Your Input: | |
| | USB1 | U6 snRNA phosphodiesterase; Phosphodiesterase responsible for the U6 snRNA 3' end processing. Acts as an exoribonuclease (RNase) responsible for trimming the poly(U) tract of the last nucleotides in the pre-U6 snRNA molecule, leading to the formation of mature U6 snRNA 3' end-terminated with a 2',3'-cyclic phosphate; Belongs to the 2H phosphoesterase superfamily. USB1 family. (265 aa) |
| | KIAA0391 | Mitochondrial ribonuclease P catalytic subunit isoform X1. (583 aa) |
| | LRRC27 | LOW QUALITY PROTEIN: leucine-rich repeat-containing protein 27. (591 aa) |
| | RNASE12 | Probable inactive ribonuclease-like protein 12; Belongs to the pancreatic ribonuclease family. (316 aa) |
| | RPP25 | Ribonuclease P protein subunit p25. (213 aa) |
| | EDC3 | Enhancer of mRNA-decapping protein 3. (507 aa) |
| | RPS3 | 40S ribosomal protein S3; Belongs to the universal ribosomal protein uS3 family. (243 aa) |
| | ENDOV | Endonuclease V isoform X1. (370 aa) |
| | RNASE4 | Ribonuclease 4; Belongs to the pancreatic ribonuclease family. (147 aa) |
| | RNASE6 | Ribonuclease K6; Belongs to the pancreatic ribonuclease family. (154 aa) |
| | LOC112410620 | LOW QUALITY PROTEIN: ribonuclease 7-like; Belongs to the pancreatic ribonuclease family. (157 aa) |
| | RNASE2 | LOW QUALITY PROTEIN: non-secretory ribonuclease; Belongs to the pancreatic ribonuclease family. (153 aa) |
| | APEX1 | DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends. (318 aa) |
| | ANG | LOW QUALITY PROTEIN: angiogenin; Belongs to the pancreatic ribonuclease family. (222 aa) |
| | RNASE1 | Ribonuclease pancreatic; Belongs to the pancreatic ribonuclease family. (151 aa) |
| | DFFB | DNAation factor subunit beta. (373 aa) |
| | ERN1 | Serine/threonine-protein kinase/endoribonuclease IRE1. (858 aa) |
| | TBL3 | Transducin beta-like protein 3. (800 aa) |
| | MEIOB | Meiosis-specific with OB domain-containing protein isoform X1. (474 aa) |
| | CPSF4L | Putative cleavage and polyadenylation specificity factor subunit 4-like protein. (176 aa) |
| | CNOT8 | CCR4-NOT transcription complex subunit 8 isoform X1. (349 aa) |
| | CNOT7 | CCR4-NOT transcription complex subunit 7. (285 aa) |
| | ERI3 | ERI1 exoribonuclease 3 isoform X1. (337 aa) |
| | INTS11 | Integrator complex subunit 11. (599 aa) |
| | EME2 | LOW QUALITY PROTEIN: probable crossover junction endonuclease EME2. (348 aa) |
| | ENPP3 | Ectonucleotide pyrophosphatase/phosphodiesterase family member 3. (874 aa) |
| | DNASE1L2 | Deoxyribonuclease; Belongs to the DNase I family. (278 aa) |
| | NTHL1 | Endonuclease III-like protein 1; Bifunctional DNA N-glycosylase with associated apurinic/apyrimidinic (AP) lyase function that catalyzes the first step in base excision repair (BER), the primary repair pathway for the repair of oxidative DNA damage. The DNA N-glycosylase activity releases the damaged DNA base from DNA by cleaving the N-glycosidic bond, leaving an AP site. The AP lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination. Primarily recognizes and repairs oxidative base damage of pyrimidines. (304 aa) |
| | LOC112408989 | LOW QUALITY PROTEIN: uncharacterized protein LOC112408989. (714 aa) |
| | POLR3K | DNA-directed RNA polymerase subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family. (108 aa) |
| | DNASE1 | Deoxyribonuclease; Belongs to the DNase I family. (284 aa) |
| | ENPP1 | Ectonucleotide pyrophosphatase/phosphodiesterase family member 1. (857 aa) |
| | PIWIL1 | Piwi-like protein 1; Belongs to the argonaute family. (861 aa) |
| | DICER1 | Endoribonuclease Dicer isoform X1; Belongs to the helicase family. Dicer subfamily. (1921 aa) |
| | YBEY | Endoribonuclease YbeY isoform X1. (172 aa) |
| | RBBP8 | DNA endonuclease RBBP8 isoform X1. (889 aa) |
| | MEI4 | Meiosis-specific protein MEI4. (389 aa) |
| | RAD51C | DNA repair protein RAD51 homolog 3. (371 aa) |
| | LOC112407960 | LOW QUALITY PROTEIN: DNA endonuclease RBBP8-like. (968 aa) |
| | ZNF215 | Zinc finger protein 215. (529 aa) |
| | RNASEH1 | Ribonuclease H1; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids. (287 aa) |
| | ELAC1 | Zinc phosphodiesterase ELAC protein 1. (363 aa) |
| | DCLRE1A | DNA cross-link repair 1A protein isoform X1. (1052 aa) |
| | RIDA | 2-iminobutanoate/2-iminopropanoate deaminase. (137 aa) |
| | POP1 | Ribonucleases P/MRP protein subunit POP1. (1016 aa) |
| | LOC112407265 | Nuclease EXOG, mitochondrial. (368 aa) |
| | TREX2 | LOW QUALITY PROTEIN: three prime repair exonuclease 2. (218 aa) |
| | NOL9 | Polynucleotide 5'-hydroxyl-kinase NOL9. (690 aa) |
| | DROSHA | Ribonuclease 3 isoform X1. (1373 aa) |
| | PAN3 | PAN2-PAN3 deadenylation complex subunit PAN3; Regulatory subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in general and miRNA-mediated mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein (PABP). PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA deca [...] (740 aa) |
| | LOC112406152 | LOW QUALITY PROTEIN: uncharacterized protein LOC112406152. (980 aa) |
| | N4BP2L1 | NEDD4-binding protein 2-like 1 isoform X1. (242 aa) |
| | EXOSC8 | Exosome complex component RRP43. (276 aa) |
| | ZC3H12C | Probable ribonuclease ZC3H12C. (908 aa) |
| | CNOT6L | CCR4-NOT transcription complex subunit 6-like isoform X3. (577 aa) |
| | RAD1 | Cell cycle checkpoint protein RAD1. (279 aa) |
| | LOC112405917 | Uncharacterized protein LOC112405917 isoform X2. (584 aa) |
| | BIVM | Basic immunoglobulin-like variable motif-containing protein isoform X1. (504 aa) |
| | MGME1 | Mitochondrial genome maintenance exonuclease 1; Metal-dependent single-stranded DNA (ssDNA) exonuclease involved in mitochondrial genome maintenance. Has preference for 5'-3' exonuclease activity but is also capable of endoduclease activity on linear substrates. Necessary for maintenance of proper 7S DNA levels. Probably involved in mitochondrial DNA (mtDNA) repair, possibly via the processing of displaced DNA containing Okazaki fragments during RNA- primed DNA synthesis on the lagging strand or via processing of DNA flaps during long-patch base excision repair; Belongs to the MGME1 family. (410 aa) |
| | ERCC5 | DNA repair protein complementing XP-G cells isoform X1. (1199 aa) |
| | DIS3 | Exosome complex exonuclease RRP44 isoform X1; Belongs to the RNR ribonuclease family. (958 aa) |
| | PLD6 | Mitochondrial cardiolipin hydrolase. (243 aa) |
| | APTX | Aprataxin isoform X1. (355 aa) |
| | KHNYN | Protein KHNYN. (670 aa) |
| | NOP9 | Nucleolar protein 9. (634 aa) |
| | NYNRIN | Protein NYNRIN. (1882 aa) |
| | PNPT1 | Polyribonucleotide nucleotidyltransferase 1, mitochondrial. (784 aa) |
| | RAG1 | V(D)J recombination-activating protein 1; Catalytic component of the RAG complex, a multiprotein complex that mediates the DNA cleavage phase during V(D)J recombination. V(D)J recombination assembles a diverse repertoire of immunoglobulin and T-cell receptor genes in developing B and T- lymphocytes through rearrangement of different V (variable), in some cases D (diversity), and J (joining) gene segments. In the RAG complex, RAG1 mediates the DNA-binding to the conserved recombination signal sequences (RSS) and catalyzes the DNA cleavage activities by introducing a double-strand break [...] (1043 aa) |
| | ELAC2 | Zinc phosphodiesterase ELAC protein 2. (836 aa) |
| | TDP2 | tyrosyl-DNA phosphodiesterase 2 isoform X1. (384 aa) |
| | TREX1 | Three-prime repair exonuclease 1. (314 aa) |
| | LOC112403992 | Nucleoside diphosphate kinase. (152 aa) |
| | NUDT21 | Cleavage and polyadenylation specificity factor subunit 5; Component of the cleavage factor Im (CFIm) complex that functions as an activator of the pre-mRNA 3'-end cleavage and polyadenylation processing required for the maturation of pre-mRNA into functional mRNAs. CFIm contributes to the recruitment of multiprotein complexes on specific sequences on the pre-mRNA 3'-end, so called cleavage and polyadenylation signals (pA signals). Most pre-mRNAs contain multiple pA signals, resulting in alternative cleavage and polyadenylation (APA) producing mRNAs with variable 3'-end formation. The [...] (227 aa) |
| | ABT1 | Activator of basal transcription 1. (275 aa) |
| | REXO2 | Oligoribonuclease, mitochondrial. (237 aa) |
| | TATDN3 | Putative deoxyribonuclease TATDN3 isoform X1. (274 aa) |
| | SWT1 | Transcriptional protein SWT1 isoform X1. (909 aa) |
| | SPO11 | Meiotic recombination protein SPO11 isoform X1. (395 aa) |
| | OGG1 | N-glycosylase/DNA lyase isoform X1. (346 aa) |
| | ANGEL2 | Protein angel homolog 2 isoform X1. (544 aa) |
| | RPP38 | Ribonuclease P protein subunit p38. (281 aa) |
| | XRN2 | 5'-3' exoribonuclease; Possesses 5'->3' exoribonuclease activity. May promote termination of transcription by RNA polymerase II. (950 aa) |
| | DBR1 | Lariat debranching enzyme. (544 aa) |
| | G3BP1 | Ras GTPase-activating protein-binding protein 1. (465 aa) |
| | CNOT1 | CCR4-NOT transcription complex subunit 1 isoform X1. (2383 aa) |
| | RPS21 | 40S ribosomal protein S21; Belongs to the eukaryotic ribosomal protein eS21 family. (81 aa) |
| | HELZ2 | LOW QUALITY PROTEIN: helicase with zinc finger domain 2. (1880 aa) |
| | DCLRE1C | Protein artemis isoform X1. (709 aa) |
| | EXOSC10 | Exosome component 10 isoform X1. (957 aa) |
| | TUT1 | Speckle targeted PIP5K1A-regulated poly(A) polymerase. (872 aa) |
| | LOC112402704 | Uncharacterized protein LOC112402704 isoform X1. (373 aa) |
| | MUS81 | Crossover junction endonuclease MUS81 isoform X1. (551 aa) |
| | CPSF7 | Cleavage and polyadenylation specificity factor subunit 7 isoform X1. (471 aa) |
| | CUNH11orf80 | Type 2 DNA topoisomerase 6 subunit B-like isoform X1. (568 aa) |
| | ISG20L2 | Interferon-stimulated 20 kDa exonuclease-like 2 isoform X1. (348 aa) |
| | FEN1 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] (380 aa) |
| | PNLDC1 | poly(A)-specific ribonuclease PNLDC1. (531 aa) |
| | ZC3H12D | Probable ribonuclease ZC3H12D. (264 aa) |
| | RAD9A | Cell cycle checkpoint control protein; Belongs to the rad9 family. (420 aa) |
| | GEN1 | Flap endonuclease GEN homolog 1. (907 aa) |
| | PIWIL2 | Piwi-like protein 2 isoform X1; Belongs to the argonaute family. (971 aa) |
| | XRCC1 | DNA repair protein XRCC1. (600 aa) |
| | XRN1 | 5'-3' exoribonuclease 1. (1703 aa) |
| | POLD1 | DNA polymerase. (1107 aa) |
| | PLD3 | Phospholipase D3. (489 aa) |
| | ERCC1 | DNA excision repair protein ERCC-1 isoform X2. (432 aa) |
| | ERCC2 | General transcription and DNA repair factor IIH helicase subunit XPD isoform X1. (823 aa) |
| | DNASE2B | Deoxyribonuclease-2-beta isoform X1. (357 aa) |
| | TRIR | Telomerase RNA component interacting RNase. (178 aa) |
| | DNASE2 | Deoxyribonuclease-2-alpha. (352 aa) |
| | RNASEH2A | Ribonuclease; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids; Belongs to the RNase HII family. (297 aa) |
| | ANKLE1 | Ankyrin repeat and LEM domain-containing protein 1. (667 aa) |
| | APEX2 | DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends. (575 aa) |
| | HORMAD1 | HORMA domain-containing protein 1. (395 aa) |
| | POLG | LOW QUALITY PROTEIN: DNA polymerase subunit gamma-1. (1227 aa) |
| | TSNAX | Translin-associated protein X isoform X1. (290 aa) |
| | LOC112413557 | DNA replication ATP-dependent helicase/nuclease DNA2 isoform X3; Belongs to the mitochondrial carrier (TC 2.A.29) family. (1316 aa) |
| | EXOSC7 | Exosome complex component RRP42. (291 aa) |
| | ZNRD1 | DNA-directed RNA polymerase subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family. (123 aa) |
| | WRN | Werner syndrome ATP-dependent helicase isoform X1. (1445 aa) |
| | ERI1 | 3'-5' exoribonuclease 1 isoform X1. (349 aa) |
| | ZRANB3 | DNA annealing helicase and endonuclease ZRANB3 isoform X1. (1078 aa) |
| | CNOT6 | CCR4-NOT transcription complex subunit 6 isoform X1. (557 aa) |
| | DCLRE1B | 5' exonuclease Apollo. (539 aa) |
| | PARN | poly(A)-specific ribonuclease PARN isoform X1. (638 aa) |
| | RNASET2 | Ribonuclease T2 isoform X1; Belongs to the RNase T2 family. (248 aa) |
| | POP7 | Ribonuclease P protein subunit p20; Component of ribonuclease P, a ribonucleoprotein complex that generates mature tRNA molecules by cleaving their 5'-ends. Also a component of the MRP ribonuclease complex, which cleaves pre-rRNA sequences; Belongs to the histone-like Alba family. (140 aa) |
| | EXOSC9 | Exosome complex component RRP45. (439 aa) |
| | ERN2 | Serine/threonine-protein kinase/endoribonuclease IRE2 isoform X1. (927 aa) |
| | ERCC4 | DNA repair endonuclease XPF. (916 aa) |
| | KRI1 | Protein KRI1 homolog isoform X1. (703 aa) |
| | TOE1 | Target of EGR1 protein 1 isoform X1. (510 aa) |
| | DNASE1L1 | Deoxyribonuclease; Belongs to the DNase I family. (317 aa) |
| | NOCT | Nocturnin. (362 aa) |
| | MBLAC1 | Metallo-beta-lactamase domain-containing protein 1. (271 aa) |
| | DNASE1L3 | Deoxyribonuclease; Belongs to the DNase I family. (303 aa) |
| | ENDOD1 | Endonuclease domain-containing 1 protein. (500 aa) |
| | RNASEK | Ribonuclease kappa. (98 aa) |
| | N4BP2 | NEDD4-binding protein 2 isoform X1. (1766 aa) |
| | MRE11 | Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (707 aa) |
| | ISG20 | Interferon-stimulated gene 20 kDa protein. (171 aa) |
| | AEN | Apoptosis-enhancing nuclease. (316 aa) |
| | RNASEL | 2-5A-dependent ribonuclease isoform X1. (736 aa) |
| | LOC112391704 | LOW QUALITY PROTEIN: ras GTPase-activating protein-binding protein 1-like. (470 aa) |
| | EXD1 | piRNA biogenesis protein EXD1 isoform X1. (588 aa) |
| | ANKRD31 | LOW QUALITY PROTEIN: putative ankyrin repeat domain-containing protein 31. (1858 aa) |
| | EDC4 | Enhancer of mRNA-decapping protein 4 isoform X1. (1401 aa) |
| | LOC112392125 | Endonuclease V-like. (244 aa) |
| | POP4 | Ribonuclease P protein subunit p29; Component of ribonuclease P, a ribonucleoprotein complex that generates mature tRNA molecules by cleaving their 5'-ends. (220 aa) |
| | NCBP1 | Nuclear cap-binding protein subunit 1. (790 aa) |
| | DCP1B | mRNA-decapping enzyme 1B isoform X1. (550 aa) |
| | RCL1 | RNA 3'-terminal phosphate cyclase-like protein. (373 aa) |
| | EXOSC3 | Exosome complex component RRP40 isoform X1. (275 aa) |
| | POLR2I | DNA-directed RNA polymerase subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family. (125 aa) |
| | ATAD5 | ATPase family AAA domain-containing protein 5. (1898 aa) |
| | XPA | DNA repair protein complementing XP-A cells. (273 aa) |
| | TATDN2 | Putative deoxyribonuclease TATDN2. (733 aa) |
| | ASTE1 | Protein asteroid homolog 1 isoform X1. (676 aa) |
| | RAD50 | DNA repair protein RAD50 isoform X1. (1312 aa) |
| | N4BP1 | NEDD4-binding protein 1. (897 aa) |
| | DDX1 | ATP-dependent RNA helicase DDX1. (740 aa) |
| | FIP1L1 | pre-mRNA 3'-end-processing factor FIP1 isoform X1. (604 aa) |
| | RPP14 | Ribonuclease P protein subunit p14. (124 aa) |
| | PDE12 | 2',5'-phosphodiesterase 12. (609 aa) |
| | DCP1A | mRNA-decapping enzyme 1A isoform X1. (579 aa) |
| | NHP2 | Ribonucloprotein; Common component of the spliceosome and rRNA processing machinery; Belongs to the eukaryotic ribosomal protein eL8 family. (153 aa) |
| | CSTF2 | Cleavage stimulation factor subunit 2 isoform X1. (577 aa) |
| | TSN | Translin isoform X1. (228 aa) |
| | DIS3L | DIS3-like exonuclease 1 isoform X1; Belongs to the RNR ribonuclease family. (990 aa) |
| | CPSF2 | Cleavage and polyadenylation specificity factor subunit 2. (782 aa) |
| | TDP1 | tyrosyl-DNA phosphodiesterase 1 isoform X1. (603 aa) |
| | PAN2 | PAN2-PAN3 deadenylation complex catalytic subunit PAN2; Catalytic subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in general and miRNA-mediated mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein (PABP). PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent [...] (1202 aa) |
| | CPSF6 | Cleavage and polyadenylation specificity factor subunit 6 isoform X1. (537 aa) |
| | ENDOU | poly(U)-specific endoribonuclease. (413 aa) |
| | SMG6 | Telomerase-binding protein EST1A isoform X2. (1411 aa) |
| | TSR1 | pre-rRNA-processing protein TSR1 homolog isoform X1. (804 aa) |
| | CUNH12orf10 | UPF0160 protein MYG1, mitochondrial. (382 aa) |
| | ERCC3 | General transcription and DNA repair factor IIH helicase subunit XPB isoform X1. (782 aa) |
| | CNOT2 | CCR4-NOT transcription complex subunit 2 isoform X1. (550 aa) |
| | TTC38 | Tetratricopeptide repeat protein 38 isoform X1. (469 aa) |
| | CCDC36 | Interactor of HORMAD1 protein 1. (593 aa) |
| | RPP40 | Ribonuclease P protein subunit p40 isoform X1. (383 aa) |
| | RPP21 | Ribonuclease P protein subunit p21 isoform X1. (154 aa) |
| | SLFNL1 | Schlafen-like protein 1. (514 aa) |
| | AGO3 | Protein argonaute-3; Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs. (860 aa) |
| | CPSF3 | Cleavage and polyadenylation specificity factor subunit 3 isoform X1. (684 aa) |
| | DXO | Decapping and exoribonuclease protein. (397 aa) |
| | ANGEL1 | Protein angel homolog 1. (668 aa) |
| | LACTB2 | Endoribonuclease LACTB2. (288 aa) |
| | ZC3H12A | Endoribonuclease ZC3H12A. (583 aa) |
| | LAS1L | Ribosomal biogenesis protein LAS1L isoform X1. (757 aa) |
| | RPP30 | Ribonuclease P protein subunit p30. (268 aa) |
| | EXD2 | Exonuclease 3'-5' domain-containing protein 2. (623 aa) |
| | AGO4 | Protein argonaute-4; Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs. (794 aa) |
| | ZC3H12B | Probable ribonuclease ZC3H12B. (694 aa) |
| | EXO5 | Exonuclease V. (370 aa) |
| | DIS3L2 | DIS3-like exonuclease 2; 3'-5'-exoribonuclease that specifically recognizes RNAs polyuridylated at their 3' end and mediates their degradation. Component of an exosome-independent RNA degradation pathway that mediates degradation of both mRNAs and miRNAs that have been polyuridylated by a terminal uridylyltransferase, such as ZCCHC11/TUT4. Mediates degradation of cytoplasmic mRNAs that have been deadenylated and subsequently uridylated at their 3'. Mediates degradation of uridylated pre-let-7 miRNAs, contributing to the maintenance of embryonic stem (ES) cells. Essential for correct mi [...] (930 aa) |
| | POLE | DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (2279 aa) |
| | CPSF4 | Cleavage and polyadenylation specificity factor subunit 4 isoform X1. (323 aa) |
| | NUDT12 | Peroxisomal NADH pyrophosphatase NUDT12. (465 aa) |
| | AGO2 | Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...] (865 aa) |
| | REXO1 | RNA exonuclease 1 homolog. (1284 aa) |
| | BOP1 | Ribosome biogenesis protein BOP1; Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome. (708 aa) |
| | EXOSC4 | Exosome complex component RRP41. (245 aa) |
| | TSEN2 | tRNA-splicing endonuclease subunit Sen2 isoform X1. (501 aa) |
| | PELO | Protein pelota homolog; May function in recognizing stalled ribosomes and triggering endonucleolytic cleavage of the mRNA, a mechanism to release non- functional ribosomes and degrade damaged mRNAs. (385 aa) |
| | ENPP2 | LOW QUALITY PROTEIN: ectonucleotide pyrophosphatase/phosphodiesterase family member 2. (955 aa) |
| | EXO1 | Exonuclease 1 isoform X1. (835 aa) |
| | POP5 | Ribonuclease P/MRP protein subunit POP5; Component of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends. (170 aa) |
| | TATDN1 | Putative deoxyribonuclease TATDN1 isoform X1. (343 aa) |
| | UTP23 | rRNA-processing protein UTP23 homolog. (248 aa) |
| | PIWIL3 | LOW QUALITY PROTEIN: piwi-like protein 3; Belongs to the argonaute family. (672 aa) |
| | APLF | Aprataxin and PNK-like factor isoform X1. (511 aa) |
| | FAN1 | Fanconi-associated nuclease; Nuclease required for the repair of DNA interstrand cross- links (ICL). Acts as a 5'-3' exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to excise an ICL from one strand through flanking incisions. Belongs to the FAN1 family. (1024 aa) |
| | SAMHD1 | Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 isoform X1. (628 aa) |
| | RRS1 | Ribosome biogenesis regulatory protein; Involved in ribosomal large subunit assembly. Belongs to the RRS1 family. (376 aa) |
| | TSEN34 | tRNA-splicing endonuclease subunit Sen34; Constitutes one of the two catalytic subunit of the tRNA- splicing endonuclease complex, a complex responsible for identification and cleavage of the splice sites in pre-tRNA. It cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3'-cyclic phosphate and 5'-OH termini. There are no conserved sequences at the splice sites, but the intron is invariably located at the same site in the gene, placing the splice sites an invariant distance from the constant structura [...] (338 aa) |
| | EME1 | Crossover junction endonuclease EME1 isoform X1. (576 aa) |
| | DCP2 | m7GpppN-mRNA hydrolase isoform X1. (452 aa) |
| | ERI2 | ERI1 exoribonuclease 2 isoform X1. (710 aa) |
| | FANCM | Fanconi anemia group M protein isoform X1. (2057 aa) |
| | REXO5 | RNA exonuclease 5. (772 aa) |
| | SLX1A | Structure-specific endonuclease subunit SLX1; Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. Has a preference for 5'-flap structures, and promotes symmetrical cleavage of static and migrating Holliday junctions (HJs). Resolves HJs by generating two pairs of ligatable, nicked duplex products. (271 aa) |
| | MARF1 | Meiosis regulator and mRNA stability factor 1 isoform X1. (1742 aa) |
| | CSTF2T | Cleavage stimulation factor subunit 2 tau variant. (626 aa) |
| | BMS1 | Ribosome biogenesis protein BMS1 homolog. (1284 aa) |
| | PCF11 | pre-mRNA cleavage complex 2 protein Pcf11 isoform X1. (1686 aa) |
| | MRPL44 | 39S ribosomal protein L44, mitochondrial. (332 aa) |
| | NOB1 | RNA-binding protein NOB1; May play a role in mRNA degradation. Belongs to the NOB1 family. (421 aa) |
| | SND1 | Staphylococcal nuclease domain-containing protein; Endonuclease that mediates miRNA decay of both protein-free and AGO2-loaded miRNAs. (910 aa) |
| | ENDOG | Endonuclease. (303 aa) |
| | REXO4 | LOW QUALITY PROTEIN: RNA exonuclease 4. (595 aa) |
| | EXOSC2 | Exosome complex component RRP4. (293 aa) |
| | EXD3 | Exonuclease mut-7 homolog isoform X1. (930 aa) |
