDHProtein LYRIC isoform X1. (612 aa)
LOC112407979Secreted frizzled-related protein 2-like. (105 aa)
GATA6Transcription factor GATA-6. (448 aa)
EPHA1Ephrin type-A receptor 1 isoform X1. (981 aa)
LOC112407988Secreted frizzled-related protein 2. (294 aa)
TNNtenascin-N. (1296 aa)
EMILIN2EMILIN-2. (992 aa)
PDPK13-phosphoinositide-dependent protein kinase 1 isoform X1. (531 aa)
CXCR3C-X-C chemokine receptor type 3; Belongs to the G-protein coupled receptor 1 family. (366 aa)
TLR3Toll-like receptor 3 isoform X2; Belongs to the Toll-like receptor family. (956 aa)
JMJD8LOW QUALITY PROTEIN: jmjC domain-containing protein 8. (265 aa)
SPHK1Sphingosine kinase 1. (391 aa)
PRKCANon-specific serine/threonine protein kinase. (541 aa)
PARP6Poly [ADP-ribose] polymerase. (631 aa)
ABL1Tyrosine-protein kinase. (1148 aa)
ENGEndoglin. (652 aa)
C5Complement C5. (1677 aa)
AAMPAngio-associated migratory cell protein isoform X1. (435 aa)
EMILIN1EMILIN-1. (1015 aa)
JAK1Tyrosine-protein kinase. (1153 aa)
ECM1Extracellular matrix protein 1 isoform X1. (544 aa)
VEGFAVascular endothelial growth factor A; Belongs to the PDGF/VEGF growth factor family. (632 aa)
SIRT1NAD-dependent protein deacetylase sirtuin-1 isoform X1. (557 aa)
NODALNodal homolog. (348 aa)
PTK2BProtein-tyrosine kinase 2-beta isoform X1; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1009 aa)
PRKD2LOW QUALITY PROTEIN: serine/threonine-protein kinase D2. (806 aa)
FUT1L-Fucosyltransferase; Belongs to the glycosyltransferase 11 family. (532 aa)
RRASRas-related protein R-Ras. (209 aa)
PAK4Non-specific serine/threonine protein kinase. (594 aa)
XBP1LOW QUALITY PROTEIN: X-box-binding protein 1. (379 aa)
EMC10ER membrane protein complex subunit 10 isoform X1. (260 aa)
CX3CR1CX3C chemokine receptor 1; Belongs to the G-protein coupled receptor 1 family. (358 aa)
Your Current Organism:
Neophocaena asiaeorientalis
NCBI taxonomy Id: 1706337
Other names: N. asiaeorientalis asiaeorientalis, Neophocaena asiaeorientalis asiaeorientalis, Yangtze finless porpoise
Server load: low (26%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.