STRINGSTRING
NOTCH1 NOTCH1 NDUFV2 NDUFV2 LOC112411691 LOC112411691 PTCD2 PTCD2 FHOD3 FHOD3 JARID2 JARID2 ADPRH ADPRH CSRP3 CSRP3 BMP2 BMP2 MAML1 MAML1 WNT3A WNT3A LOC112413221 LOC112413221 SRF SRF NEBL NEBL ITGB1 ITGB1 MESP1 MESP1 EGLN1 EGLN1 ALPK3 ALPK3 SLC9A1 SLC9A1 ADRA1A ADRA1A TGFB1 TGFB1 PPP1R13L PPP1R13L ALDH1A2 ALDH1A2 VWA5B2 VWA5B2 PRMT1 PRMT1 CUNH3orf58 CUNH3orf58 NRAP NRAP LRP2 LRP2 SMAD7 SMAD7 XIRP2 XIRP2 ZFPM2 ZFPM2 ATG5 ATG5 BVES BVES SMAD4 SMAD4 NOG NOG TBX2 TBX2 HEG1 HEG1 LOC112406197 LOC112406197 LOC112406157 LOC112406157 LOC112406076 LOC112406076 HNRNPU HNRNPU SGCG SGCG FGF9 FGF9 NKX2-5 NKX2-5 MYOCD MYOCD MYLK3 MYLK3 NEB NEB ADPRHL1 ADPRHL1 TREX1 TREX1 LOC112404308 LOC112404308 PROX1 PROX1 MYL3 MYL3 BMP7 BMP7 S1PR1 S1PR1 GATA5 GATA5 TBX20 TBX20 TENM4 TENM4 MYBPC3 MYBPC3 MTOR MTOR VWA5B1 VWA5B1 TNNT2 TNNT2 TNNI1 TNNI1 LMNA LMNA LRRC10B LRRC10B NKX2-6 NKX2-6 IRX3 IRX3 LOC112401497 LOC112401497 PKP2 PKP2 WNT5A WNT5A TNNC1 TNNC1 PDGFRA PDGFRA MYL10 MYL10 MYL7 MYL7 FHL2 FHL2 CHD7 CHD7 TCAP TCAP RARA RARA MYLK2 MYLK2 MED1 MED1 TBX5 TBX5 TBX3 TBX3 FOXH1 FOXH1 MYO18B MYO18B PLEC PLEC ANKRD1 ANKRD1 CAV3 CAV3 ISL1 ISL1 SHOX2 SHOX2 DSP DSP ASB2 ASB2 BMPR1A BMPR1A DLL4 DLL4 CXADR CXADR MEF2A MEF2A LOC112392050 LOC112392050 TBX18 TBX18 SAV1 SAV1 GREM1 GREM1 MEF2C MEF2C LOC112392071 LOC112392071 TGFBR1 TGFBR1 BMP4 BMP4 ACADM ACADM ZFPM1 ZFPM1 LOC112393583 LOC112393583 EDNRA EDNRA TGFB2 TGFB2 ZMPSTE24 ZMPSTE24 MAPK11 MAPK11 BMP10 BMP10 RARB RARB IFT20 IFT20 LRRC10 LRRC10 SMAD1 SMAD1 ARID2 ARID2 GATA6 GATA6 DSG2 DSG2 WNT2 WNT2 SIK1 SIK1 MYL2 MYL2 PLN PLN NPRL3 NPRL3 HEY2 HEY2 POU4F1 POU4F1 SGCD SGCD PRKAR1A PRKAR1A HAND1 HAND1 GJC1 GJC1 ZIC3 ZIC3 RYR2 RYR2 NOX4 NOX4 ACTN2 ACTN2 CBY1 CBY1 ENG ENG TSC1 TSC1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
NOTCH1LOW QUALITY PROTEIN: neurogenic locus notch homolog protein 1. (2633 aa)
NDUFV2NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial isoform X1. (249 aa)
LOC112411691Retinoic acid receptor beta-like. (329 aa)
PTCD2LOW QUALITY PROTEIN: pentatricopeptide repeat-containing protein 2, mitochondrial. (384 aa)
FHOD3LOW QUALITY PROTEIN: FH1/FH2 domain-containing protein 3. (1229 aa)
JARID2Protein Jumonji isoform X1. (1235 aa)
ADPRHADP-ribosylarginine hydrolase. (373 aa)
CSRP3Cysteine and glycine-rich protein 3 isoform X1. (194 aa)
BMP2Bone morphogenetic protein 2 isoform X1. (395 aa)
MAML1LOW QUALITY PROTEIN: mastermind-like protein 1. (983 aa)
WNT3AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (352 aa)
LOC112413221Zeta-sarcoglycan. (181 aa)
SRFSerum response factor isoform X1. (535 aa)
NEBLNebulette isoform X1. (1013 aa)
ITGB1Integrin beta; Belongs to the integrin beta chain family. (801 aa)
MESP1Mesoderm posterior protein 1. (265 aa)
EGLN1Egl nine homolog 1. (225 aa)
ALPK3Alpha-protein kinase 3. (1664 aa)
SLC9A1Sodium/hydrogen exchanger; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. (816 aa)
ADRA1Aalpha-1A adrenergic receptor. (466 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (391 aa)
PPP1R13LrelA-associated inhibitor. (808 aa)
ALDH1A2Retinal dehydrogenase 2 isoform X1; Belongs to the aldehyde dehydrogenase family. (526 aa)
VWA5B2Von Willebrand factor A domain-containing protein 5B2. (1248 aa)
PRMT1Protein arginine N-methyltransferase 1 isoform X1; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. (371 aa)
CUNH3orf58Deleted in autism protein 1 isoform X1. (430 aa)
NRAPNebulin-related-anchoring protein isoform X1. (1593 aa)
LRP2Low-density lipoprotein receptor-related protein 2 isoform X1. (4651 aa)
SMAD7Mothers against decapentaplegic homolog. (426 aa)
XIRP2Xin actin-binding repeat-containing protein 2 isoform X1. (3323 aa)
ZFPM2Zinc finger protein ZFPM2. (1150 aa)
ATG5Autophagy protein 5; Involved in autophagic vesicle formation. (275 aa)
BVESBlood vessel epicardial substance. (360 aa)
SMAD4Mothers against decapentaplegic homolog. (599 aa)
NOGNoggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. (232 aa)
TBX2T-box transcription factor TBX2. (588 aa)
HEG1Protein HEG homolog 1. (1138 aa)
LOC112406197Alpha-protein kinase 2-like isoform X4. (1680 aa)
LOC112406157LOW QUALITY PROTEIN: alpha-protein kinase 2-like. (231 aa)
LOC112406076Protein HEG homolog 1-like. (419 aa)
HNRNPUHeterogeneous nuclear ribonucleoprotein U isoform X1. (825 aa)
SGCGGamma-sarcoglycan. (291 aa)
FGF9Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
NKX2-5Homeobox protein Nkx-2.5. (323 aa)
MYOCDMyocardin isoform X1. (937 aa)
MYLK3Myosin light chain kinase 3. (800 aa)
NEBNebulin isoform X1. (4186 aa)
ADPRHL1Protein ADP-ribosylarginine hydrolase-like protein 1. (354 aa)
TREX1Three-prime repair exonuclease 1. (314 aa)
LOC112404308LOW QUALITY PROTEIN: NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial-like. (258 aa)
PROX1Prospero homeobox protein 1 isoform X1. (737 aa)
MYL3Myosin light chain 3. (197 aa)
BMP7Bone morphogenetic protein 7. (431 aa)
S1PR1Sphingosine 1-phosphate receptor 1; Belongs to the G-protein coupled receptor 1 family. (382 aa)
GATA5LOW QUALITY PROTEIN: transcription factor GATA-5. (364 aa)
TBX20T-box transcription factor TBX20. (449 aa)
TENM4Teneurin-4. (2769 aa)
MYBPC3Myosin-binding protein C, cardiac-type. (1277 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2548 aa)
VWA5B1Von Willebrand factor A domain-containing protein 5B1. (1214 aa)
TNNT2Troponin T, cardiac muscle isoform X1. (333 aa)
TNNI1Troponin I, slow skeletal muscle. (166 aa)
LMNALamin; Belongs to the intermediate filament family. (664 aa)
LRRC10BLeucine-rich repeat-containing protein 10B. (292 aa)
NKX2-6Homeobox protein Nkx-2.6. (302 aa)
IRX3Iroquois-class homeodomain protein IRX-3. (501 aa)
LOC112401497Zeta-sarcoglycan-like. (139 aa)
PKP2Plakophilin-2. (826 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (380 aa)
TNNC1Troponin C, slow skeletal and cardiac muscles. (161 aa)
PDGFRAPlatelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. (1089 aa)
MYL10Myosin regulatory light chain 10. (147 aa)
MYL7Myosin regulatory light chain 2, atrial isoform isoform X1. (176 aa)
FHL2Four and a half LIM domains protein 2. (279 aa)
CHD7LOW QUALITY PROTEIN: chromodomain-helicase-DNA-binding protein 7. (3000 aa)
TCAPTelethonin isoform X1. (167 aa)
RARALOW QUALITY PROTEIN: retinoic acid receptor alpha. (572 aa)
MYLK2Myosin light chain kinase 2, skeletal/cardiac muscle. (615 aa)
MED1Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1579 aa)
TBX5T-box transcription factor TBX5. (519 aa)
TBX3LOW QUALITY PROTEIN: T-box transcription factor TBX3. (734 aa)
FOXH1Forkhead box protein H1. (360 aa)
MYO18BUnconventional myosin-XVIIIb; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (2607 aa)
PLECLOW QUALITY PROTEIN: plectin. (4609 aa)
ANKRD1Ankyrin repeat domain-containing protein 1. (319 aa)
CAV3Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (151 aa)
ISL1Insulin gene enhancer protein ISL-1. (349 aa)
SHOX2Short stature homeobox protein 2 isoform X1. (333 aa)
DSPDesmoplakin isoform X1. (2874 aa)
ASB2Ankyrin repeat and SOCS box protein 2. (600 aa)
BMPR1AReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
DLL4Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (685 aa)
CXADRCoxsackievirus and adenovirus receptor isoform X1. (365 aa)
MEF2AMyocyte-specific enhancer factor 2A isoform X1. (501 aa)
LOC112392050Nebulin-like. (89 aa)
TBX18T-box transcription factor TBX18. (612 aa)
SAV1Protein salvador homolog 1. (384 aa)
GREM1Gremlin. (184 aa)
MEF2CMyocyte-specific enhancer factor 2C isoform X4. (483 aa)
LOC112392071Nebulin-like. (115 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (438 aa)
BMP4Bone morphogenetic protein 4 isoform X1. (420 aa)
ACADMMedium-chain specific acyl-CoA dehydrogenase, mitochondrial isoform X1. (421 aa)
ZFPM1Zinc finger protein ZFPM1. (998 aa)
LOC112393583Nebulin-like. (2260 aa)
EDNRAEndothelin-1 receptor isoform X1; Belongs to the G-protein coupled receptor 1 family. (427 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
ZMPSTE24CAAX prenyl protease; Proteolytically removes the C-terminal three residues of farnesylated proteins; Belongs to the peptidase M48A family. (473 aa)
MAPK11Mitogen-activated protein kinase. (376 aa)
BMP10Bone morphogenetic protein 10. (423 aa)
RARBRetinoic acid receptor beta. (311 aa)
IFT20LOW QUALITY PROTEIN: intraflagellar transport protein 20 homolog. (159 aa)
LRRC10Leucine-rich repeat-containing protein 10. (279 aa)
SMAD1Mothers against decapentaplegic homolog. (465 aa)
ARID2AT-rich interactive domain-containing protein 2. (1836 aa)
GATA6Transcription factor GATA-6. (448 aa)
DSG2Desmoglein-2. (1105 aa)
WNT2Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (360 aa)
SIK1Serine/threonine-protein kinase SIK1. (657 aa)
MYL2Myosin regulatory light chain 2, ventricular/cardiac muscle isoform. (166 aa)
PLNCardiac phospholamban; Reversibly inhibits the activity of ATP2A2 in cardiac sarcoplasmic reticulum by decreasing the apparent affinity of the ATPase for Ca(2+). Modulates the contractility of the heart muscle in response to physiological stimuli via its effects on ATP2A2. Modulates calcium re-uptake during muscle relaxation and plays an important role in calcium homeostasis in the heart muscle. The degree of ATP2A2 inhibition depends on the oligomeric state of PLN. (52 aa)
NPRL3GATOR complex protein NPRL3 isoform X1. (621 aa)
HEY2Hairy/enhancer-of-split related with YRPW motif protein 2. (337 aa)
POU4F1POU domain protein. (320 aa)
SGCDDelta-sarcoglycan. (289 aa)
PRKAR1AcAMP-dependent protein kinase type I-alpha regulatory subunit. (380 aa)
HAND1Heart- and neural crest derivatives-expressed protein 1. (218 aa)
GJC1Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. (396 aa)
ZIC3Zinc finger protein ZIC 3. (455 aa)
RYR2Ryanodine receptor 2. (4971 aa)
NOX4NADPH oxidase 4 isoform X1. (530 aa)
ACTN2Alpha-actinin-2 isoform X1. (894 aa)
CBY1Protein chibby homolog 1 isoform X1. (156 aa)
ENGEndoglin. (652 aa)
TSC1Hamartin isoform X1. (1169 aa)
Your Current Organism:
Neophocaena asiaeorientalis
NCBI taxonomy Id: 1706337
Other names: N. asiaeorientalis asiaeorientalis, Neophocaena asiaeorientalis asiaeorientalis, Yangtze finless porpoise
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