(46 nodes) Regulation of glucose import network (Neophocaena asiaeorientalis)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:
	C1QTNF12	Adipolin. (267 aa)
	IRS1	Insulin receptor substrate 1. (1248 aa)
	PID1	PTB-containing, cubilin and LRP1-interacting protein isoform X1. (217 aa)
	OSTN	Osteocrin. (132 aa)
	OPN3	LOW QUALITY PROTEIN: opsin-3; Belongs to the G-protein coupled receptor 1 family. (521 aa)
	PTPN11	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (597 aa)
	STXBP3	Syntaxin-binding protein 3; Belongs to the STXBP/unc-18/SEC1 family. (592 aa)
	INSR	Tyrosine-protein kinase receptor. (1382 aa)
	APPL1	DCC-interacting protein 13-alpha isoform X1. (708 aa)
	GPC3	Glypican-3; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family. (580 aa)
	INS	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (110 aa)
	FGF19	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (363 aa)
	PEA15	Astrocytic phosphoprotein PEA-15. (130 aa)
	HK2	Hexokinase-2. (917 aa)
	SLC1A2	Amino acid transporter. (574 aa)
	ERFE	Erythroferrone. (273 aa)
	PIK3R1	Phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1. (724 aa)
	RHOQ	Rho-related GTP-binding protein RhoQ isoform X1. (280 aa)
	IRS2	Insulin receptor substrate 2. (702 aa)
	OCLN	Occludin; May play a role in the formation and regulation of the tight junction (TJ) paracellular permeability barrier. Belongs to the ELL/occludin family. (520 aa)
	PTH	Parathyroid hormone; PTH elevates calcium level by dissolving the salts in bone and preventing their renal excretion; Belongs to the parathyroid hormone family. (119 aa)
	AKT1	RAC-alpha serine/threonine-protein kinase; Belongs to the protein kinase superfamily. (339 aa)
	ITLN1	LOW QUALITY PROTEIN: intelectin-1. (206 aa)
	ENPP1	Ectonucleotide pyrophosphatase/phosphodiesterase family member 1. (857 aa)
	AKT2	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
	RTN2	Reticulon. (471 aa)
	GSK3A	Glycogen synthase kinase-3 alpha. (320 aa)
	FGF21	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
	ADIPOQ	Adiponectin. (243 aa)
	LOC112414965	LOW QUALITY PROTEIN: growth factor receptor-bound protein 10-like. (543 aa)
	GRB10	Growth factor receptor-bound protein 10. (588 aa)
	LEP	Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...] (167 aa)
	ASPSCR1	Tether containing UBX domain for GLUT4 isoform X1. (575 aa)
	CAPN10	Calpain-10 isoform X1; Belongs to the peptidase C2 family. (848 aa)
	IGF1	Insulin-like growth factor I isoform X1. (208 aa)
	RNASEL	2-5A-dependent ribonuclease isoform X1. (736 aa)
	TERT	Telomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA-dependent extension of 3'-chromosomal termini with the 6-nuc [...] (1136 aa)
	MEF2A	Myocyte-specific enhancer factor 2A isoform X1. (501 aa)
	APPL2	DCC-interacting protein 13-beta isoform X1. (661 aa)
	LOC112392089	RAC-alpha serine/threonine-protein kinase. (138 aa)
	CREBL2	cAMP-responsive element-binding protein-like 2 isoform X1. (132 aa)
	NFE2L2	Nuclear factor erythroid 2-related factor 2 isoform X1. (622 aa)
	PRKCI	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (597 aa)
	LOC112392549	Prorelaxin. (183 aa)
	POU4F2	POU domain protein. (408 aa)
	OSBPL8	Oxysterol-binding protein; Belongs to the OSBP family. (889 aa)

Your Current Organism:

Neophocaena asiaeorientalis

NCBI taxonomy Id: 1706337
Other names: N. asiaeorientalis asiaeorientalis, Neophocaena asiaeorientalis asiaeorientalis, Yangtze finless porpoise

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ADIPOQ	APPL1	A0A341DAP3	A0A341BJ25	Adiponectin.	DCC-interacting protein 13-alpha isoform X1.	0.539
ADIPOQ	APPL2	A0A341DAP3	A0A341AFJ1	Adiponectin.	DCC-interacting protein 13-beta isoform X1.	0.512
ADIPOQ	FGF21	A0A341DAP3	A0A341DBA5	Adiponectin.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.669
ADIPOQ	IGF1	A0A341DAP3	A0A341ADG7	Adiponectin.	Insulin-like growth factor I isoform X1.	0.544
ADIPOQ	INS	A0A341DAP3	A0A341BTK8	Adiponectin.	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	0.819
ADIPOQ	INSR	A0A341DAP3	A0A341BIP5	Adiponectin.	Tyrosine-protein kinase receptor.	0.459
ADIPOQ	IRS1	A0A341DAP3	A0A341B0M9	Adiponectin.	Insulin receptor substrate 1.	0.624
ADIPOQ	IRS2	A0A341DAP3	A0A341C791	Adiponectin.	Insulin receptor substrate 2.	0.472
ADIPOQ	LEP	A0A341DAP3	A0A341CVH9	Adiponectin.	Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...]	0.916
AKT1	APPL1	A0A341CGU0	A0A341BJ25	RAC-alpha serine/threonine-protein kinase; Belongs to the protein kinase superfamily.	DCC-interacting protein 13-alpha isoform X1.	0.869
AKT1	APPL2	A0A341CGU0	A0A341AFJ1	RAC-alpha serine/threonine-protein kinase; Belongs to the protein kinase superfamily.	DCC-interacting protein 13-beta isoform X1.	0.859
AKT1	GSK3A	A0A341CGU0	A0A341DBH0	RAC-alpha serine/threonine-protein kinase; Belongs to the protein kinase superfamily.	Glycogen synthase kinase-3 alpha.	0.881
AKT1	IGF1	A0A341CGU0	A0A341ADG7	RAC-alpha serine/threonine-protein kinase; Belongs to the protein kinase superfamily.	Insulin-like growth factor I isoform X1.	0.477
AKT1	INS	A0A341CGU0	A0A341BTK8	RAC-alpha serine/threonine-protein kinase; Belongs to the protein kinase superfamily.	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	0.576
AKT1	IRS1	A0A341CGU0	A0A341B0M9	RAC-alpha serine/threonine-protein kinase; Belongs to the protein kinase superfamily.	Insulin receptor substrate 1.	0.543
AKT1	IRS2	A0A341CGU0	A0A341C791	RAC-alpha serine/threonine-protein kinase; Belongs to the protein kinase superfamily.	Insulin receptor substrate 2.	0.431
AKT1	LOC112392089	A0A341CGU0	A0A341AFJ6	RAC-alpha serine/threonine-protein kinase; Belongs to the protein kinase superfamily.	RAC-alpha serine/threonine-protein kinase.	0.846
AKT1	NFE2L2	A0A341CGU0	A0A341AHP2	RAC-alpha serine/threonine-protein kinase; Belongs to the protein kinase superfamily.	Nuclear factor erythroid 2-related factor 2 isoform X1.	0.690
AKT1	PIK3R1	A0A341CGU0	A0A341C200	RAC-alpha serine/threonine-protein kinase; Belongs to the protein kinase superfamily.	Phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1.	0.876
AKT2	APPL1	A0A341DDW1	A0A341BJ25	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	DCC-interacting protein 13-alpha isoform X1.	0.869