(105 nodes) Regulation of B cell activation network (Neophocaena asiaeorientalis)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:
	KMT5C	Histone-lysine N-methyltransferase KMT5C. (460 aa)
	IRS2	Insulin receptor substrate 2. (702 aa)
	TFRC	Transferrin receptor protein 1 isoform X1. (772 aa)
	MSH2	DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (934 aa)
	TNFSF13B	Tumor necrosis factor ligand superfamily member 13B; Belongs to the tumor necrosis factor family. (283 aa)
	LOC112404909	Uncharacterized protein FLJ26957. (251 aa)
	ZFP36L2	mRNA decay activator protein ZFP36L2. (492 aa)
	PELI1	E3 ubiquitin-protein ligase pellino homolog; E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. (418 aa)
	NDFIP1	NEDD4 family-interacting protein 1. (221 aa)
	PCID2	PCI domain-containing protein 2. (399 aa)
	RIF1	Telomere-associated protein RIF1. (2389 aa)
	TNFRSF13B	Tumor necrosis factor receptor superfamily member 13B isoform X1. (284 aa)
	IL7	Interleukin-7 isoform X1. (226 aa)
	IL10	Interleukin-10. (178 aa)
	FCRL3	Fc receptor-like protein 3 isoform X1. (726 aa)
	NFATC2	Nuclear factor of activated T-cells, cytoplasmic 2 isoform X1. (943 aa)
	SLAMF8	SLAM family member 8 isoform X1. (284 aa)
	BAD	Bcl2-associated agonist of cell death. (168 aa)
	MAD2L2	Mitotic spindle assembly checkpoint protein MAD2B. (211 aa)
	KMT5B	Histone-lysine N-methyltransferase KMT5B isoform X1. (883 aa)
	CLCF1	Cardiotrophin-like cytokine factor 1. (215 aa)
	CD81	Tetraspanin. (442 aa)
	TNFSF13	Tumor necrosis factor ligand superfamily member 13 isoform X1; Belongs to the tumor necrosis factor family. (262 aa)
	TBC1D10C	Carabin isoform X1. (458 aa)
	ADA	Adenosine deaminase isoform X1. (402 aa)
	CD40	Tumor necrosis factor receptor superfamily member 5 isoform X1. (293 aa)
	NOD2	Nucleotide-binding oligomerization domain-containing protein 2 isoform X1. (1021 aa)
	BTK	Tyrosine-protein kinase. (687 aa)
	CD320	CD320 antigen. (370 aa)
	LOC112400529	Toll-like receptor 9 isoform X4. (1323 aa)
	FOXP3	LOW QUALITY PROTEIN: forkhead box protein P3. (452 aa)
	IL21	Interleukin; Belongs to the IL-15/IL-21 family. (146 aa)
	LOC112399174	Signal transducer and activator of transcription. (618 aa)
	CD19	B-lymphocyte antigen CD19 isoform X1. (571 aa)
	TBX21	T-box transcription factor TBX21. (501 aa)
	STAT5A	Signal transducer and activator of transcription. (726 aa)
	LYN	Tyrosine-protein kinase. (518 aa)
	CD38	ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1. (291 aa)
	IKZF3	Zinc finger protein Aiolos isoform X1. (528 aa)
	MMP14	Matrix metalloproteinase-14. (582 aa)
	LOC112397808	Guanine nucleotide exchange factor VAV3-like. (757 aa)
	BST1	ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 2 isoform X1. (357 aa)
	INPP5D	Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1. (1187 aa)
	ZFP36L1	mRNA decay activator protein ZFP36L1. (338 aa)
	LOC112396133	G-protein coupled receptor 183; Belongs to the G-protein coupled receptor 1 family. (360 aa)
	PAXIP1	PAX-interacting protein 1 isoform X1. (941 aa)
	CTLA4	Cytotoxic T-lymphocyte protein 4 isoform X1. (223 aa)
	CD28	T-cell-specific surface glycoprotein CD28. (265 aa)
	NFAM1	NFAT activation molecule 1. (264 aa)
	TNFRSF13C	Tumor necrosis factor receptor superfamily member 13C. (161 aa)
	PAWR	PRKC apoptosis WT1 regulator protein. (183 aa)
	SH3KBP1	SH3 domain-containing kinase-binding protein 1 isoform X1. (628 aa)
	NCKAP1L	Nck-associated protein 1-like isoform X1. (1156 aa)
	STAT6	Signal transducer and activator of transcription. (859 aa)
	BANK1	B-cell scaffold protein with ankyrin repeats isoform X1. (795 aa)
	ATAD5	ATPase family AAA domain-containing protein 5. (1898 aa)
	EXOSC6	Exosome complex component MTR3. (275 aa)
	EXOSC3	Exosome complex component RRP40 isoform X1. (275 aa)
	LOC112392034	Signal transducer and activator of transcription 5A-like. (105 aa)
	TYROBP	TYRO protein tyrosine kinase-binding protein isoform X1. (126 aa)
	SUPT6H	Transcription elongation factor spt6; Transcription elongation factor that enhances transcription elongation by RNA polymerase II (RNAPII). Belongs to the SPT6 family. (1726 aa)
	PTPN6	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (595 aa)
	MEF2C	Myocyte-specific enhancer factor 2C isoform X4. (483 aa)
	CD27	CD27 antigen. (251 aa)
	CD22	B-cell receptor CD22 isoform X1. (916 aa)
	AKIRIN2	Akirin-2. (201 aa)
	TP53BP1	TP53-binding protein 1 isoform X1. (1975 aa)
	SYK	Tyrosine-protein kinase. (626 aa)
	CD74	HLA class II histocompatibility antigen gamma chain isoform X1. (278 aa)
	FAM35A	Protein FAM35A isoform X1. (905 aa)
	NSD2	Histone-lysine N-methyltransferase NSD2 isoform X1. (1373 aa)
	SAMSN1	SAM domain-containing protein SAMSN-1. (372 aa)
	LOC112415475	Sialic acid-binding Ig-like lectin 10. (704 aa)
	XBP1	LOW QUALITY PROTEIN: X-box-binding protein 1. (379 aa)
	TGFB1	Transforming growth factor beta; Belongs to the TGF-beta family. (391 aa)
	PKN1	Serine/threonine-protein kinase N1 isoform X1. (950 aa)
	IL27RA	Interleukin-27 receptor subunit alpha isoform X1. (656 aa)
	AHR	Aryl hydrocarbon receptor. (845 aa)
	BCL6	B-cell lymphoma 6 protein. (706 aa)
	ATM	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3064 aa)
	EPHB2	Ephrin type-B receptor 2. (963 aa)
	THEMIS2	Protein THEMIS2 isoform X1. (648 aa)
	CDKN1A	Cyclin-dependent kinase inhibitor 1. (164 aa)
	LOC112413803	Polycomb complex protein BMI-1. (326 aa)
	TNFRSF21	Tumor necrosis factor receptor superfamily member 21. (652 aa)
	WNT3A	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (352 aa)
	SFRP1	Secreted frizzled-related protein 1. (296 aa)
	CUNH20orf196	Uncharacterized protein C20orf196 homolog isoform X1. (225 aa)
	PTPRC	Receptor-type tyrosine-protein phosphatase C isoform X1. (1258 aa)
	CARD11	Caspase recruitment domain-containing protein 11 isoform X1. (1154 aa)
	HMCES	Abasic site processing protein HMCES; Sensor of abasic sites in single-stranded DNA (ssDNA) required to preserve genome integrity by promoting error-free repair of abasic sites. Acts as an enzyme that recognizes and binds abasic sites in ssDNA at replication forks and chemically modifies the lesion by forming a covalent cross-link with DNA. The HMCES DNA-protein cross- link is then degraded by the proteasome. Promotes error-free repair of abasic sites by acting as a 'suicide' enzyme that is degraded, thereby protecting abasic sites from translesion synthesis (TLS) polymerases and endon [...] (353 aa)
	MORN5	MORN repeat-containing protein 5 isoform X1. (172 aa)
	HMCN2	Hemicentin-2. (5080 aa)
	PPP2R3C	Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma isoform X1. (453 aa)
	BLK	Tyrosine-protein kinase. (501 aa)
	LOC112410324	CMRF35-like molecule 8 isoform X1. (378 aa)
	FOXJ1	Forkhead box protein J1. (421 aa)
	TNFAIP3	Tumor necrosis factor alpha-induced protein 3. (785 aa)
	SASH3	SAM and SH3 domain-containing protein 3. (380 aa)
	RC3H1	Roquin-1 isoform X1. (1135 aa)
	SLC15A4	Solute carrier family 15 member 4 isoform X1. (273 aa)
	IL2RG	Cytokine receptor common subunit gamma isoform X1. (381 aa)
	THOC1	THO complex subunit 1. (657 aa)
	LOC112408000	Guanine nucleotide exchange factor VAV3. (209 aa)
	BCL2	Apoptosis regulator Bcl-2 isoform X1. (233 aa)

Your Current Organism:

Neophocaena asiaeorientalis

NCBI taxonomy Id: 1706337
Other names: N. asiaeorientalis asiaeorientalis, Neophocaena asiaeorientalis asiaeorientalis, Yangtze finless porpoise

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ATAD5	ATM	A0A341ALK1	A0A341D6S5	ATPase family AAA domain-containing protein 5.	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	0.642
ATAD5	MAD2L2	A0A341ALK1	A0A341BS27	ATPase family AAA domain-containing protein 5.	Mitotic spindle assembly checkpoint protein MAD2B.	0.637
ATAD5	MSH2	A0A341ALK1	A0A341C626	ATPase family AAA domain-containing protein 5.	DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR).	0.406
ATAD5	PAXIP1	A0A341ALK1	A0A341AXZ9	ATPase family AAA domain-containing protein 5.	PAX-interacting protein 1 isoform X1.	0.426
ATM	ATAD5	A0A341D6S5	A0A341ALK1	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	ATPase family AAA domain-containing protein 5.	0.642
ATM	BCL2	A0A341D6S5	A0A341C880	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Apoptosis regulator Bcl-2 isoform X1.	0.563
ATM	CDKN1A	A0A341D6S5	A0A341D568	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Cyclin-dependent kinase inhibitor 1.	0.497
ATM	LOC112413803	A0A341D6S5	A0A341D4P0	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Polycomb complex protein BMI-1.	0.511
ATM	MSH2	A0A341D6S5	A0A341C626	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR).	0.649
ATM	NSD2	A0A341D6S5	A0A341ACY3	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Histone-lysine N-methyltransferase NSD2 isoform X1.	0.656
ATM	PAXIP1	A0A341D6S5	A0A341AXZ9	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	PAX-interacting protein 1 isoform X1.	0.946
ATM	RIF1	A0A341D6S5	A0A341C0X7	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Telomere-associated protein RIF1.	0.902
ATM	TP53BP1	A0A341D6S5	A0A341AEG9	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	TP53-binding protein 1 isoform X1.	0.978
BAD	BCL2	A0A341BTD6	A0A341C880	Bcl2-associated agonist of cell death.	Apoptosis regulator Bcl-2 isoform X1.	0.996
BANK1	BTK	A0A341AMJ7	A0A341BJB2	B-cell scaffold protein with ankyrin repeats isoform X1.	Tyrosine-protein kinase.	0.447
BANK1	CD19	A0A341AMJ7	A0A341BDC1	B-cell scaffold protein with ankyrin repeats isoform X1.	B-lymphocyte antigen CD19 isoform X1.	0.704
BANK1	CD22	A0A341AMJ7	A0A341AG56	B-cell scaffold protein with ankyrin repeats isoform X1.	B-cell receptor CD22 isoform X1.	0.479
BANK1	LYN	A0A341AMJ7	A0A341B8C4	B-cell scaffold protein with ankyrin repeats isoform X1.	Tyrosine-protein kinase.	0.584
BCL2	ATM	A0A341C880	A0A341D6S5	Apoptosis regulator Bcl-2 isoform X1.	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	0.563
BCL2	BAD	A0A341C880	A0A341BTD6	Apoptosis regulator Bcl-2 isoform X1.	Bcl2-associated agonist of cell death.	0.996