(51 nodes) Negative regulation of ERK1 and ERK2 cascade network (Neophocaena asiaeorientalis)

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

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associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:
	PSCA	Prostate stem cell antigen. (124 aa)
	DUPD1	Dual specificity protein phosphatase; Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate. Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (216 aa)
	SYNJ2BP	Synaptojanin-2-binding protein. (145 aa)
	PTPRR	Receptor-type tyrosine-protein phosphatase R isoform X1. (410 aa)
	C1QL4	Complement C1q-like protein 4. (238 aa)
	ITGB1BP1	Integrin beta-1-binding protein 1 isoform X1. (206 aa)
	FBLN1	Fibulin-1; Incorporated into fibronectin-containing matrix fibers. May play a role in cell adhesion and migration along protein fibers within the extracellular matrix (ECM). Could be important for certain developmental processes and contribute to the supramolecular organization of ECM architecture, in particular to those of basement membranes. (693 aa)
	LOC112394359	Receptor-type tyrosine-protein phosphatase R-like. (121 aa)
	TIMP3	Metalloproteinase inhibitor 3. (211 aa)
	SPRED1	Sprouty-related, EVH1 domain-containing protein 1 isoform X1. (445 aa)
	DUSP6	Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (381 aa)
	DUSP9	Dual specificity protein phosphatase 9. (525 aa)
	SMAD4	Mothers against decapentaplegic homolog. (599 aa)
	SPRY2	Protein sprouty homolog 2. (315 aa)
	DUSP3	Dual specificity protein phosphatase; Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate. Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (157 aa)
	NDRG2	Protein NDRG2 isoform X1. (371 aa)
	SLC9A3R1	Na(+)/H(+) exchange regulatory cofactor NHE-RF; Scaffold protein that connects plasma membrane proteins with members of the ezrin/moesin/radixin family and thereby helps to link them to the actin cytoskeleton and to regulate their surface expression. (366 aa)
	DAB2IP	Disabled homolog 2-interacting protein isoform X1. (1071 aa)
	ABL1	Tyrosine-protein kinase. (1148 aa)
	GPER1	G-protein coupled estrogen receptor 1; Belongs to the G-protein coupled receptor 1 family. (358 aa)
	RAPGEF1	Rap guanine nucleotide exchange factor 1. (1094 aa)
	PTPN2	Tyrosine-protein phosphatase non-receptor type. (396 aa)
	RANBP9	Ran-binding protein 9. (762 aa)
	EPHA4	Ephrin type-A receptor 4 isoform X1. (986 aa)
	PTPRC	Receptor-type tyrosine-protein phosphatase C isoform X1. (1258 aa)
	DLG2	Disks large homolog 2 isoform X1. (905 aa)
	EMILIN1	EMILIN-1. (1015 aa)
	DUSP26	Dual specificity protein phosphatase; Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate. Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (211 aa)
	DUSP4	Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (396 aa)
	EPHB2	Ephrin type-B receptor 2. (963 aa)
	ADIPOQ	Adiponectin. (243 aa)
	VRK3	Inactive serine/threonine-protein kinase VRK3. (435 aa)
	LIF	Leukemia inhibitory factor. (202 aa)
	FLCN	Folliculin isoform X1. (576 aa)
	SPRY4	Protein sprouty homolog 4. (299 aa)
	DLG1	Disks large homolog 1 isoform X1; Belongs to the MAGUK family. (927 aa)
	ATF3	Cyclic AMP-dependent transcription factor ATF-3. (181 aa)
	DUSP10	Dual specificity protein phosphatase 10; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (482 aa)
	TNIP1	TNFAIP3-interacting protein 1 isoform X1. (653 aa)
	PTPN1	Tyrosine-protein phosphatase non-receptor type. (424 aa)
	NLRP6	LOW QUALITY PROTEIN: NACHT, LRR and PYD domains-containing protein 6. (895 aa)
	TBC1D10C	Carabin isoform X1. (458 aa)
	EZR	Ezrin. (586 aa)
	PIN1	Peptidyl-prolyl cis-trans isomerase. (163 aa)
	LOC112400529	Toll-like receptor 9 isoform X4. (1323 aa)
	SPRY1	Protein sprouty homolog 1. (319 aa)
	PHB	Prohibitin. (272 aa)
	TNIP3	LOW QUALITY PROTEIN: TNFAIP3-interacting protein 3. (370 aa)
	SEMA6A	semaphorin-6A isoform X1; Belongs to the semaphorin family. (1044 aa)
	LYN	Tyrosine-protein kinase. (518 aa)
	CUNH3orf33	Protein C3orf33 homolog isoform X1. (320 aa)

Your Current Organism:

Neophocaena asiaeorientalis

NCBI taxonomy Id: 1706337
Other names: N. asiaeorientalis asiaeorientalis, Neophocaena asiaeorientalis asiaeorientalis, Yangtze finless porpoise

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ABL1	EPHA4	A0A341CTZ6	A0A341CYV2	Tyrosine-protein kinase.	Ephrin type-A receptor 4 isoform X1.	0.920
ABL1	EPHB2	A0A341CTZ6	A0A341D6F6	Tyrosine-protein kinase.	Ephrin type-B receptor 2.	0.917
ABL1	RAPGEF1	A0A341CTZ6	A0A341CXC6	Tyrosine-protein kinase.	Rap guanine nucleotide exchange factor 1.	0.579
ABL1	SPRED1	A0A341CTZ6	A0A341ACJ5	Tyrosine-protein kinase.	Sprouty-related, EVH1 domain-containing protein 1 isoform X1.	0.582
DLG1	DLG2	A0A341BYZ1	A0A341CZU5	Disks large homolog 1 isoform X1; Belongs to the MAGUK family.	Disks large homolog 2 isoform X1.	0.890
DLG2	DLG1	A0A341CZU5	A0A341BYZ1	Disks large homolog 2 isoform X1.	Disks large homolog 1 isoform X1; Belongs to the MAGUK family.	0.890
DUPD1	VRK3	A0A341B1Y9	A0A341DAZ8	Dual specificity protein phosphatase; Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate. Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily.	Inactive serine/threonine-protein kinase VRK3.	0.624
DUSP10	TBC1D10C	A0A341BX34	A0A341BPA9	Dual specificity protein phosphatase 10; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily.	Carabin isoform X1.	0.410
DUSP10	VRK3	A0A341BX34	A0A341DAZ8	Dual specificity protein phosphatase 10; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily.	Inactive serine/threonine-protein kinase VRK3.	0.418
DUSP26	VRK3	A0A341D1F8	A0A341DAZ8	Dual specificity protein phosphatase; Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate. Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily.	Inactive serine/threonine-protein kinase VRK3.	0.624
DUSP3	LOC112394359	A0A341CP38	A0A341AQR8	Dual specificity protein phosphatase; Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate. Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily.	Receptor-type tyrosine-protein phosphatase R-like.	0.808
DUSP3	PTPRR	A0A341CP38	A0A341AUD2	Dual specificity protein phosphatase; Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate. Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily.	Receptor-type tyrosine-protein phosphatase R isoform X1.	0.808
DUSP3	VRK3	A0A341CP38	A0A341DAZ8	Dual specificity protein phosphatase; Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate. Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily.	Inactive serine/threonine-protein kinase VRK3.	0.969
DUSP4	DUSP6	A0A341D495	A0A341C5R7	Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily.	Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily.	0.530
DUSP4	SPRED1	A0A341D495	A0A341ACJ5	Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily.	Sprouty-related, EVH1 domain-containing protein 1 isoform X1.	0.416
DUSP4	SPRY2	A0A341D495	A0A341CN76	Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily.	Protein sprouty homolog 2.	0.499
DUSP4	SPRY4	A0A341D495	A0A341C024	Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily.	Protein sprouty homolog 4.	0.529
DUSP4	VRK3	A0A341D495	A0A341DAZ8	Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily.	Inactive serine/threonine-protein kinase VRK3.	0.413
DUSP6	DUSP4	A0A341C5R7	A0A341D495	Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily.	Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily.	0.530
DUSP6	DUSP9	A0A341C5R7	A0A341C9U0	Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily.	Dual specificity protein phosphatase 9.	0.562