STRINGSTRING
STAT6 STAT6 AREG AREG MTA3 MTA3 IFT74 IFT74 DACH1 DACH1 IRS2 IRS2 TEK TEK IFT80 IFT80 TNFSF11 TNFSF11 PDX1 PDX1 RB1 RB1 TGFA TGFA PRKX PRKX STK3 STK3 NOG NOG WNT16 WNT16 TBX2 TBX2 CAV2 CAV2 CCL5 CCL5 WNT2 WNT2 CAV1 CAV1 SCARB1 SCARB1 COL8A1 COL8A1 FGL1 FGL1 YAP1 YAP1 ERN1 ERN1 SOX9 SOX9 SMO SMO NOTCH1 NOTCH1 NKX2-8 NKX2-8 NRARP NRARP MAPK1 MAPK1 DLG2 DLG2 LGR4 LGR4 NOTCH2 NOTCH2 WDR77 WDR77 FERMT1 FERMT1 RUNX2 RUNX2 THAP1 THAP1 CUNH6orf89 CUNH6orf89 LOC112413664 LOC112413664 PPARD PPARD BAK1 BAK1 SFN SFN KDF1 KDF1 TGFB1 TGFB1 TP63 TP63 XBP1 XBP1 EAF2 EAF2 LOC112404739 LOC112404739 FLCN FLCN EHF EHF HGF HGF HMX2 HMX2 MKI67 MKI67 AR AR APOA1 APOA1 SIDT2 SIDT2 DLG1 DLG1 PROX1 PROX1 A4GNT A4GNT BMPER BMPER NCSTN NCSTN CEBPB CEBPB EPHA2 EPHA2 ZEB1 ZEB1 IRF6 IRF6 HLX HLX OVOL1 OVOL1 BAD BAD CCND1 CCND1 IGFBP3 IGFBP3 FGF7 FGF7 LOC112401545 LOC112401545 ESR1 ESR1 LOXL2 LOXL2 IQGAP3 IQGAP3 NKX2-6 NKX2-6 NOX5 NOX5 PROK2 PROK2 NKX3-1 NKX3-1 KDR KDR GPC3 GPC3 WNT5A WNT5A STK4 STK4 IFT52 IFT52 FGF2 FGF2 LOC112399586 LOC112399586 IGFBP4 IGFBP4 RASGRF1 RASGRF1 PROK1 PROK1 EGF EGF SERPINB1 SERPINB1 MED1 MED1 SDR16C5 SDR16C5 MTSS1 MTSS1 TRIM24 TRIM24 FGF10 FGF10 FST FST STK11 STK11 EYA1 EYA1 COL8A2 COL8A2 SHH SHH VSTM4 VSTM4 IL6 IL6 PSEN1 PSEN1 BMPR2 BMPR2 LIMS2 LIMS2 LGR5 LGR5 ID2 ID2 ITGB1BP1 ITGB1BP1 FAP FAP CDH13 CDH13 SERPINF1 SERPINF1 AGAP2 AGAP2 NF1 NF1 BTRC BTRC BMP4 BMP4 TGFBR1 TGFBR1 ESRP2 ESRP2 IFT57 IFT57 MAP2K1 MAP2K1 HSF4 HSF4 MEF2C MEF2C ST8SIA1 ST8SIA1 PHB2 PHB2 SAV1 SAV1 CD109 CD109 CDKN1B CDKN1B PHOX2B PHOX2B BMPR1A BMPR1A PURA PURA FSHR FSHR B4GALT1 B4GALT1 EREG EREG PTCH1 PTCH1 FGF9 FGF9 DRD2 DRD2 CTNNB1 CTNNB1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
STAT6Signal transducer and activator of transcription. (859 aa)
AREGAmphiregulin isoform X1. (253 aa)
MTA3Metastasis-associated protein MTA3 isoform X1. (538 aa)
IFT74Intraflagellar transport protein 74 homolog isoform X3. (600 aa)
DACH1Dachshund homolog 1. (517 aa)
IRS2Insulin receptor substrate 2. (702 aa)
TEKAngiopoietin-1 receptor isoform X1. (1125 aa)
IFT80Intraflagellar transport protein 80 homolog isoform X1. (777 aa)
TNFSF11Tumor necrosis factor ligand superfamily member 11; Belongs to the tumor necrosis factor family. (323 aa)
PDX1Pancreas/duodenum homeobox protein 1. (289 aa)
RB1Retinoblastoma-associated protein. (816 aa)
TGFAProtransforming growth factor alpha isoform X1. (290 aa)
PRKXcAMP-dependent protein kinase catalytic subunit PRKX isoform X1. (327 aa)
STK3Serine/threonine-protein kinase 3. (491 aa)
NOGNoggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. (232 aa)
WNT16Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (362 aa)
TBX2T-box transcription factor TBX2. (588 aa)
CAV2Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (162 aa)
CCL5C-C motif chemokine. (91 aa)
WNT2Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (360 aa)
CAV1Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (178 aa)
SCARB1Scavenger receptor class B member 1 isoform X1; Belongs to the CD36 family. (511 aa)
COL8A1Collagen alpha-1(VIII) chain. (744 aa)
FGL1Fibrinogen-like protein 1. (315 aa)
YAP1Transcriptional coactivator YAP1. (416 aa)
ERN1Serine/threonine-protein kinase/endoribonuclease IRE1. (858 aa)
SOX9Transcription factor SOX-9. (486 aa)
SMOSmoothened homolog; Belongs to the G-protein coupled receptor Fz/Smo family. (783 aa)
NOTCH1LOW QUALITY PROTEIN: neurogenic locus notch homolog protein 1. (2633 aa)
NKX2-8Homeobox protein Nkx-2.8. (235 aa)
NRARPNotch-regulated ankyrin repeat-containing protein. (114 aa)
MAPK1Mitogen-activated protein kinase. (343 aa)
DLG2Disks large homolog 2 isoform X1. (905 aa)
LGR4Leucine-rich repeat-containing G-protein coupled receptor 4. (1061 aa)
NOTCH2Neurogenic locus notch homolog protein 2 isoform X1. (2485 aa)
WDR77Methylosome protein 50 isoform X1. (342 aa)
FERMT1Fermitin family homolog 1 isoform X1. (677 aa)
RUNX2Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. (408 aa)
THAP1THAP domain-containing protein 1 isoform X1. (284 aa)
CUNH6orf89Bombesin receptor-activated protein C6orf89 homolog isoform X1. (355 aa)
LOC112413664Lysyl oxidase homolog 3-like. (153 aa)
PPARDPeroxisome proliferator-activated receptor delta. (441 aa)
BAK1Bcl-2 homologous antagonist/killer isoform X1. (239 aa)
SFN14-3-3 protein sigma; Belongs to the 14-3-3 family. (248 aa)
KDF1Keratinocyte differentiation factor 1. (398 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (391 aa)
TP63Tumor protein 63 (p63); Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. (680 aa)
XBP1LOW QUALITY PROTEIN: X-box-binding protein 1. (379 aa)
EAF2ELL-associated factor 2. (264 aa)
LOC112404739Olfactory receptor. (320 aa)
FLCNFolliculin isoform X1. (576 aa)
EHFETS homologous factor isoform X1. (300 aa)
HGFHepatocyte growth factor isoform X1; Belongs to the peptidase S1 family. (734 aa)
HMX2Homeobox protein HMX2. (274 aa)
MKI67Proliferation marker protein Ki-67. (2619 aa)
ARAndrogen receptor isoform X1. (893 aa)
APOA1Apolipoprotein A-I. (265 aa)
SIDT2SID1 transmembrane family member 2 isoform X2. (856 aa)
DLG1Disks large homolog 1 isoform X1; Belongs to the MAGUK family. (927 aa)
PROX1Prospero homeobox protein 1 isoform X1. (737 aa)
A4GNTalpha-1,4-N-acetylglucosaminyltransferase. (341 aa)
BMPERBMP-binding endothelial regulator protein. (685 aa)
NCSTNNicastrin. (709 aa)
CEBPBCCAAT/enhancer-binding protein. (346 aa)
EPHA2Ephrin type-A receptor 2. (975 aa)
ZEB1LOW QUALITY PROTEIN: zinc finger E-box-binding homeobox 1. (1042 aa)
IRF6Interferon regulatory factor 6 isoform X1. (467 aa)
HLXH2.0-like homeobox protein. (486 aa)
OVOL1Putative transcription factor Ovo-like 1. (441 aa)
BADBcl2-associated agonist of cell death. (168 aa)
CCND1G1/S-specific cyclin-D1; Belongs to the cyclin family. (295 aa)
IGFBP3Insulin-like growth factor-binding protein 3. (120 aa)
FGF7Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (194 aa)
LOC112401545LOW QUALITY PROTEIN: serine/threonine-protein kinase 3-like. (375 aa)
ESR1Estrogen receptor. (604 aa)
LOXL2Lysyl oxidase homolog 2. (774 aa)
IQGAP3Ras GTPase-activating-like protein IQGAP3. (1633 aa)
NKX2-6Homeobox protein Nkx-2.6. (302 aa)
NOX5LOW QUALITY PROTEIN: NADPH oxidase 5. (739 aa)
PROK2Prokineticin-2 isoform X1. (169 aa)
NKX3-1Homeobox protein Nkx-3.1. (241 aa)
KDRVascular endothelial growth factor receptor 2 isoform X4; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1356 aa)
GPC3Glypican-3; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family. (580 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (380 aa)
STK4Serine/threonine-protein kinase 4 isoform X1. (487 aa)
IFT52Intraflagellar transport protein 52 homolog isoform X1. (456 aa)
FGF2Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (304 aa)
LOC112399586Lipase; Belongs to the AB hydrolase superfamily. Lipase family. (399 aa)
IGFBP4Insulin-like growth factor-binding protein 4. (258 aa)
RASGRF1Ras-specific guanine nucleotide-releasing factor 1 isoform X1. (1292 aa)
PROK1LOW QUALITY PROTEIN: prokineticin-1. (105 aa)
EGFPro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (1238 aa)
SERPINB1Leukocyte elastase inhibitor; Belongs to the serpin family. (268 aa)
MED1Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1579 aa)
SDR16C5Epidermal retinol dehydrogenase 2; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (308 aa)
MTSS1Metastasis suppressor protein 1 isoform X1. (802 aa)
TRIM24Transcription intermediary factor 1-alpha isoform X1. (1050 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
FSTFollistatin. (344 aa)
STK11Serine/threonine-protein kinase STK11 isoform X1. (546 aa)
EYA1Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (589 aa)
COL8A2Collagen alpha-2(VIII) chain. (657 aa)
SHHSonic hedgehog protein. (328 aa)
VSTM4V-set and transmembrane domain-containing protein 4. (334 aa)
IL6Interleukin-6. (208 aa)
PSEN1Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (468 aa)
BMPR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1012 aa)
LIMS2LIM and senescent cell antigen-like-containing domain protein; Adapter protein in a cytoplasmic complex linking beta- integrins to the actin cytoskeleton, bridges the complex to cell surface receptor tyrosine kinases and growth factor receptors. (336 aa)
LGR5Leucine-rich repeat-containing G-protein coupled receptor 5 isoform X1. (907 aa)
ID2DNA-binding protein inhibitor ID-2. (134 aa)
ITGB1BP1Integrin beta-1-binding protein 1 isoform X1. (206 aa)
FAPProlyl endopeptidase FAP; Belongs to the peptidase S9B family. (760 aa)
CDH13Cadherin-13. (713 aa)
SERPINF1Pigment epithelium-derived factor; Belongs to the serpin family. (416 aa)
AGAP2arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2 isoform X1. (836 aa)
NF1Neurofibromin isoform X1. (2841 aa)
BTRCF-box/WD repeat-containing protein 1A isoform X1. (605 aa)
BMP4Bone morphogenetic protein 4 isoform X1. (420 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (438 aa)
ESRP2Epithelial splicing regulatory protein 2 isoform X1. (767 aa)
IFT57Intraflagellar transport protein 57 homolog. (427 aa)
MAP2K1Dual specificity mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
HSF4Heat shock factor protein 4 isoform X1. (490 aa)
MEF2CMyocyte-specific enhancer factor 2C isoform X4. (483 aa)
ST8SIA1alpha-N-acetylneuraminide alpha-2,8-sialyltransferase isoform X1; Belongs to the glycosyltransferase 29 family. (356 aa)
PHB2Prohibitin. (299 aa)
SAV1Protein salvador homolog 1. (384 aa)
CD109CD109 antigen isoform X1. (1358 aa)
CDKN1BCyclin-dependent kinase inhibitor 1B. (198 aa)
PHOX2BPaired mesoderm homeobox protein 2B. (262 aa)
BMPR1AReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
PURATranscriptional activator protein Pur-alpha. (206 aa)
FSHRFollicle-stimulating hormone receptor; G protein-coupled receptor for follitropin, the follicle- stimulating hormone. Through cAMP production activates the downstream PI3K-AKT and ERK1/ERK2 signaling pathways. (695 aa)
B4GALT1Beta-1,4-galactosyltransferase 1. (402 aa)
EREGProepiregulin. (163 aa)
PTCH1Protein patched homolog 1 isoform X1. (1297 aa)
FGF9Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
DRD2D(2) dopamine receptor isoform X2; Belongs to the G-protein coupled receptor 1 family. (443 aa)
CTNNB1Catenin beta-1. (781 aa)
Your Current Organism:
Neophocaena asiaeorientalis
NCBI taxonomy Id: 1706337
Other names: N. asiaeorientalis asiaeorientalis, Neophocaena asiaeorientalis asiaeorientalis, Yangtze finless porpoise
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