(78 nodes) Negative regulation of small molecule metabolic process network (Neophocaena asiaeorientalis)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

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Known Interactions

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experimentally determined

Predicted Interactions

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protein homology

Your Input:
	ACADVL	Very long-chain specific acyl-CoA dehydrogenase, mitochondrial isoform X1. (655 aa)
	CRY1	Cryptochrome-1 isoform X1. (587 aa)
	APPL2	DCC-interacting protein 13-beta isoform X1. (661 aa)
	TIGAR	Fructose-2,6-bisphosphatase TIGAR isoform X1. (269 aa)
	LOC112392028	RE1-silencing transcription factor-like. (305 aa)
	GIT1	ARF GTPase-activating protein GIT1 isoform X1. (708 aa)
	INSIG2	Insulin-induced gene protein; Mediates feedback control of cholesterol synthesis. Belongs to the INSIG family. (225 aa)
	NFKB1	Nuclear factor NF-kappa-B p105 subunit isoform X1. (977 aa)
	ERLIN1	Erlin-1 isoform X1. (369 aa)
	CBFA2T3	Protein CBFA2T3. (823 aa)
	TSPO	Translocator protein. (183 aa)
	LOC112394343	25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial; Belongs to the cytochrome P450 family. (508 aa)
	MST1	LOW QUALITY PROTEIN: hepatocyte growth factor-like protein; Belongs to the peptidase S1 family. (732 aa)
	PPARA	Peroxisome proliferator-activated receptor alpha. (468 aa)
	EP300	Histone acetyltransferase p300. (2399 aa)
	MFSD2A	Sodium-dependent lysophosphatidylcholine symporter 1 isoform X1. (529 aa)
	LOC112395012	Cytochrome P450 27C1; Belongs to the cytochrome P450 family. (399 aa)
	LOC112396202	Dimethylaniline monooxygenase [N-oxide-forming]. (532 aa)
	FMO2	Dimethylaniline monooxygenase [N-oxide-forming]. (537 aa)
	FMO3	Flavin-containing monooxygenase. (281 aa)
	PARP1	Poly [ADP-ribose] polymerase; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair. (1013 aa)
	INSIG1	Insulin-induced gene protein; Mediates feedback control of cholesterol synthesis. Belongs to the INSIG family. (294 aa)
	PID1	PTB-containing, cubilin and LRP1-interacting protein isoform X1. (217 aa)
	DDIT4	DNA damage-inducible transcript 4 protein. (229 aa)
	FMO1	Dimethylaniline monooxygenase [N-oxide-forming]. (539 aa)
	FMO4	Dimethylaniline monooxygenase [N-oxide-forming]. (577 aa)
	ACACB	acetyl-CoA carboxylase 2. (2456 aa)
	SIRT4	NAD-dependent protein lipoamidase sirtuin-4, mitochondrial; Acts as NAD-dependent protein lipoamidase, ADP-ribosyl transferase and deacetylase. Catalyzes more efficiently removal of lipoyl- and biotinyl- than acetyl-lysine modifications. Inhibits the pyruvate dehydrogenase complex (PDH) activity via the enzymatic hydrolysis of the lipoamide cofactor from the E2 component, DLAT, in a phosphorylation-independent manner. Catalyzes the transfer of ADP- ribosyl groups onto target proteins, including mitochondrial GLUD1, inhibiting GLUD1 enzyme activity. Acts as a negative regulator of mitoc [...] (314 aa)
	PLEK	Pleckstrin. (350 aa)
	BRCA1	Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...] (1870 aa)
	TRIB3	Tribbles homolog 3. (357 aa)
	SNAI2	Zinc finger protein SNAI2. (268 aa)
	GFI1	Zinc finger protein Gfi-1 isoform X1. (420 aa)
	STAT3	Signal transducer and activator of transcription. (770 aa)
	FIS1	Mitochondrial fission 1 protein; Involved in the fragmentation of the mitochondrial network and its perinuclear clustering. (152 aa)
	NUPR1	Nuclear protein 1. (82 aa)
	SIRT6	NAD-dependent protein deacetylase sirtuin-6. (354 aa)
	PLIN5	Perilipin; Belongs to the perilipin family. (457 aa)
	ATCAY	Caytaxin. (371 aa)
	ETFBKMT	Electron transfer flavoprotein beta subunit lysine methyltransferase. (266 aa)
	FAM3A	Protein FAM3A isoform X3. (230 aa)
	REST	RE1-silencing transcription factor isoform X2. (450 aa)
	GCK	Phosphotransferase. (537 aa)
	ACTN3	Alpha-actinin-3. (902 aa)
	INS	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (110 aa)
	FGF19	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (363 aa)
	SNAI1	Zinc finger protein SNAI1. (264 aa)
	RD3	Protein RD3. (267 aa)
	ATP2B4	Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1243 aa)
	APOC3	Apolipoprotein C-III. (99 aa)
	PROX1	Prospero homeobox protein 1 isoform X1. (737 aa)
	PDZD3	Na(+)/H(+) exchange regulatory cofactor NHE-RF4 isoform X1. (546 aa)
	ERFE	Erythroferrone. (273 aa)
	FLCN	Folliculin isoform X1. (576 aa)
	NCOR1	Nuclear receptor corepressor 1 isoform X1. (2454 aa)
	FBP1	Fructose-1,6-bisphosphatase 1; Belongs to the FBPase class 1 family. (338 aa)
	PIBF1	Progesterone-induced-blocking factor 1 isoform X1. (757 aa)
	C1QTNF3	Complement C1q tumor necrosis factor-related protein 3 isoform X1. (319 aa)
	BMP5	Bone morphogenetic protein 5 isoform X2. (455 aa)
	HDAC4	Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1071 aa)
	DKK3	Dickkopf-related protein 3. (349 aa)
	FAM3C	LOW QUALITY PROTEIN: protein FAM3C. (227 aa)
	SIK1	Serine/threonine-protein kinase SIK1. (657 aa)
	PGP	Glycerol-3-phosphate phosphatase. (396 aa)
	C1QTNF12	Adipolin. (267 aa)
	SOX9	Transcription factor SOX-9. (486 aa)
	SLC4A1	Anion exchange protein. (963 aa)
	SLC27A4	Long-chain fatty acid transport protein 4. (643 aa)
	ACMSD	2-amino-3-carboxymuconate-6-semialdehyde decarboxylase; Converts alpha-amino-beta-carboxymuconate-epsilon- semialdehyde (ACMS) to alpha-aminomuconate semialdehyde (AMS). Belongs to the metallo-dependent hydrolases superfamily. (353 aa)
	PRMT3	Protein arginine N-methyltransferase 3 isoform X1; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. (530 aa)
	LEPR	Leptin receptor isoform X1. (1165 aa)
	BMP2	Bone morphogenetic protein 2 isoform X1. (395 aa)
	ERLIN2	Erlin-2 isoform X1. (339 aa)
	MALRD1	MAM and LDL-receptor class A domain-containing protein 1. (2180 aa)
	SIRT1	NAD-dependent protein deacetylase sirtuin-1 isoform X1. (557 aa)
	WDTC1	WD and tetratricopeptide repeats protein 1 isoform X1. (679 aa)
	ADIPOQ	Adiponectin. (243 aa)
	DKKL1	Dickkopf-like protein 1 isoform X1. (235 aa)

Your Current Organism:

Neophocaena asiaeorientalis

NCBI taxonomy Id: 1706337
Other names: N. asiaeorientalis asiaeorientalis, Neophocaena asiaeorientalis asiaeorientalis, Yangtze finless porpoise

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACACB	ACADVL	A0A341B2Z4	A0A341A8Y3	acetyl-CoA carboxylase 2.	Very long-chain specific acyl-CoA dehydrogenase, mitochondrial isoform X1.	0.519
ACACB	ADIPOQ	A0A341B2Z4	A0A341DAP3	acetyl-CoA carboxylase 2.	Adiponectin.	0.423
ACACB	BRCA1	A0A341B2Z4	A0A341B5Q8	acetyl-CoA carboxylase 2.	Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...]	0.802
ACACB	INS	A0A341B2Z4	A0A341BTK8	acetyl-CoA carboxylase 2.	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	0.412
ACACB	PPARA	A0A341B2Z4	A0A341AU51	acetyl-CoA carboxylase 2.	Peroxisome proliferator-activated receptor alpha.	0.414
ACACB	TRIB3	A0A341B2Z4	A0A341B745	acetyl-CoA carboxylase 2.	Tribbles homolog 3.	0.435
ACADVL	ACACB	A0A341A8Y3	A0A341B2Z4	Very long-chain specific acyl-CoA dehydrogenase, mitochondrial isoform X1.	acetyl-CoA carboxylase 2.	0.519
ACADVL	ACMSD	A0A341A8Y3	A0A341CYV6	Very long-chain specific acyl-CoA dehydrogenase, mitochondrial isoform X1.	2-amino-3-carboxymuconate-6-semialdehyde decarboxylase; Converts alpha-amino-beta-carboxymuconate-epsilon- semialdehyde (ACMS) to alpha-aminomuconate semialdehyde (AMS). Belongs to the metallo-dependent hydrolases superfamily.	0.445
ACADVL	PPARA	A0A341A8Y3	A0A341AU51	Very long-chain specific acyl-CoA dehydrogenase, mitochondrial isoform X1.	Peroxisome proliferator-activated receptor alpha.	0.511
ACMSD	ACADVL	A0A341CYV6	A0A341A8Y3	2-amino-3-carboxymuconate-6-semialdehyde decarboxylase; Converts alpha-amino-beta-carboxymuconate-epsilon- semialdehyde (ACMS) to alpha-aminomuconate semialdehyde (AMS). Belongs to the metallo-dependent hydrolases superfamily.	Very long-chain specific acyl-CoA dehydrogenase, mitochondrial isoform X1.	0.445
ADIPOQ	ACACB	A0A341DAP3	A0A341B2Z4	Adiponectin.	acetyl-CoA carboxylase 2.	0.423
ADIPOQ	APPL2	A0A341DAP3	A0A341AFJ1	Adiponectin.	DCC-interacting protein 13-beta isoform X1.	0.512
ADIPOQ	INS	A0A341DAP3	A0A341BTK8	Adiponectin.	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	0.819
ADIPOQ	LEPR	A0A341DAP3	A0A341D0I4	Adiponectin.	Leptin receptor isoform X1.	0.570
ADIPOQ	PGP	A0A341DAP3	A0A341CKM6	Adiponectin.	Glycerol-3-phosphate phosphatase.	0.418
ADIPOQ	PLIN5	A0A341DAP3	A0A341BHG2	Adiponectin.	Perilipin; Belongs to the perilipin family.	0.679
ADIPOQ	PPARA	A0A341DAP3	A0A341AU51	Adiponectin.	Peroxisome proliferator-activated receptor alpha.	0.619
ADIPOQ	SIRT1	A0A341DAP3	A0A341D5L9	Adiponectin.	NAD-dependent protein deacetylase sirtuin-1 isoform X1.	0.534
ADIPOQ	STAT3	A0A341DAP3	A0A341BEB1	Adiponectin.	Signal transducer and activator of transcription.	0.433
APOC3	DDIT4	A0A341BY79	A0A341B121	Apolipoprotein C-III.	DNA damage-inducible transcript 4 protein.	0.410