(51 nodes) Vesicle docking network (Neophocaena asiaeorientalis)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	VPS11	Vacuolar protein sorting-associated protein 11 homolog; Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes. Belongs to the VPS11 family. (941 aa)
	UNC13C	Protein unc-13 homolog C isoform X1. (2217 aa)
	USO1	General vesicular transport factor p115 isoform X1. (970 aa)
	CEP83	Centrosomal protein of 83 kDa. (701 aa)
	BVES	Blood vessel epicardial substance. (360 aa)
	CFTR	Cystic fibrosis transmembrane conductance regulator; Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane. Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelial fluid layer. (1482 aa)
	CAV2	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (162 aa)
	STX6	Syntaxin-6; Belongs to the syntaxin family. (255 aa)
	STX7	Syntaxin-7 isoform X1; Belongs to the syntaxin family. (289 aa)
	STX19	Syntaxin-19. (294 aa)
	STX2	Syntaxin-2; Belongs to the syntaxin family. (259 aa)
	IVL	Involucrin; Part of the insoluble cornified cell envelope (CE) of stratified squamous epithelia. (296 aa)
	UNC13B	Protein unc-13 homolog B. (1603 aa)
	RABEPK	Rab9 effector protein with kelch motifs isoform X1. (372 aa)
	STXBP1	Syntaxin-binding protein 1 isoform X1; Belongs to the STXBP/unc-18/SEC1 family. (580 aa)
	RAB12	Ras-related protein Rab-12. (288 aa)
	LOC112412211	LOW QUALITY PROTEIN: syntaxin-17-like. (302 aa)
	RAB10	Ras-related protein Rab-10. (200 aa)
	RAB3C	Ras-related protein Rab-3C. (227 aa)
	EXOC2	Exocyst complex component 2; Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. Belongs to the SEC5 family. (929 aa)
	STX10	Syntaxin-10; Belongs to the syntaxin family. (249 aa)
	RAB8A	Ras-related protein Rab-8A. (278 aa)
	RAB3A	Ras-related protein Rab-3A. (220 aa)
	STX12	Syntaxin-12; Belongs to the syntaxin family. (274 aa)
	PPFIA3	LOW QUALITY PROTEIN: liprin-alpha-3. (1197 aa)
	UNC13A	Protein unc-13 homolog A. (1647 aa)
	SCFD2	Sec1 family domain-containing protein 2; Belongs to the STXBP/unc-18/SEC1 family. (684 aa)
	RAB13	Ras-related protein Rab-13. (203 aa)
	STX11	Syntaxin-11; Belongs to the syntaxin family. (287 aa)
	STX8	Syntaxin-8 isoform X1. (236 aa)
	STX3	Syntaxin-3 isoform X1; Belongs to the syntaxin family. (306 aa)
	STX5	Syntaxin-5 isoform X1; Belongs to the syntaxin family. (355 aa)
	STX16	Syntaxin-16 isoform X1; Belongs to the syntaxin family. (326 aa)
	VPS18	Vacuolar protein sorting-associated protein 18 homolog isoform X1. (973 aa)
	RAB8B	Ras-related protein Rab-8B isoform X2. (207 aa)
	STX17	Syntaxin-17; Belongs to the syntaxin family. (314 aa)
	EXOC4	Exocyst complex component 4. (975 aa)
	RAB3B	Ras-related protein Rab-3B. (219 aa)
	TSNARE1	t-SNARE domain-containing protein 1. (819 aa)
	PLEK	Pleckstrin. (350 aa)
	STXBP3	Syntaxin-binding protein 3; Belongs to the STXBP/unc-18/SEC1 family. (592 aa)
	CLN3	Battenin. (436 aa)
	YKT6	Synaptobrevin homolog YKT6 isoform X1; Belongs to the synaptobrevin family. (203 aa)
	STX1B	syntaxin-1B isoform X1; Belongs to the syntaxin family. (260 aa)
	STX4	Syntaxin-4; Belongs to the syntaxin family. (289 aa)
	RAB3D	Ras-related protein Rab-3D. (219 aa)
	STXBP2	Syntaxin-binding protein 2; Belongs to the STXBP/unc-18/SEC1 family. (593 aa)
	STX1A	syntaxin-1A; Belongs to the syntaxin family. (288 aa)
	RAB15	Ras-related protein Rab-15 isoform X1. (219 aa)
	CTBP2	C-terminal-binding protein 2 isoform X1. (983 aa)
	NDRG4	Protein NDRG4 isoform X1. (402 aa)

Your Current Organism:

Neophocaena asiaeorientalis

NCBI taxonomy Id: 1706337
Other names: N. asiaeorientalis asiaeorientalis, Neophocaena asiaeorientalis asiaeorientalis, Yangtze finless porpoise

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CAV2	RAB13	A0A341CG35	A0A341BP40	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Ras-related protein Rab-13.	0.479
CEP83	RAB8A	A0A341C6Z0	A0A341D896	Centrosomal protein of 83 kDa.	Ras-related protein Rab-8A.	0.489
CEP83	STX5	A0A341C6Z0	A0A341BS31	Centrosomal protein of 83 kDa.	Syntaxin-5 isoform X1; Belongs to the syntaxin family.	0.651
CEP83	USO1	A0A341C6Z0	A0A341C5V1	Centrosomal protein of 83 kDa.	General vesicular transport factor p115 isoform X1.	0.643
CFTR	CTBP2	A0A341CFI2	A0A341BXB2	Cystic fibrosis transmembrane conductance regulator; Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane. Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelial fluid layer.	C-terminal-binding protein 2 isoform X1.	0.532
CFTR	STX16	A0A341CFI2	A0A341BWB1	Cystic fibrosis transmembrane conductance regulator; Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane. Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelial fluid layer.	Syntaxin-16 isoform X1; Belongs to the syntaxin family.	0.469
CTBP2	CFTR	A0A341BXB2	A0A341CFI2	C-terminal-binding protein 2 isoform X1.	Cystic fibrosis transmembrane conductance regulator; Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane. Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelial fluid layer.	0.532
EXOC2	EXOC4	A0A341D5G2	A0A341AT54	Exocyst complex component 2; Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. Belongs to the SEC5 family.	Exocyst complex component 4.	0.999
EXOC2	RAB10	A0A341D5G2	A0A341D2A4	Exocyst complex component 2; Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. Belongs to the SEC5 family.	Ras-related protein Rab-10.	0.744
EXOC2	RAB12	A0A341D5G2	A0A341CXH2	Exocyst complex component 2; Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. Belongs to the SEC5 family.	Ras-related protein Rab-12.	0.568
EXOC2	RAB13	A0A341D5G2	A0A341BP40	Exocyst complex component 2; Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. Belongs to the SEC5 family.	Ras-related protein Rab-13.	0.744
EXOC2	RAB15	A0A341D5G2	A0A341BWJ4	Exocyst complex component 2; Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. Belongs to the SEC5 family.	Ras-related protein Rab-15 isoform X1.	0.744
EXOC2	RAB8A	A0A341D5G2	A0A341D896	Exocyst complex component 2; Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. Belongs to the SEC5 family.	Ras-related protein Rab-8A.	0.744
EXOC2	RAB8B	A0A341D5G2	A0A341AJR5	Exocyst complex component 2; Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. Belongs to the SEC5 family.	Ras-related protein Rab-8B isoform X2.	0.744
EXOC2	STXBP1	A0A341D5G2	A0A341CWX0	Exocyst complex component 2; Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. Belongs to the SEC5 family.	Syntaxin-binding protein 1 isoform X1; Belongs to the STXBP/unc-18/SEC1 family.	0.541
EXOC2	STXBP2	A0A341D5G2	A0A341BG11	Exocyst complex component 2; Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. Belongs to the SEC5 family.	Syntaxin-binding protein 2; Belongs to the STXBP/unc-18/SEC1 family.	0.541
EXOC2	STXBP3	A0A341D5G2	A0A341B846	Exocyst complex component 2; Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. Belongs to the SEC5 family.	Syntaxin-binding protein 3; Belongs to the STXBP/unc-18/SEC1 family.	0.563
EXOC4	EXOC2	A0A341AT54	A0A341D5G2	Exocyst complex component 4.	Exocyst complex component 2; Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. Belongs to the SEC5 family.	0.999
EXOC4	RAB10	A0A341AT54	A0A341D2A4	Exocyst complex component 4.	Ras-related protein Rab-10.	0.795
EXOC4	RAB12	A0A341AT54	A0A341CXH2	Exocyst complex component 4.	Ras-related protein Rab-12.	0.600