STRINGSTRING
RFFL RFFL BIRC6 BIRC6 FGG FGG FGB FGB IGF1 IGF1 TERT TERT ITGA6 ITGA6 LGALS3 LGALS3 TGFBR1 TGFBR1 NOL3 NOL3 BMP4 BMP4 ITPRIP ITPRIP FAIM2 FAIM2 COL2A1 COL2A1 RIPK1 RIPK1 EYA1 EYA1 UNC5B UNC5B LOC112396076 LOC112396076 FGF10 FGF10 CSF2 CSF2 BRCA1 BRCA1 RB1CC1 RB1CC1 ZMYND11 ZMYND11 LOC112398198 LOC112398198 SRC SRC IL1B IL1B HMOX1 HMOX1 PSME3 PSME3 ITPRIPL2 ITPRIPL2 HTT HTT LOC112400428 LOC112400428 EYA2 EYA2 PELI3 PELI3 LMNA LMNA PARK7 PARK7 RELA RELA SH3RF1 SH3RF1 IL19 IL19 FAIM FAIM GCLM GCLM PEA15 PEA15 ITGAV ITGAV IL7 IL7 AR AR CTNNA1 CTNNA1 HGF HGF MAPK7 MAPK7 GFRAL GFRAL BCL2 BCL2 GDNF GDNF RAF1 RAF1 STRADB STRADB CFLAR CFLAR LOC112407979 LOC112407979 RPS6KB1 RPS6KB1 PHIP PHIP LOC112407988 LOC112407988 RNF34 RNF34 EYA4 EYA4 TNFAIP3 TNFAIP3 DDX3X DDX3X YAP1 YAP1 TMBIM1 TMBIM1 SCG2 SCG2 ZC3HC1 ZC3HC1 PAK5 PAK5 EYA3 EYA3 SIAH2 SIAH2 GSK3B GSK3B GATA1 GATA1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
RFFLE3 ubiquitin-protein ligase rififylin isoform X1. (393 aa)
BIRC6LOW QUALITY PROTEIN: baculoviral IAP repeat-containing protein 6. (4870 aa)
FGGFibrinogen gamma chain isoform X1. (445 aa)
FGBFibrinogen beta chain isoform X1. (495 aa)
IGF1Insulin-like growth factor I isoform X1. (208 aa)
TERTTelomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA-dependent extension of 3'-chromosomal termini with the 6-nuc [...] (1136 aa)
ITGA6Integrin alpha-6 isoform X2; Belongs to the integrin alpha chain family. (977 aa)
LGALS3Galectin. (256 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (438 aa)
NOL3Nucleolar protein 3. (202 aa)
BMP4Bone morphogenetic protein 4 isoform X1. (420 aa)
ITPRIPInositol 1,4,5-trisphosphate receptor-interacting protein. (556 aa)
FAIM2Protein lifeguard 2; Belongs to the BI1 family. (316 aa)
COL2A1Collagen alpha-1(II) chain. (1487 aa)
RIPK1Receptor-interacting serine/threonine-protein kinase 1. (667 aa)
EYA1Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (589 aa)
UNC5BNetrin receptor UNC5B. (945 aa)
LOC112396076ATP-dependent RNA helicase DDX3X-like; Belongs to the DEAD box helicase family. (656 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
CSF2Granulocyte-macrophage colony-stimulating factor. (134 aa)
BRCA1Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...] (1870 aa)
RB1CC1RB1-inducible coiled-coil protein 1 isoform X1. (1658 aa)
ZMYND11Zinc finger MYND domain-containing protein 11 isoform X1. (617 aa)
LOC112398198Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (490 aa)
SRCTyrosine-protein kinase. (601 aa)
IL1BMultifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (266 aa)
HMOX1Heme oxygenase; Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase. (288 aa)
PSME3Proteasome activator complex subunit 3 isoform X1. (265 aa)
ITPRIPL2Inositol 1,4,5-trisphosphate receptor-interacting protein-like 2. (532 aa)
HTTHuntingtin. (3165 aa)
LOC112400428LOW QUALITY PROTEIN: catenin alpha-1-like. (875 aa)
EYA2Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (537 aa)
PELI3E3 ubiquitin-protein ligase pellino homolog; E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. (469 aa)
LMNALamin; Belongs to the intermediate filament family. (664 aa)
PARK7Protein/nucleic acid deglycase DJ-1. (189 aa)
RELATranscription factor p65. (562 aa)
SH3RF1E3 ubiquitin-protein ligase SH3RF1. (712 aa)
IL19Interleukin-19. (177 aa)
FAIMFas apoptotic inhibitory molecule 1. (179 aa)
GCLMGlutamate--cysteine ligase regulatory subunit. (363 aa)
PEA15Astrocytic phosphoprotein PEA-15. (130 aa)
ITGAVIntegrin alpha-V; Belongs to the integrin alpha chain family. (985 aa)
IL7Interleukin-7 isoform X1. (226 aa)
ARAndrogen receptor isoform X1. (893 aa)
CTNNA1Catenin alpha-1. (906 aa)
HGFHepatocyte growth factor isoform X1; Belongs to the peptidase S1 family. (734 aa)
MAPK7Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (732 aa)
GFRALLOW QUALITY PROTEIN: GDNF family receptor alpha-like. (397 aa)
BCL2Apoptosis regulator Bcl-2 isoform X1. (233 aa)
GDNFGlial cell line-derived neurotrophic factor isoform X1. (211 aa)
RAF1RAF proto-oncogene serine/threonine-protein kinase isoform X1. (648 aa)
STRADBSTE20-related kinase adapter protein beta isoform X1. (418 aa)
CFLARCASP8 and FADD-like apoptosis regulator isoform X1; Belongs to the peptidase C14A family. (532 aa)
LOC112407979Secreted frizzled-related protein 2-like. (105 aa)
RPS6KB1Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (525 aa)
PHIPPH-interacting protein. (1650 aa)
LOC112407988Secreted frizzled-related protein 2. (294 aa)
RNF34E3 ubiquitin-protein ligase RNF34. (376 aa)
EYA4Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (639 aa)
TNFAIP3Tumor necrosis factor alpha-induced protein 3. (785 aa)
DDX3XATP-dependent RNA helicase DDX3X isoform X1; Belongs to the DEAD box helicase family. (662 aa)
YAP1Transcriptional coactivator YAP1. (416 aa)
TMBIM1Protein lifeguard 3; Belongs to the BI1 family. (308 aa)
SCG2Secretogranin-2. (616 aa)
ZC3HC1Nuclear-interacting partner of ALK isoform X1. (513 aa)
PAK5Non-specific serine/threonine protein kinase. (719 aa)
EYA3Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (573 aa)
SIAH2E3 ubiquitin-protein ligase; E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. (198 aa)
GSK3BGlycogen synthase kinase-3 beta isoform X1; Belongs to the protein kinase superfamily. (433 aa)
GATA1Erythroid transcription factor. (413 aa)
Your Current Organism:
Neophocaena asiaeorientalis
NCBI taxonomy Id: 1706337
Other names: N. asiaeorientalis asiaeorientalis, Neophocaena asiaeorientalis asiaeorientalis, Yangtze finless porpoise
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