STRINGSTRING
EGF EGF TAL1 TAL1 LRP8 LRP8 PSEN1 PSEN1 CSF1R CSF1R LOC112395196 LOC112395196 RELN RELN ERBB3 ERBB3 IL23A IL23A VTN VTN ZZEF1 ZZEF1 IL15 IL15 CBLB CBLB IFNG IFNG ITGA5 ITGA5 SOCS4 SOCS4 BANK1 BANK1 UNC119 UNC119 PLCG2 PLCG2 IL34 IL34 FGF8 FGF8 NEURL1 NEURL1 TNFRSF1A TNFRSF1A PTPN6 PTPN6 TNFSF18 TNFSF18 GREM1 GREM1 FGFR3 FGFR3 LTK LTK SEMA4D SEMA4D GPRC5A GPRC5A LRRK1 LRRK1 APP APP SYK SYK CD74 CD74 IGF1 IGF1 EPHA7 EPHA7 SAMSN1 SAMSN1 ALK ALK TMEM102 TMEM102 DVL2 DVL2 HCLS1 HCLS1 PARP9 PARP9 GATA1 GATA1 CADM4 CADM4 RAP2B RAP2B PDGFD PDGFD LIF LIF FBXW9 FBXW9 CBLC CBLC RACK1 RACK1 OSM OSM NF2 NF2 IL12B IL12B ADRA1A ADRA1A CRLF1 CRLF1 PTK2B PTK2B HRG HRG IL6ST IL6ST TREM2 TREM2 VEGFA VEGFA NRP1 NRP1 CD80 CD80 IL31RA IL31RA AGT AGT WNT3A WNT3A EGFR EGFR LOC112413275 LOC112413275 SFRP1 SFRP1 NRG1 NRG1 LOC112412348 LOC112412348 GHRL GHRL TSG101 TSG101 PRNP PRNP PTPRC PTPRC EPHA4 EPHA4 LOC112412378 LOC112412378 PTPN2 PTPN2 NEDD9 NEDD9 ERBB4 ERBB4 CSPG4 CSPG4 ABL1 ABL1 NOX4 NOX4 GRM5 GRM5 SOCS3 SOCS3 PDGFB PDGFB CHMP6 CHMP6 HES5 HES5 ITGB3 ITGB3 LOC112410324 LOC112410324 PECAM1 PECAM1 TNFRSF18 TNFRSF18 MLST8 MLST8 CNOT7 CNOT7 PRKCZ PRKCZ IL22RA2 IL22RA2 SH2B3 SH2B3 CAV1 CAV1 LOC112407988 LOC112407988 GGNBP2 GGNBP2 ALKAL2 ALKAL2 LOC112407979 LOC112407979 IBTK IBTK HPX HPX LOC112407482 LOC112407482 GFRA1 GFRA1 ADRA2A ADRA2A PLPP3 PLPP3 TGFA TGFA AFAP1L2 AFAP1L2 RIPK2 RIPK2 INPP5F INPP5F THBS4 THBS4 HTR2A HTR2A IL11 IL11 IL12A IL12A LOC112406229 LOC112406229 LOC112406232 LOC112406232 RICTOR RICTOR EPGN EPGN AREG AREG PIBF1 PIBF1 EREG EREG BTC BTC NCAPG2 NCAPG2 PRKCE PRKCE SOCS5 SOCS5 GAS6 GAS6 CD44 CD44 HES1 HES1 HBEGF HBEGF HGF HGF PAK2 PAK2 SH2D1B SH2D1B IL7 IL7 CBL CBL LOC112403425 LOC112403425 FAM72A FAM72A SH3BP5L SH3BP5L PTK6 PTK6 CASS4 CASS4 PTPN1 PTPN1 ZGPAT ZGPAT MTOR MTOR ERRFI1 ERRFI1 CLCF1 CLCF1 ARHGEF2 ARHGEF2 IGF2 IGF2 CD81 CD81 FGF7 FGF7 CNTF CNTF STAP1 STAP1 LRP4 LRP4 EFNA1 EFNA1 HAX1 HAX1 IL6R IL6R CD40 CD40 DMTN DMTN NCF1 NCF1 KIT KIT IL5 IL5 SH3BP5 SH3BP5 ARL2BP ARL2BP NOD2 NOD2 VPS25 VPS25 LOC112400718 LOC112400718 PRKCD PRKCD ZFYVE28 ZFYVE28 PDGFC PDGFC LOC112399814 LOC112399814 IL21 IL21 DOK7 DOK7 CTF1 CTF1 DGKQ DGKQ LOC112399259 LOC112399259 FGFR1OP FGFR1OP SRCIN1 SRCIN1 EPO EPO PDCL3 PDCL3 SOCS1 SOCS1 CSF3 CSF3 MVP MVP SRC SRC ABI1 ABI1 EFNA5 EFNA5 LYN LYN ANGPT4 ANGPT4 RAP2C RAP2C BST1 BST1 LOC112397463 LOC112397463 CSF2 CSF2 LOC112396611 LOC112396611 PTPN11 PTPN11 ENPP2 ENPP2 FGF10 FGF10 FYN FYN ISL1 ISL1 LOC112396592 LOC112396592 ERCC6 ERCC6 RAP2A RAP2A BMP6 BMP6
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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EGFPro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (1238 aa)
TAL1T-cell acute lymphocytic leukemia protein 1 isoform X1. (199 aa)
LRP8Low-density lipoprotein receptor-related protein 8. (796 aa)
PSEN1Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (468 aa)
CSF1RMacrophage colony-stimulating factor 1 receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (961 aa)
LOC112395196Serine protease inhibitor Kazal-type 1-like. (79 aa)
RELNReelin. (3336 aa)
ERBB3Receptor tyrosine-protein kinase erbB-3 isoform X1. (1337 aa)
IL23AInterleukin-23 subunit alpha. (189 aa)
VTNVitronectin. (481 aa)
ZZEF1Zinc finger ZZ-type and EF-hand domain-containing protein 1. (2912 aa)
IL15Interleukin; Belongs to the IL-15/IL-21 family. (180 aa)
CBLBE3 ubiquitin-protein ligase CBL-B isoform X1. (983 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (166 aa)
ITGA5Integrin alpha-5; Belongs to the integrin alpha chain family. (1053 aa)
SOCS4Suppressor of cytokine signaling 4. (440 aa)
BANK1B-cell scaffold protein with ankyrin repeats isoform X1. (795 aa)
UNC119Protein unc-119 homolog A. (145 aa)
PLCG21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1265 aa)
IL34Interleukin-34. (219 aa)
FGF8Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (244 aa)
NEURL1E3 ubiquitin-protein ligase NEURL1 isoform X1. (574 aa)
TNFRSF1ATumor necrosis factor receptor superfamily member 1A. (445 aa)
PTPN6Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (595 aa)
TNFSF18Tumor necrosis factor ligand superfamily member 18. (178 aa)
GREM1Gremlin. (184 aa)
FGFR3Fibroblast growth factor receptor. (804 aa)
LTKLOW QUALITY PROTEIN: leukocyte tyrosine kinase receptor. (880 aa)
SEMA4Dsemaphorin-4D; Belongs to the semaphorin family. (863 aa)
GPRC5ARetinoic acid-induced protein 3. (357 aa)
LRRK1Leucine-rich repeat serine/threonine-protein kinase 1 isoform X1. (2016 aa)
APPAmyloid-beta A4 protein isoform X1. (767 aa)
SYKTyrosine-protein kinase. (626 aa)
CD74HLA class II histocompatibility antigen gamma chain isoform X1. (278 aa)
IGF1Insulin-like growth factor I isoform X1. (208 aa)
EPHA7Ephrin type-A receptor 7. (1006 aa)
SAMSN1SAM domain-containing protein SAMSN-1. (372 aa)
ALKTyrosine-protein kinase receptor. (1616 aa)
TMEM102Transmembrane protein 102. (393 aa)
DVL2Segment polarity protein dishevelled homolog DVL-2 isoform X1. (785 aa)
HCLS1Hematopoietic lineage cell-specific protein. (479 aa)
PARP9Poly [ADP-ribose] polymerase 9 isoform X1. (847 aa)
GATA1Erythroid transcription factor. (413 aa)
CADM4Cell adhesion molecule 4. (391 aa)
RAP2BRas-related protein Rap-2b. (183 aa)
PDGFDPlatelet-derived growth factor D isoform X1. (396 aa)
LIFLeukemia inhibitory factor. (202 aa)
FBXW9F-box/WD repeat-containing protein 9 isoform X1. (463 aa)
CBLCE3 ubiquitin-protein ligase CBL-C. (492 aa)
RACK1Receptor of activated protein C kinase 1. (317 aa)
OSMoncostatin-M. (248 aa)
NF2Merlin isoform X3. (619 aa)
IL12BInterleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. (329 aa)
ADRA1Aalpha-1A adrenergic receptor. (466 aa)
CRLF1Cytokine receptor-like factor 1. (410 aa)
PTK2BProtein-tyrosine kinase 2-beta isoform X1; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1009 aa)
HRGLOW QUALITY PROTEIN: histidine-rich glycoprotein. (427 aa)
IL6STInterleukin-6 receptor subunit beta. (918 aa)
TREM2Triggering receptor expressed on myeloid cells 2. (230 aa)
VEGFAVascular endothelial growth factor A; Belongs to the PDGF/VEGF growth factor family. (632 aa)
NRP1Neuropilin; Belongs to the neuropilin family. (924 aa)
CD80T-lymphocyte activation antigen CD80 isoform X1. (294 aa)
IL31RALOW QUALITY PROTEIN: interleukin-31 receptor subunit alpha. (516 aa)
AGTAngiotensinogen; Belongs to the serpin family. (477 aa)
WNT3AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (352 aa)
EGFRReceptor protein-tyrosine kinase. (1156 aa)
LOC112413275LOW QUALITY PROTEIN: transmembrane protein 102-like. (508 aa)
SFRP1Secreted frizzled-related protein 1. (296 aa)
NRG1Pro-neuregulin-1, membrane-bound isoform isoform X1. (699 aa)
LOC112412348Transmembrane protein 102-like. (511 aa)
GHRLAppetite-regulating hormone. (168 aa)
TSG101Tumor susceptibility gene 101 protein isoform X1. (431 aa)
PRNPMajor prion protein; Belongs to the prion family. (261 aa)
PTPRCReceptor-type tyrosine-protein phosphatase C isoform X1. (1258 aa)
EPHA4Ephrin type-A receptor 4 isoform X1. (986 aa)
LOC112412378F-box/WD repeat-containing protein 7. (540 aa)
PTPN2Tyrosine-protein phosphatase non-receptor type. (396 aa)
NEDD9Enhancer of filamentation 1 isoform X2. (829 aa)
ERBB4Receptor protein-tyrosine kinase. (1308 aa)
CSPG4Chondroitin sulfate proteoglycan 4. (2315 aa)
ABL1Tyrosine-protein kinase. (1148 aa)
NOX4NADPH oxidase 4 isoform X1. (530 aa)
GRM5LOW QUALITY PROTEIN: metabotropic glutamate receptor 5. (1106 aa)
SOCS3Suppressor of cytokine signaling 3. (237 aa)
PDGFBPlatelet-derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (209 aa)
CHMP6Charged multivesicular body protein 6 isoform X1. (202 aa)
HES5Transcription factor HES-5. (94 aa)
ITGB3Integrin beta; Belongs to the integrin beta chain family. (789 aa)
LOC112410324CMRF35-like molecule 8 isoform X1. (378 aa)
PECAM1Platelet endothelial cell adhesion molecule isoform X2. (812 aa)
TNFRSF18Tumor necrosis factor receptor superfamily member 18. (237 aa)
MLST8Target of rapamycin complex subunit LST8 isoform X1. (326 aa)
CNOT7CCR4-NOT transcription complex subunit 7. (285 aa)
PRKCZLOW QUALITY PROTEIN: protein kinase C zeta type; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (546 aa)
IL22RA2Interleukin-22 receptor subunit alpha-2. (230 aa)
SH2B3LOW QUALITY PROTEIN: SH2B adapter protein 3. (504 aa)
CAV1Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (178 aa)
LOC112407988Secreted frizzled-related protein 2. (294 aa)
GGNBP2Gametogenetin-binding protein 2 isoform X1. (704 aa)
ALKAL2LOW QUALITY PROTEIN: ALK and LTK ligand 2. (151 aa)
LOC112407979Secreted frizzled-related protein 2-like. (105 aa)
IBTKInhibitor of Bruton tyrosine kinase isoform X1. (1329 aa)
HPXHemopexin; Binds heme and transports it to the liver for breakdown and iron recovery, after which the free hemopexin returns to the circulation. (455 aa)
LOC112407482LOW QUALITY PROTEIN: phosphatidylinositide phosphatase SAC2-like. (707 aa)
GFRA1GDNF family receptor alpha; Belongs to the GDNFR family. (468 aa)
ADRA2ALOW QUALITY PROTEIN: alpha-2A adrenergic receptor. (430 aa)
PLPP3Phospholipid phosphatase 3. (272 aa)
TGFAProtransforming growth factor alpha isoform X1. (290 aa)
AFAP1L2Actin filament-associated protein 1-like 2 isoform X1. (897 aa)
RIPK2Receptor-interacting serine/threonine-protein kinase 2. (387 aa)
INPP5FPhosphatidylinositide phosphatase SAC2. (1012 aa)
THBS4Thrombospondin-4. (961 aa)
HTR2A5-hydroxytryptamine receptor 2A. (470 aa)
IL11Interleukin-11. (199 aa)
IL12AInterleukin-12 subunit alpha; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated Killer cells, and stimulate the production of IFN-gamma by resting PBMC. (222 aa)
LOC112406229Lateral signaling target protein 2 homolog. (825 aa)
LOC112406232Reelin-like. (112 aa)
RICTORRapamycin-insensitive companion of mTOR isoform X1. (1732 aa)
EPGNEpigen isoform X1. (153 aa)
AREGAmphiregulin isoform X1. (253 aa)
PIBF1Progesterone-induced-blocking factor 1 isoform X1. (757 aa)
EREGProepiregulin. (163 aa)
BTCProbetacellulin isoform X1. (178 aa)
NCAPG2Condensin-2 complex subunit G2 isoform X1. (1140 aa)
PRKCEProtein kinase C epsilon type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays essential roles in the regulation of multiple cellular processes linked to cytoskeletal proteins, such as cell adhesion, motility, migration and cell cycle, functions in neuron growth and ion channel regulation, and is involved in immune response, cancer cell invasion and regulation of apoptosis. Mediates cell adhesion to the extracellular matrix via integrin- dependent signaling, by mediating angiotensin-2-induced activation of integrin beta- [...] (737 aa)
SOCS5Suppressor of cytokine signaling 5. (536 aa)
GAS6Growth arrest-specific protein 6. (540 aa)
CD44CD44 antigen isoform X15. (783 aa)
HES1Transcription factor HES-1. (280 aa)
HBEGFProheparin-binding EGF-like growth factor. (208 aa)
HGFHepatocyte growth factor isoform X1; Belongs to the peptidase S1 family. (734 aa)
PAK2Non-specific serine/threonine protein kinase. (523 aa)
SH2D1BSH2 domain-containing protein 1B isoform X1. (136 aa)
IL7Interleukin-7 isoform X1. (226 aa)
CBLE3 ubiquitin-protein ligase CBL. (915 aa)
LOC112403425Protein kinase C zeta type-like. (85 aa)
FAM72AProtein FAM72A isoform X2. (149 aa)
SH3BP5LSH3 domain-binding protein 5-like. (385 aa)
PTK6LOW QUALITY PROTEIN: protein-tyrosine kinase 6. (367 aa)
CASS4Cas scaffolding protein family member 4 isoform X1. (821 aa)
PTPN1Tyrosine-protein phosphatase non-receptor type. (424 aa)
ZGPATZinc finger CCCH-type with G patch domain-containing protein isoform X1. (513 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2548 aa)
ERRFI1ERBB receptor feedback inhibitor 1. (459 aa)
CLCF1Cardiotrophin-like cytokine factor 1. (215 aa)
ARHGEF2Rho guanine nucleotide exchange factor 2 isoform X1. (1175 aa)
IGF2Insulin-like growth factor II isoform X1. (184 aa)
CD81Tetraspanin. (442 aa)
FGF7Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (194 aa)
CNTFCiliary neurotrophic factor. (200 aa)
STAP1LOW QUALITY PROTEIN: signal-transducing adaptor protein 1. (166 aa)
LRP4Low-density lipoprotein receptor-related protein 4. (1914 aa)
EFNA1ephrin-A1 isoform X1; Belongs to the ephrin family. (224 aa)
HAX1HCLS1-associated protein X-1; Recruits the Arp2/3 complex to the cell cortex and regulates reorganization of the cortical actin cytoskeleton via its interaction with KCNC3 and the Arp2/3 complex. Slows down the rate of inactivation of KCNC3 channels. Promotes GNA13-mediated cell migration. Involved in the clathrin-mediated endocytosis pathway. May be involved in internalization of ABC transporters such as ABCB11. May inhibit CASP9 and CASP3. Promotes cell survival. May regulate intracellular calcium pools. (277 aa)
IL6RInterleukin-6 receptor subunit alpha. (465 aa)
CD40Tumor necrosis factor receptor superfamily member 5 isoform X1. (293 aa)
DMTNDematin isoform X1. (405 aa)
NCF1Neutrophil cytosol factor 1 isoform X1. (393 aa)
KITMast/stem cell growth factor receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (976 aa)
IL5Interleukin-5; Factor that induces terminal differentiation of late- developing B-cells to immunoglobulin secreting cells. (135 aa)
SH3BP5SH3 domain-binding protein 5. (451 aa)
ARL2BPADP-ribosylation factor-like protein 2-binding protein isoform X1. (163 aa)
NOD2Nucleotide-binding oligomerization domain-containing protein 2 isoform X1. (1021 aa)
VPS25Vacuolar protein-sorting-associated protein 25. (176 aa)
LOC112400718Hyaluronidase. (781 aa)
PRKCDProtein kinase C delta type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays contrasting roles in cell death and cell survival by functioning as a pro-apoptotic protein during DNA damage-induced apoptosis, but acting as an anti- apoptotic protein during cytokine receptor-initiated cell death, is involved in tumor suppression; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (675 aa)
ZFYVE28Lateral signaling target protein 2 homolog. (227 aa)
PDGFCPlatelet-derived growth factor C isoform X1. (314 aa)
LOC112399814LOW QUALITY PROTEIN: phosducin-like protein 3. (237 aa)
IL21Interleukin; Belongs to the IL-15/IL-21 family. (146 aa)
DOK7Protein Dok-7 isoform X1. (457 aa)
CTF1LOW QUALITY PROTEIN: cardiotrophin-1. (201 aa)
DGKQDiacylglycerol kinase. (1041 aa)
LOC112399259LOW QUALITY PROTEIN: cardiotrophin-2-like. (202 aa)
FGFR1OPFGFR1 oncogene partner. (434 aa)
SRCIN1SRC kinase signaling inhibitor 1. (1476 aa)
EPOErythropoietin. (266 aa)
PDCL3Phosducin-like protein 3. (240 aa)
SOCS1Suppressor of cytokine signaling 1. (214 aa)
CSF3Granulocyte colony-stimulating factor. (195 aa)
MVPMajor vault protein. (890 aa)
SRCTyrosine-protein kinase. (601 aa)
ABI1Abl interactor 1 isoform X1. (352 aa)
EFNA5ephrin-A5 isoform X1; Belongs to the ephrin family. (228 aa)
LYNTyrosine-protein kinase. (518 aa)
ANGPT4Angiopoietin-4. (498 aa)
RAP2CRas-related protein Rap-2c isoform X1. (183 aa)
BST1ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 2 isoform X1. (357 aa)
LOC112397463Interleukin-3-like. (149 aa)
CSF2Granulocyte-macrophage colony-stimulating factor. (134 aa)
LOC112396611Chondroitin sulfate proteoglycan 4-like isoform X1. (396 aa)
PTPN11Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (597 aa)
ENPP2LOW QUALITY PROTEIN: ectonucleotide pyrophosphatase/phosphodiesterase family member 2. (955 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
FYNTyrosine-protein kinase. (537 aa)
ISL1Insulin gene enhancer protein ISL-1. (349 aa)
LOC112396592Chondroitin sulfate proteoglycan 4-like. (183 aa)
ERCC6DNA excision repair protein ERCC-6. (1485 aa)
RAP2ARas-related protein Rap-2a isoform X1. (183 aa)
BMP6Bone morphogenetic protein 6. (309 aa)
Your Current Organism:
Neophocaena asiaeorientalis
NCBI taxonomy Id: 1706337
Other names: N. asiaeorientalis asiaeorientalis, Neophocaena asiaeorientalis asiaeorientalis, Yangtze finless porpoise
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