STRINGSTRING
ARIH2 ARIH2 TRIM21 TRIM21 RNF115 RNF115 HECTD1 HECTD1 UBE2G1 UBE2G1 RNF135 RNF135 RNF5 RNF5 RNF126 RNF126 TRAF3IP2 TRAF3IP2 LOC112397789 LOC112397789 UBE2V2 UBE2V2 ITCH ITCH BFAR BFAR TRIM56 TRIM56 PRKN PRKN PRPF19 PRPF19 PELI3 PELI3 ZFP91 ZFP91 UBE2T UBE2T UBE2V1 UBE2V1 RNF186 RNF186 TRAF5 TRAF5 RNF168 RNF168 UBE2B UBE2B TRAF6 TRAF6 PELI1 PELI1 UBE2N UBE2N RNF152 RNF152 UBE2S UBE2S TRAF3 TRAF3 UBE2O UBE2O LOC112410180 LOC112410180 TRAF2 TRAF2 TRAF1 TRAF1 WWP2 WWP2 LOC112412378 LOC112412378 LOC112412569 LOC112412569 UBE2E3 UBE2E3 RNF8 RNF8 FBXW9 FBXW9 MAGEL2 MAGEL2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ARIH2RBR-type E3 ubiquitin transferase. (491 aa)
TRIM21E3 ubiquitin-protein ligase TRIM21. (469 aa)
RNF115E3 ubiquitin-protein ligase RNF115. (293 aa)
HECTD1E3 ubiquitin-protein ligase HECTD1 isoform X1. (2610 aa)
UBE2G1Ubiquitin-conjugating enzyme E2 G1; Belongs to the ubiquitin-conjugating enzyme family. (170 aa)
RNF135LOW QUALITY PROTEIN: E3 ubiquitin-protein ligase RNF135. (447 aa)
RNF5E3 ubiquitin-protein ligase RNF5. (180 aa)
RNF126LOW QUALITY PROTEIN: E3 ubiquitin-protein ligase RNF126. (319 aa)
TRAF3IP2Adapter protein CIKS isoform X1. (564 aa)
LOC112397789Ubiquitin-conjugating enzyme E2 E2; Belongs to the ubiquitin-conjugating enzyme family. (201 aa)
UBE2V2Ubiquitin-conjugating enzyme E2 variant 2. (145 aa)
ITCHE3 ubiquitin-protein ligase. (862 aa)
BFARBifunctional apoptosis regulator. (450 aa)
TRIM56E3 ubiquitin-protein ligase TRIM56. (755 aa)
PRKNE3 ubiquitin-protein ligase parkin; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. (465 aa)
PRPF19pre-mRNA-processing factor 19. (521 aa)
PELI3E3 ubiquitin-protein ligase pellino homolog; E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. (469 aa)
ZFP91E3 ubiquitin-protein ligase ZFP91. (561 aa)
UBE2TUbiquitin-conjugating enzyme E2 T; Belongs to the ubiquitin-conjugating enzyme family. (195 aa)
UBE2V1Ubiquitin-conjugating enzyme E2 variant 1 isoform X1. (181 aa)
RNF186RING finger protein 186. (226 aa)
TRAF5TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (558 aa)
RNF168E3 ubiquitin-protein ligase RNF168; E3 ubiquitin-protein ligase required for accumulation of repair proteins to sites of DNA damage. Acts with UBE2N/UBC13 to amplify the RNF8-dependent histone ubiquitination. Recruited to sites of DNA damage at double-strand breaks (DSBs) by binding to ubiquitinated histone H2A and H2AX and amplifies the RNF8-dependent H2A ubiquitination, promoting the formation of 'Lys-63'-linked ubiquitin conjugates. This leads to concentrate ubiquitinated histones H2A and H2AX at DNA lesions to the threshold required for recruitment of TP53BP1 and BRCA1. Also recrui [...] (571 aa)
UBE2BUbiquitin-conjugating enzyme E2 B isoform X1; Belongs to the ubiquitin-conjugating enzyme family. (152 aa)
TRAF6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (570 aa)
PELI1E3 ubiquitin-protein ligase pellino homolog; E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. (418 aa)
UBE2NUbiquitin-conjugating enzyme E2 N; Belongs to the ubiquitin-conjugating enzyme family. (152 aa)
RNF152E3 ubiquitin-protein ligase RNF152. (203 aa)
UBE2SUbiquitin-conjugating enzyme E2 S; Belongs to the ubiquitin-conjugating enzyme family. (223 aa)
TRAF3TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (572 aa)
UBE2O(E3-independent) E2 ubiquitin-conjugating enzyme isoform X1. (1173 aa)
LOC112410180(E3-independent) E2 ubiquitin-conjugating enzyme-like. (188 aa)
TRAF2TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (516 aa)
TRAF1TNF receptor-associated factor. (415 aa)
WWP2E3 ubiquitin-protein ligase. (868 aa)
LOC112412378F-box/WD repeat-containing protein 7. (540 aa)
LOC112412569Zinc finger protein RFP. (513 aa)
UBE2E3Ubiquitin-conjugating enzyme E2 E3 isoform X1; Belongs to the ubiquitin-conjugating enzyme family. (220 aa)
RNF8E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...] (487 aa)
FBXW9F-box/WD repeat-containing protein 9 isoform X1. (463 aa)
MAGEL2MAGE-like protein 2. (1192 aa)
Your Current Organism:
Neophocaena asiaeorientalis
NCBI taxonomy Id: 1706337
Other names: N. asiaeorientalis asiaeorientalis, Neophocaena asiaeorientalis asiaeorientalis, Yangtze finless porpoise
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