STRINGSTRING
WNT11 WNT11 TP63 TP63 ERCC2 ERCC2 TGFB1 TGFB1 BABAM1 BABAM1 BYSL BYSL KDF1 KDF1 SFN SFN YTHDF2 YTHDF2 RUNX2 RUNX2 WNT2B WNT2B LOC112411691 LOC112411691 XRCC5 XRCC5 WNT3 WNT3 SOX9 SOX9 AXIN2 AXIN2 NFIB NFIB YAP1 YAP1 LOC112407988 LOC112407988 RNF43 RNF43 LOC112407979 LOC112407979 CEP120 CEP120 OSR2 OSR2 BRCA2 BRCA2 NR2E1 NR2E1 HOXA3 HOXA3 IRS2 IRS2 CTNNB1 CTNNB1 FGF9 FGF9 PTCH1 PTCH1 LIG4 LIG4 SIX2 SIX2 HMX2 HMX2 SCRG1 SCRG1 IRF6 IRF6 OVOL1 OVOL1 FGF4 FGF4 NES NES GBA GBA CTC1 CTC1 KDR KDR WNT5A WNT5A FGF2 FGF2 HOXB4 HOXB4 TRIM71 TRIM71 PRRX1 PRRX1 TBX3 TBX3 SART3 SART3 FGF10 FGF10 SHOX2 SHOX2 CDKN2C CDKN2C SHH SHH ARIH2 ARIH2 RARB RARB IFT20 IFT20 WNT10B WNT10B WNT1 WNT1 RARG RARG NF1 NF1 FGF8 FGF8 SHB SHB GLI3 GLI3 ETV6 ETV6 CD109 CD109 ELL3 ELL3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
WNT11Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa)
TP63Tumor protein 63 (p63); Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. (680 aa)
ERCC2General transcription and DNA repair factor IIH helicase subunit XPD isoform X1. (823 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (391 aa)
BABAM1BRISC and BRCA1-A complex member 1. (330 aa)
BYSLBystin. (433 aa)
KDF1Keratinocyte differentiation factor 1. (398 aa)
SFN14-3-3 protein sigma; Belongs to the 14-3-3 family. (248 aa)
YTHDF2YTH domain-containing family protein 2 isoform X1. (580 aa)
RUNX2Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. (408 aa)
WNT2BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (393 aa)
LOC112411691Retinoic acid receptor beta-like. (329 aa)
XRCC5X-ray repair cross-complementing protein 5 isoform X1. (766 aa)
WNT3Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (453 aa)
SOX9Transcription factor SOX-9. (486 aa)
AXIN2Axin-2. (720 aa)
NFIBNuclear factor 1; Recognizes and binds the palindromic sequence 5'- TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication. (570 aa)
YAP1Transcriptional coactivator YAP1. (416 aa)
LOC112407988Secreted frizzled-related protein 2. (294 aa)
RNF43E3 ubiquitin-protein ligase RNF43 isoform X1. (784 aa)
LOC112407979Secreted frizzled-related protein 2-like. (105 aa)
CEP120Centrosomal protein of 120 kDa. (987 aa)
OSR2Protein odd-skipped-related 2 isoform X1. (312 aa)
BRCA2Breast cancer type 2 susceptibility protein. (3435 aa)
NR2E1Nuclear receptor subfamily 2 group E member 1. (385 aa)
HOXA3LOW QUALITY PROTEIN: homeobox protein Hox-A3. (405 aa)
IRS2Insulin receptor substrate 2. (702 aa)
CTNNB1Catenin beta-1. (781 aa)
FGF9Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
PTCH1Protein patched homolog 1 isoform X1. (1297 aa)
LIG4DNA ligase. (911 aa)
SIX2Homeobox protein SIX2 isoform X1. (298 aa)
HMX2Homeobox protein HMX2. (274 aa)
SCRG1Scrapie-responsive protein 1. (98 aa)
IRF6Interferon regulatory factor 6 isoform X1. (467 aa)
OVOL1Putative transcription factor Ovo-like 1. (441 aa)
FGF4Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (156 aa)
NESLOW QUALITY PROTEIN: nestin; Belongs to the intermediate filament family. (1538 aa)
GBAGlucosylceramidase. (568 aa)
CTC1CST complex subunit CTC1 isoform X1. (1208 aa)
KDRVascular endothelial growth factor receptor 2 isoform X4; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1356 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (380 aa)
FGF2Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (304 aa)
HOXB4LOW QUALITY PROTEIN: homeobox protein Hox-B4. (282 aa)
TRIM71E3 ubiquitin-protein ligase TRIM71. (596 aa)
PRRX1Paired mesoderm homeobox protein 1. (245 aa)
TBX3LOW QUALITY PROTEIN: T-box transcription factor TBX3. (734 aa)
SART3Squamous cell carcinoma antigen recognized by T-cells 3 isoform X1. (978 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
SHOX2Short stature homeobox protein 2 isoform X1. (333 aa)
CDKN2CCyclin-dependent kinase 4 inhibitor C. (168 aa)
SHHSonic hedgehog protein. (328 aa)
ARIH2RBR-type E3 ubiquitin transferase. (491 aa)
RARBRetinoic acid receptor beta. (311 aa)
IFT20LOW QUALITY PROTEIN: intraflagellar transport protein 20 homolog. (159 aa)
WNT10BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (389 aa)
WNT1Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (370 aa)
RARGRetinoic acid receptor gamma isoform X2. (458 aa)
NF1Neurofibromin isoform X1. (2841 aa)
FGF8Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (244 aa)
SHBLOW QUALITY PROTEIN: SH2 domain-containing adapter protein B. (649 aa)
GLI3Transcriptional activator GLI3. (1587 aa)
ETV6Transcription factor ETV6 isoform X1. (394 aa)
CD109CD109 antigen isoform X1. (1358 aa)
ELL3RNA polymerase II elongation factor ELL3 isoform X1. (354 aa)
Your Current Organism:
Neophocaena asiaeorientalis
NCBI taxonomy Id: 1706337
Other names: N. asiaeorientalis asiaeorientalis, Neophocaena asiaeorientalis asiaeorientalis, Yangtze finless porpoise
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