(37 nodes) Mammary gland morphogenesis network (Neophocaena asiaeorientalis)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	GLI3	Transcriptional activator GLI3. (1587 aa)
	PHB2	Prohibitin. (299 aa)
	BMP4	Bone morphogenetic protein 4 isoform X1. (420 aa)
	NFKB1	Nuclear factor NF-kappa-B p105 subunit isoform X1. (977 aa)
	BTRC	F-box/WD repeat-containing protein 1A isoform X1. (605 aa)
	VDR	Vitamin D3 receptor. (427 aa)
	STAT6	Signal transducer and activator of transcription. (859 aa)
	MST1	LOW QUALITY PROTEIN: hepatocyte growth factor-like protein; Belongs to the peptidase S1 family. (732 aa)
	LOC112394306	C-C motif chemokine. (97 aa)
	DDR1	Tyrosine-protein kinase receptor. (932 aa)
	NRG3	Pro-neuregulin-3, membrane-bound isoform isoform X3. (613 aa)
	FGF10	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
	BSX	Brain-specific homeobox protein homolog. (232 aa)
	SCRIB	LOW QUALITY PROTEIN: protein scribble homolog. (1575 aa)
	CSF1	Macrophage colony-stimulating factor 1. (513 aa)
	TBX3	LOW QUALITY PROTEIN: T-box transcription factor TBX3. (734 aa)
	MED1	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1579 aa)
	SRC	Tyrosine-protein kinase. (601 aa)
	RXFP1	Relaxin receptor 1. (653 aa)
	WNT5A	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (380 aa)
	ESR1	Estrogen receptor. (604 aa)
	NTN1	Netrin-1. (604 aa)
	KDM5B	Lysine-specific demethylase 5B. (1311 aa)
	LRP5	Low-density lipoprotein receptor-related protein 5 isoform X1. (1461 aa)
	ELF3	ETS-related transcription factor Elf-3. (372 aa)
	EPHA2	Ephrin type-A receptor 2. (975 aa)
	AR	Androgen receptor isoform X1. (893 aa)
	PTCH1	Protein patched homolog 1 isoform X1. (1297 aa)
	AREG	Amphiregulin isoform X1. (253 aa)
	TBX2	T-box transcription factor TBX2. (588 aa)
	CAV1	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (178 aa)
	PML	Protein PML isoform X1. (965 aa)
	LRRC1	Leucine-rich repeat-containing protein 1. (443 aa)
	CSMD2	CUB and sushi domain-containing protein 2. (3656 aa)
	SOSTDC1	Sclerostin domain-containing protein 1. (206 aa)
	TGFB1	Transforming growth factor beta; Belongs to the TGF-beta family. (391 aa)
	CSMD1	CUB and sushi domain-containing protein 1. (3778 aa)

Your Current Organism:

Neophocaena asiaeorientalis

NCBI taxonomy Id: 1706337
Other names: N. asiaeorientalis asiaeorientalis, Neophocaena asiaeorientalis asiaeorientalis, Yangtze finless porpoise

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AR	ESR1	A0A341BZY8	A0A341BP96	Androgen receptor isoform X1.	Estrogen receptor.	0.608
AR	MED1	A0A341BZY8	A0A341B6X9	Androgen receptor isoform X1.	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	0.681
AR	SRC	A0A341BZY8	A0A341B9I2	Androgen receptor isoform X1.	Tyrosine-protein kinase.	0.706
AR	STAT6	A0A341BZY8	A0A341AR17	Androgen receptor isoform X1.	Signal transducer and activator of transcription.	0.497
AREG	ESR1	A0A341C5Y1	A0A341BP96	Amphiregulin isoform X1.	Estrogen receptor.	0.459
AREG	SRC	A0A341C5Y1	A0A341B9I2	Amphiregulin isoform X1.	Tyrosine-protein kinase.	0.731
BMP4	FGF10	A0A341AL27	A0A341B1S0	Bone morphogenetic protein 4 isoform X1.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.769
BMP4	PTCH1	A0A341AL27	A0A341C534	Bone morphogenetic protein 4 isoform X1.	Protein patched homolog 1 isoform X1.	0.590
BMP4	TBX3	A0A341AL27	A0A341B6F2	Bone morphogenetic protein 4 isoform X1.	LOW QUALITY PROTEIN: T-box transcription factor TBX3.	0.516
BMP4	WNT5A	A0A341AL27	A0A341BKG2	Bone morphogenetic protein 4 isoform X1.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.587
BTRC	GLI3	A0A341AMB0	A0A341AHX0	F-box/WD repeat-containing protein 1A isoform X1.	Transcriptional activator GLI3.	0.953
BTRC	NFKB1	A0A341AMB0	A0A341AM93	F-box/WD repeat-containing protein 1A isoform X1.	Nuclear factor NF-kappa-B p105 subunit isoform X1.	0.840
CAV1	EPHA2	A0A341CI23	A0A341BVH9	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Ephrin type-A receptor 2.	0.550
CAV1	ESR1	A0A341CI23	A0A341BP96	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Estrogen receptor.	0.902
CAV1	LRP5	A0A341CI23	A0A341BRX5	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Low-density lipoprotein receptor-related protein 5 isoform X1.	0.624
CAV1	SRC	A0A341CI23	A0A341B9I2	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Tyrosine-protein kinase.	0.971
CAV1	TGFB1	A0A341CI23	A0A341DAG8	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Transforming growth factor beta; Belongs to the TGF-beta family.	0.466
CSF1	EPHA2	A0A341B4Y9	A0A341BVH9	Macrophage colony-stimulating factor 1.	Ephrin type-A receptor 2.	0.843
CSF1	LOC112394306	A0A341B4Y9	A0A341AU57	Macrophage colony-stimulating factor 1.	C-C motif chemokine.	0.579
CSF1	SRC	A0A341B4Y9	A0A341B9I2	Macrophage colony-stimulating factor 1.	Tyrosine-protein kinase.	0.699