STRINGSTRING
GPC3 GPC3 PYGO2 PYGO2 SIAH2 SIAH2 GSK3B GSK3B SDC1 SDC1 LOC112401545 LOC112401545 LRP5 LRP5 SCYL2 SCYL2 BCL9L BCL9L WNT8A WNT8A LATS2 LATS2 FGF9 FGF9 DIXDC1 DIXDC1 CTNNB1 CTNNB1 FOXO3 FOXO3 TCF7L2 TCF7L2 EDA EDA PLPP3 PLPP3 STK3 STK3 LOC112407979 LOC112407979 WNT11 WNT11 WNT16 WNT16 FZD7 FZD7 LOC112407988 LOC112407988 WNT2 WNT2 CAV1 CAV1 FZD10 FZD10 RSPO3 RSPO3 AXIN1 AXIN1 DVL1 DVL1 YAP1 YAP1 LOC112409981 LOC112409981 EDNRB EDNRB WNT9B WNT9B FZD2 FZD2 SOX9 SOX9 SOST SOST PYGO1 PYGO1 FZD3 FZD3 SOSTDC1 SOSTDC1 FRZB FRZB WNT4 WNT4 FZD1 FZD1 LOC112413704 LOC112413704 WNT3A WNT3A WNT9A WNT9A SFRP1 SFRP1 WNT2B WNT2B LGR4 LGR4 WNT7A WNT7A EDN1 EDN1 FZD4 FZD4 RAPGEF1 RAPGEF1 RECK RECK WNT10A WNT10A WNT6 WNT6 CBY1 CBY1 LOC112410850 LOC112410850 DVL3 DVL3 WNT3 WNT3 SHH SHH FZD5 FZD5 ISL1 ISL1 EXT1 EXT1 LEF1 LEF1 RAB5A RAB5A WNT7B WNT7B SFRP4 SFRP4 FZD6 FZD6 TCF7L1 TCF7L1 TCF7 TCF7 FGF2 FGF2 JUP JUP STK4 STK4 HESX1 HESX1 FZD9 FZD9 DVL2 DVL2 CTDNEP1 CTDNEP1 GATA3 GATA3 BCL9 BCL9 WNT5B WNT5B CDH3 CDH3 LRP6 LRP6 LOC112392971 LOC112392971 SFRP5 SFRP5 EDNRA EDNRA WNT8B WNT8B WNT1 WNT1 WNT10B WNT10B WNT5A WNT5A
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
GPC3Glypican-3; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family. (580 aa)
PYGO2Pygopus homolog 2. (406 aa)
SIAH2E3 ubiquitin-protein ligase; E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. (198 aa)
GSK3BGlycogen synthase kinase-3 beta isoform X1; Belongs to the protein kinase superfamily. (433 aa)
SDC1Syndecan; Cell surface proteoglycan; Belongs to the syndecan proteoglycan family. (310 aa)
LOC112401545LOW QUALITY PROTEIN: serine/threonine-protein kinase 3-like. (375 aa)
LRP5Low-density lipoprotein receptor-related protein 5 isoform X1. (1461 aa)
SCYL2SCY1-like protein 2 isoform X1. (928 aa)
BCL9LB-cell CLL/lymphoma 9-like protein isoform X1. (1493 aa)
WNT8AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (352 aa)
LATS2Serine/threonine-protein kinase LATS2. (805 aa)
FGF9Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
DIXDC1Dixin isoform X1. (688 aa)
CTNNB1Catenin beta-1. (781 aa)
FOXO3Forkhead box protein O3. (672 aa)
TCF7L2Transcription factor 7-like 2 isoform X1. (510 aa)
EDAectodysplasin-A; Belongs to the tumor necrosis factor family. (259 aa)
PLPP3Phospholipid phosphatase 3. (272 aa)
STK3Serine/threonine-protein kinase 3. (491 aa)
LOC112407979Secreted frizzled-related protein 2-like. (105 aa)
WNT11Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa)
WNT16Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (362 aa)
FZD7Frizzled-7; Belongs to the G-protein coupled receptor Fz/Smo family. (574 aa)
LOC112407988Secreted frizzled-related protein 2. (294 aa)
WNT2Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (360 aa)
CAV1Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (178 aa)
FZD10Frizzled-10; Belongs to the G-protein coupled receptor Fz/Smo family. (581 aa)
RSPO3R-spondin-3. (275 aa)
AXIN1Axin-1 isoform X1. (866 aa)
DVL1Segment polarity protein dishevelled homolog DVL-1. (706 aa)
YAP1Transcriptional coactivator YAP1. (416 aa)
LOC112409981ectodysplasin-A-like. (214 aa)
EDNRBEndothelin receptor type B; Belongs to the G-protein coupled receptor 1 family. (443 aa)
WNT9BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (602 aa)
FZD2Frizzled-2; Belongs to the G-protein coupled receptor Fz/Smo family. (709 aa)
SOX9Transcription factor SOX-9. (486 aa)
SOSTSclerostin. (212 aa)
PYGO1Pygopus homolog 1. (493 aa)
FZD3Frizzled-3; Belongs to the G-protein coupled receptor Fz/Smo family. (468 aa)
SOSTDC1Sclerostin domain-containing protein 1. (206 aa)
FRZBSecreted frizzled-related protein 3. (325 aa)
WNT4Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (361 aa)
FZD1Frizzled-1; Belongs to the G-protein coupled receptor Fz/Smo family. (644 aa)
LOC112413704LOW QUALITY PROTEIN: frizzled-8-like; Belongs to the G-protein coupled receptor Fz/Smo family. (420 aa)
WNT3AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (352 aa)
WNT9AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (428 aa)
SFRP1Secreted frizzled-related protein 1. (296 aa)
WNT2BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (393 aa)
LGR4Leucine-rich repeat-containing G-protein coupled receptor 4. (1061 aa)
WNT7AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (349 aa)
EDN1Endothelin-1. (202 aa)
FZD4Frizzled-4; Belongs to the G-protein coupled receptor Fz/Smo family. (537 aa)
RAPGEF1Rap guanine nucleotide exchange factor 1. (1094 aa)
RECKReversion-inducing cysteine-rich protein with Kazal motifs isoform X1. (971 aa)
WNT10AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (417 aa)
WNT6Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (365 aa)
CBY1Protein chibby homolog 1 isoform X1. (156 aa)
LOC112410850Casein kinase I isoform X1; Belongs to the protein kinase superfamily. (416 aa)
DVL3Segment polarity protein dishevelled homolog DVL-3 isoform X1. (716 aa)
WNT3Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (453 aa)
SHHSonic hedgehog protein. (328 aa)
FZD5Frizzled-5; Belongs to the G-protein coupled receptor Fz/Smo family. (555 aa)
ISL1Insulin gene enhancer protein ISL-1. (349 aa)
EXT1Exostosin-1; Belongs to the glycosyltransferase 47 family. (746 aa)
LEF1Lymphoid enhancer-binding factor 1 isoform X1. (414 aa)
RAB5ARas-related protein Rab-5A isoform X1. (215 aa)
WNT7BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (356 aa)
SFRP4Secreted frizzled-related protein 4 isoform X1. (346 aa)
FZD6Frizzled-6; Belongs to the G-protein coupled receptor Fz/Smo family. (712 aa)
TCF7L1Transcription factor 7-like 1 isoform X1. (463 aa)
TCF7Transcription factor 7 isoform X1. (303 aa)
FGF2Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (304 aa)
JUPJunction plakoglobin. (744 aa)
STK4Serine/threonine-protein kinase 4 isoform X1. (487 aa)
HESX1Homeobox expressed in ES cells 1 isoform X1. (185 aa)
FZD9Frizzled-9; Belongs to the G-protein coupled receptor Fz/Smo family. (564 aa)
DVL2Segment polarity protein dishevelled homolog DVL-2 isoform X1. (785 aa)
CTDNEP1CTD nuclear envelope phosphatase 1 isoform X1. (244 aa)
GATA3Trans-acting T-cell-specific transcription factor GATA-3 isoform X1. (444 aa)
BCL9B-cell CLL/lymphoma 9 protein isoform X1. (1426 aa)
WNT5BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (361 aa)
CDH3Cadherin-3 isoform X1; Cadherins are calcium-dependent cell adhesion proteins. (826 aa)
LRP6Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. (1614 aa)
LOC112392971LOW QUALITY PROTEIN: proto-oncogene FRAT1-like. (250 aa)
SFRP5Secreted frizzled-related protein 5. (446 aa)
EDNRAEndothelin-1 receptor isoform X1; Belongs to the G-protein coupled receptor 1 family. (427 aa)
WNT8BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (325 aa)
WNT1Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (370 aa)
WNT10BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (389 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (380 aa)
Your Current Organism:
Neophocaena asiaeorientalis
NCBI taxonomy Id: 1706337
Other names: N. asiaeorientalis asiaeorientalis, Neophocaena asiaeorientalis asiaeorientalis, Yangtze finless porpoise
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