(67 nodes) Oogenesis network (Neophocaena asiaeorientalis)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ZNF830	Zinc finger protein 830. (380 aa)
	GPR149	Probable G-protein coupled receptor 149. (746 aa)
	LOC112415969	Histone H3.3-like. (251 aa)
	NANOS2	Nanos homolog 2; Belongs to the nanos family. (138 aa)
	CCDC155	Protein KASH5. (571 aa)
	BHMG1	Basic helix-loop-helix and HMG box domain-containing protein 1. (633 aa)
	ERCC1	DNA excision repair protein ERCC-1 isoform X2. (432 aa)
	NANOS3	Nanos homolog 3; Belongs to the nanos family. (175 aa)
	ATM	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3064 aa)
	HORMAD1	HORMA domain-containing protein 1. (395 aa)
	YTHDF2	YTH domain-containing family protein 2 isoform X1. (580 aa)
	TDRD6	Tudor domain-containing protein 6 isoform X1. (2106 aa)
	DDX20	Probable ATP-dependent RNA helicase DDX20. (822 aa)
	EDN1	Endothelin-1. (202 aa)
	IHH	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. (410 aa)
	TDRKH	Tudor and KH domain-containing protein isoform X1. (561 aa)
	SOHLH1	Spermatogenesis- and oogenesis-specific basic helix-loop-helix-containing protein 1. (321 aa)
	DMC1	Meiotic recombination protein DMC1/LIM15 homolog; Belongs to the RecA family. (340 aa)
	LOC112411000	LOW QUALITY PROTEIN: zinc finger X-chromosomal protein-like. (811 aa)
	LOC112410315	Histone H3; Belongs to the histone H3 family. (136 aa)
	MEIOC	Meiosis-specific coiled-coil domain-containing protein MEIOC. (723 aa)
	INHBB	Inhibin beta B chain. (345 aa)
	TDRD5	Tudor domain-containing protein 5. (1036 aa)
	MEI4	Meiosis-specific protein MEI4. (389 aa)
	TDRD1	Tudor domain-containing protein 1. (1046 aa)
	ZFY	Zinc finger Y-chromosomal protein. (800 aa)
	NANOS1	Nanos homolog 1; Belongs to the nanos family. (128 aa)
	BRCA2	Breast cancer type 2 susceptibility protein. (3435 aa)
	FOXO3	Forkhead box protein O3. (672 aa)
	BCL2	Apoptosis regulator Bcl-2 isoform X1. (233 aa)
	CTNNB1	Catenin beta-1. (781 aa)
	PLD6	Mitochondrial cardiolipin hydrolase. (243 aa)
	REC8	Meiotic recombination protein REC8 homolog isoform X1. (584 aa)
	TNFAIP6	Tumor necrosis factor-inducible gene 6 protein isoform X1. (284 aa)
	LOC112404240	Histone H3.3-like. (136 aa)
	SPO11	Meiotic recombination protein SPO11 isoform X1. (395 aa)
	TDRD10	Tudor domain-containing protein 10 isoform X1. (382 aa)
	CUNH14orf39	Protein SIX6OS1. (690 aa)
	TDRD15	LOW QUALITY PROTEIN: tudor domain-containing protein 15. (1981 aa)
	PIWIL2	Piwi-like protein 2 isoform X1; Belongs to the argonaute family. (971 aa)
	PAQR6	LOW QUALITY PROTEIN: membrane progestin receptor delta. (368 aa)
	PAQR5	Membrane progestin receptor gamma isoform X1. (330 aa)
	NPM2	Nucleoplasmin-2 isoform X1. (216 aa)
	GDF9	Growth/differentiation factor 9 isoform X1. (454 aa)
	FBXO5	F-box only protein 5 isoform X1. (448 aa)
	ZGLP1	GATA-type zinc finger protein 1. (288 aa)
	ZP3	Zona pellucida sperm-binding protein 3. (421 aa)
	MARF1	Meiosis regulator and mRNA stability factor 1 isoform X1. (1742 aa)
	SRC	Tyrosine-protein kinase. (601 aa)
	CDC25B	M-phase inducer phosphatase 2 isoform X1. (574 aa)
	AURKC	Aurora kinase C; Belongs to the protein kinase superfamily. (296 aa)
	PTN	Pleiotrophin isoform X1. (168 aa)
	WASHC5	WASH complex subunit 5 isoform X1. (1160 aa)
	YTHDC1	YTH domain-containing protein 1 isoform X1. (737 aa)
	PTX3	Pentraxin-related protein PTX3. (382 aa)
	EHMT2	Histone-lysine N-methyltransferase EHMT2. (1242 aa)
	STRA8	Stimulated by retinoic acid gene 8 protein homolog. (409 aa)
	CCDC36	Interactor of HORMAD1 protein 1. (593 aa)
	SEBOX	Homeobox protein SEBOX. (190 aa)
	LGR5	Leucine-rich repeat-containing G-protein coupled receptor 5 isoform X1. (907 aa)
	EDNRA	Endothelin-1 receptor isoform X1; Belongs to the G-protein coupled receptor 1 family. (427 aa)
	BMPR1B	Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
	LOC112392549	Prorelaxin. (183 aa)
	MTHFSD	Methenyltetrahydrofolate synthase domain-containing protein isoform X2. (384 aa)
	TDRD7	Tudor domain-containing protein 7. (1098 aa)
	PDE3A	Phosphodiesterase. (1134 aa)
	TRIP13	Pachytene checkpoint protein 2 homolog; Belongs to the AAA ATPase family. (415 aa)

Your Current Organism:

Neophocaena asiaeorientalis

NCBI taxonomy Id: 1706337
Other names: N. asiaeorientalis asiaeorientalis, Neophocaena asiaeorientalis asiaeorientalis, Yangtze finless porpoise

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ATM	BCL2	A0A341D6S5	A0A341C880	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Apoptosis regulator Bcl-2 isoform X1.	0.563
ATM	BRCA2	A0A341D6S5	A0A341C9R8	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Breast cancer type 2 susceptibility protein.	0.907
ATM	CTNNB1	A0A341D6S5	A0A341C5R9	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Catenin beta-1.	0.499
ATM	DMC1	A0A341D6S5	A0A341CU34	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Meiotic recombination protein DMC1/LIM15 homolog; Belongs to the RecA family.	0.812
ATM	ERCC1	A0A341D6S5	A0A341DB68	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	DNA excision repair protein ERCC-1 isoform X2.	0.665
ATM	HORMAD1	A0A341D6S5	A0A341D6E1	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	HORMA domain-containing protein 1.	0.485
ATM	LOC112404240	A0A341D6S5	A0A341BYW2	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Histone H3.3-like.	0.601
ATM	LOC112410315	A0A341D6S5	A0A341CPG2	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Histone H3; Belongs to the histone H3 family.	0.601
ATM	LOC112415969	A0A341D6S5	A0A341DCZ1	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Histone H3.3-like.	0.601
ATM	REC8	A0A341D6S5	A0A341C3B1	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Meiotic recombination protein REC8 homolog isoform X1.	0.411
ATM	SPO11	A0A341D6S5	A0A341BWW9	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Meiotic recombination protein SPO11 isoform X1.	0.771
ATM	SRC	A0A341D6S5	A0A341B9I2	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Tyrosine-protein kinase.	0.469
ATM	TRIP13	A0A341D6S5	A0A341AAT3	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Pachytene checkpoint protein 2 homolog; Belongs to the AAA ATPase family.	0.499
AURKC	LOC112404240	A0A341B7A2	A0A341BYW2	Aurora kinase C; Belongs to the protein kinase superfamily.	Histone H3.3-like.	0.492
AURKC	LOC112410315	A0A341B7A2	A0A341CPG2	Aurora kinase C; Belongs to the protein kinase superfamily.	Histone H3; Belongs to the histone H3 family.	0.492
AURKC	LOC112415969	A0A341B7A2	A0A341DCZ1	Aurora kinase C; Belongs to the protein kinase superfamily.	Histone H3.3-like.	0.492
AURKC	TRIP13	A0A341B7A2	A0A341AAT3	Aurora kinase C; Belongs to the protein kinase superfamily.	Pachytene checkpoint protein 2 homolog; Belongs to the AAA ATPase family.	0.496
BCL2	ATM	A0A341C880	A0A341D6S5	Apoptosis regulator Bcl-2 isoform X1.	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	0.563
BCL2	CTNNB1	A0A341C880	A0A341C5R9	Apoptosis regulator Bcl-2 isoform X1.	Catenin beta-1.	0.713
BCL2	FOXO3	A0A341C880	A0A341C9P0	Apoptosis regulator Bcl-2 isoform X1.	Forkhead box protein O3.	0.477