STRINGSTRING
TPRA1 TPRA1 CTDSP1 CTDSP1 PLK3 PLK3 NACC2 NACC2 BRINP1 BRINP1 ABL1 ABL1 PRAP1 PRAP1 PML PML SLC9A3R1 SLC9A3R1 BIRC5 BIRC5 MFSD11 MFSD11 MEIOC MEIOC FHL1 FHL1 EME2 EME2 KNTC1 KNTC1 GPR132 GPR132 TAOK3 TAOK3 DONSON DONSON BRINP2 BRINP2 FOXO4 FOXO4 RAD9B RAD9B PRKDC PRKDC CDC6 CDC6 EME1 EME1 DCUN1D3 DCUN1D3 RBL1 RBL1 TAOK2 TAOK2 PHKG1 PHKG1 PLK1 PLK1 JADE1 JADE1 BUB1 BUB1 ZNF655 ZNF655 CDK5RAP3 CDK5RAP3 KANK2 KANK2 TOPBP1 TOPBP1 RBL2 RBL2 HUS1 HUS1 PINX1 PINX1 FBXO5 FBXO5 BRD7 BRD7 ORC1 ORC1 CLSPN CLSPN CDC73 CDC73 LOC112395411 LOC112395411 E2F7 E2F7 BRINP3 BRINP3 CTDSP2 CTDSP2 CRLF3 CRLF3 LOC112394151 LOC112394151 ZWILCH ZWILCH FBXO31 FBXO31 NABP2 NABP2 FOXN3 FOXN3 PKD2 PKD2 LOC112393727 LOC112393727 ZNF207 ZNF207 RFWD3 RFWD3 BMP4 BMP4 TAOK1 TAOK1 TIPIN TIPIN NAE1 NAE1 ATF2 ATF2 HASPIN HASPIN INHBA INHBA NABP1 NABP1 KHDC3L KHDC3L AVEN AVEN CDKN1B CDKN1B FBXO7 FBXO7 MRE11 MRE11 BTG3 BTG3 ZNF830 ZNF830 MAD2L1 MAD2L1 CHMP4C CHMP4C BUB1B BUB1B ZFYVE19 ZFYVE19 DACT1 DACT1 NLE1 NLE1 TRIP13 TRIP13 ZFP36L1 ZFP36L1 HECA HECA CHEK1 CHEK1 CHFR CHFR PLK5 PLK5 GPNMB GPNMB FZR1 FZR1 RAD21 RAD21 SCRIB SCRIB BRCA1 BRCA1 MUC1 MUC1 INTS3 INTS3 RAD9A RAD9A NEK11 NEK11 AURKB AURKB PIDD1 PIDD1 MUS81 MUS81 CCND1 CCND1 MIIP MIIP CDKN1C CDKN1C CDK2AP2 CDK2AP2 OVOL1 OVOL1 WAC WAC ANGEL2 ANGEL2 DTL DTL BMP7 BMP7 TPR TPR BTG2 BTG2 NME6 NME6 DLG1 DLG1 BUB3 BUB3 CUNH10orf90 CUNH10orf90 TREX1 TREX1 TOM1L2 TOM1L2 IK IK SPDL1 SPDL1 PTPN3 PTPN3 ZFP36L2 ZFP36L2 LOC112404902 LOC112404902 SDE2 SDE2 BTG4 BTG4 CTNNB1 CTNNB1 MSH2 MSH2 GAS1 GAS1 ZW10 ZW10 BRCC3 BRCC3 BTG1 BTG1 BCL2 BCL2 CRADD CRADD ABRAXAS1 ABRAXAS1 RAD17 RAD17 RB1 RB1 CTDSPL CTDSPL NBN NBN RINT1 RINT1 STK33 STK33 USP47 USP47 INIP INIP TTK TTK TEX14 TEX14 CASP2 CASP2 TOM1L1 TOM1L1 UIMC1 UIMC1 APC APC EZH2 EZH2 MTBP MTBP CHEK2 CHEK2 NOP53 NOP53 TRIM35 TRIM35 FZD3 FZD3 BABAM1 BABAM1 SYF2 SYF2 ATM ATM TICRR TICRR LOC112414307 LOC112414307 BLM BLM CDKN1A CDKN1A LRRC1 LRRC1 CDK1 CDK1 BABAM2 BABAM2 MRNIP MRNIP FANCD2 FANCD2 DLG2 DLG2 KLHL22 KLHL22 PSMG2 PSMG2 MAD1L1 MAD1L1 VPS4A VPS4A XPC XPC
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
TPRA1Transmembrane protein adipocyte-associated 1 isoform X3. (472 aa)
CTDSP1Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1. (261 aa)
PLK3Serine/threonine-protein kinase PLK. (647 aa)
NACC2LOW QUALITY PROTEIN: nucleus accumbens-associated protein 2. (568 aa)
BRINP1BMP/retinoic acid-inducible neural-specific protein 1. (761 aa)
ABL1Tyrosine-protein kinase. (1148 aa)
PRAP1Proline-rich acidic protein 1. (150 aa)
PMLProtein PML isoform X1. (965 aa)
SLC9A3R1Na(+)/H(+) exchange regulatory cofactor NHE-RF; Scaffold protein that connects plasma membrane proteins with members of the ezrin/moesin/radixin family and thereby helps to link them to the actin cytoskeleton and to regulate their surface expression. (366 aa)
BIRC5Baculoviral IAP repeat-containing protein 5. (142 aa)
MFSD11UNC93-like protein MFSD11 isoform X1. (449 aa)
MEIOCMeiosis-specific coiled-coil domain-containing protein MEIOC. (723 aa)
FHL1Four and a half LIM domains protein 1 isoform X1. (339 aa)
EME2LOW QUALITY PROTEIN: probable crossover junction endonuclease EME2. (348 aa)
KNTC1Kinetochore-associated protein 1. (2207 aa)
GPR132Probable G-protein coupled receptor 132; Belongs to the G-protein coupled receptor 1 family. (342 aa)
TAOK3Serine/threonine-protein kinase TAO3. (898 aa)
DONSONLOW QUALITY PROTEIN: protein downstream neighbor of Son. (686 aa)
BRINP2BMP/retinoic acid-inducible neural-specific protein 2. (784 aa)
FOXO4Forkhead box protein O4. (512 aa)
RAD9BCell cycle checkpoint control protein; Belongs to the rad9 family. (413 aa)
PRKDCDNA-dependent protein kinase catalytic subunit isoform X1; Belongs to the PI3/PI4-kinase family. (4129 aa)
CDC6Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. (647 aa)
EME1Crossover junction endonuclease EME1 isoform X1. (576 aa)
DCUN1D3DCN1-like protein. (304 aa)
RBL1Retinoblastoma-like protein 1 isoform X1. (1073 aa)
TAOK2Serine/threonine-protein kinase TAO2 isoform X1. (1234 aa)
PHKG1Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform; Belongs to the protein kinase superfamily. (387 aa)
PLK1Serine/threonine-protein kinase PLK. (597 aa)
JADE1Protein Jade-1 isoform X1. (858 aa)
BUB1Mitotic checkpoint serine/threonine-protein kinase BUB1. (1083 aa)
ZNF655Zinc finger protein 655 isoform X1. (181 aa)
CDK5RAP3CDK5 regulatory subunit-associated protein 3 isoform X1. (538 aa)
KANK2KN motif and ankyrin repeat domain-containing protein 2 isoform X1. (858 aa)
TOPBP1DNA topoisomerase 2-binding protein 1. (1520 aa)
RBL2Retinoblastoma-like protein 2 isoform X1. (1141 aa)
HUS1Checkpoint protein; Belongs to the HUS1 family. (227 aa)
PINX1PIN2/TERF1-interacting telomerase inhibitor 1. (314 aa)
FBXO5F-box only protein 5 isoform X1. (448 aa)
BRD7Bromodomain-containing protein 7 isoform X1. (652 aa)
ORC1Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. (863 aa)
CLSPNClaspin. (1336 aa)
CDC73Parafibromin. (355 aa)
LOC112395411E3 ubiquitin-protein ligase TRIM39. (488 aa)
E2F7Transcription factor E2F7. (905 aa)
BRINP3BMP/retinoic acid-inducible neural-specific protein 3. (766 aa)
CTDSP2Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 2. (271 aa)
CRLF3Cytokine receptor-like factor 3 isoform X1. (430 aa)
LOC112394151C-C motif chemokine. (99 aa)
ZWILCHProtein zwilch homolog. (589 aa)
FBXO31F-box only protein 31 isoform X1. (453 aa)
NABP2LOW QUALITY PROTEIN: SOSS complex subunit B1. (179 aa)
FOXN3Forkhead box protein N3 isoform X1. (488 aa)
PKD2Polycystin-2 isoform X1. (782 aa)
LOC112393727Putative tripartite motif-containing protein 75. (246 aa)
ZNF207BUB3-interacting and GLEBS motif-containing protein ZNF207 isoform X1. (495 aa)
RFWD3E3 ubiquitin-protein ligase RFWD3 isoform X1. (808 aa)
BMP4Bone morphogenetic protein 4 isoform X1. (420 aa)
TAOK1Serine/threonine-protein kinase TAO1. (1001 aa)
TIPINTIMELESS-interacting protein; Plays an important role in the control of DNA replication and the maintenance of replication fork stability. Belongs to the CSM3 family. (290 aa)
NAE1NEDD8-activating enzyme E1 regulatory subunit; Regulatory subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M. Belongs to the ubiquitin-activating E1 family. ULA1 subfamily. (534 aa)
ATF2Cyclic AMP-dependent transcription factor ATF-2 isoform X1. (505 aa)
HASPINSerine/threonine-protein kinase haspin. (781 aa)
INHBAInhibin beta A chain. (474 aa)
NABP1SOSS complex subunit B2. (204 aa)
KHDC3LKHDC3-like protein. (221 aa)
AVENCell death regulator Aven. (218 aa)
CDKN1BCyclin-dependent kinase inhibitor 1B. (198 aa)
FBXO7F-box only protein 7 isoform X1. (523 aa)
MRE11Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (707 aa)
BTG3Protein BTG3 isoform X1. (252 aa)
ZNF830Zinc finger protein 830. (380 aa)
MAD2L1Mitotic spindle assembly checkpoint protein MAD2A. (205 aa)
CHMP4CCharged multivesicular body protein 4c. (237 aa)
BUB1BMitotic checkpoint serine/threonine-protein kinase BUB1 beta. (1062 aa)
ZFYVE19abscission/NoCut checkpoint regulator isoform X1. (415 aa)
DACT1Dapper homolog 1. (691 aa)
NLE1Notchless protein homolog 1. (485 aa)
TRIP13Pachytene checkpoint protein 2 homolog; Belongs to the AAA ATPase family. (415 aa)
ZFP36L1mRNA decay activator protein ZFP36L1. (338 aa)
HECAHeadcase protein homolog. (415 aa)
CHEK1Serine/threonine-protein kinase Chk1; Belongs to the protein kinase superfamily. (476 aa)
CHFRE3 ubiquitin-protein ligase CHFR. (634 aa)
PLK5LOW QUALITY PROTEIN: inactive serine/threonine-protein kinase PLK5. (561 aa)
GPNMBTransmembrane glycoprotein NMB. (553 aa)
FZR1Fizzy-related protein homolog. (493 aa)
RAD21Double-strand-break repair protein rad21 homolog isoform X1. (630 aa)
SCRIBLOW QUALITY PROTEIN: protein scribble homolog. (1575 aa)
BRCA1Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...] (1870 aa)
MUC1Mucin-1. (784 aa)
INTS3Integrator complex subunit 3 isoform X1. (1069 aa)
RAD9ACell cycle checkpoint control protein; Belongs to the rad9 family. (420 aa)
NEK11LOW QUALITY PROTEIN: serine/threonine-protein kinase Nek11. (492 aa)
AURKBAurora kinase B isoform X1; Belongs to the protein kinase superfamily. (345 aa)
PIDD1P53-induced death domain-containing protein 1. (914 aa)
MUS81Crossover junction endonuclease MUS81 isoform X1. (551 aa)
CCND1G1/S-specific cyclin-D1; Belongs to the cyclin family. (295 aa)
MIIPMigration and invasion-inhibitory protein isoform X1. (385 aa)
CDKN1CCyclin-dependent kinase inhibitor 1C. (179 aa)
CDK2AP2Cyclin-dependent kinase 2-associated protein 2 isoform X1. (134 aa)
OVOL1Putative transcription factor Ovo-like 1. (441 aa)
WACWW domain-containing adapter protein with coiled-coil isoform X1. (606 aa)
ANGEL2Protein angel homolog 2 isoform X1. (544 aa)
DTLDenticleless protein homolog. (730 aa)
BMP7Bone morphogenetic protein 7. (431 aa)
TPRNucleoprotein TPR isoform X1. (2438 aa)
BTG2Protein BTG2. (162 aa)
NME6Nucleoside diphosphate kinase. (202 aa)
DLG1Disks large homolog 1 isoform X1; Belongs to the MAGUK family. (927 aa)
BUB3Mitotic checkpoint protein BUB3 isoform X1. (328 aa)
CUNH10orf90Centrosomal protein C10orf90 homolog isoform X1. (794 aa)
TREX1Three-prime repair exonuclease 1. (314 aa)
TOM1L2TOM1-like protein 2 isoform X5; Belongs to the TOM1 family. (528 aa)
IKProtein Red. (553 aa)
SPDL1Protein Spindly; Required for the localization of dynein and dynactin to the mitotic kintochore. Dynein is believed to control the initial lateral interaction between the kinetochore and spindle microtubules and to facilitate the subsequent formation of end-on kinetochore-microtubule attachments mediated by the NDC80 complex. Also required for correct spindle orientation. Does not appear to be required for the removal of spindle assembly checkpoint (SAC) proteins from the kinetochore upon bipolar spindle attachment. (620 aa)
PTPN3Tyrosine-protein phosphatase non-receptor type; May act at junctions between the membrane and the cytoskeleton. (944 aa)
ZFP36L2mRNA decay activator protein ZFP36L2. (492 aa)
LOC112404902LOW QUALITY PROTEIN: baculoviral IAP repeat-containing protein 5-like. (215 aa)
SDE2Replication stress response regulator SDE2 isoform X1. (453 aa)
BTG4Protein BTG4. (230 aa)
CTNNB1Catenin beta-1. (781 aa)
MSH2DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (934 aa)
GAS1LOW QUALITY PROTEIN: growth arrest-specific protein 1. (332 aa)
ZW10Centromere/kinetochore protein zw10 homolog isoform X1. (779 aa)
BRCC3Lys-63-specific deubiquitinase BRCC36 isoform X1. (316 aa)
BTG1Protein BTG1. (134 aa)
BCL2Apoptosis regulator Bcl-2 isoform X1. (233 aa)
CRADDDeath domain-containing protein CRADD isoform X1. (199 aa)
ABRAXAS1BRCA1-A complex subunit Abraxas 1 isoform X1. (361 aa)
RAD17Cell cycle checkpoint protein RAD17 isoform X1. (709 aa)
RB1Retinoblastoma-associated protein. (816 aa)
CTDSPLCTD small phosphatase-like protein. (384 aa)
NBNNibrin; Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double- strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. (727 aa)
RINT1RAD50-interacting protein 1. (792 aa)
STK33Serine/threonine-protein kinase 33 isoform X1. (527 aa)
USP47Ubiquitin carboxyl-terminal hydrolase 47 isoform X1; Belongs to the peptidase C19 family. (1355 aa)
INIPSOSS complex subunit C isoform X1. (120 aa)
TTKDual specificity protein kinase TTK isoform X1. (864 aa)
TEX14Inactive serine/threonine-protein kinase TEX14 isoform X1. (1533 aa)
CASP2Caspase-2 isoform X1; Belongs to the peptidase C14A family. (452 aa)
TOM1L1TOM1-like protein 1; Belongs to the TOM1 family. (475 aa)
UIMC1BRCA1-A complex subunit RAP80 isoform X1. (630 aa)
APCAdenomatous polyposis coli protein isoform X1. (2863 aa)
EZH2Histone-lysine N-methyltransferase EZH2 isoform X1. (751 aa)
MTBPMdm2-binding protein. (902 aa)
CHEK2Serine/threonine-protein kinase Chk2. (544 aa)
NOP53Ribosome biogenesis protein NOP53 isoform X1. (564 aa)
TRIM35Tripartite motif-containing protein 35 isoform X1. (493 aa)
FZD3Frizzled-3; Belongs to the G-protein coupled receptor Fz/Smo family. (468 aa)
BABAM1BRISC and BRCA1-A complex member 1. (330 aa)
SYF2pre-mRNA-splicing factor SYF2. (245 aa)
ATMSerine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3064 aa)
TICRRTreslin. (1902 aa)
LOC112414307LOW QUALITY PROTEIN: pre-mRNA-splicing factor SYF2-like. (246 aa)
BLMBloom syndrome protein isoform X1. (1447 aa)
CDKN1ACyclin-dependent kinase inhibitor 1. (164 aa)
LRRC1Leucine-rich repeat-containing protein 1. (443 aa)
CDK1Cyclin-dependent kinase 1; Belongs to the protein kinase superfamily. (297 aa)
BABAM2BRISC and BRCA1-A complex member 2 isoform X1. (402 aa)
MRNIPMRN complex-interacting protein isoform X1. (374 aa)
FANCD2Fanconi anemia group D2 protein. (1449 aa)
DLG2Disks large homolog 2 isoform X1. (905 aa)
KLHL22Kelch-like protein 22 isoform X1. (673 aa)
PSMG2Proteasome assembly chaperone 2; Chaperone protein which promotes assembly of the 20S proteasome as part of a heterodimer with PSMG1. Belongs to the PSMG2 family. (264 aa)
MAD1L1Mitotic spindle assembly checkpoint protein MAD1 isoform X1. (717 aa)
VPS4AVacuolar protein sorting-associated protein 4A isoform X1; Belongs to the AAA ATPase family. (472 aa)
XPCDNA repair protein complementing XP-C cells. (959 aa)
Your Current Organism:
Neophocaena asiaeorientalis
NCBI taxonomy Id: 1706337
Other names: N. asiaeorientalis asiaeorientalis, Neophocaena asiaeorientalis asiaeorientalis, Yangtze finless porpoise
Server load: low (20%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.