STRINGSTRING
SELENOT SELENOT ADCY8 ADCY8 SIRT4 SIRT4 PTPN11 PTPN11 SOX4 SOX4 LOC112396164 LOC112396164 PPP3CB PPP3CB IRS1 IRS1 RBP4 RBP4 MIDN MIDN FFAR4 FFAR4 KLF7 KLF7 ALOX5 ALOX5 IL6 IL6 NOS2 NOS2 ILDR1 ILDR1 RPH3AL RPH3AL GCG GCG CHGA CHGA IFNG IFNG ACVR1C ACVR1C GPR68 GPR68 DOC2B DOC2B SLC35F5 SLC35F5 FFAR1 FFAR1 LOC112392028 LOC112392028 LOC112391992 LOC112391992 CRHBP CRHBP FFAR3 FFAR3 TM7SF3 TM7SF3 CD74 CD74 NLGN2 NLGN2 FGB FGB FGG FGG KCNJ11 KCNJ11 CA2 CA2 AACS AACS INHBB INHBB SSTR5 SSTR5 BAIAP3 BAIAP3 C1QTNF12 C1QTNF12 BIRC5 BIRC5 CAPN10 CAPN10 PAX8 PAX8 GHRH GHRH EFNA5 EFNA5 NR1D1 NR1D1 MPC2 MPC2 SLC9B2 SLC9B2 TFAP2B TFAP2B ICA1 ICA1 STXBP5L STXBP5L SLC8B1 SLC8B1 PICK1 PICK1 BLK BLK PLA2G6 PLA2G6 LRRC8A LRRC8A LEP LEP GPER1 GPER1 LOC112412344 LOC112412344 UCN UCN FKBP1B FKBP1B GHRL GHRL SFRP1 SFRP1 NDUFAF2 NDUFAF2 LOC112413274 LOC112413274 LOC112414024 LOC112414024 ADCYAP1 ADCYAP1 RASL10B RASL10B PFKL PFKL CCL5 CCL5 PASK PASK HMGN3 HMGN3 CFTR CFTR STXBP4 STXBP4 ADCY5 ADCY5 SYT9 SYT9 ADRA2A ADRA2A RFX6 RFX6 TRH TRH TCF7L2 TCF7L2 NKX6-1 NKX6-1 GHRHR GHRHR FOXO1 FOXO1 PDX1 PDX1 TNFSF11 TNFSF11 SRI SRI GRP GRP IRS2 IRS2 ARHGEF7 ARHGEF7 DRD2 DRD2 LOC112404902 LOC112404902 PRKCE PRKCE LOC112404949 LOC112404949 HFE HFE C2CD2L C2CD2L SIDT2 SIDT2 GPLD1 GPLD1 NR1H4 NR1H4 KCNB1 KCNB1 LOC112402820 LOC112402820 BAD BAD LRP5 LRP5 CDK16 CDK16 LOC112402169 LOC112402169 ANO1 ANO1 HIF1A HIF1A S100A8 S100A8 SLC25A22 SLC25A22 TCIRG1 TCIRG1 VSNL1 VSNL1 GCK GCK PRKN PRKN HNF4A HNF4A REST REST CLOCK CLOCK FAM3D FAM3D CDV3 CDV3 GIP GIP TFR2 TFR2 NNAT NNAT IL1B IL1B CRH CRH CHD7 CHD7
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SELENOTSelenoprotein T; Belongs to the SelWTH family. Selenoprotein T subfamily. (195 aa)
ADCY8Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1249 aa)
SIRT4NAD-dependent protein lipoamidase sirtuin-4, mitochondrial; Acts as NAD-dependent protein lipoamidase, ADP-ribosyl transferase and deacetylase. Catalyzes more efficiently removal of lipoyl- and biotinyl- than acetyl-lysine modifications. Inhibits the pyruvate dehydrogenase complex (PDH) activity via the enzymatic hydrolysis of the lipoamide cofactor from the E2 component, DLAT, in a phosphorylation-independent manner. Catalyzes the transfer of ADP- ribosyl groups onto target proteins, including mitochondrial GLUD1, inhibiting GLUD1 enzyme activity. Acts as a negative regulator of mitoc [...] (314 aa)
PTPN11Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (597 aa)
SOX4Transcription factor SOX-4. (285 aa)
LOC112396164Calcium uniporter protein, mitochondrial-like. (89 aa)
PPP3CBSerine/threonine-protein phosphatase. (480 aa)
IRS1Insulin receptor substrate 1. (1248 aa)
RBP4Retinol-binding protein; Retinol-binding protein that mediates retinol transport in blood plasma. (196 aa)
MIDNMidnolin. (442 aa)
FFAR4Free fatty acid receptor 4 isoform X1. (375 aa)
KLF7Krueppel-like factor 7 isoform X1. (303 aa)
ALOX5Arachidonate 5-lipoxygenase isoform X1. (696 aa)
IL6Interleukin-6. (208 aa)
NOS2Nitric oxide synthase; Produces nitric oxide (NO). (1157 aa)
ILDR1Immunoglobulin-like domain-containing receptor 1. (549 aa)
RPH3ALLOW QUALITY PROTEIN: rab effector Noc2. (344 aa)
GCGGlucagon isoform X1. (180 aa)
CHGAchromogranin-A isoform X1. (445 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (166 aa)
ACVR1CReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (493 aa)
GPR68Ovarian cancer G-protein coupled receptor 1; Belongs to the G-protein coupled receptor 1 family. (371 aa)
DOC2BDouble C2-like domain-containing protein beta. (421 aa)
SLC35F5Solute carrier family 35 member F5 isoform X1. (524 aa)
FFAR1Free fatty acid receptor 1. (300 aa)
LOC112392028RE1-silencing transcription factor-like. (305 aa)
LOC112391992Neuroligin-2-like. (82 aa)
CRHBPCorticotropin-releasing factor-binding protein; Binds CRF and inactivates it. May prevent inappropriate pituitary-adrenal stimulation in pregnancy. Belongs to the CRF-binding protein family. (322 aa)
FFAR3LOW QUALITY PROTEIN: free fatty acid receptor 3. (372 aa)
TM7SF3Transmembrane 7 superfamily member 3. (570 aa)
CD74HLA class II histocompatibility antigen gamma chain isoform X1. (278 aa)
NLGN2Neuroligin-2. (509 aa)
FGBFibrinogen beta chain isoform X1. (495 aa)
FGGFibrinogen gamma chain isoform X1. (445 aa)
KCNJ11ATP-sensitive inward rectifier potassium channel 11. (388 aa)
CA2Carbonic anhydrase 2; Belongs to the alpha-carbonic anhydrase family. (260 aa)
AACSacetoacetyl-CoA synthetase isoform X1. (672 aa)
INHBBInhibin beta B chain. (345 aa)
SSTR5Somatostatin receptor type 5; Belongs to the G-protein coupled receptor 1 family. (365 aa)
BAIAP3BAI1-associated protein 3 isoform X1. (1152 aa)
C1QTNF12Adipolin. (267 aa)
BIRC5Baculoviral IAP repeat-containing protein 5. (142 aa)
CAPN10Calpain-10 isoform X1; Belongs to the peptidase C2 family. (848 aa)
PAX8Paired box protein Pax-8 isoform X1. (458 aa)
GHRHSomatoliberin. (106 aa)
EFNA5ephrin-A5 isoform X1; Belongs to the ephrin family. (228 aa)
NR1D1LOW QUALITY PROTEIN: nuclear receptor subfamily 1 group D member 1. (595 aa)
MPC2Mitochondrial pyruvate carrier; Mediates the uptake of pyruvate into mitochondria. Belongs to the mitochondrial pyruvate carrier (MPC) (TC 2.A.105) family. (155 aa)
SLC9B2Sodium/hydrogen exchanger 9B2 isoform X1. (536 aa)
TFAP2BTranscription factor AP-2-beta isoform X1. (469 aa)
ICA1Islet cell autoantigen 1 isoform X1. (480 aa)
STXBP5LSyntaxin-binding protein 5-like isoform X1. (1186 aa)
SLC8B1Mitochondrial sodium/calcium exchanger protein isoform X1; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (600 aa)
PICK1PRKCA-binding protein. (417 aa)
BLKTyrosine-protein kinase. (501 aa)
PLA2G685/88 kDa calcium-independent phospholipase A2 isoform X6. (835 aa)
LRRC8AVolume-regulated anion channel subunit LRRC8A. (810 aa)
LEPLeptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...] (167 aa)
GPER1G-protein coupled estrogen receptor 1; Belongs to the G-protein coupled receptor 1 family. (358 aa)
LOC112412344Neuroligin-2-like. (366 aa)
UCNUrocortin. (126 aa)
FKBP1BPeptidylprolyl isomerase. (80 aa)
GHRLAppetite-regulating hormone. (168 aa)
SFRP1Secreted frizzled-related protein 1. (296 aa)
NDUFAF2NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 2. (169 aa)
LOC112413274LOW QUALITY PROTEIN: neuroligin-2-like. (366 aa)
LOC112414024Ubiquinol-cytochrome-c reductase complex assembly factor 2. (136 aa)
ADCYAP1Pituitary adenylate cyclase-activating polypeptide. (176 aa)
RASL10BRas-like protein family member 10B isoform X1. (204 aa)
PFKLATP-dependent 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily. (732 aa)
CCL5C-C motif chemokine. (91 aa)
PASKPAS domain-containing serine/threonine-protein kinase. (1334 aa)
HMGN3High mobility group nucleosome-binding domain-containing protein 3 isoform X1. (130 aa)
CFTRCystic fibrosis transmembrane conductance regulator; Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane. Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelial fluid layer. (1482 aa)
STXBP4Syntaxin-binding protein 4 isoform X1. (588 aa)
ADCY5Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1204 aa)
SYT9Synaptotagmin-9. (503 aa)
ADRA2ALOW QUALITY PROTEIN: alpha-2A adrenergic receptor. (430 aa)
RFX6DNA-binding protein RFX6. (928 aa)
TRHPro-thyrotropin-releasing hormone; Functions as a regulator of the biosynthesis of TSH in the anterior pituitary gland and as a neurotransmitter/ neuromodulator in the central and peripheral nervous systems. (255 aa)
TCF7L2Transcription factor 7-like 2 isoform X1. (510 aa)
NKX6-1Homeobox protein Nkx-6.1. (366 aa)
GHRHRGrowth hormone-releasing hormone receptor isoform X1; Belongs to the G-protein coupled receptor 2 family. (456 aa)
FOXO1Forkhead box protein O1. (511 aa)
PDX1Pancreas/duodenum homeobox protein 1. (289 aa)
TNFSF11Tumor necrosis factor ligand superfamily member 11; Belongs to the tumor necrosis factor family. (323 aa)
SRISorcin. (198 aa)
GRPGastrin-releasing peptide isoform X1. (139 aa)
IRS2Insulin receptor substrate 2. (702 aa)
ARHGEF7Rho guanine nucleotide exchange factor 7 isoform X1. (705 aa)
DRD2D(2) dopamine receptor isoform X2; Belongs to the G-protein coupled receptor 1 family. (443 aa)
LOC112404902LOW QUALITY PROTEIN: baculoviral IAP repeat-containing protein 5-like. (215 aa)
PRKCEProtein kinase C epsilon type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays essential roles in the regulation of multiple cellular processes linked to cytoskeletal proteins, such as cell adhesion, motility, migration and cell cycle, functions in neuron growth and ion channel regulation, and is involved in immune response, cancer cell invasion and regulation of apoptosis. Mediates cell adhesion to the extracellular matrix via integrin- dependent signaling, by mediating angiotensin-2-induced activation of integrin beta- [...] (737 aa)
LOC112404949Calcium uniporter protein, mitochondrial. (109 aa)
HFEHereditary hemochromatosis protein isoform X1; Belongs to the MHC class I family. (356 aa)
C2CD2LLOW QUALITY PROTEIN: phospholipid transfer protein C2CD2L. (701 aa)
SIDT2SID1 transmembrane family member 2 isoform X2. (856 aa)
GPLD1Phosphatidylinositol-glycan-specific phospholipase D. (849 aa)
NR1H4Bile acid receptor isoform X1. (486 aa)
KCNB1Potassium voltage-gated channel subfamily B member 1; Belongs to the potassium channel family. (858 aa)
LOC112402820LOW QUALITY PROTEIN: chymotrypsin-like elastase family member 2A; Belongs to the peptidase S1 family. (285 aa)
BADBcl2-associated agonist of cell death. (168 aa)
LRP5Low-density lipoprotein receptor-related protein 5 isoform X1. (1461 aa)
CDK16Cyclin-dependent kinase 16; Belongs to the protein kinase superfamily. (496 aa)
LOC112402169V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. (259 aa)
ANO1Anoctamin. (994 aa)
HIF1AHypoxia-inducible factor 1-alpha. (823 aa)
S100A8Protein S100; Belongs to the S-100 family. (89 aa)
SLC25A22Mitochondrial glutamate carrier 1; Belongs to the mitochondrial carrier (TC 2.A.29) family. (359 aa)
TCIRG1V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. (589 aa)
VSNL1Visinin-like protein 1 isoform X1. (191 aa)
GCKPhosphotransferase. (537 aa)
PRKNE3 ubiquitin-protein ligase parkin; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. (465 aa)
HNF4AHepatocyte nuclear factor 4-alpha isoform X1. (484 aa)
RESTRE1-silencing transcription factor isoform X2. (450 aa)
CLOCKCircadian locomoter output cycles protein kaput. (848 aa)
FAM3DProtein FAM3D. (221 aa)
CDV3Protein CDV3 homolog isoform X1. (155 aa)
GIPGastric inhibitory polypeptide isoform X1. (143 aa)
TFR2Transferrin receptor protein 2. (805 aa)
NNATNeuronatin isoform X3. (125 aa)
IL1BMultifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (266 aa)
CRHCorticoliberin. (193 aa)
CHD7LOW QUALITY PROTEIN: chromodomain-helicase-DNA-binding protein 7. (3000 aa)
Your Current Organism:
Neophocaena asiaeorientalis
NCBI taxonomy Id: 1706337
Other names: N. asiaeorientalis asiaeorientalis, Neophocaena asiaeorientalis asiaeorientalis, Yangtze finless porpoise
Server load: low (28%) [HD]