STRINGSTRING
NSD2 NSD2 MMP16 MMP16 MEF2D MEF2D IGF1 IGF1 LRRK1 LRRK1 SMPD3 SMPD3 SEMA4D SEMA4D TULP3 TULP3 COL3A1 COL3A1 CDX1 CDX1 OGN OGN MEF2C MEF2C ATF2 ATF2 GLI3 GLI3 PTPN6 PTPN6 FGF8 FGF8 INSIG2 INSIG2 PAFAH1B1 PAFAH1B1 GLG1 GLG1 ANKRD11 ANKRD11 BMP4 BMP4 ZFPM1 ZFPM1 LOC112392686 LOC112392686 BMPR1B BMPR1B FOXN3 FOXN3 TRIP11 TRIP11 GPR68 GPR68 NAB2 NAB2 RARG RARG PPIB PPIB BBX BBX WNT1 WNT1 SMAD1 SMAD1 SLC10A7 SLC10A7 ZNF385A ZNF385A LRRC17 LRRC17 RHOA RHOA COL2A1 COL2A1 EP300 EP300 TWIST1 TWIST1 RARB RARB MAPK11 MAPK11 ZMPSTE24 ZMPSTE24 TAL1 TAL1 TTC9 TTC9 BMP6 BMP6 MPIG6B MPIG6B SHOX2 SHOX2 SULF1 SULF1 INSIG1 INSIG1 MYOC MYOC MBTPS2 MBTPS2 CITED2 CITED2 NPPC NPPC WISP1 WISP1 OSTN OSTN EXT1 EXT1 FLI1 FLI1 PTPN11 PTPN11 TMEM107 TMEM107 EVC EVC PITX2 PITX2 TRPV4 TRPV4 TMEM119 TMEM119 MEIS1 MEIS1 MMP14 MMP14 MED1 MED1 MSX1 MSX1 RARA RARA SFRP4 SFRP4 ABI1 ABI1 SRC SRC IMPAD1 IMPAD1 PHOSPHO1 PHOSPHO1 ASXL1 ASXL1 TGM2 TGM2 VKORC1 VKORC1 P3H1 P3H1 TBXT TBXT COL1A1 COL1A1 HOXB4 HOXB4 PAPSS2 PAPSS2 PDGFC PDGFC ATP6AP1 ATP6AP1 CHAD CHAD FOXP1 FOXP1 TFAP2A TFAP2A KIT KIT SULF2 SULF2 BGLAP BGLAP CTC1 CTC1 LTBP3 LTBP3 IFITM5 IFITM5 THBS3 THBS3 ACTN3 ACTN3 EXT2 EXT2 LRP5 LRP5 DHRS3 DHRS3 AMER1 AMER1 LOC112402955 LOC112402955 FGF4 FGF4 ANXA6 ANXA6 PAX1 PAX1 LTF LTF PLXNB1 PLXNB1 LOC112403696 LOC112403696 NEUROG1 NEUROG1 TIFAB TIFAB DCANP1 DCANP1 DDR2 DDR2 SMAD5 SMAD5 PLS3 PLS3 FGF18 FGF18 SH3PXD2B SH3PXD2B TMEM38B TMEM38B PHOSPHO2 PHOSPHO2 RANBP3L RANBP3L RAB23 RAB23 EPYC EPYC IFT80 IFT80 HOXA11 HOXA11 SNX10 SNX10 TNFSF11 TNFSF11 ADAMTS12 ADAMTS12 BGN BGN LOC112407189 LOC112407189 OSR2 OSR2 SCUBE2 SCUBE2 DCHS1 DCHS1 PAPPA2 PAPPA2 SH2B3 SH2B3 PEX7 PEX7 CBS CBS CCDC154 CCDC154 GJA1 GJA1 BNC2 BNC2 FREM1 FREM1 CER1 CER1 SLC38A10 SLC38A10 NOTUM NOTUM AXIN2 AXIN2 SOX9 SOX9 MAP2K6 MAP2K6 SERPINH1 SERPINH1 MIGA2 MIGA2 LEP LEP NPR2 NPR2 IHH IHH ATG9A ATG9A LOC112411691 LOC112411691 PTPRC PTPRC GP9 GP9 LEPR LEPR TRIM45 TRIM45 SBDS SBDS CSGALNACT1 CSGALNACT1 BMP2 BMP2 COL13A1 COL13A1 PIP4K2A PIP4K2A ECM1 ECM1 RUNX2 RUNX2 SP5 SP5 SRF SRF VPS33B VPS33B ALPL ALPL DLX5 DLX5 WASF2 WASF2 MATN1 MATN1 COMP COMP THPO THPO MEGF8 MEGF8 MMP13 MMP13 EBP EBP
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
NSD2Histone-lysine N-methyltransferase NSD2 isoform X1. (1373 aa)
MMP16Matrix metalloproteinase-16. (607 aa)
MEF2DMyocyte-specific enhancer factor 2D. (504 aa)
IGF1Insulin-like growth factor I isoform X1. (208 aa)
LRRK1Leucine-rich repeat serine/threonine-protein kinase 1 isoform X1. (2016 aa)
SMPD3Sphingomyelin phosphodiesterase 3. (653 aa)
SEMA4Dsemaphorin-4D; Belongs to the semaphorin family. (863 aa)
TULP3Tubby-like protein; Belongs to the TUB family. (464 aa)
COL3A1Collagen alpha-1(III) chain. (1463 aa)
CDX1Homeobox protein CDX-1. (278 aa)
OGNMimecan. (299 aa)
MEF2CMyocyte-specific enhancer factor 2C isoform X4. (483 aa)
ATF2Cyclic AMP-dependent transcription factor ATF-2 isoform X1. (505 aa)
GLI3Transcriptional activator GLI3. (1587 aa)
PTPN6Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (595 aa)
FGF8Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (244 aa)
INSIG2Insulin-induced gene protein; Mediates feedback control of cholesterol synthesis. Belongs to the INSIG family. (225 aa)
PAFAH1B1Platelet-activating factor acetylhydrolase IB subunit alpha; Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integrity, the peripheral transport of microtubule fragments and the coupling of the nucleus and centrosome. Required during brain development for the proliferation of neuronal precursors and the migration of newly formed neurons from the ven [...] (410 aa)
GLG1Golgi apparatus protein 1. (1177 aa)
ANKRD11Ankyrin repeat domain-containing protein 11 isoform X1. (2627 aa)
BMP4Bone morphogenetic protein 4 isoform X1. (420 aa)
ZFPM1Zinc finger protein ZFPM1. (998 aa)
LOC112392686LOW QUALITY PROTEIN: pyridoxal phosphate phosphatase PHOSPHO2-like. (241 aa)
BMPR1BSerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
FOXN3Forkhead box protein N3 isoform X1. (488 aa)
TRIP11Thyroid receptor-interacting protein 11 isoform X1. (1979 aa)
GPR68Ovarian cancer G-protein coupled receptor 1; Belongs to the G-protein coupled receptor 1 family. (371 aa)
NAB2NGFI-A-binding protein 2. (522 aa)
RARGRetinoic acid receptor gamma isoform X2. (458 aa)
PPIBPeptidyl-prolyl cis-trans isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family. (216 aa)
BBXHMG box transcription factor BBX. (941 aa)
WNT1Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (370 aa)
SMAD1Mothers against decapentaplegic homolog. (465 aa)
SLC10A7Sodium/bile acid cotransporter; Does not show transport activity towards bile acids or steroid sulfates; Belongs to the bile acid:sodium symporter (BASS) (TC 2.A.28) family. (340 aa)
ZNF385AZinc finger protein 385A isoform X1. (403 aa)
LRRC17Leucine-rich repeat-containing protein 17. (440 aa)
RHOATransforming protein RhoA. (193 aa)
COL2A1Collagen alpha-1(II) chain. (1487 aa)
EP300Histone acetyltransferase p300. (2399 aa)
TWIST1LOW QUALITY PROTEIN: twist-related protein 1. (152 aa)
RARBRetinoic acid receptor beta. (311 aa)
MAPK11Mitogen-activated protein kinase. (376 aa)
ZMPSTE24CAAX prenyl protease; Proteolytically removes the C-terminal three residues of farnesylated proteins; Belongs to the peptidase M48A family. (473 aa)
TAL1T-cell acute lymphocytic leukemia protein 1 isoform X1. (199 aa)
TTC9LOW QUALITY PROTEIN: tetratricopeptide repeat protein 9A. (265 aa)
BMP6Bone morphogenetic protein 6. (309 aa)
MPIG6BMegakaryocyte and platelet inhibitory receptor G6b. (248 aa)
SHOX2Short stature homeobox protein 2 isoform X1. (333 aa)
SULF1Extracellular sulfatase; Exhibits arylsulfatase activity and highly specific endoglucosamine-6-sulfatase activity. It can remove sulfate from the C- 6 position of glucosamine within specific subregions of intact heparin. Belongs to the sulfatase family. (882 aa)
INSIG1Insulin-induced gene protein; Mediates feedback control of cholesterol synthesis. Belongs to the INSIG family. (294 aa)
MYOCMyocilin isoform X1. (474 aa)
MBTPS2Membrane-bound transcription factor site-2 protease isoform X1. (635 aa)
CITED2Cbp/p300-interacting transactivator 2. (263 aa)
NPPCC-type natriuretic peptide. (127 aa)
WISP1WNT1-inducible-signaling pathway protein 1. (281 aa)
OSTNOsteocrin. (132 aa)
EXT1Exostosin-1; Belongs to the glycosyltransferase 47 family. (746 aa)
FLI1Friend leukemia integration 1 transcription factor isoform X1. (474 aa)
PTPN11Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (597 aa)
TMEM107Transmembrane protein 107 isoform X1. (140 aa)
EVCEllis-van Creveld syndrome protein isoform X1. (1032 aa)
PITX2Homeobox protein. (325 aa)
TRPV4Transient receptor potential cation channel subfamily V member 4 isoform X1; Belongs to the transient receptor (TC 1.A.4) family. (881 aa)
TMEM119Transmembrane protein 119 isoform X1. (363 aa)
MEIS1Homeobox protein Meis1 isoform X1. (465 aa)
MMP14Matrix metalloproteinase-14. (582 aa)
MED1Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1579 aa)
MSX1Homeobox protein MSX-1. (303 aa)
RARALOW QUALITY PROTEIN: retinoic acid receptor alpha. (572 aa)
SFRP4Secreted frizzled-related protein 4 isoform X1. (346 aa)
ABI1Abl interactor 1 isoform X1. (352 aa)
SRCTyrosine-protein kinase. (601 aa)
IMPAD1Inositol monophosphatase 3 isoform X1. (364 aa)
PHOSPHO1Phosphoethanolamine/phosphocholine phosphatase isoform X1. (286 aa)
ASXL1Putative Polycomb group protein ASXL1. (1517 aa)
TGM2Protein-glutamine gamma-glutamyltransferase 2. (687 aa)
VKORC1Vitamin K epoxide reductase complex subunit 1 isoform X1. (163 aa)
P3H1Prolyl 3-hydroxylase 1. (736 aa)
TBXTBrachyury protein isoform X1. (435 aa)
COL1A1Collagen alpha-1(I) chain. (1463 aa)
HOXB4LOW QUALITY PROTEIN: homeobox protein Hox-B4. (282 aa)
PAPSS2Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 2 isoform X1. (635 aa)
PDGFCPlatelet-derived growth factor C isoform X1. (314 aa)
ATP6AP1V-type proton ATPase subunit S1. (468 aa)
CHADChondroadherin. (359 aa)
FOXP1Forkhead box protein P1 isoform X1. (673 aa)
TFAP2ATranscription factor AP-2-alpha isoform X1. (496 aa)
KITMast/stem cell growth factor receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (976 aa)
SULF2Extracellular sulfatase Sulf-2. (865 aa)
BGLAPOsteocalcin; Binds strongly to apatite and calcium. (148 aa)
CTC1CST complex subunit CTC1 isoform X1. (1208 aa)
LTBP3Latent-transforming growth factor beta-binding protein 3 isoform X1. (1211 aa)
IFITM5Interferon-induced transmembrane protein 5. (133 aa)
THBS3Thrombospondin-3 isoform X1. (956 aa)
ACTN3Alpha-actinin-3. (902 aa)
EXT2Exostosin-2 isoform X1; Belongs to the glycosyltransferase 47 family. (718 aa)
LRP5Low-density lipoprotein receptor-related protein 5 isoform X1. (1461 aa)
DHRS3Short-chain dehydrogenase/reductase 3 isoform X1. (368 aa)
AMER1APC membrane recruitment protein 1. (1129 aa)
LOC112402955Guanine nucleotide-binding protein G(S) subunit alpha isoforms XLas-like. (946 aa)
FGF4Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (156 aa)
ANXA6Annexin. (673 aa)
PAX1LOW QUALITY PROTEIN: paired box protein Pax-1. (445 aa)
LTFLactotransferrin isoform X1; Belongs to the transferrin family. (711 aa)
PLXNB1LOW QUALITY PROTEIN: plexin-B1. (2123 aa)
LOC112403696LOW QUALITY PROTEIN: pyridoxal phosphate phosphatase PHOSPHO2-like. (241 aa)
NEUROG1Neurogenin-1. (244 aa)
TIFABTRAF-interacting protein with FHA domain-containing protein B. (247 aa)
DCANP1LOW QUALITY PROTEIN: dendritic cell nuclear protein 1. (256 aa)
DDR2Discoidin domain-containing receptor 2. (820 aa)
SMAD5Mothers against decapentaplegic homolog. (465 aa)
PLS3Plastin-3. (585 aa)
FGF18Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (300 aa)
SH3PXD2BSH3 and PX domain-containing protein 2B. (853 aa)
TMEM38BTrimeric intracellular cation channel type B isoform X1. (291 aa)
PHOSPHO2Pyridoxal phosphate phosphatase PHOSPHO2. (241 aa)
RANBP3LRan-binding protein 3-like isoform X1. (491 aa)
RAB23Ras-related protein Rab-23. (237 aa)
EPYCEpiphycan. (321 aa)
IFT80Intraflagellar transport protein 80 homolog isoform X1. (777 aa)
HOXA11Homeobox protein Hox-A11. (318 aa)
SNX10Sorting nexin-10. (201 aa)
TNFSF11Tumor necrosis factor ligand superfamily member 11; Belongs to the tumor necrosis factor family. (323 aa)
ADAMTS12A disintegrin and metalloproteinase with thrombospondin motifs 12 isoform X1. (1609 aa)
BGNBiglycan; May be involved in collagen fiber assembly. Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class I subfamily. (387 aa)
LOC112407189Cytochrome P450 26B1; Belongs to the cytochrome P450 family. (512 aa)
OSR2Protein odd-skipped-related 2 isoform X1. (312 aa)
SCUBE2Signal peptide, CUB and EGF-like domain-containing protein 2. (890 aa)
DCHS1Protocadherin-16. (3294 aa)
PAPPA2Pappalysin-2 isoform X1. (1789 aa)
SH2B3LOW QUALITY PROTEIN: SH2B adapter protein 3. (504 aa)
PEX7Peroxisomal biogenesis factor 7 isoform X1. (323 aa)
CBSCystathionine beta-synthase; Belongs to the cysteine synthase/cystathionine beta- synthase family. (562 aa)
CCDC154LOW QUALITY PROTEIN: coiled-coil domain-containing protein 154. (699 aa)
GJA1Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. (381 aa)
BNC2Zinc finger protein basonuclin-2 isoform X1. (1049 aa)
FREM1FRAS1-related extracellular matrix protein 1 isoform X1. (2175 aa)
CER1Cerberus isoform X1. (273 aa)
SLC38A10Putative sodium-coupled neutral amino acid transporter 10 isoform X1. (1093 aa)
NOTUMPalmitoleoyl-protein carboxylesterase NOTUM. (478 aa)
AXIN2Axin-2. (720 aa)
SOX9Transcription factor SOX-9. (486 aa)
MAP2K6Dual specificity mitogen-activated protein kinase kinase 6; Belongs to the protein kinase superfamily. (334 aa)
SERPINH1Serpin H1; Belongs to the serpin family. (418 aa)
MIGA2Mitoguardin 2 isoform X1. (600 aa)
LEPLeptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...] (167 aa)
NPR2Guanylate cyclase. (1056 aa)
IHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (410 aa)
ATG9AAutophagy-related protein 9; Involved in autophagy and cytoplasm to vacuole transport (Cvt) vesicle formation. Plays a key role in the organization of the preautophagosomal structure/phagophore assembly site (PAS), the nucleating site for formation of the sequestering vesicle. Belongs to the ATG9 family. (839 aa)
LOC112411691Retinoic acid receptor beta-like. (329 aa)
PTPRCReceptor-type tyrosine-protein phosphatase C isoform X1. (1258 aa)
GP9Platelet glycoprotein IX isoform X1. (316 aa)
LEPRLeptin receptor isoform X1. (1165 aa)
TRIM45Tripartite motif-containing protein 45. (580 aa)
SBDSRibosome maturation protein SBDS. (250 aa)
CSGALNACT1Hexosyltransferase. (524 aa)
BMP2Bone morphogenetic protein 2 isoform X1. (395 aa)
COL13A1Collagen alpha-1(XIII) chain isoform X1. (655 aa)
PIP4K2APhosphatidylinositol 5-phosphate 4-kinase type-2 alpha. (347 aa)
ECM1Extracellular matrix protein 1 isoform X1. (544 aa)
RUNX2Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. (408 aa)
SP5Transcription factor Sp5. (399 aa)
SRFSerum response factor isoform X1. (535 aa)
VPS33BVacuolar protein sorting-associated protein 33B; Belongs to the STXBP/unc-18/SEC1 family. (617 aa)
ALPLAlkaline phosphatase. (524 aa)
DLX5Homeobox protein DLX-5. (289 aa)
WASF2LOW QUALITY PROTEIN: wiskott-Aldrich syndrome protein family member 2. (491 aa)
MATN1Cartilage matrix protein. (495 aa)
COMPCartilage oligomeric matrix protein. (756 aa)
THPOThrombopoietin isoform X1. (349 aa)
MEGF8Multiple epidermal growth factor-like domains protein 8. (2784 aa)
MMP13Collagenase 3. (471 aa)
EBP3-beta-hydroxysteroid-Delta(8), Delta(7)-isomerase. (230 aa)
Your Current Organism:
Neophocaena asiaeorientalis
NCBI taxonomy Id: 1706337
Other names: N. asiaeorientalis asiaeorientalis, Neophocaena asiaeorientalis asiaeorientalis, Yangtze finless porpoise
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