(30 nodes) Adipose tissue development network (Neophocaena asiaeorientalis)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	FTO	Alpha-ketoglutarate-dependent dioxygenase FTO isoform X1. (505 aa)
	PUM2	Pumilio homolog 2 isoform X1. (1065 aa)
	PPARGC1A	Peroxisome proliferator-activated receptor gamma coactivator 1-alpha isoform X1. (799 aa)
	PGRMC2	LOW QUALITY PROTEIN: membrane-associated progesterone receptor component 2; Belongs to the cytochrome b5 family. (247 aa)
	CSF1	Macrophage colony-stimulating factor 1. (513 aa)
	PAXIP1	PAX-interacting protein 1 isoform X1. (941 aa)
	SPTLC2	Serine palmitoyltransferase 2. (537 aa)
	ARRDC3	Arrestin domain-containing protein 3 isoform X1. (414 aa)
	ATF2	Cyclic AMP-dependent transcription factor ATF-2 isoform X1. (505 aa)
	LEP	Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...] (167 aa)
	DYRK1B	Dual specificity tyrosine-phosphorylation-regulated kinase 1B isoform X1. (686 aa)
	EBF2	Transcription factor COE2 isoform X2. (581 aa)
	XBP1	LOW QUALITY PROTEIN: X-box-binding protein 1. (379 aa)
	SLC25A25	Calcium-binding mitochondrial carrier protein SCaMC-2 isoform X4; Belongs to the mitochondrial carrier (TC 2.A.29) family. (513 aa)
	ARID5B	AT-rich interactive domain-containing protein 5B isoform X1. (1184 aa)
	PPARD	Peroxisome proliferator-activated receptor delta. (441 aa)
	HRAS	GTPase HRas isoform X1. (189 aa)
	LRP5	Low-density lipoprotein receptor-related protein 5 isoform X1. (1461 aa)
	AMER1	APC membrane recruitment protein 1. (1129 aa)
	DHRS7B	Dehydrogenase/reductase SDR family member 7B; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (310 aa)
	LOC112406112	Zinc finger protein 516-like. (491 aa)
	SELENOM	Selenoprotein M. (142 aa)
	LOC112406122	Zinc finger protein 516-like. (375 aa)
	SPART	Spartin isoform X1. (667 aa)
	PIK3CA	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
	VPS13B	Vacuolar protein sorting-associated protein 13B. (3993 aa)
	UMODL1	Uromodulin-like 1. (1321 aa)
	RASAL2	Ras GTPase-activating protein nGAP isoform X1. (1418 aa)
	SOX8	Transcription factor SOX-8. (378 aa)
	BBS4	Bardet-Biedl syndrome 4 protein isoform X1. (519 aa)

Your Current Organism:

Neophocaena asiaeorientalis

NCBI taxonomy Id: 1706337
Other names: N. asiaeorientalis asiaeorientalis, Neophocaena asiaeorientalis asiaeorientalis, Yangtze finless porpoise

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AMER1	LRP5	A0A341BT68	A0A341BRX5	APC membrane recruitment protein 1.	Low-density lipoprotein receptor-related protein 5 isoform X1.	0.485
ATF2	PPARGC1A	A0A341AHM6	A0A341BGJ3	Cyclic AMP-dependent transcription factor ATF-2 isoform X1.	Peroxisome proliferator-activated receptor gamma coactivator 1-alpha isoform X1.	0.581
EBF2	PPARGC1A	A0A341DBV6	A0A341BGJ3	Transcription factor COE2 isoform X2.	Peroxisome proliferator-activated receptor gamma coactivator 1-alpha isoform X1.	0.529
HRAS	PIK3CA	A0A341BRC9	A0A341CAB4	GTPase HRas isoform X1.	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.	0.983
HRAS	RASAL2	A0A341BRC9	A0A341CIA5	GTPase HRas isoform X1.	Ras GTPase-activating protein nGAP isoform X1.	0.866
LEP	PPARGC1A	A0A341CVH9	A0A341BGJ3	Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...]	Peroxisome proliferator-activated receptor gamma coactivator 1-alpha isoform X1.	0.660
LOC112406112	LOC112406122	A0A341C711	A0A341C714	Zinc finger protein 516-like.	Zinc finger protein 516-like.	0.904
LOC112406122	LOC112406112	A0A341C714	A0A341C711	Zinc finger protein 516-like.	Zinc finger protein 516-like.	0.904
LRP5	AMER1	A0A341BRX5	A0A341BT68	Low-density lipoprotein receptor-related protein 5 isoform X1.	APC membrane recruitment protein 1.	0.485
PIK3CA	HRAS	A0A341CAB4	A0A341BRC9	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.	GTPase HRas isoform X1.	0.983
PPARD	PPARGC1A	A0A341D4F0	A0A341BGJ3	Peroxisome proliferator-activated receptor delta.	Peroxisome proliferator-activated receptor gamma coactivator 1-alpha isoform X1.	0.705
PPARGC1A	ATF2	A0A341BGJ3	A0A341AHM6	Peroxisome proliferator-activated receptor gamma coactivator 1-alpha isoform X1.	Cyclic AMP-dependent transcription factor ATF-2 isoform X1.	0.581
PPARGC1A	EBF2	A0A341BGJ3	A0A341DBV6	Peroxisome proliferator-activated receptor gamma coactivator 1-alpha isoform X1.	Transcription factor COE2 isoform X2.	0.529
PPARGC1A	LEP	A0A341BGJ3	A0A341CVH9	Peroxisome proliferator-activated receptor gamma coactivator 1-alpha isoform X1.	Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...]	0.660
PPARGC1A	PPARD	A0A341BGJ3	A0A341D4F0	Peroxisome proliferator-activated receptor gamma coactivator 1-alpha isoform X1.	Peroxisome proliferator-activated receptor delta.	0.705
RASAL2	HRAS	A0A341CIA5	A0A341BRC9	Ras GTPase-activating protein nGAP isoform X1.	GTPase HRas isoform X1.	0.866