STRINGSTRING
LOC112395012 LOC112395012 ATP1A1 ATP1A1 MALRD1 MALRD1 ERLIN2 ERLIN2 STAR STAR BMP2 BMP2 DDX20 DDX20 LEP LEP SEC14L5 SEC14L5 DKK3 DKK3 BMP5 BMP5 LHCGR LHCGR LOC112405163 LOC112405163 SREBF1 SREBF1 EGR1 EGR1 PROX1 PROX1 ABCG4 ABCG4 SCAP SCAP SNAI1 SNAI1 H6PD H6PD FGF19 FGF19 SF1 SF1 APOB APOB REST REST IGFBP7 IGFBP7 FGFR4 FGFR4 DGKQ DGKQ GFI1 GFI1 ARMC5 ARMC5 NR0B1 NR0B1 STARD4 STARD4 SNAI2 SNAI2 NR1D1 NR1D1 LOC112398221 LOC112398221 INSIG1 INSIG1 BMP6 BMP6 PODN PODN LOC112394343 LOC112394343 DHH DHH IFNG IFNG ERLIN1 ERLIN1 NFKB1 NFKB1 INSIG2 INSIG2 LOC112392028 LOC112392028 LPCAT3 LPCAT3 CGA CGA PDE8B PDE8B DKKL1 DKKL1 SEC14L2 SEC14L2 LOC112415152 LOC112415152 LOC112415149 LOC112415149 CLCN2 CLCN2 SIRT1 SIRT1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
LOC112395012Cytochrome P450 27C1; Belongs to the cytochrome P450 family. (399 aa)
ATP1A1Sodium/potassium-transporting ATPase subunit alpha. (1021 aa)
MALRD1MAM and LDL-receptor class A domain-containing protein 1. (2180 aa)
ERLIN2Erlin-2 isoform X1. (339 aa)
STARSteroidogenic acute regulatory protein, mitochondrial; Plays a key role in steroid hormone synthesis by enhancing the metabolism of cholesterol into pregnenolone. Mediates the transfer of cholesterol from the outer mitochondrial membrane to the inner mitochondrial membrane where it is cleaved to pregnenolone. (336 aa)
BMP2Bone morphogenetic protein 2 isoform X1. (395 aa)
DDX20Probable ATP-dependent RNA helicase DDX20. (822 aa)
LEPLeptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...] (167 aa)
SEC14L5SEC14-like protein 5. (694 aa)
DKK3Dickkopf-related protein 3. (349 aa)
BMP5Bone morphogenetic protein 5 isoform X2. (455 aa)
LHCGRLutropin-choriogonadotropic hormone receptor; Receptor for lutropin-choriogonadotropic hormone. The activity of this receptor is mediated by G proteins which activate adenylate cyclase; Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily. (528 aa)
LOC112405163LOW QUALITY PROTEIN: insulin-like growth factor-binding protein 7. (106 aa)
SREBF1Sterol regulatory element-binding protein 1. (1199 aa)
EGR1Early growth response protein; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Belongs to the EGR C2H2-type zinc-finger protein family. (531 aa)
PROX1Prospero homeobox protein 1 isoform X1. (737 aa)
ABCG4ATP-binding cassette sub-family G member 4 isoform X1. (646 aa)
SCAPSterol regulatory element-binding protein cleavage-activating protein isoform X1. (1306 aa)
SNAI1Zinc finger protein SNAI1. (264 aa)
H6PDGDH/6PGL endoplasmic bifunctional protein isoform X1. (840 aa)
FGF19Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (363 aa)
SF1Splicing factor 1 isoform X1. (613 aa)
APOBApolipoprotein B-100. (4565 aa)
RESTRE1-silencing transcription factor isoform X2. (450 aa)
IGFBP7Insulin-like growth factor-binding protein 7. (279 aa)
FGFR4Fibroblast growth factor receptor. (810 aa)
DGKQDiacylglycerol kinase. (1041 aa)
GFI1Zinc finger protein Gfi-1 isoform X1. (420 aa)
ARMC5Armadillo repeat-containing protein 5. (827 aa)
NR0B1Nuclear receptor subfamily 0 group B member 1. (464 aa)
STARD4stAR-related lipid transfer protein 4 isoform X1. (224 aa)
SNAI2Zinc finger protein SNAI2. (268 aa)
NR1D1LOW QUALITY PROTEIN: nuclear receptor subfamily 1 group D member 1. (595 aa)
LOC112398221Cholesterol 7-alpha-monooxygenase; Belongs to the cytochrome P450 family. (501 aa)
INSIG1Insulin-induced gene protein; Mediates feedback control of cholesterol synthesis. Belongs to the INSIG family. (294 aa)
BMP6Bone morphogenetic protein 6. (309 aa)
PODNPodocan. (607 aa)
LOC11239434325-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial; Belongs to the cytochrome P450 family. (508 aa)
DHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (396 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (166 aa)
ERLIN1Erlin-1 isoform X1. (369 aa)
NFKB1Nuclear factor NF-kappa-B p105 subunit isoform X1. (977 aa)
INSIG2Insulin-induced gene protein; Mediates feedback control of cholesterol synthesis. Belongs to the INSIG family. (225 aa)
LOC112392028RE1-silencing transcription factor-like. (305 aa)
LPCAT3Lysophospholipid acyltransferase 5; Belongs to the membrane-bound acyltransferase family. (487 aa)
CGAGlycoprotein hormones alpha chain; Belongs to the glycoprotein hormones subunit alpha family. (120 aa)
PDE8BPhosphodiesterase. (445 aa)
DKKL1Dickkopf-like protein 1 isoform X1. (235 aa)
SEC14L2SEC14-like protein 2. (403 aa)
LOC112415152LOW QUALITY PROTEIN: putative SEC14-like protein 6. (367 aa)
LOC112415149LOW QUALITY PROTEIN: SEC14-like protein 3. (401 aa)
CLCN2Chloride channel protein 2. (904 aa)
SIRT1NAD-dependent protein deacetylase sirtuin-1 isoform X1. (557 aa)
Your Current Organism:
Neophocaena asiaeorientalis
NCBI taxonomy Id: 1706337
Other names: N. asiaeorientalis asiaeorientalis, Neophocaena asiaeorientalis asiaeorientalis, Yangtze finless porpoise
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