(45 nodes) Defense response to Gram-negative bacterium network (Neophocaena asiaeorientalis)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	HMGB2	High mobility group protein B2. (210 aa)
	CST11	Cystatin-11. (138 aa)
	DEFB127	LOW QUALITY PROTEIN: beta-defensin 127. (121 aa)
	LBP	Lipopolysaccharide-binding protein. (481 aa)
	BPI	Bactericidal permeability-increasing protein. (483 aa)
	LOC112399095	Reactive oxygen species modulator 1. (79 aa)
	LOC112399310	Apoptosis-associated speck-like protein containing a CARD isoform X1. (195 aa)
	UMOD	Uromodulin. (643 aa)
	LOC112399406	Apoptosis-associated speck-like protein containing a CARD isoform X1. (191 aa)
	LOC112403787	Antibacterial peptide PMAP-37-like. (146 aa)
	LOC112403786	Cathelicidin-4-like. (149 aa)
	LOC112403785	Cathelicidin-6-like. (159 aa)
	TUSC2	Tumor suppressor candidate 2. (110 aa)
	RARRES2	Retinoic acid receptor responder protein 2. (166 aa)
	AQP1	Aquaporin-1; Belongs to the MIP/aquaporin (TC 1.A.8) family. (271 aa)
	IL12B	Interleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. (329 aa)
	DEFB1	Beta-defensin 1 isoform X1. (108 aa)
	IL22RA1	Interleukin-22 receptor subunit alpha-1. (581 aa)
	IL17A	interleukin-17A isoform X1. (155 aa)
	IL17F	interleukin-17F. (165 aa)
	TREM2	Triggering receptor expressed on myeloid cells 2. (230 aa)
	TREM1	LOW QUALITY PROTEIN: triggering receptor expressed on myeloid cells 1. (340 aa)
	LOC112413745	60S ribosomal protein L30-like. (122 aa)
	SLC11A1	Natural resistance-associated macrophage protein 1 isoform X1. (586 aa)
	TLR4	Toll-like receptor 4 isoform X1; Belongs to the Toll-like receptor family. (841 aa)
	LOC112411498	60S ribosomal protein L30-like. (115 aa)
	DEFB136	Beta-defensin 136. (75 aa)
	RNASE6	Ribonuclease K6; Belongs to the pancreatic ribonuclease family. (154 aa)
	LOC112410620	LOW QUALITY PROTEIN: ribonuclease 7-like; Belongs to the pancreatic ribonuclease family. (157 aa)
	LOC112408947	LOW QUALITY PROTEIN: major histocompatibility complex class I-related gene protein; Belongs to the MHC class I family. (249 aa)
	RPL30	60S ribosomal protein L30. (115 aa)
	DROSHA	Ribonuclease 3 isoform X1. (1373 aa)
	CD160	LOW QUALITY PROTEIN: CD160 antigen. (311 aa)
	BPIFC	BPI fold-containing family C protein. (522 aa)
	CHGA	chromogranin-A isoform X1. (445 aa)
	IL23A	Interleukin-23 subunit alpha. (189 aa)
	LYZ	Lysozyme; Lysozymes have primarily a bacteriolytic function; those in tissues and body fluids are associated with the monocyte-macrophage system and enhance the activity of immunoagents. Belongs to the glycosyl hydrolase 22 family. (148 aa)
	LOC112396312	Neutrophil elastase-like; Belongs to the peptidase S1 family. (338 aa)
	GSDMD	gasdermin-D isoform X1. (487 aa)
	PRKD1	Serine/threonine-protein kinase D1 isoform X1. (796 aa)
	MPEG1	Macrophage-expressed gene 1 protein. (717 aa)
	LOC112402012	Macrophage-expressed gene 1 protein-like. (729 aa)
	F2	Prothrombin; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing; Belongs to the peptidase S1 family. (623 aa)
	LTF	Lactotransferrin isoform X1; Belongs to the transferrin family. (711 aa)
	LYPD8	ly6/PLAUR domain-containing protein 8. (334 aa)

Your Current Organism:

Neophocaena asiaeorientalis

NCBI taxonomy Id: 1706337
Other names: N. asiaeorientalis asiaeorientalis, Neophocaena asiaeorientalis asiaeorientalis, Yangtze finless porpoise

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AQP1	UMOD	A0A341C7Q7	A0A341BEH7	Aquaporin-1; Belongs to the MIP/aquaporin (TC 1.A.8) family.	Uromodulin.	0.541
BPI	LBP	A0A341B9Y5	A0A341B8L7	Bactericidal permeability-increasing protein.	Lipopolysaccharide-binding protein.	0.942
BPI	LOC112410620	A0A341B9Y5	A0A341CQR7	Bactericidal permeability-increasing protein.	LOW QUALITY PROTEIN: ribonuclease 7-like; Belongs to the pancreatic ribonuclease family.	0.438
BPI	LTF	A0A341B9Y5	A0A341BWX0	Bactericidal permeability-increasing protein.	Lactotransferrin isoform X1; Belongs to the transferrin family.	0.719
BPI	TLR4	A0A341B9Y5	A0A341CVM2	Bactericidal permeability-increasing protein.	Toll-like receptor 4 isoform X1; Belongs to the Toll-like receptor family.	0.660
CHGA	LYZ	A0A341AQ75	A0A341AT70	chromogranin-A isoform X1.	Lysozyme; Lysozymes have primarily a bacteriolytic function; those in tissues and body fluids are associated with the monocyte-macrophage system and enhance the activity of immunoagents. Belongs to the glycosyl hydrolase 22 family.	0.459
CST11	LTF	A0A341BXX8	A0A341BWX0	Cystatin-11.	Lactotransferrin isoform X1; Belongs to the transferrin family.	0.405
DEFB1	DEFB127	A0A341DAA6	A0A341B7L1	Beta-defensin 1 isoform X1.	LOW QUALITY PROTEIN: beta-defensin 127.	0.482
DEFB1	DEFB136	A0A341DAA6	A0A341CR36	Beta-defensin 1 isoform X1.	Beta-defensin 136.	0.631
DEFB1	LOC112403785	A0A341DAA6	A0A341BZV8	Beta-defensin 1 isoform X1.	Cathelicidin-6-like.	0.410
DEFB127	DEFB1	A0A341B7L1	A0A341DAA6	LOW QUALITY PROTEIN: beta-defensin 127.	Beta-defensin 1 isoform X1.	0.482
DEFB136	DEFB1	A0A341CR36	A0A341DAA6	Beta-defensin 136.	Beta-defensin 1 isoform X1.	0.631
F2	LOC112396312	A0A341BRQ7	A0A341AZ36	Prothrombin; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing; Belongs to the peptidase S1 family.	Neutrophil elastase-like; Belongs to the peptidase S1 family.	0.961
GSDMD	HMGB2	A0A341B416	A0A341BXA6	gasdermin-D isoform X1.	High mobility group protein B2.	0.577
GSDMD	LOC112396312	A0A341B416	A0A341AZ36	gasdermin-D isoform X1.	Neutrophil elastase-like; Belongs to the peptidase S1 family.	0.950
GSDMD	LOC112399310	A0A341B416	A0A341BBC0	gasdermin-D isoform X1.	Apoptosis-associated speck-like protein containing a CARD isoform X1.	0.547
GSDMD	LOC112399406	A0A341B416	A0A341BF66	gasdermin-D isoform X1.	Apoptosis-associated speck-like protein containing a CARD isoform X1.	0.547
GSDMD	TLR4	A0A341B416	A0A341CVM2	gasdermin-D isoform X1.	Toll-like receptor 4 isoform X1; Belongs to the Toll-like receptor family.	0.527
HMGB2	GSDMD	A0A341BXA6	A0A341B416	High mobility group protein B2.	gasdermin-D isoform X1.	0.577
HMGB2	TLR4	A0A341BXA6	A0A341CVM2	High mobility group protein B2.	Toll-like receptor 4 isoform X1; Belongs to the Toll-like receptor family.	0.666