STRINGSTRING
TWIST1 TWIST1 NOTCH4 NOTCH4 SEMA3D SEMA3D SHH SHH TGFB2 TGFB2 HEYL HEYL NRP2 NRP2 DLG5 DLG5 CDH2 CDH2 ISL1 ISL1 CITED2 CITED2 LOC112396048 LOC112396048 FGF10 FGF10 LOC112397124 LOC112397124 SEMA6D SEMA6D EXT1 EXT1 CORO1C CORO1C HTR2B HTR2B LEF1 LEF1 TRIM28 TRIM28 FLNA FLNA TBX3 TBX3 MSX1 MSX1 SNAI2 SNAI2 SEMA6A SEMA6A FAM83D FAM83D SEMA4C SEMA4C TGFBR3 TGFBR3 MAPK3 MAPK3 TGFBR3L TGFBR3L NRTN NRTN SEMA3G SEMA3G SEMA6B SEMA6B FAM208A FAM208A WNT5A WNT5A EFNB1 EFNB1 OSR1 OSR1 FAM172A FAM172A KBTBD8 KBTBD8 EFNA1 EFNA1 SIX1 SIX1 LOXL2 LOXL2 SEMA4A SEMA4A HIF1A HIF1A ADAM15 ADAM15 AMER1 AMER1 LAMA5 LAMA5 ANXA6 ANXA6 TBX20 TBX20 BMP7 BMP7 SNAI1 SNAI1 HAND2 HAND2 RET RET HES1 HES1 GBX2 GBX2 RTN4 RTN4 SEMA5A SEMA5A SIX2 SIX2 RANBP3L RANBP3L BCL2 BCL2 GDNF GDNF AMELX AMELX SEMA5B SEMA5B SMAD4 SMAD4 WNT11 WNT11 NOG NOG WNT16 WNT16 ROCK1 ROCK1 TMEM100 TMEM100 WNT2 WNT2 EPB41L5 EPB41L5 TCF21 TCF21 HEY2 HEY2 SOX8 SOX8 GSC GSC EDNRB EDNRB SOX9 SOX9 SOX10 SOX10 DDX5 DDX5 DDX17 DDX17 AKNA AKNA SMO SMO SEMA7A SEMA7A ENG ENG NOTCH1 NOTCH1 SEMA6C SEMA6C FN1 FN1 ERBB4 ERBB4 WNT10A WNT10A RADIL RADIL MAPK1 MAPK1 EDN1 EDN1 SFRP1 SFRP1 FGFR1 FGFR1 KLHL12 KLHL12 BMP2 BMP2 LOC112413323 LOC112413323 LOXL3 LOXL3 RDH10 RDH10 LOC112413664 LOC112413664 NRP1 NRP1 CUL7 CUL7 SEMA4F SEMA4F SEMA4B SEMA4B FRZB FRZB PEF1 PEF1 PHACTR4 PHACTR4 TGFB1 TGFB1 ALDH1A2 ALDH1A2 WWTR1 WWTR1 GSK3B GSK3B OTUD5 OTUD5 BMPR1A BMPR1A PHOX2B PHOX2B LOC112390775 LOC112390775 PDCD6 PDCD6 SEMA3C SEMA3C TCOF1 TCOF1 SEMA4D SEMA4D MEF2C MEF2C LOC112392060 LOC112392060 LRP6 LRP6 LOC112391722 LOC112391722 NOLC1 NOLC1 FGF8 FGF8 JAG1 JAG1 TGFBR1 TGFBR1 BMP4 BMP4 PPP3R2 PPP3R2 RFLNB RFLNB EDNRA EDNRA SEMA4G SEMA4G ACVR1 ACVR1 SEMA3F SEMA3F LOC112394195 LOC112394195 HMGA2 HMGA2 SEMA3A SEMA3A SEMA3E SEMA3E SEMA3B SEMA3B
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
TWIST1LOW QUALITY PROTEIN: twist-related protein 1. (152 aa)
NOTCH4Neurogenic locus notch homolog protein 4 isoform X1. (1993 aa)
SEMA3Dsemaphorin-3D; Belongs to the semaphorin family. (777 aa)
SHHSonic hedgehog protein. (328 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
HEYLHairy/enhancer-of-split related with YRPW motif-like protein isoform X1. (357 aa)
NRP2Neuropilin; Belongs to the neuropilin family. (931 aa)
DLG5Disks large homolog 5; Belongs to the MAGUK family. (1921 aa)
CDH2Cadherin-2; Cadherins are calcium-dependent cell adhesion proteins. (995 aa)
ISL1Insulin gene enhancer protein ISL-1. (349 aa)
CITED2Cbp/p300-interacting transactivator 2. (263 aa)
LOC112396048Cytochrome P450 26C1; Belongs to the cytochrome P450 family. (489 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
LOC112397124Hyaluronan synthase 2. (552 aa)
SEMA6Dsemaphorin-6D isoform X1; Belongs to the semaphorin family. (1073 aa)
EXT1Exostosin-1; Belongs to the glycosyltransferase 47 family. (746 aa)
CORO1CCoronin; Belongs to the WD repeat coronin family. (474 aa)
HTR2B5-hydroxytryptamine receptor 2B. (479 aa)
LEF1Lymphoid enhancer-binding factor 1 isoform X1. (414 aa)
TRIM28Transcription intermediary factor 1-beta. (983 aa)
FLNAfilamin-A isoform X1. (2592 aa)
TBX3LOW QUALITY PROTEIN: T-box transcription factor TBX3. (734 aa)
MSX1Homeobox protein MSX-1. (303 aa)
SNAI2Zinc finger protein SNAI2. (268 aa)
SEMA6Asemaphorin-6A isoform X1; Belongs to the semaphorin family. (1044 aa)
FAM83DProtein FAM83D. (560 aa)
SEMA4Csemaphorin-4C; Belongs to the semaphorin family. (833 aa)
TGFBR3Transforming growth factor beta receptor type 3 isoform X1. (851 aa)
MAPK3Mitogen-activated protein kinase 3. (265 aa)
TGFBR3LLOW QUALITY PROTEIN: transforming growth factor-beta receptor type 3-like protein. (412 aa)
NRTNNeurturin. (197 aa)
SEMA3Gsemaphorin-3G isoform X1; Belongs to the semaphorin family. (773 aa)
SEMA6BLOW QUALITY PROTEIN: semaphorin-6B; Belongs to the semaphorin family. (516 aa)
FAM208AProtein TASOR isoform X1. (1667 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (380 aa)
EFNB1ephrin-B1 isoform X1; Belongs to the ephrin family. (346 aa)
OSR1LOW QUALITY PROTEIN: protein odd-skipped-related 1. (326 aa)
FAM172AProtein FAM172A isoform X1. (416 aa)
KBTBD8Kelch repeat and BTB domain-containing protein 8 isoform X1. (601 aa)
EFNA1ephrin-A1 isoform X1; Belongs to the ephrin family. (224 aa)
SIX1Homeobox protein SIX1. (284 aa)
LOXL2Lysyl oxidase homolog 2. (774 aa)
SEMA4Asemaphorin-4A isoform X1; Belongs to the semaphorin family. (762 aa)
HIF1AHypoxia-inducible factor 1-alpha. (823 aa)
ADAM15Disintegrin and metalloproteinase domain-containing protein 15 isoform X1. (866 aa)
AMER1APC membrane recruitment protein 1. (1129 aa)
LAMA5LOW QUALITY PROTEIN: laminin subunit alpha-5. (3401 aa)
ANXA6Annexin. (673 aa)
TBX20T-box transcription factor TBX20. (449 aa)
BMP7Bone morphogenetic protein 7. (431 aa)
SNAI1Zinc finger protein SNAI1. (264 aa)
HAND2Heart- and neural crest derivatives-expressed protein 2. (208 aa)
RETProto-oncogene tyrosine-protein kinase receptor Ret; Receptor tyrosine-protein kinase involved in numerous cellular mechanisms including cell proliferation, neuronal navigation, cell migration, and cell differentiation upon binding with glial cell derived neurotrophic factor family ligands. (1113 aa)
HES1Transcription factor HES-1. (280 aa)
GBX2Homeobox protein GBX-2 isoform X1. (348 aa)
RTN4Reticulon. (1193 aa)
SEMA5Asemaphorin-5A isoform X1. (1073 aa)
SIX2Homeobox protein SIX2 isoform X1. (298 aa)
RANBP3LRan-binding protein 3-like isoform X1. (491 aa)
BCL2Apoptosis regulator Bcl-2 isoform X1. (233 aa)
GDNFGlial cell line-derived neurotrophic factor isoform X1. (211 aa)
AMELXLOW QUALITY PROTEIN: amelogenin, X isoform. (184 aa)
SEMA5Bsemaphorin-5B isoform X1. (1102 aa)
SMAD4Mothers against decapentaplegic homolog. (599 aa)
WNT11Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa)
NOGNoggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. (232 aa)
WNT16Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (362 aa)
ROCK1Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1354 aa)
TMEM100Transmembrane protein 100. (134 aa)
WNT2Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (360 aa)
EPB41L5Band 4.1-like protein 5 isoform X1. (746 aa)
TCF21Transcription factor 21. (179 aa)
HEY2Hairy/enhancer-of-split related with YRPW motif protein 2. (337 aa)
SOX8Transcription factor SOX-8. (378 aa)
GSCHomeobox protein goosecoid. (256 aa)
EDNRBEndothelin receptor type B; Belongs to the G-protein coupled receptor 1 family. (443 aa)
SOX9Transcription factor SOX-9. (486 aa)
SOX10Transcription factor SOX-10. (468 aa)
DDX5Probable ATP-dependent RNA helicase DDX5; Belongs to the DEAD box helicase family. (614 aa)
DDX17Probable ATP-dependent RNA helicase DDX17 isoform X1; Belongs to the DEAD box helicase family. (652 aa)
AKNAAT-hook-containing transcription factor isoform X1. (1439 aa)
SMOSmoothened homolog; Belongs to the G-protein coupled receptor Fz/Smo family. (783 aa)
SEMA7Asemaphorin-7A; Belongs to the semaphorin family. (665 aa)
ENGEndoglin. (652 aa)
NOTCH1LOW QUALITY PROTEIN: neurogenic locus notch homolog protein 1. (2633 aa)
SEMA6CLOW QUALITY PROTEIN: semaphorin-6C; Belongs to the semaphorin family. (884 aa)
FN1Fibronectin isoform X5. (2478 aa)
ERBB4Receptor protein-tyrosine kinase. (1308 aa)
WNT10AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (417 aa)
RADILRas-associating and dilute domain-containing protein. (1072 aa)
MAPK1Mitogen-activated protein kinase. (343 aa)
EDN1Endothelin-1. (202 aa)
SFRP1Secreted frizzled-related protein 1. (296 aa)
FGFR1Fibroblast growth factor receptor. (722 aa)
KLHL12Kelch-like protein 12 isoform X5. (684 aa)
BMP2Bone morphogenetic protein 2 isoform X1. (395 aa)
LOC112413323LOW QUALITY PROTEIN: amelogenin, Y isoform-like. (178 aa)
LOXL3Lysyl oxidase homolog 3 isoform X1. (615 aa)
RDH10Retinol dehydrogenase 10; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (341 aa)
LOC112413664Lysyl oxidase homolog 3-like. (153 aa)
NRP1Neuropilin; Belongs to the neuropilin family. (924 aa)
CUL7Cullin-7; Belongs to the cullin family. (1693 aa)
SEMA4Fsemaphorin-4F isoform X3; Belongs to the semaphorin family. (772 aa)
SEMA4Bsemaphorin-4B; Belongs to the semaphorin family. (822 aa)
FRZBSecreted frizzled-related protein 3. (325 aa)
PEF1Peflin isoform X1. (290 aa)
PHACTR4Phosphatase and actin regulator. (747 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (391 aa)
ALDH1A2Retinal dehydrogenase 2 isoform X1; Belongs to the aldehyde dehydrogenase family. (526 aa)
WWTR1WW domain-containing transcription regulator protein 1. (400 aa)
GSK3BGlycogen synthase kinase-3 beta isoform X1; Belongs to the protein kinase superfamily. (433 aa)
OTUD5OTU domain-containing protein 5. (447 aa)
BMPR1AReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
PHOX2BPaired mesoderm homeobox protein 2B. (262 aa)
LOC112390775Folate receptor alpha-like. (251 aa)
PDCD6Programmed cell death protein 6 isoform X1. (189 aa)
SEMA3Csemaphorin-3C; Belongs to the semaphorin family. (751 aa)
TCOF1Treacle protein isoform X1. (1499 aa)
SEMA4Dsemaphorin-4D; Belongs to the semaphorin family. (863 aa)
MEF2CMyocyte-specific enhancer factor 2C isoform X4. (483 aa)
LOC112392060Fibroblast growth factor receptor 1-like. (98 aa)
LRP6Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. (1614 aa)
LOC112391722LOW QUALITY PROTEIN: nucleolar and coiled-body phosphoprotein 1-like. (718 aa)
NOLC1Nucleolar and coiled-body phosphoprotein 1. (708 aa)
FGF8Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (244 aa)
JAG1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1177 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (438 aa)
BMP4Bone morphogenetic protein 4 isoform X1. (420 aa)
PPP3R2LOW QUALITY PROTEIN: calcineurin subunit B type 2. (229 aa)
RFLNBrefilin-B. (166 aa)
EDNRAEndothelin-1 receptor isoform X1; Belongs to the G-protein coupled receptor 1 family. (427 aa)
SEMA4Gsemaphorin-4G isoform X1; Belongs to the semaphorin family. (857 aa)
ACVR1Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (509 aa)
SEMA3Fsemaphorin-3F; Belongs to the semaphorin family. (744 aa)
LOC112394195ALX homeobox protein 1. (326 aa)
HMGA2High mobility group protein HMGI-C. (109 aa)
SEMA3Asemaphorin-3A; Belongs to the semaphorin family. (772 aa)
SEMA3Esemaphorin-3E; Belongs to the semaphorin family. (715 aa)
SEMA3Bsemaphorin-3B isoform X1; Belongs to the semaphorin family. (748 aa)
Your Current Organism:
Neophocaena asiaeorientalis
NCBI taxonomy Id: 1706337
Other names: N. asiaeorientalis asiaeorientalis, Neophocaena asiaeorientalis asiaeorientalis, Yangtze finless porpoise
Server load: low (22%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.